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WO2006087359A1 - Composition ozonisee d'origine animale - Google Patents

Composition ozonisee d'origine animale Download PDF

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Publication number
WO2006087359A1
WO2006087359A1 PCT/EP2006/060016 EP2006060016W WO2006087359A1 WO 2006087359 A1 WO2006087359 A1 WO 2006087359A1 EP 2006060016 W EP2006060016 W EP 2006060016W WO 2006087359 A1 WO2006087359 A1 WO 2006087359A1
Authority
WO
WIPO (PCT)
Prior art keywords
liver oil
cod liver
preparation
ozonized
ozonization
Prior art date
Application number
PCT/EP2006/060016
Other languages
English (en)
Inventor
Antonello Pietrangelo
Valter Travagli
Original Assignee
Pharma Medical Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Medical Limited filed Critical Pharma Medical Limited
Publication of WO2006087359A1 publication Critical patent/WO2006087359A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/006—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by oxidation

Definitions

  • the present invention relates to an ozonized cod liver oil, to pharmaceutical and cosmetic compositions containing said oil and to a process for the preparation thereof.
  • compositions In particular, antibacterial, antiviral and antifungal activities of these ozonized compositions have been described. Moreover, the use of these compositions for topical applications has been described both in therapeutic and cosmetic fields.
  • ozonized cod liver oil has particularly advantageous technological and applicative features compared to both the untreated raw material and vegetable oils subjected to ozonization.
  • cod liver oil exhibits much higher antimicrobial activities than those observed in ozonized vegetable oils or fats.
  • the ozonization treatment does not change the typical tissue and epidermal regenerative properties of cod liver oil, considering its natural components (especially vitamin A and vitamin D).
  • the present inventors have found that, in contrast to ozonized vegetable oils, the ozonized cod liver oil is not irritating to the skin and has unexpected technological features and unexpected features with respect to spreadability, organoleptic properties and physical and chemical stability, allowing also perfect miscibility with the various auxiliary substances commonly used to obtain specific pharmaceutical forms.
  • this invention relates to ozonized cod liver oil, to a process for its preparation and to pharmaceutical and cosmetic compositions comprising said oil.
  • Figure 1A shows a 13 C NMR spectrum of ozonized cod liver oil.
  • Figure 1 B shows a 1 H NMR spectrum of ozonized cod liver oil.
  • a first object of this invention is an ozonized cod liver oil.
  • Cod liver oil ozonization is performed using a commercial ozone generator at a temperature comprised between +20° and +40 0 C, more preferably +30°C.
  • the ozone-oxygen mixture required for the ozonization process is obtained from medical oxygen.
  • the gas employed for said process is produced by means of a suitable apparatus. It contains between 95% and 99.5% oxygen and 0.5% and 5% ozone, depending on gas flow and on the electrical gradient used.
  • the so-obtained ozone-oxygen mixture is bubbled continuously through the whole volume of cod liver oil during the entire ozonization process.
  • the ozonized cod liver oil of the present invention unlike vegetable oils subjected to similar transformation, has an excellent chemical stability and remains stable for at least six months under standard storage conditions.
  • the present invention relates also to compositions for pharmaceutical and cosmetic use, comprising the above-mentioned cod liver oil in association with appropriate excipients and/or diluents.
  • the cod liver oil ozonized according to the present invention has marked antibacterial, antiviral, antifungal and reepithelizing properties. Therefore, according to a further aspect, the present invention relates to the use of ozonized cod liver oil for the preparation of a composition having the above- mentioned properties.
  • this invention refers to the use of ozonized cod liver oil for the preparation of medicaments for the treatment of bacterial, viral or fungine infections, acne, chalazion, gengivitis, dermatitis, sores, especially pressure sores, ulcers, especially gastric and duodenal ulcers and ulcers in the oropharyngeal cavity.
  • the present invention relates to the use of ozonized cod liver oil for the preparation of a cosmetic or pharmaceutical composition for the treatment of cellulitis .
  • compositions of the present invention can have a formulation suitable for topical or systemic administration.
  • the ozonized cod liver oil of the invention has rehologic properties that are especially suitable for administration by the topical route.
  • the ozonization reaction causes an increase in cod liver oil viscosity, thus improving the features of spreadability and permanence of this composition on the site of action.
  • Use for topical administration refers to the composition as such or mixed with appropriate auxiliary substances, in order to obtain pharmaceutical and/or cosmetic formulations allowing the desired delivery, permanence in the site of action and posology.
  • Auxiliary substances for external use which can be mixed with the ozonized cod liver oil of the invention are, for instance, vaseline oil, lanolin, solid paraffin and emulsifying agents.
  • cod liver oil can be administered as such, without any excipient, or in the form of soft gelatinous capsules.
  • the iodine index according to the method described in FU Xl Ed., was measured in cod liver oil samples prepared according to the procedure described in Example 1, with the exception that the ozonization time was changed. In fact, this parameter is important in order to correlate the transformation potential of the preparation following the ozonization process.
  • the peroxide index has been measured as function of the ozonization- time using the method described in FU Xl Ed. This method is commonly used as indicator of the quality of the oil ozonization process and as control, since it is simple, fast and accurate.
  • cod liver oil ozonization involves a progressive decrease of the signals originated from olefinic carbons at 130 ppm and the appearance of new signals at 103 ppm, which can be attributed to formation of ozonide.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Birds (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une huile de foie de morue ozonisée, des compositions pharmaceutiques et cosmétiques contenant cette huile, ainsi qu'un procédé de préparation de cette huile.
PCT/EP2006/060016 2005-02-18 2006-02-16 Composition ozonisee d'origine animale WO2006087359A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2005A000245 2005-02-18
IT000245A ITMI20050245A1 (it) 2005-02-18 2005-02-18 Composto di origine animale ozonizzato

