WO2008041608A1

WO2008041608A1 - Skin external preparation and hair-care product

Info

Publication number: WO2008041608A1
Application number: PCT/JP2007/068838
Authority: WO
Inventors: Motohide Matsui
Original assignee: Yugen Gaisha Matsui
Priority date: 2006-09-28
Filing date: 2007-09-27
Publication date: 2008-04-10
Also published as: JP4857347B2; JPWO2008041608A1

Abstract

It is intended to provide a skin external preparation which can exert an excellent effect of improving skin symptoms because of containing molybdenum and a hair-care product which can exert an excellent hair-growing or hair-nourishing effect because of containing molybdenum or iron. By using molybdenum in a skin external preparation, skin symptoms such as chapped skin, spots, acne, pimples, atopic dermatitis and athlete's foot can be improved owing to the function of molybdenum. Since molybdenum is an inorganic substance having a high stability, the production process and the storage stability can be easily managed and the qualities of the product can be easily maintained.

Description

Specification

Skin preparations and hair preparations

Technical field

TECHNICAL FIELD [0001] The present invention relates to a skin external preparation applied to the skin and a hair preparation that promotes hair growth and hair growth, and in particular, by containing molybdenum, it can provide an excellent skin symptom improving effect. The present invention relates to a hair preparation that can obtain an excellent hair growth or hair growth effect by containing an agent and molybdenum or iron.

Background art

[0002] Various skin symptoms, rough skin, spots, acne, pimples, atopic dermatitis, and athlete's foot are caused by various factors such as social environment, stress, aging, internal and external environmental changes, and constitution. . For the purpose of preventing or ameliorating such skin symptoms, whitening agents, antioxidants, anti-inflammatory agents, cell activators, blood circulation promoters, moisturizers, antibacterial agents, UV protection agents, skin quality improving agents, wrinkle improving agents, wrinkles Skin external preparations containing preventive agents and the like are widely marketed.

[0003] For example, in the topical skin preparation for the purpose of preventing or improving stain improvement, a substance having a whitening effect, that is, a substance that suppresses melanin production is mainly used. Kojic acid, vitamin C and Those containing derivatives, cysteine and the like and those containing hydroquinone are known (see Patent Document 1).

[0004] Also, millet refers to a superficial chronic inflammatory condition that occurs in the pores of the skin, the follicular sebaceous system, and one of the causes is propionic bacteria that is resident in the skin. Knes (Propionibacterium acnes) is thought to be involved. Propione butter mucnes are present in the pores of the skin and break down lipids (sebum) to produce free fatty acids. This free fatty acid is known to have comedone-forming action and inflammation-inducing action. Conventionally, as an anti-acne agent, an external preparation for skin having an antibacterial action against propionobacterial acnes, a sebum secretion inhibiting action, and a keratolytic action has been widely used (see Patent Document 2).

[0005] Furthermore, for atopic dermatitis, an external preparation for skin consisting of corticosteroids has been used (see Patent Document 3). In addition, the skin called atopic dermatitis and sensitive skin It is intended to prevent and ameliorate skin problems caused by chronic hypodermis function such as dryness, roughness, strength, quickness, eczema, scales, and irritability. , Amino acid derivatives, heparin-like substances, compounds such as vitamin E, plant extracts, and other skin external preparations have been proposed, including ingredients that are considered to have a moisturizing effect! (Patent Documents 4-8) reference).

[0006] In addition, for athlete's foot (mycosis) caused by ringworm, chloronazole hydrochloride, benzoquinone derivatives, polyene macrolide and azole antibacterial agents, and cefme antibiotics are antibacterial agents. Formulated skin external preparations are widely known. In addition, various kinds of staphylococcus aureus (staphylococci, streptococci), which are the causative bacteria of staphylococcus, which are the causative bacteria of skin infections due to breakthrough from breakthroughs and atopic dermatitis Antibiotics are blended into topical skin preparations as antibacterial agents and used for their treatment.

[0007] Furthermore, in recent years, the social environment, stress, dietary habits, and the like have contributed to an increasing number of people who suffer from thinning hair, hair loss, and hair loss. There are a large number of commercially available hair preparations that contain various herbal medicines and drugs that improve such thinning, hair loss and hair loss, and prevent or treat them.

[0008] As an example of an active ingredient having a hair-growth effect and a hair growth effect contained in a hair material, minoxidil known to have a vasodilatory action by an ATP-dependent potassium channel opening action is known (Patent Literature). 9). In addition, as active ingredients expected to have a hair-growth effect, blood pepper promoting substances such as red pepper tincture, assembly extract, ginseng extract and nicotine derivatives, female hormone agents such as estradiol, keratolytic agents such as salicylic acid and resorcin Anti-inflammatory agents such as glycyrrhetinic acid and sicon extract are known. In addition, many plant extracts, crude drugs, and synthetic chemicals have been proposed as hair restorers (see Patent Documents 10 and 11).

Patent Document 1: Japanese Patent Laid-Open No. 58-154507

Patent Document 2: Japanese Patent Laid-Open No. 2005-289876

Patent Document 3: Japanese Patent Laid-Open No. 9157171

Patent Document 4: Japanese Patent Laid-Open No. 61-30567

Patent Document 5: JP-A-11 302155

Patent Document 6: Japanese Unexamined Patent Publication No. 2000-143486 Patent Document 7: Japanese Unexamined Patent Publication No. 2000-302660

Patent Document 8: Japanese Patent Laid-Open No. 2002-293735

Patent Document 9: US Patent No. 4139619

Patent Document 10: Reissue 2004/084848

Patent Document 11: U.S. Pat.No. 4,139,619

Disclosure of the invention

Problems to be solved by the invention

[0009] However, in the topical skin preparations that have been said to have a whitening action so far, among those formulated as a whitening action substance, the effect of suppressing tyrosinase activity is extremely slow except for hydroquinone. However, there was a problem that the effect of improving skin pigmentation was not sufficient. On the other hand, hydroquinone is limited in its general use because of its power sensitization effect.

[0010] In addition, there is a problem that many existing external preparations for treating acne have many side effects. For example, female hormones having a sebum secretion-inhibiting action, and antibiotics such as erythromycin and tetracycline having an antibacterial action are known to cause gastrointestinal disorders. In addition, iow, camphor, sulfa drugs, etc., which have a keratolytic action, have a problem in that the irritation to the skin around the affected area due to repeated application becomes intense.

[0011] Further, the adrenal cortex hormone used for atopic dermatitis has a problem that a great effect can be expected, but side effects occur and the skin becomes keloid. In addition, the ingredients disclosed in Patent Documents 3 to 8 above have an effect of improving skin symptoms such as atopic dermatitis and sensitive skin to some extent, but the stratum corneum softening action, barrier function recovery, moisture The holding action was not always satisfactory (Allergi, Vol. 52, No. 12, 1101-1103, 2003).

[0012] In addition, antibacterial agents used against ringworm, Staphylococcus aureus, and Pseudomonas aeruginosa have problems such as skin irritation, discomfort, and appearance of resistant bacteria. However, because fungi are the same eukaryotes as higher organisms, the development of antifungal agents with excellent toxicity and low toxicity, low side effects, and therapeutic effects is difficult, except for antibiotics that are particularly effective. It became difficult to develop!

