JP2000212057A - Cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic composition which efficiently inhibits a skin roughness, dry feeding of the skin, etc., and is safe for people having an inflammatory dermatitis such as atopic dermatitis, by making the composition contain red wine and an antiinflammatory medicine and/or a humectant. SOLUTION: This cosmetic composition contains (A) red wine, (B) an antiinflammatory medicine and/or a humectant, and preferably further (C) one or more substances selected from the group consisting of surfactants, antioxidants, UV light-preventing agents, chelating agents, pH-adjusting agents, sterilizers, vitamins, perfumes, pigments and their mixtures. The components A and B are preferably compounded in an A:B weight ratio of 1:0.0001 to 1:800,000. The cosmetic is preferably prepared in the form of a skin lotion, a milky lotion, a skin cream for external use, or a bathing agent. The component A is preferably compounded in an amount of 0.001-5 wt.% based on the basis of the cosmetic.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention can be expected to have an effect of improving allergic dermatitis such as atopic dermatitis and the like, and can suppress inflammation such as rash and itching of the skin and bulkiness of the skin. The present invention relates to a cosmetic composition, which can be used for a lotion, a milky lotion, an external skin cream, a bath preparation and the like.

[0002]

2. Description of the Related Art Conventionally, various forms of cosmetics for skin such as rough skin and rash have been developed and marketed.
However, these cosmetics are not always effective for people with allergic dermatitis such as atopic dermatitis, and in fact, their use is avoided. This is considered to be due to the fact that factors such as general skin roughness and allergic dermatitis are different.

[0003] By the way, conventionally, fermented alcohol such as wine, sake, brandy and the like or alcohol distillation residue thereof will give an appropriate stimulus to the skin and promote metabolism, so that it is added to cosmetics such as bath salts. (For example, Japanese Patent Application Laid-Open No. 62-59206).
Also, specific plant extracts such as grape extract, and proanthocyanidins (polyphenols) contained in red wine and the like
Is also known to have antioxidant activity (e.g.,
JP-A-61-16982). Furthermore, many cosmetics utilizing the action of this proanthocyanidin have been proposed. For example, cosmetics containing a plant extract such as grape and one or more of hyaluronic acid and a salt thereof (Japanese Patent Application Laid-Open No.
No. 7510), an external preparation for skin containing proanthocyanidins and a cell activator (Japanese Patent Application Laid-Open No. 6-336422),
External preparation for skin containing proanthocyanidin and mucopolysaccharide and / or protein (JP-A-6-336423), external preparation for skin containing proanthocyanidin and anti-inflammatory agent (JP-A-6-336421), proanthocyanidin There is known an external preparation for skin containing an active oxygen scavenger and / or an antioxidant (JP-A-6-336419).

[0004] However, any of the conventionally proposed cosmetics using proanthocyanidins exhibit an effect on rough skin and the like, and are examined to be effective for people with allergic dermatitis. Absent. In addition, hitherto, cosmetics not combined with proanthocyanidins, grape extracts, or the like, and in which red wine is combined with an anti-inflammatory agent and / or a humectant have not been known.

[0005]

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide a method for protecting a person with allergic dermatitis such as atopic dermatitis which is safe, and effectively suppresses rough skin and rough skin. It is an object of the present invention to provide a cosmetic composition which can be used as a form such as a lotion, a milky lotion, a cream for external use on the skin or a bath agent.

[0006]

Means for Solving the Problems The present inventors have conducted intensive studies in order to solve the above-mentioned problems, and as a result, it has been found that proanthocyanidin itself or a plant containing the same can be used for people with atopic dermatitis. It has been found that the skin improving effect can be obtained more effectively by adding an alcohol-fermented red wine than the extract and combining the red wine with an anti-inflammatory agent and / or a humectant. . That is, according to the present invention, there is provided a cosmetic composition comprising red wine and an anti-inflammatory agent and / or a humectant.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in more detail. The cosmetic composition of the present invention contains red wine, an anti-inflammatory agent and / or a humectant, and can be used in the form of a lotion, a milky lotion, an external skin cream or a bath salt.