Publications (1)

Publication Number Publication Date
WO2006087359A1 true WO2006087359A1 (fr) 2006-08-24

Family

ID=36452920

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/060016 WO2006087359A1 (fr) 2005-02-18 2006-02-16 Composition ozonisee d'origine animale

Country Status (2)

Country Link
IT (1) ITMI20050245A1 (fr)
WO (1) WO2006087359A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1938792A1 (fr) * 2006-12-29 2008-07-02 Vanity Line S.p.A. Composé complexe cosmétique
FR2929516A1 (fr) * 2008-04-03 2009-10-09 Carilene Lab Composition dermatologique utilisable notamment pour le soin et la prevention des escarres
IT201600078872A1 (it) * 2016-07-27 2018-01-27 Fb Vision S R L Olio e dispositivo per l'igiene dell'area oculare e perioculare
WO2018225006A1 (fr) * 2017-06-08 2018-12-13 Project & Communications Ltd. Formulation à usage oral comprenant de l'huile ozonisée pour prévenir et/ou traiter des maladies tissulaires systémiques provoquées par inflammation des monocytes
EP3506876B1 (fr) * 2016-08-31 2021-03-03 Unigroup ApS Composition pour le traitement du champignon des ongles

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451480A (en) * 1982-04-16 1984-05-29 James Howard Brown Method of treating acne using ozonized materials
FR2730636A1 (fr) * 1995-02-16 1996-08-23 Cosmart Ag Huile vegetale naturelle enrichie en ozonides, compositions cosmetiques ou pharmaceutiques la contenant et utilisations
FR2753374A1 (fr) * 1996-09-19 1998-03-20 Rivadis Lab Composition cosmetique comportant au moins un extrait vegetal, des huiles vegetales peroxydees pour la peau
RU2131673C1 (ru) * 1998-04-17 1999-06-20 Педдер Валерий Викторович Способ получения озонированного масла "отрисан"
JPH11292773A (ja) * 1998-04-10 1999-10-26 Nof Corp 肝油、精製方法および用途
RU2147877C1 (ru) * 1999-09-13 2000-04-27 Чернеховская Наталья Евгеньевна Способ лечения язв желудка и двенадцатиперстной кишки
DE19932570A1 (de) * 1999-07-13 2001-01-18 Gerhard Steidl Präparat zur antimikrobiellen Behandlung im Zahnbereich
RU2238097C2 (ru) * 2002-05-24 2004-10-20 Вятская государственная сельскохозяйственная академия Препарат для лечения и профилактики эндометрита и мастита у коров и способ его приготовления