[0013] In addition, hair preparations that have been proposed as hair growth agents and hair growth agents so far have few or no significant hair growth effects and hair growth effects. There was a problem that individual differences were large. Therefore, the development of new hair growth agents and hair growth agents that are highly effective is required.

[0014] Furthermore, since active ingredients used in many conventional skin external preparations or many commercially available hair restorers and hair growth agents are organic compounds, they may become unstable depending on the environment. However, there was a problem that attention had to be paid to the manufacturing process and storage stability management (quality maintenance).

[0015] The present invention has been made in order to solve the above-described problems, and by containing molybdenum, a skin external preparation capable of obtaining an excellent skin symptom improvement effect, and containing molybdenum or iron The purpose of the present invention is to provide a hair preparation that can provide an excellent hair growth or hair growth effect!

Means for solving the problem

[0016] In order to achieve this object, the external preparation for skin according to claim 1 contains molybdenum.

[0017] The external preparation for skin according to claim 2 is the external preparation for skin according to claim 1, containing red porcelain clay, which is a composition containing molybdenum.

[0018] The skin external preparation according to claim 3 is the skin external preparation according to claim 1 or 2, further containing clay.

[0019] The skin external preparation according to claim 4 contains the liquid substance having fluidity in the skin external preparation according to any one of claims 1 to 3, and molybdenum is a simple substance or a compound. It is formed into a powder, and is formed into one of a suspension, gel, cream, and paste by mixing the liquid substance and powder.

[0020] The skin external preparation according to claim 5 is the same as the skin external preparation according to claim 4, and the liquid substance is acidic having a pH value of about 2 to about 5.

[0021] The hair preparation according to claim 6 is a hair preparation that promotes hair growth or hair growth, and contains molybdenum. [0022] The hair preparation according to claim 7 is the hair preparation according to claim 6, further comprising iron.

[0023] The hair preparation according to claim 8 is a hair preparation that promotes hair growth, and is characterized by containing iron.

[0024] A hair preparation according to claim 9 is the hair preparation according to any one of claims 6 to 8, and contains red porcelain clay, which is a composition containing molybdenum and iron. And

[0025] The hair preparation according to claim 10 is the hair preparation according to any one of claims 6 to 9, and further contains clay.

[0026] A hair preparation according to claim 11 is the hair preparation according to any one of claims 6 to 10, which contains a fluid substance having fluidity, and molybdenum or iron is a simple substance or a compound. Is formed into a powder form, and is characterized in that it is formed into any one of suspension, gel, cream and paste by mixing the liquid substance and powder.

[0027] The hair preparation according to claim 12 is the hair preparation according to claim 11, wherein the liquid substance is acidic having a pH value of about 2 to about 5.

The invention's effect

[0028] According to the external preparation for skin according to claim 1, since it contains molybdenum, the action of the molybdenum can improve rough skin, spots, acne, pimples, atopic dermatitis, and skin symptoms of athlete's foot. There is an effect that can be done. In addition, since molybdenum is a stable inorganic substance, it has good chemical stability against environmental changes. Therefore, compared to organic active ingredients that prevent or ameliorate skin symptoms used in general topical skin preparations, it is easier to manage manufacturing processes and storage stability that are less prone to degradation and denaturation. In addition, the quality can be easily maintained.

[0029] According to the external preparation for skin according to claim 2, in addition to the effect of the external preparation for skin according to claim 1, it contains red porcelain clay, which is a composition containing molybdenum. Red porcelain clay is a naturally calculated mineral mainly composed of ferric oxide and contains a small amount of molybdenum. For this reason, it is possible to produce a skin external preparation that can improve rough skin, spots, acne, pimples, atopic dermatitis, and skin symptoms of athlete's foot by simply using the produced red clay. For this reason, complex chemical synthesis processes for obtaining active ingredients that improve the above-mentioned skin symptoms, There is an effect that the extraction process of the active ingredient from the material can be omitted and the manufacturing process can be simplified.

[0030] According to the external preparation for skin according to claim 3, in addition to the effect exhibited by the external preparation for skin according to claim 1 or 2, it further contains clay, so that it provides a cleaning effect due to the adsorption action of clay. If you can power S! When washing and / or flowing the external preparation for skin applied to the user, the dirt component of the skin can be removed by the adsorption action of the contained clay. For this reason, it is possible to give the user a good feeling of use and to remove dirt on the skin such as pore dirt and sebum secretion, and to further improve the function of improving skin symptoms. There is.

[0031] In particular, in the case of a skin external preparation subordinate to claim 2, if the skin external preparation is removed from the application portion, the skin may be peeled by the action of clay. Since the red porcelain clay on the skin is also removed, the power S can be used to suppress the occurrence of coloring even if it contains red porcelain clay.

[0032] According to the external preparation for skin according to claim 4, in addition to the effect exhibited by the external preparation for skin according to any one of claims 1 to 3, molybdenum is obtained by molding a simple substance or a compound into powder. Yes, it is formed into a dosage form of suspension, gel, cream, or paste by mixing such powder and liquid substance, so the molybdenum powder is scattered and the external preparation for skin is removed from the application site. the can be suppressed, an effect force ^s that it is possible to improve the handling property at the time of use.

[0033] According to the external preparation for skin according to claim 5, in addition to the effect exhibited by the external preparation for skin according to claim 4, the liquid substance is acidic with a pH value of about 2 to about 5, so There is an effect that can be suppressed. In addition, when applied to the human body, it is possible to maintain a good pH balance of the human skin, which is weakly acidic, and to suppress the occurrence of troubles such as rough skin for the user!

[0034] According to the hair preparation of claim 6, since molybdenum is contained, hair growth can be promoted by the action of the molybdenum. Molybdenum is a stable inorganic substance, so it has good chemical stability against environmental changes. For this reason, compared with the active ingredient of the organic substance which has the hair growth and the hair growth effect used for a general hair material, deterioration and In addition to facilitating the management of the manufacturing process and storage stability where denaturation is unlikely to occur, the quality can be easily maintained.

[0035] According to the hair preparation according to claim 7, in addition to the effect exhibited by the hair preparation according to claim 6, the hair preparation further contains iron, so that the effect of the iron can promote hair growth. is there. Furthermore, coupled with the hair growth promoting effect of molybdenum, there is an effect that the user can realize the effect of improving hair loss more effectively. In addition, iron is an inexpensive metal that is generally commercially available and can be supplied stably. Furthermore, many of the compounds are easily available because their supply forms have been established. Therefore, the use of iron as an active ingredient for hair growth has the effect of making it easy to secure raw materials.

[0036] According to the hair preparation of claim 8, since iron is contained, hair growth can be promoted by the action of the iron. Iron is a cheap metal that is generally available on the market and can be supplied stably. Furthermore, many of the compounds are readily available because their supply forms have been established. Therefore, by using iron as an active ingredient for hair growth, there is an effect that securing of raw materials can be facilitated.