[0008] The red wine used in the present invention is obtained by crushing black grapes, fermenting them, then separating and producing the pericarp, seeds, etc., or by separating and then ripening them to obtain a normal production method. In addition, commercially available products can be used. Usually, the alcohol content of red wine is about 5 to 20%, and the amount of contained proanthocyanidins is usually
0.05% by weight or more is preferable.

In the cosmetic composition of the present invention, the mixing ratio of red wine can be appropriately selected according to the form of the cosmetic, but is usually 0.0001 relative to the total amount of the cosmetic.
-10% by weight, preferably 0.001-5% by weight. If the amount is less than 0.0001% by weight, it is difficult to obtain a desired skin improving effect. If the amount is more than 10% by weight, irritation increases, which is not preferable.

The anti-inflammatory agent used in the present invention includes, for example, glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, allantoin, hinokitiol, paeoniflorin, cordyceps, plant extracts having an anti-inflammatory effect, and mixtures thereof. . Examples of the plant for obtaining a plant extract having an anti-inflammatory effect include, for example, licorice, yokuinin, hinoki, oak (butcher bloom), horse chestnut (Aesculus chinensis), mukuroji (mukanshi), loquat, mint (melissa, kosuihakka) , Lemon balm), Saxifraga (Kojisou), Lavender, Rosemary (Mannenrou), Amacha, Kawamogi (Inchikou), Bodaiju (European daidai), Perilla (Soyo), Guyouyou, Ogon,
Asparagus (shoubakubu, Dutch sword),
Aloe, Ginkgo, Ages, Ononis, Kingfisher,
Honeysuckle, peonies, soybeans, tormentilla,
Tamasakitsu Lahuzi, Chimpi, Tencha, Izayoibara
(Silk, spruce), oak and the like.

[0011] In the cosmetic composition of the present invention, the mixing ratio of the anti-inflammatory agent can be appropriately selected according to the form of the cosmetic. It is 001 to 5% by weight, preferably 0.01 to 1% by weight. If the amount is less than 0.001% by weight, a desired skin improving effect is hardly obtained, which is not preferable.

The humectant used in the present invention is a water-soluble humectant,
Any of oil-based humectants may be used. As a water-soluble humectant,
For example, glycerin, propylene glycol, 1,3-
Polyhydric alcohols such as butylene glycol and polyethylene glycol; sugars and derivatives thereof such as glucose, sorbitol, dextrin and lactose; amino acids and derivatives thereof such as collagen and derivatives thereof, keratin and derivatives thereof, sodium glutamate and trimethylglycine; and chondroitin sulfate Water-soluble polymers such as sodium, sodium pyrrolidonecarboxylate, sodium hyaluronate, and carboxyvinyl polymer; yeast extracts, seaweed extracts, plant extracts having a moisturizing action; and mixtures thereof. Examples of oily humectants include vegetable oils such as castor oil, olive oil, grape seed oil, cacao oil, camellia oil, coconut oil, wood wax, jojoba oil, avocado oil; beeswax, spermaceti, lanolin, carnauba wax,
Waxes such as candelilla wax; hydrocarbons such as squalane, liquid paraffin, microcrystalline wax, ceresin wax, paraffin wax, petrolatum;
Fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, behenic acid; higher alcohols such as cetanol, stearyl alcohol, hexyldecanol, octyldodecanol, lauryl alcohol; isopropyl myristate, isopropyl palmitate And esters such as octyldodecyl myristate, octyldodecyl oleate and cholesteryl oleate; sodium polyacrylate, crystalline cellulose, various plant essential oils, and mixtures thereof.

[0013] In the cosmetic composition of the present invention, the mixing ratio of the humectant when it is added can be appropriately selected according to the form of the cosmetic.
0.001 to 99.99% by weight, preferably 0.01 to
65% by weight. If the amount is less than 0.001% by weight, a desired skin improving effect is hardly obtained, which is not preferable.

In the cosmetic composition of the present invention, the mixing ratio of the above-mentioned essential components, red wine, and an anti-inflammatory agent and / or a humectant is not particularly limited as long as the desired skin improving effect of the present invention can be obtained. But preferably in a weight ratio of 1: 0.
0001 to 800,000, particularly preferably 1: 0.0
01-650000 is desirable.