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451480A (en) * 1982-04-16 1984-05-29 James Howard Brown Method of treating acne using ozonized materials
FR2730636A1 (fr) * 1995-02-16 1996-08-23 Cosmart Ag Huile vegetale naturelle enrichie en ozonides, compositions cosmetiques ou pharmaceutiques la contenant et utilisations
FR2753374A1 (fr) * 1996-09-19 1998-03-20 Rivadis Lab Composition cosmetique comportant au moins un extrait vegetal, des huiles vegetales peroxydees pour la peau
JPH11292773A (ja) * 1998-04-10 1999-10-26 Nof Corp 肝油、精製方法および用途
RU2131673C1 (ru) * 1998-04-17 1999-06-20 Педдер Валерий Викторович Способ получения озонированного масла "отрисан"
DE19932570A1 (de) * 1999-07-13 2001-01-18 Gerhard Steidl Präparat zur antimikrobiellen Behandlung im Zahnbereich
RU2147877C1 (ru) * 1999-09-13 2000-04-27 Чернеховская Наталья Евгеньевна Способ лечения язв желудка и двенадцатиперстной кишки
RU2238097C2 (ru) * 2002-05-24 2004-10-20 Вятская государственная сельскохозяйственная академия Препарат для лечения и профилактики эндометрита и мастита у коров и способ его приготовления

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EPODOC EUROPEAN PATENT OFFICE, THE HAGUE, NL; XP002383433 *
DATABASE EPODOC EUROPEAN PATENT OFFICE, THE HAGUE, NL; XP002383434 *
DATABASE EPODOC EUROPEAN PATENT OFFICE, THE HAGUE, NL; XP002383435 *
PATENT ABSTRACTS OF JAPAN vol. 2000, no. 01 31 January 2000 (2000-01-31) *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1938792A1 (fr) * 2006-12-29 2008-07-02 Vanity Line S.p.A. Composé complexe cosmétique
FR2929516A1 (fr) * 2008-04-03 2009-10-09 Carilene Lab Composition dermatologique utilisable notamment pour le soin et la prevention des escarres
WO2009125117A3 (fr) * 2008-04-03 2010-05-20 Laboratoires Carilene Composition dermatologique utilisable notamment pour le soin et la prevention des escarres
US8507007B2 (en) 2008-04-03 2013-08-13 Laboratoires Carilene Dermatological composition that can be used in particular for the care and prevention of eschars
IT201600078872A1 (it) * 2016-07-27 2018-01-27 Fb Vision S R L Olio e dispositivo per l'igiene dell'area oculare e perioculare
WO2018020456A1 (fr) * 2016-07-27 2018-02-01 Fb Vision S.R.L. Huile et dispositif pour le nettoyage de la zone oculaire et péri-oculaire
EP3506876B1 (fr) * 2016-08-31 2021-03-03 Unigroup ApS Composition pour le traitement du champignon des ongles
WO2018225006A1 (fr) * 2017-06-08 2018-12-13 Project & Communications Ltd. Formulation à usage oral comprenant de l'huile ozonisée pour prévenir et/ou traiter des maladies tissulaires systémiques provoquées par inflammation des monocytes

Also Published As

Publication number Publication date
ITMI20050245A1 (it) 2006-08-19

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