[0037] According to the hair preparation described in claim 9, in addition to the effect of the hair preparation described in any one of claims 6 to 8, it contains red porcelain clay, which is a composition containing molybdenum and iron. Red porcelain clay is a naturally calculated mineral mainly composed of ferric oxide and contains a small amount of molybdenum. Therefore, it is possible to produce a hair material that promotes hair growth and hair growth simply by using the produced red porcelain clay. This eliminates the need for complicated chemical synthesis processes for obtaining active ingredients that promote hair growth and hair growth, and the extraction process of active ingredients from raw materials, thus simplifying the production process. .

[0038] In addition, when manufacturing hair containing both components of molybdenum and iron! / Because both components are contained in red porcelain clay, molybdenum and iron are blended separately. There is an effect that process management and raw material management can be facilitated without the need for management.

[0039] According to the hair preparation according to claim 10, in addition to the effect of the hair preparation according to any one of claims 6 to 9, since the clay further contains clay, a cleaning effect by the adsorption action of clay is imparted. If you can do S! When washing or flowing hair applied to the user, the dirt component of the skin can be removed by the adsorption action of the contained clay. others Therefore, it is possible to give a good feeling to the user, and it is effective in preventing and treating hair loss caused by pore dirt.

[0040] In particular, in the hair material subordinate to claim 9, there is a concern about the coloring of the application part by red porcelain clay. Since red porcelain clay is also removed, the occurrence of coloring can be suppressed even if it contains red porcelain clay.

[0041] According to the hair preparation according to claim 11, in addition to the effect exhibited by the hair preparation according to any of claims 6 to 10, molybdenum or iron is obtained by molding a simple substance or a compound into powder. In addition, the powder and liquid substance are mixed to form a suspension, gel, cream, or paste dosage form, which prevents powder scattering and hair loss from the application site. It is possible to improve the handleability during use.

[0042] According to the hair preparation according to claim 12, in addition to the effect exhibited by the hair preparation according to claim 11, the liquid substance is acidic with a pH value of about 2 to about 5 and therefore suppresses the propagation of miscellaneous bacteria. There is an effect that can be done. In addition, when applied to the human body, it is possible to maintain a good pH balance of the human skin, which is weakly acidic, and to prevent troubles such as rough skin for the user from occurring! .

Brief Description of Drawings

[0043] FIG. 1 is a diagram showing a hair growth state when a hair material prepared by the formulation of Example 14 shown in Table 4 is applied.

BEST MODE FOR CARRYING OUT THE INVENTION

[0044] Hereinafter, the present invention will be described in detail. Molybdenum used in the present invention is composed of a simple substance or a compound and is a known substance. As a method for obtaining the product, a commercially available product may be used, or purification and production may be performed based on a known method.

Examples of the molybdenum compound include molybdenum dioxide, molybdenum trioxide, molybdenum pentachloride, ammonium heptamolybdate, molybdenum boride, molybdenum carbide, dimolybdenum carbide, molybdenum disulfide, molybdenum selenide, molybdenum silicide, and tellurium. Examples thereof include inorganic compounds such as molybdenum, molybdenum nitride, and molybdic acid, and organic metal compounds such as pentaethoxymolybdenum.

[0046] Among these compounds, a single compound may be blended, or two or more may be combined. You may join yourself. Furthermore, you may mix | blend in combination with a molybdenum simple substance.

In addition, as the molybdenum used in the present invention, not only a pure simple substance or compound but also a composition containing molybdenum (molybdenum simple substance or molybdenum compound) may be used! /. That is, natural minerals containing molybdenum and mixtures thereof can be used as they are for the external preparation for skin and hair preparations. If necessary, for example, it may be subjected to a purification step in the state of a composition containing molybdenum in order to remove heavy metals and unnecessary materials.

[0048] Examples of the power and composition include, for example, red porcelain clay, which is a natural mineral, molybdenum lead steel, molybdenite steel, which is a molybdenum ore, and mixtures of such natural minerals (for example, red clay (Towa Co., Ltd., The same applies to the following)), and further, alloys including molybdenum as one component and eutectic with other metal elements and non-metal elements are exemplified.

[0049] Such a composition may be used alone or in combination with the above molybdenum compound or molybdenum alone. Molybdenum may be mixed not only in a molecular state but also in an ionic state dissolved in a predetermined solvent into a skin external preparation or hair preparation.

[0050] By containing molybdenum, the external preparation for skin of the present invention has the effect of improving skin symptoms such as rough skin, spots (pigmentation), acne, pimples, atopic dermatitis, athlete's foot, etc. S I'll do it.

[0051] Further, the hair preparation of the present invention can exhibit a hair growth effect by containing molybdenum. Here, hair growth means the generation of new hair from the hair root in the hair loss state (hair root that was hairless) and the increase in bristle!

[0052] Furthermore, the external preparation for skin and hair preparation of the present invention may contain iron. Iron used in the present invention is composed of a simple substance or a compound and is a known substance. As a method for obtaining the product, a commercially available product may be used, or purification and production may be performed based on a known method.

[0053] Examples of the iron compound include ferrous oxide, ferric oxide, iron tetroxide, iron disilicide, sodium iron oxide, ferric perchlorate, ferric bromide, iron selenide. , Iron iron trioxide, iron ferric pentoxide, iron nitride, ferric oxytungstate, nineteen barium oxide Inorganic compounds such as iron sulfide, iron disulfide, iron tetraoxyvanadate, iron boride, ferric boride, iron iodide, iron phosphide, ferric phosphide, triiron phosphide, tris (2, 4 —Pentandionato) Iron (II I), Ferrous sulfamate, Ferrous octylate, Tripotassium trioxalate, Ferrous formate, Ferrous dulconate, Ferrous tartrate, Ferric stearate, Lactic acid Examples thereof include organometallic compounds such as ferrous iron and ferric laurate.

[0054] Among these compounds, a single compound may be blended, or two or more may be blended in combination. Furthermore, you may mix | blend in combination with iron simple substance. Iron may be mixed not only in a molecular state but also in an ionic state dissolved in a predetermined solvent into a skin external preparation or hair preparation.

[0055] In addition, as the iron used in the present invention, not only a pure simple substance or compound, but also a composition containing iron (iron simple substance or iron compound) may be used. That is, natural minerals containing iron and mixtures thereof can be used as they are for the external preparation for skin and hair preparations. If necessary, it may be subjected to a purification step in the form of a composition containing iron in order to remove heavy metals and unnecessary materials, for example.

[0056] Examples of the power and mulch composition include clays such as the above red clay, Nishiyama loess (Inagaki Mining Co., Ltd., the same shall apply hereinafter), red porcelain clay, which is a natural mineral described above, and other natural clays. Examples include iron ore, power, and iron ore manufactured as raw materials, as well as alloys that are eutectic with other metal elements and non-metallic elements with iron as one component. Such a composition may be used alone or in combination with the above iron compound or iron alone.

[0057] In particular, red clay is a natural mineral produced in the People's Republic of China, which is a powder mainly composed of ferric oxide, but also a composition containing molybdenum. For this reason, by using red porcelain clay, both iron and molybdenum can be mixed into the external preparation for skin or hair by simply mixing one sample (red porcelain clay).