[0015] The cosmetic composition of the present invention may be used in accordance with other desired purposes and the like within a range not to impair the object of the present invention.
In order to form a lotion, a milky lotion, an external skin cream or a bath salt, various commonly used safe components can be appropriately combined and blended. For example, various surfactants such as anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants; antioxidants, ultraviolet inhibitors, chelating agents, pH adjusters, bactericides, vitamins, and fragrances , A dye or a mixture thereof, but are not limited thereto. The mixing ratio of these optional components can be appropriately selected and determined according to the purpose.

Examples of the anionic surfactant include alkyl sulfate, polyoxyethylene alkyl ether sulfate, sulfosuccinate, taurine derivative, sarcosine derivative, amide ether sulfate, ether phosphate, fatty acid salt, and ether carboxylate. , A sulfonate or a mixture thereof.

Examples of the cationic surfactant include an alkyltrimethylammonium salt, an alkyldimethylammonium salt and a mixture thereof.

Examples of the nonionic surfactant include lecithin derivatives, propylene glycol fatty acid esters,
Glycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyglycerin fatty acid ester,
Sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbite fatty acid ester, polyoxyethylene alkylphenylformaldehyde condensate, polyoxyethylene castor oil,
Polyoxyethylene hydrogenated castor oil, polyoxyethylene sterol, polyoxyethylene hydrogenated sterol,
Polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene lanolin, polyoxyethylene lanolin alcohol, polyoxyethylene beeswax derivative, polyoxyethylene alkylamine, Examples thereof include polyoxyethylene fatty acid amide, polyoxyethylene alkyl ether phosphoric acid, and mixtures thereof.

Examples of the amphoteric surfactant include alkyl betaine amphoteric surfactants, alkyl amido betaine amphoteric surfactants, imidazoline amphoteric surfactants, glycine amphoteric surfactants, and amine oxide amphoteric surfactants. And an acylmethyl-β-alanine amphoteric surfactant or a mixture thereof.

Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, vitamins E, propyl gallate or a mixture thereof.

Examples of UV inhibitors include, for example, 4-methoxybenzophenone, octyldimethylparaaminobenzoate, ethylhexylparamethoxycinnamate,
Examples thereof include fine particle titanium oxide, fine particle zinc, and a mixture thereof.

Examples of the chelating agent include edetates, pyrophosphates, hexane metaphosphates, gluconates, and mixtures thereof.

Examples of the pH adjuster include sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, sodium carbonate, potassium carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate. , Disodium hydrogen phosphate, dipotassium hydrogen phosphate, citric acid, sodium citrate or a mixture thereof.

Examples of the bactericide include lysodium chloride, benzoate, sorbate, dihydroacetate, paraoxybenzoate, benzethonium chloride, phenoxyethanol, chlorhexidine gluconate, isopropylmethylphenol, cetylpyridinium chloride, and pirocton ora. Examples include min, zinc pyrithione, 2,2,4-trichloro-2′-hydroxydiphenyl ether, triclocarban, triclosan, benzalkonium chloride, and mixtures thereof.

As vitamins, for example, vitamin A
And its derivatives, vitamin B ₂ , vitamin C and its derivatives, vitamin E and its derivatives, pantothenic acid and its derivatives, niacin, biotin, and mixtures thereof.