[0058] The hair preparation of the present invention can exhibit a hair-growth effect by containing iron. Here, hair growth means that the hair that is currently growing becomes thicker, causing firmness and stiffness.

[0059] Molybdenum and iron were dissolved not only in a molecular state but also in a predetermined solvent. You may mix with hair material in an ionic state.

[0060] In the present invention, it is desirable to further contain clay in order to improve the feeling of use of the external preparation for skin or hair preparation and to further improve the effect of improving the skin condition. The clay used is not particularly limited and can be appropriately selected according to the purpose.For example, natural products, refined natural products, modified natural products or synthesized products, etc. Is mentioned. Specifically, Nishiyama black clay, Nakdong blue clay, Nakdong four black clay, Ikutayama special clay, Nishiyama yellow clay, Chinese ocher (the above, Inagaki Mining Co., Ltd., the same shall apply hereinafter), red soil as described above, Other than these, natural or synthetic clay minerals such as montmorillonite, bentonite and acid clay with montmorillonite as the main component, and smectite groups such as pidelite, nontronite, sabonite, saconite, hectorite, stevensite, etc. And kaolinite clay minerals such as kaolinite, nacrite, datekite and halloysite. In addition, mica group (my power), chlorite group, neurophyllite, porcelain stone, and tar may be used. As for the strength and mulberry clay, one kind may be used alone, or two or more kinds may be used in combination.

[0061] By including these clays in the external preparation for skin or hair preparation, dirt on the skin is adsorbed by the adsorption action of the clay. Therefore, if the external preparation for skin or hair preparation is washed away from the site of use, these The ability to remove dirt from S. Therefore, a good feeling of use can be given to the user after using the skin external preparation or hair preparation. In addition, if an external preparation for skin is used, it can be used with the power S to improve skin symptoms such as stains and acne by removing power and scum.

[0062] Moreover, since the cleansing (cleaning) effect can be obtained by using this external preparation for skin, it is not necessary to clean the use site with a scissors or a cleaning agent after using the external preparation for skin. In addition, in daily life, the skin external preparation can be used as a substitute for the cleaning agent, and the face cleaning and the skin external preparation can be performed at one time, which is convenient.

[0063] If this hair preparation is used, the same cleaning effect as that obtained using shampoo or sarcophagus can be obtained. Therefore, after using the hair preparation, it is not necessary to clean the use site with shampoo or sarcophagus. . In addition, in daily life, this hair preparation can be used as a substitute for shampoo and sarcophagus. It is easy to use.

[0064] Furthermore, many clay minerals contain iron compounds. For example, the above clays such as Nishiyama black clay, Nakdong blue clay, Nakdong four black clay, Ikutayama special clay, Nishiyama loess, Chinese loess, etc. contain ferric oxide. Therefore, iron can be blended in the skin external preparation or hair preparation at the same time by blending clay.

[0065] In addition, when molybdenum is mixed with a skin external preparation or hair preparation! / When using red porcelain clay, coloring may occur in the coated area, but mixing with clay is necessary. Therefore, generation of force and rust coloring can be avoided.

[0066] In addition to or in place of the above-mentioned clay, various powders commonly used in cosmetics, specifically, silica, titanium oxide, zinc oxide, lithium cobalt titanate, hydroxide Chromium, manganese violet, carbon black, sericite, calcium carbonate, aluminum silicate, barium sulfate, zeolite, alumina, zirconium oxide, magnesium oxide, magnesium carbonate, boron nitride and other inorganic powders, etc. It may be used.

[0067] The skin external preparation of the present invention may further contain various known active ingredients for improving skin symptoms. The compounding ingredients are not particularly limited. For example, antibacterial agents include io, hinokitiol, triclosan, trichlorohydroxydiphenyl ether, trichlorocarbanilide, chlorhexidine dalconate, halocarpan, Black mouth fenesin, benzethonium chloride, benzalkonium chloride, lysozyme chloride, chlorhexidine chloride, alkyldiaminoethyldaricin hydrochloride, chlorhexidine hydrochloride, chlorhexidine darconate, phenoxyethanol, isopropylmethylphenol, carboxylic acid, Sorbic acid, potassium sorbate, benzoic acid, sodium benzoate, paraoxybenzoic acid estenore, noraclonole metacresol monole, timonore, hexaclofen phen, benoreberine, resonoresin, cetyl chloride Lysinium and derivatives thereof, Photosensitive element 201, Photosensitive element 301, Bis (2-pyridylthio 1-oxide) zinc, zinc pyrithione, azulene, sodium mononitroguaiacol, undecylenic acid, thianthol, hinokitiol, dokudami extract, Clara extract, etc. Is given.

[0068] Examples of keratin softeners include io or io compounds, camphor, sulfa, salicylic acid, Resorcin, urea and the like.

[0069] Anti-inflammatory agents include glycyrrhizic acid, glycyrrhetinic acid and their derivatives and salts (eg, dipotassium glycyrrhizinate, ketoprofen glycyrrhizinate), ibuprofenconol, indomethacin, diclofenac, piroxicam, pranoprofen, phenol birfenfen, In addition to loxoprofen, cortisone acetate, hydrocortisone, dexamethasone, prednisolone, betamethasone, felbinac, etc., aloe extract, arnica extract, ashtaba extract, turmeric extract, hypericum extract, force mitre extract, yellowfin extract, Comfrey extract, perilla extract, birch extract, honeysuckle extract, sage extract, mukuroji extract, eucalyptus extract, mugwort extract, ripe beetle extract, jujube extract, tareson extract , Oubata extract, Waremokou extract, Rengesou extract etc. like et be.

[0070] These antibacterial agents, keratin softeners, and anti-inflammatory agents can be used in one kind or two or more kinds as necessary. Among the above active ingredients, particularly preferred ones include io or thio compounds, isopropylmethylphenol, glycyrrhizic acid, glycyrrhetinic acid and derivatives thereof, and salts thereof. By using these active ingredients together with the skin external preparation of the present invention, it is possible to reduce the amount of known antibacterial agents, keratin softeners, and anti-inflammatory agents that cause side effects. It is expected to improve the safety of

[0071] Further, in the external preparation for skin of the present invention, if necessary, additives used for normal external preparations for skin, for example, aqueous components, oily components, alcohols, esters, surfactants, antioxidants One or more components such as an agent, an ultraviolet absorber, a thickener, a fragrance, an antioxidant, a pH adjuster, and a chelating agent can be blended.

[0072] Furthermore, one or more agents selected from a whitening agent, an antioxidant, a cell activator, a blood circulation promoter, a moisturizer, a wrinkle improving agent, and a wrinkle-preventing agent are added to the external preparation for skin of the present invention. Also good.

[0073] Examples of the whitening agent include vitamin C and its derivatives or salts thereof (ascorbic acid, L-ascorbic acid, sodium ascorbate, sodium L-ascorbate, canolesium asconolelevate, estenore L-ascorenolevate stearate, L-asconolenic acid) Sodium disodium sulfate, magnesium ascorbate phosphate pentahydrate, Sodium scorbate phosphate, darcoside ascorbate, ascorbyl palmitate, ascorbyl dipalmitate), glycine, threonine, hydroxyproline or aspartic acid, or an acyl derivative of each of these amino acids or salts thereof, arbutin, dartathione, Examples include kojic acid, cysteine, and derivatives thereof.

[0074] Antioxidants include, for example, vitamin E and its derivatives (dl α (/ 3, γ) tocopherol, acetic acid dl——tocopherol, nicotinic acid 1 dl——tocopheronole, linoinore acid 1 dl——tocopherol, konsuccinic acid dl——tocopherol and its derivatives such as tocopheronol and ubiquinones, etc., vitamin A and its derivatives (retinoyl palmitate, retinol acetate, etc.) And derivatives thereof, retinal such as dehydroretinal and derivatives thereof, etc., carotenoids (such as carotene, lycopene and wastaxanthin), vitamin B and derivatives thereof (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride) , Pyridoxine dioctanoate, flavin adenine nucleotide, Nocobalamin, folic acid, nicotinic acid amide, nicotinic acid benzyl, nicotinic acid, choline, etc.), vitamin C and its derivatives or salts thereof (ascorbic acid, L-ascorbic acid, sodium ascorbate, sodium lascorbate, ascos Calcium norlevate, L-ascorbate stearate, L-ascorbate disodium disodium, ascorbate magnesium phosphate pentahydrate, ascorbyl phosphate sodium, ascorbyl darcoside, ascorbyl palmitate, dipalmitin Acid corvol, etc.), vitamin D and its derivatives (Ergocalcifellonole, colecanoreciferonore, dihydroxystannanol, etc.), polyphenolate, noretin and its derivatives, thio Examples include urine, taurine, hydroquinone and derivatives thereof, histidine and derivatives thereof, catechins, glabrizine, glabrene, liquiritin, isoliquiritin and kanzo extract containing these, darthathione and derivatives thereof, gallic acid and derivatives thereof It is done.

[0075] Examples of the cell activator include a material that promotes collagen synthesis and a material that has an action of improving skin quality.

[0076] Examples of materials that promote collagen synthesis include ascorbic acid, transforming growth factor beta 1, platelet-derived growth factor, and base. Cuck Fibro Blast Growth Factor, Insulin Like Growth Factor 1, etc. In addition, vitamin A and its derivatives (retinol and its derivatives such as retinol palmitate and retinol acetate, retinal and its derivatives such as dehydroretinal), carotenoids (such as carotene, lycopene and wastaxanthin), vitamin B and its derivatives Derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine diotatanoate, flavin adenine nucleotide, cyanocobalamin, folic acid, nicotinic acid amide, nicotinic acid amide, nicotinic acid, choline, etc.) , Vitamin C and its derivatives or salts thereof (ascorbic acid, L-ascorbic acid, sodium ascorbate, L—sodium ascorbate, calcium ascorbate, L-stecorbate steari Acid esters, disodium L-ascorbate sulfate, ester magnesium ascorbate phosphate pentahydrate, sodium ascorbate phosphate, glucose ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, etc.), ribonucleic acid and And salts thereof, α- and γ-linolenic acid, xanthine and their derivatives caffeine. Further examples include barley extract, silk protein and its degradation products or derivatives thereof, and hydroxyproline.

[0077] Examples of the material having a skin quality improving action include allantoin, aloe extract, carrot extract, placenta extract, bovine blood protein, yeast fermented metabolite and the like.

Examples of the blood circulation promoter include al two force extract, red pepper tincture, yew extract, tocopherol acetate, γ-oryzanol and the like.

[0078] Examples of the humectant include glycerin, 1,3-butylene glycol, sonorebitol, erythritol, pentaerythritol, trenosose, inositole, gnolecose, xylitoleole, manoletos, manoleitol, xylose, fructose, and sucrose Derivatives such as collagen, elastin, keratin, fibronectin or their derivatives, hydrolysates and their salts, hyaluronic acid, chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin and keratan sulfate. Saccharides and their derivatives or their salts, serine, glycine, theanine, aspartic acid, asparagine, arginine, alanine, valine, isoleucine, threonine, lysine, hydroxylysine, cis Tin, Sith Amino acids such as tin, methionine, phenylenolanine, tyrosine, proline, hydroxyproline, taine norenitin, citrulline, pyrrolidone carboxylic acid and their derivatives and their salts, dextrin and derivatives thereof, sugars such as honey, sugar Examples include lipid, ceramide, mucin, urea, carrot extract, aloe extract, cordyceps extract, bracent extract, jojoba oil, royal jelly, hydrolyzed collagen, hydrolyzed keratin, and trehalose.

[0079] Examples of the wrinkle improving agent or wrinkle preventing agent include alanine (Japanese Patent Application No. 9-220240), guanidine derivatives or acid addition salts thereof (Japanese Patent Application No. 8-274628).

[0080] The compounding amount of each component in the external preparation for skin of the present invention may be appropriately examined in consideration of the user's purpose of use, sex, age, symptoms, etc., but the molybdenum compounding amount (for compounds) the amount of elemental molybdenum, which is converted from the composition ratio), relative to the entire skin external preparation, 0.5 00001～;. is 100 weight ^_0/0, preferably <is 0. 0002-10 0 wt ⁰ / _0, in particular a good Mashiku (or 0. 0002- 1.2 wt ^_0/0, further ί this preferred (or a 0. 00025-0. 002 weight ^_0/0.

[0081] The hair material of the present invention may further contain various known medicinal ingredients. There are no particular restrictions on the ingredients, but for example, Kureiso, Gomiko, Peony skin, Kiso, Birch skin, Gokazane, Semi-summer, Daihuang, Beef knee, Eggplant, Rice cake, Dried rice , Chenseed, licorice, hundred, ground bone skin, shiihu, hempen, white birch, persimmon, katsura, bitter, naruto, wisteria, bone hunting, flower bud, yellow ginseng, carrot, black bean, garlic, bamboo ginseng , Prosthetic fat, toki, chicken blood wisteria, dansang, safflower, peach seed, windbreak, beetroot, fistula, yam, half-supported lotus, potato plum, side cocoon leaf, kaikinsha, this medicine, asen medicine, musk, ambition , Check cow, quintuplet, glaze, car maiko, candy, clove, lion, chisenn, daisen, ginger, chili, lazy incense, rosin, genus shoko, summer hay, saiko, chen Chen 蒿, fruiting, yokuyyun, su Herbal medicines such as leaves, nagi, 荊芥 ho, cattle bean, Tsuneyama, poxoku and valerian root, and extracts of these herbal medicines (tinctures, extracts, etc.), lantana (Japanese) : Lanternacamaara) and its extract, minoxidil and other potassium channel openers, pantotenyl ether, pantothenic acid, calcium pantothenate, vitamin A and its derivatives, vitamin B1 and its derivatives, vitamin B2 And its derivatives, vitamin B6 and its derivatives, vitamin E and its derivatives, cephalanthin, nicotinic acid, nicotinic acid benge Nore, nicotinamide, biotin, D-pantothel alcohol, isopropylmethylphenol, hinokitiol, 1 menthol, soluble cystine, otavirox, benzalkonium chloride, benzotonium chloride, salicylic acid, resorcin, resorcin monoacetate, pyridoxine hydrochloride, Diphenhydramine hydrochloride, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, allantoin, glyceryl pentadecanoate, sufingosylphosphylcholine, oxendron, chlorazinone acetate, 11 α-hydroxyprogesterone, 4 androsten-3-one 11/3 —Strong Norebonic acid, Cyproterone acetate, Chlorhexidine, Dalconsanchlorhexidine, Yi, d-Camphor, dl—Strongnor, Sulfisoquin The ability to mention sazoles, prostaglandins and their derivatives, cyclosporine, cephalanthin, estradiol, ethur estradiol, diazoxide, tannin, tannic acid, water-soluble chitin derivatives, etc. . These ingredients can be blended as a single ingredient or in combination of two or more! /.