To prepare various cosmetics using the cosmetic composition of the present invention, in the case of a lotion, for example, POE hydrogenated castor oil, fragrance and the like are dissolved in a mixed solution of ethanol and isoprene glycol. It can be obtained by adding this to purified water in which an ultraviolet ray inhibitor, a preservative, etc. are dissolved, further adding red wine, dipotassium glycyrrhizinate, a pH adjuster, a colorant, etc., and uniformly stirring.
It is not limited to this. In the case of latex, for example,
Olive oil, liquid paraffin, POE oleyl ether, sorbitan sesquiolate, preservatives, etc. are heated and mixed, and purified water obtained by heating and dissolving hyaluronic acid, propylene glycol, carboxyvinyl polymer, pH adjuster, etc. is added thereto, and emulsified. , Red wine, ethanol, UV inhibitors, pigments, flavors, etc., and then uniformly stirred, but the present invention is not limited thereto. In the case of cream, for example, cetyl alcohol, stearyl alcohol, stearic acid, liquid paraffin, petrolatum, sorbitan monostearate, POE
Monostearate, preservatives, etc. are heated and mixed, and purified water obtained by heating and dissolving 1,3-butylene glycol, a pH adjuster, etc. is added and emulsified. After cooling, red wine, dipotassium glycyrrhizinate, an ultraviolet ray inhibitor, a dye, a fragrance Can be obtained by, for example, a method of uniformly stirring the mixture, but is not limited thereto. In the case of a bathing agent, for example, ethanol, isoprene glycol, POE hydrogenated castor oil, an ultraviolet ray inhibitor, a preservative, a fragrance and the like are mixed, and this is mixed with red wine, dipotassium glycyrrhizinate, glycerin, 1,3,
A method in which butylene glycol, triethanolamine laurate, a pH adjuster, a colorant, etc. are added to purified water and stirred uniformly, or 1,3-butylene glycol, isopropyl palmitate, liquid paraffin, PO
E-hardened castor oil, a UV inhibitor, a preservative, a fragrance, etc. are mixed, and red wine, a chamomile extract, a pH adjuster, purified water in which a pigment, etc. are dissolved are added thereto, and the mixture is uniformly stirred. However, the present invention is not limited to these.

[0027]

The cosmetic composition of the present invention is not a proanthocyanidin itself or a plant extract containing a proanthocyanidin such as a grape extract not subjected to alcohol fermentation. And the combination thereof contains a combination thereof, so that a person having allergic dermatitis such as atopic dermatitis can obtain a skin-improving effect with peace of mind, and can be used as a lotion, a milky lotion, a skin external cream or a bath agent, etc. .

[0028]

The present invention will be described in more detail with reference to the following Examples and Comparative Examples, but the present invention is not limited thereto. The red wine used in the examples had an alcohol content of 14%, and contained 0.2% by weight of proanthocyanidins.
A commercially available red wine containing 0.01% by weight of red wine and 0.00002 parts by weight of proanthocyanidin was used. The grape extract used in the examples is a hot water extract and has not been subjected to alcohol fermentation. The grape extract used contained 4.5% by weight of proanthocyanidins.

Examples 1 to 3 and Comparative Examples 1 to 5 Each component shown in Table 1 was mixed and prepared to produce a lotion. The obtained lotion was applied to the affected part twice a morning and evening by a panel of 20 adults with atopic dermatitis, and evaluated by self-judgment one month later. The evaluation was 5 points for atopic dermatitis significantly improved, 4 points for improvement, 3 points for no change, 2 points for deterioration, and 1 point for extremely deteriorated. evaluated. Table 1 shows the results. From the results in Table 1, the lotion of the present invention is
Compared to Comparative Example 1 not containing red wine, Comparative Example 2 not containing dipotassium glycyrrhizinate as an anti-inflammatory agent, and Comparative Examples 3 to 5 using proanthocyanidin or grape extract instead of red wine, atopic dermatitis was observed. It was found that a remarkable effect was obtained.

[0030]

[Table 1]

Examples 4 to 11 Each component shown in Table 2 was mixed and prepared to produce a lotion. The same tests as in Examples 1 to 3 were performed on the obtained lotion. Table 2 shows the results.

[0032]

[Table 2]

Examples 12 to 14 and Comparative Examples 6 to 10 Each component shown in Table 3 was mixed and prepared to produce an emulsion. The same test as in Examples 1 to 3 was performed on the obtained emulsion. Table 3 shows the results. From the results shown in Table 3, the emulsion of the present invention contains Comparative Example 6 containing no red wine, Comparative Example 7 containing no dipotassium glycyrrhizinate as an anti-inflammatory agent, Comparative Example using proanthocyanidin or grape extract instead of red wine. It was found that a remarkable effect on atopic dermatitis was obtained as compared with 8 to 10.

[0034]

[Table 3]

Examples 15 to 22 Each component shown in Table 4 was mixed and prepared to produce an emulsion. The same test as in Examples 1 to 3 was performed on the obtained emulsion. Table 4 shows the results.