[0082] In addition to the above, various anti-inflammatory agents may be added to the hair preparation of the present invention.

Anti-inflammatory agents include, for example, thiamine hydrochloride, riboflavin, riboflavin acetate, pyridoxine hydrochloride, flavin adenine dinucleotide, nicotinamide, choline chloride, aloe extract, albi extract, ashitaba extract, turquoise extract Extract, yellowfin extract, hypericum extract, ripe mitsu extract, comfrey extract, honeysuckle extract, sage extract, potato mokko extract, perilla extract, birch extract, mukuroji extract, eucalyptus extract, Examples include mugwort extract, lotus root extract, chondroitin sulfate and its derivatives.

[0083] In addition, the hair preparation of the present invention includes, as necessary, additive carbohydrates used in normal skin cosmetics, such as aqueous components, oily components, alcohols, esters, surfactants, antioxidants. It is possible to combine ingredients such as chemicals, UV absorbers, thickeners, fragrances, antioxidants, pH adjusters, chelating agents. Further, a humectant such as glycerin, carrot extract, aloe extract, cordyceps extract, placenta extract, jojoba oil, royal jelly, hydrolyzed collagen, hydrolyzed keratin, trehalose and the like may be appropriately blended.

[0084] The blending amount of each component in the hair preparation of the present invention may be appropriately determined in consideration of the purpose of use, sex, age, symptoms, etc. of the user. The amount of elemental molybdenum, which is converted from adult ratio) for the entire hair fee, 0.00001 ~; a 100 weight ^_0/0, preferably (or, 0. 0003-10 0 wt ^_0/0. Yes, especially ί this is preferably (or 0. 0003-1. 2 weight ^_0/0.

[0085] The amount of iron blended (the amount of the iron element converted from the composition ratio for the compound) is 0.05 to 100% by weight with respect to the entire hair preparation. / ₀ , preferably 0.1 to 40.0% by weight, particularly preferably 0.4 to 2.5% by weight.

[0086] Since molybdenum and iron can be processed into powders and foils, the hair preparation of the present invention can be provided in powder and metal foil dosage forms to which no liquid substance is added. For this reason, when the hair material is formed with a force and a dosage form, the blending amount of molybdenum and iron in the hair material can be up to 100% by weight.

[0087] The topical skin preparation of the present invention is preferably administered parenterally. As the dosage form, a dosage form that is preferred for external use is not limited to the powder form and metal foil form described above, but a liquid or gel that is a liquid substance is added to the powder, and various additives are added as necessary. Liquid dosage forms such as suspensions, emulsions, lotions, etc., semisolid dosage forms such as ointments, gels, creams, pastes, etc., and skin external preparations formulated into liquids or semisolids It can be made into a dosage form of a cataplasm or a patch that is held on a carrier. As a result, the external preparation for skin of the present invention can be provided in various forms such as, for example, lotion, milky lotion, cream, cleansing agent and knock, as well as a soap and a bath preparation.

[0088] The hair preparation of the present invention can be administered parenterally. As an example of the dosage form, an external preparation can be mentioned, and the dosage form is not limited to the above-mentioned powder form and metal foil form, but can be a liquid or gel that is a liquid substance in powder, and various types as required. In addition, liquid dosage forms such as suspensions, emulsions and lotions, semi-solid dosage forms such as ointments, gels, creams and pastes, and liquid and semi-solid forms can be added. It can be made into a dosage form of a poultice in which the formulated hair is held on a carrier. Thereby, the hair preparation of the present invention can be provided in various forms such as hair tonic, hair lotion, hair cream, shampoo, rinse, hair treatment, hair pack, hair foam, pomade and the like.

[0089] The hair preparation of the present invention may be administered orally. An example of the dosage form is an internal preparation in which the above-mentioned powdery molybdenum is mixed with a liquid substance. That's the power S.

[0090] Examples of the liquid substance include water, water-soluble organic solvents such as alcohol, and mixtures thereof. Examples of water-soluble organic solvents include methanol, ethanol, propylene glycol, glycerin and the like.

[0091] In the case of a semi-solid dosage form, various waxes and waxes, higher alcohols, polyhydric alcohols, inorganic pigments and the like can be blended. Examples of waxes and waxes include beeswax and synthetic waxes. Examples of the higher alcohol include cetyl alcohol, and examples of the polyhydric alcohol include glycerin, petrolatum, lanolin and the like.

[0092] If the dosage form of the external preparation for skin or hair preparation is a dosage form prepared by adding such a liquid substance, the user is bothered by powder scattering during use and advanced handling of the metal foil. It is possible to improve the handleability of the external preparation for skin or hair preparation. Furthermore, among the dosage forms prepared by adding a liquid substance, in particular, if it is a slurry that is a suspension with a high solid concentration or a semi-solid dosage form such as an ointment, gel, cream, paste, etc. The external preparation for skin or hair material can be retained in the application part.

[0093] Here, acidic water is preferably used as the liquid substance to be mixed with the external preparation for skin or hair preparation of the present invention. The strength and acid water should be ρΗ value force ρΗ2.0 to ρΗ7 · 0 (7.0 not included) measured at room temperature, and ρΗ2.0 to ρΗ6 · 5. Moreover, it is more preferable that the pH is 2.0 to 5.0. By using such acidic water to produce a skin external preparation or hair preparation, the pH value of the skin external preparation or hair preparation can be set to acidic, and even weakly acidic (4≤pH <6). it can.

[0094] By setting the pH value of the external preparation for skin or hair preparation to the acidic side, propagation of various bacteria in the stored external preparation for skin or hair preparation can be suppressed. In addition, since the pH value of the human skin surface is weakly acidic at around 5.0, even if a skin external preparation or hair preparation is used by making the pH value of the external preparation for skin weakly acidic, Can maintain the pH balance of human skin. Furthermore, since the pH value of acidic water is 2.0 or more, it is necessary to ensure the safety of handling with the force S.

[0095] It should be noted that the external preparation for skin and hair preparation of the present invention is preferably weakly acidic when used. However, on the other hand, during storage, it is desirable that the pH value is 5.0 or lower in order to suppress the growth of various bacteria. Therefore, in the initial state, the skin external preparation or hair preparation is adjusted to acidity of pH 2 to pH 4, and adjusted to weak acidity (4≤pH 6) by adding a predetermined amount of water during use. Good thing, too. If the pH value of the external preparation for skin or hair preparation cannot be adjusted to the acidic side simply by using acidic water, various acids and buffering agents can be added.

[0096] Next, the present invention will be described in more detail based on Examples and Comparative Examples, but the present invention is not limited to these Examples.

[0097] [Examples:! To 4 and Comparative Examples 1 and 2]

Example;! ~ 4 and Comparative Samples 1 and 2 (external skin preparations) were prepared in paste form by mixing each component (powder and acidic water) in a mortar according to the formulation in Table 1 below. did. In Table 1, the formulations of Examples 1 to 4 and Comparative Examples 1 and 2 are shown in parts by weight.

[0098] [Table 1]

Table 2 shows the contents of iron and molybdenum in the powders used in Examples 1 to 4 and Comparative Examples 1 and 2. In Table 2, the contents of iron and molybdenum are expressed as% by weight in the whole powder. In addition, the iron and molybdenum contents shown in Table 2 were determined based on the content of the iron compound or molybdenum compound in the powder (excluding the molybdenum content in red porcelain clay) and its composition formula. The contents of iron and molybdenum compounds in each powder are shown in parentheses. The molybdenum content in red porcelain clay is a value determined by quantitative analysis using ICP emission spectrometry. Also, examples; The acid water used in ˜4 and Comparative Examples 1 and 2 was Kinminesen (ρΗ2.2). In addition, the pH value of Kinminesen is a value measured at room temperature (25 ° C) by the glass electrode method. [0099] [Table 2]

In Example 1, red clay (Powder Co., Ltd., trade name “Seto Akachi No. 7”, hereinafter the same), which is a powder containing iron and molybdenum, was used. This red clay is a clay produced by mixing red clay and yellow clay in a range of several percent (2% to 7%). As shown in Table 2, because red porcelain clay is a composition containing molybdenum as its main component and ferric oxide, a skin external preparation containing iron and molybdenum was prepared by using red clay. . Therefore, the molybdenum content in the skin external preparation of Example 1 is substantially 0.000256 to 0.000894 weight ^_0/0.

[0100] In Example 2, Nishiyama Loess, which is a clay containing iron but not molybdenum

(Inagaki Mining Co., Ltd., 16 mesh under, particle size of about lmm or less, the same shall apply hereinafter) and red porcelain clay (Inagaki Mining Co., Ltd., main primary grain size up to 0. did. Therefore, the molybdenum content in the external preparation for skin of Example 2 was about 0.005% by weight.

[0101] In Example 3, according to the composition of Table 1, Nishiyama loess was mixed with molybdenum trioxide (trade name “Mo Powder ca. 0.7 μm”, the same shall apply hereinafter) to Molybdenum trioxide. A topical skin preparation was prepared. In Example 4, according to the formulation in Table 1, Suguro Shiguro clay, which is a clay containing iron but not containing molybdenum (Inagaki Mining Co., Ltd., 16 mesh under, particle size of about lmm or less, the same shall apply hereinafter) A topical skin preparation was prepared by mixing molybdenum trioxide with the above. Therefore, the molybdenum content in the skin external preparations of Examples 3 and 4 was about 0.00185% by weight.

[0102] In Comparative Example 1, a topical skin preparation was prepared by adding acidic water to Nishiyama Loess, and in Comparative Example 2, a topical skin preparation was prepared by adding acidic water to Sakdong Sieguro clay. Each did not contain molybdenum! / And used as a test sample. [0103] (Evaluation test)

The test sample was applied to the spotted area of the subject's face 2-3 times, and then the test sample was applied to the entire face and left for about 15 minutes. Thereafter, the face was washed with water, the test sample was removed, and a normal cosmetic (for example, lotion or cream) was applied. This was performed twice daily, morning and evening, and the condition of the face of the subject from the start of the test was visually observed. The results of this test are shown in Table 3.

[0104] In Table 3, the result of visual evaluation is X when there is no change compared to the start, and the effect of improving skin roughness (improving skin gloss and ablation) and the effect of stains compared to the start. Each case is indicated by a circle. In addition, there were 4 subjects in Example 1, 2 subjects in Example 2, 7 subjects in Example 3, and 8 subjects in Example 4, and the test samples in each Example were continued for 1 week. The results used are shown. There were 4 subjects in each of Comparative Examples 1 and 2, and the results of continuous use of the test samples in each Comparative Example for 2 weeks were shown.

[0105] [Table 3]

As is apparent from Table 3, in each of Examples ;! to 4 and Comparative Examples 1 and 2, an effect of improving skin roughness (an improvement in skin gloss and elasticity) was observed. However, no improvement was observed in the skin external preparations of Comparative Examples 1 and 2 that did not contain molybdenum, and only the test samples of Examples 1 to 4 containing molybdenum showed an improvement effect on the stain. It was.

[Examples 5 to 8]

In Examples 5 to 8, the effectiveness of the external preparation for skin of the present invention against acne was evaluated. The test samples used in Examples 5-8 were the same as the test samples used in Examples;!-4.

[0107] (Use test)

The test sample was applied to the entire face of the subject and left for about 15 minutes. Thereafter, the face was washed with water, the test sample was removed, and a normal cosmetic (for example, lotion or cream) was applied. This is done once a day, and the state of the subject's face is visually observed from the start of the test. Followed up. The number of subjects was one in each of Examples 5 to 8.

[0108] As a result, acne became inconspicuous in each subject by continuous use of each of the external preparations of Examples 5 to 8 for 1 week, and improvement of acne symptoms was observed.

[Examples 9 to 11]

In Examples 9 to 11; the effectiveness of the external preparation for skin of the present invention against atopic dermatitis was evaluated. The test samples used in Examples 9 to 11 were the same as the test samples used in Examples 2 to 4.

[0110] (Use test)

The test sample was applied to a site where inflammation of the subject's atopic dermatitis was observed and left for about 15 minutes. Thereafter, the test sample was removed by washing with water. This was performed once a day, and the skin condition of the subject from the start of the test was visually observed. The number of subjects was one in each of Examples 9 to 11;

[0111] As a result, improvement of atopic dermatitis was observed in each subject by continuous use of each skin external preparation of Examples 9 to 11 for 1 day to 10 days.

[0112] [Example 12]

In Example 12, the effectiveness of the topical skin preparation of the present invention against pimples was evaluated.

. The test sample used in Example 12 was the same as the test sample used in Example 4.

[0113] (Use test)

In addition to athlete's foot symptoms caused by ringworm, the test sample was applied to the skin of a subject who had a pimple caused by Pseudomonas aeruginosa (staphylococci, streptococci) and left for about 20 minutes. Thereafter, the test sample was removed by washing with water. This was continuously performed once a day, and the skin condition of the subject from the start of the test was visually observed. As a result, the condition of pimples and athlete's foot symptom (itchiness) was improved from the second day of continuous use, and clear improvement of skin symptoms was observed by continuous use for 6 days.