[0036]

[Table 4]

Examples 23 to 25 and Comparative Examples 11 to 15 The components shown in Table 5 were mixed and prepared to prepare a cream for external use on the skin. About the obtained skin external use cream, Example 1
The same tests as in No. 3 were performed. Table 5 shows the results. Table 5
According to the results, the external skin cream of the present invention contains Comparative Example 11 containing no red wine, Comparative Example 12 containing no dipotassium glycyrrhizinate as an anti-inflammatory agent, Comparative Example using proanthocyanidin or grape extract instead of red wine. It was found that a remarkable effect on atopic dermatitis was obtained as compared with 13 to 15.

[0038]

[Table 5]

Examples 26 to 33 The components shown in Table 6 were mixed and prepared to produce a cream for external use on the skin. About the obtained skin external use cream, Example 1
The same tests as in No. 3 were performed. Table 6 shows the results.

[0040]

[Table 6]

Examples 34 to 36 and Comparative Examples 16 to 20 The components shown in Table 7 were mixed and prepared to produce a liquid bath agent. 25 g of the bath salt was added to the obtained liquid bath salt by a panel of 20 adults having atopic dermatitis.
Dissolved in about 200 liters of bath water at least 15 times a day
They were bathed for a minute and evaluated one month later by self-judgment. The evaluation was 5 points for atopic dermatitis significantly improved, 4 points for improvement, 3 points for no change, 2 points for deterioration, and 1 point for extremely deteriorated. evaluated. Table 7 shows the results. From the results shown in Table 7, the liquid bath preparation of the present invention used Comparative Example 16 without red wine, Comparative Example 17 without dipotassium glycyrrhizinate as an anti-inflammatory agent, and used proanthocyanidin or grape extract instead of red wine. As compared with Comparative Examples 18 to 20,
It was found that a remarkable effect was obtained for atopic dermatitis.

[0042]

[Table 7]

Examples 37 to 44 Each component shown in Table 8 was mixed and prepared to produce a liquid bath preparation. The same tests as in Examples 34 to 36 were performed on the obtained liquid bath additives. Table 8 shows the results.

[0044]

[Table 8]

Examples 45 to 47 and Comparative Examples 21 to 26 The components shown in Table 9 were mixed and prepared to produce a powder bath agent. The same tests as in Examples 34 to 36 were performed on the obtained powder bath additives. Table 9 shows the results. From the results in Table 9, the liquid bath preparation of the present invention used Comparative Example 21 without red wine, Comparative Example 22 without dipotassium glycyrrhizinate as an anti-inflammatory agent, and used proanthocyanidin or grape extract instead of red wine. Comparative Examples 23 to 26
It was found that a remarkable effect on atopic dermatitis was obtained as compared to

[0046]

[Table 9]

Examples 48 to 55 The components shown in Table 10 were mixed and prepared to produce a powder bath agent. The same test as in Examples 34 to 36 was performed on the obtained powder bath agent. Table 10 shows the results.

[0048]

[Table 10]

 ──────────────────────────────────────────────────続 き Continued on the front page F-term (reference) 4C083 AA032 AA111 AA112 AA122 AB172 AB312 AB352 AC022 AC072 AC092 AC102 AC122 AC242 AC352 AC392 AC402 AC432 AC442 AC542 AC582 AC682 AC712 AD092 AD112 AD202 AD332 AD432 AD532 AD611 BB01 BB44 BB41 BB44 BB44 BB44 BB51 CC04 CC05 CC25 DD17 DD23 DD31 EE06 EE13

Claims (4)

[Claims] 1. A cosmetic composition comprising red wine and an anti-inflammatory and / or humectant. 2. The mixing ratio of red wine to an anti-inflammatory agent and / or humectant is 1: 0.0001 to 8000 by weight.
The cosmetic composition according to claim 1, wherein the cosmetic composition is 00. 3. One or more selected from the group consisting of surfactants, antioxidants, UV inhibitors, chelating agents, pH adjusters, bactericides, vitamins, fragrances, dyes, and mixtures thereof. 2. The method according to claim 1, further comprising:
Or the cosmetic composition according to 2. 4. The cosmetic according to claim 1, wherein the cosmetic is in the form of a lotion, an emulsion, an external skin cream or a bath agent.
The cosmetic composition according to any one of claims 3 to 3.