[0114] [Example 13]

In Example 13, a topical skin preparation was prepared by adding acidic water (200 parts by weight) to molybdenum trioxide (1 part by weight) and used as a test sample. [0115] (Use test)

The test sample of Example 13 was applied to the subject's skin. This was continued daily and the skin condition from the start of the test was visually observed. In addition, the frequency | count of application | coating per day was set to any of! ~ 3 times according to the test subject's symptom. As a result, as in Examples 1 to 12, continuous use for 1 to 10 days showed improvement effects on rough skin, spots, pimples, atopic dermatitis, athlete's foot symptoms, eczema and insect bites. There is one subject for each case. In addition, according to Example 13, it was found that an effect of preventing itching can be obtained.

[0116] In each of the above examples, skin troubles during the test period were not problematic even in the safety of one person.

[Examples 14 to 21 and Comparative Examples 3 and 4]

The test samples (hair preparations) of Examples 14 to 21 and Comparative Examples 3 and 4 were mixed with each component (powder and acidic water) in a mortar according to the formulation shown in Table 4 below. Examples 14 to 20 and Comparative Examples Example 3 was prepared in the form of a paste, and Example 21 and Comparative Example 4 were prepared in liquid form. In Table 4, the formulations of Examples 14 to 21, Comparative Example 3, and Comparative Example 4 are shown in parts by weight.

[0118] [Table 4]

In addition, the contents of iron and molybdenum in the powders used in Examples 14 to 21 and Comparative Examples 3 and ⁴ are as shown in Table 2. Further, as the acidic water used in Examples 14 to 21 and Comparative Examples 3 and 4, Kinbetsu (ρ 泉 2 · 2) was used as in Examples 1 to 13. [0119] In Example 14, red clay, which is a powder containing iron and molybdenum (Towa Co., Ltd., trade name "Seto Akachi No. 7", the same shall apply hereinafter) was used. This red clay is a clay produced by mixing 2% to 7% of red clay with ocher and Shigaraki. As shown in Table 2, red porcelain clay is a composition containing molybdenum as a main component and ferric oxide. Therefore, a hair material containing iron and molybdenum was prepared by using red clay. .

[0120] In Example 15, Nishiyama yellow clay (Inagaki Mining Co., Ltd., 16 mesh under, particle size of about lmm or less, the same shall apply hereinafter), which is a clay containing iron but not molybdenum, red clay (Inagaki) Mining Co., Ltd., a hair material mixed with main primary grain size up to 0. In Example 16, hair mixed with red porcelain clay to Suguro Shiguro clay (Inagaki Mining Co., Ltd., 16 mesh under, particle size of approximately lmm or less, the same shall apply hereinafter), which is a clay containing iron but not molybdenum. A material was prepared.

[0121] In Examples 17 and 18, a hair preparation prepared by mixing molybdenum trioxide (High Purity Science Laboratory Co., Ltd., trade name “Mo Powder ca. 0.7 μm”, the same shall apply hereinafter) with Nishiyama loess according to the formulation. Was made. In Examples 19 and 20, hair tribes were prepared by mixing molybdenum trioxide with Sakdong Sieguro clay according to the formulation. Thus, also in Examples 14 to 20, hair samples containing iron and molybdenum were used as test samples. In Example 21, hair was prepared by adding acidic water to molybdenum trioxide and used as a test sample.

[0122] In Comparative Example 3, hair material was prepared by adding acidic water to Nishiyama loess, and used as a test sample containing no molybdenum. In Comparative Example 4, acid water was used as a test sample.

[0123] (Test method)

After the subject's head was moistened with water or hot water, the test samples of Examples 14 to 20 and Comparative Example 3 were applied, and the scalp massage was arbitrarily performed and left for 15 to 20 minutes. Thereafter, the test sample was washed away with water or hot water. This was carried out once a day, and the time course of the hair condition of the head after 3 months from the start of the test was observed visually. In addition, 100 ml of the test sample of Example 21 and Comparative Example 4 was orally administered once a day, and the time-dependent changes in the hair condition of the head after 3 months from the start of the test were visually observed. Take The test results are shown in Table 5. In Example 21, a stock solution in which 10 mg of molybdenum trioxide was added to 200 ml of acidic water was prepared, and at the time of administration, 20 ml of the stock solution was diluted with 2000 ml of acidic water to adjust the formulation shown in Table 4. Force administered to the subjects.

[0124] The result of the visual evaluation is X when there is no change compared to the start, and hair growth (the hair became thicker, firmer, stiffer than the start) or hair growth compared to the start. The case where the occurrence of hair from the root that was hairless at the start and the increase in bristles is indicated by ○.

[0125] [Table 5]

As is clear from Table 5, the hair preparations of the present invention containing molybdenum (Examples 14 to 21) showed an excellent hair growth promoting effect. In addition, the hair preparation of the present invention containing iron (Examples 14 to 21) also showed an excellent hair growth effect. On the other hand, in the hair samples of Comparative Examples not containing molybdenum (Comparative Example 3 and Comparative Example 4), the force was not generated. In addition, it is estimated that the hair growth effect was also obtained in Comparative Example 3 and Comparative Example 4 because Kinmine Izumi used as acidic water contained iron.

[Example 22]

In Example 22, the same test sample as in Example 21 was applied to the scalp of the subject, and scalp massage was arbitrarily performed. This was carried out once a day, and the time-dependent change in the hair state of the head after 3 months from the start of the test was observed visually. As a result, similar to Example 14 to Example 21, excellent hair growth promoting effects and hair growth effects were obtained.

[0127] Further, in order to show the effects of the hair preparation of the present invention (Examples 14 to 22) in an easy-to-understand manner, FIG.

[0128] Fig. 1 is a diagram showing a progress state after the hair preparation of Example 14 was applied to the head of a subject. Fig. 1 (a) shows the head of the subject in the initial state (before the test), and Fig. 1 (b) shows the subject on day 41 who applied the hair preparation of Example 14 according to the test method described above. It is the figure which showed the head part. As can be seen from FIG. 1, apparent hair growth and hair growth were observed on the subject's head.

Claims

The scope of the claims

[I] A skin external preparation characterized by containing molybdenum.

[2] The external preparation for skin according to claim 1, comprising red porcelain clay, which is a composition containing molybdenum.

[3] The external preparation for skin according to claim 1 or 2, further comprising clay.

[4] Contains a liquid material having fluidity,

Molybdenum is a simple substance or compound formed into powder,

The mixture of the liquid substance and the powder is formed into a dosage form of any one of a suspension, gel, cream, and paste. A skin external preparation according to any one of the above.

5. The skin external preparation according to claim 4, wherein the liquid substance is acidic with a pH value of about 2 to about 5.

[6] A hair material that promotes hair growth or hair growth and contains molybdenum.

7. The hair preparation according to claim 6, further comprising iron.

[8] A hair material for promoting hair growth, characterized by containing iron.

[9] The hair preparation according to [6], [8] or [1], which contains red porcelain clay, which is a composition containing molybdenum and iron.

[10] The hair material according to any one of [6] to [9], further comprising clay.

[I I] Contains a liquid material having fluidity,

Molybdenum or iron is obtained by molding a simple substance or a compound into powder, and is formed into a dosage form of suspension, gel, cream, or paste by mixing the liquid substance and powder. The hair material according to any one of claims 6 to 10, wherein the hair material is a hair material.

12. The hair material according to claim 11, wherein the liquid substance is acidic with a pH value of about 2 to about 5.