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WO2002081528A1 - Polymere qui a la particularite de reconnaitre l'acide biliaire, procede de fabrication correspondant, polymere absorbant l'acide biliaire et agents diminuant le cholesterol - Google Patents

Polymere qui a la particularite de reconnaitre l'acide biliaire, procede de fabrication correspondant, polymere absorbant l'acide biliaire et agents diminuant le cholesterol Download PDF

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Publication number
WO2002081528A1
WO2002081528A1 PCT/JP2002/003323 JP0203323W WO02081528A1 WO 2002081528 A1 WO2002081528 A1 WO 2002081528A1 JP 0203323 W JP0203323 W JP 0203323W WO 02081528 A1 WO02081528 A1 WO 02081528A1
Authority
WO
WIPO (PCT)
Prior art keywords
bile acid
polymer
cholesterol
lowering agents
same
Prior art date
Application number
PCT/JP2002/003323
Other languages
English (en)
Japanese (ja)
Inventor
Takayuki Oka
Shinichiro Kitahara
Original Assignee
Sekisui Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sekisui Chemical Co., Ltd. filed Critical Sekisui Chemical Co., Ltd.
Publication of WO2002081528A1 publication Critical patent/WO2002081528A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/268—Polymers created by use of a template, e.g. molecularly imprinted polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur un polymère capable d'absorber de manière sélective de l'acide biliaire seul et sur des agents diminuant le cholestérol. Elle se rapporte à un polymère présentant la particularité de reconnaître l'acide biliaire ou à un polymère absorbant l'acide biliaire et possédant un site d'absorption spécifique, ce polymère étant formé par le procédé d'imprégnation moléculaire, à au moins un acide biliaire et un composés capables de former ensemble une micelle avec de l'acide biliaire, et à des agents diminuant le cholestérol et contenant ce polymère en tant que composant principal.
PCT/JP2002/003323 2001-04-05 2002-04-03 Polymere qui a la particularite de reconnaitre l'acide biliaire, procede de fabrication correspondant, polymere absorbant l'acide biliaire et agents diminuant le cholesterol WO2002081528A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2001-107352 2001-04-05
JP2001107352 2001-04-05
JP2001-261726 2001-08-30
JP2001261725 2001-08-30
JP2001261726 2001-08-30
JP2001-261725 2001-08-30

Publications (1)

Publication Number Publication Date
WO2002081528A1 true WO2002081528A1 (fr) 2002-10-17

Family

ID=27346469

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/003323 WO2002081528A1 (fr) 2001-04-05 2002-04-03 Polymere qui a la particularite de reconnaitre l'acide biliaire, procede de fabrication correspondant, polymere absorbant l'acide biliaire et agents diminuant le cholesterol

Country Status (1)

Country Link
WO (1) WO2002081528A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112472686A (zh) * 2020-12-07 2021-03-12 中国药科大学 一种peg-pla-sn38连接物的脂质纳米粒及其制备方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198395A (en) * 1976-05-25 1980-04-15 Etablissement Viridis Novel hypocholesterolemic resin
WO1993013781A1 (fr) * 1992-01-14 1993-07-22 Hisamitsu Pharmaceutical Co., Inc. Reducteur du taux de cholesterol
JPH07206687A (ja) * 1993-05-20 1995-08-08 Sekisui Chem Co Ltd 経口コレステロール低下剤及びその製造方法
JPH07241463A (ja) * 1994-03-07 1995-09-19 Sekisui Chem Co Ltd 胆汁酸吸着剤
JPH07316061A (ja) * 1994-05-23 1995-12-05 Sekisui Chem Co Ltd コレステロール低下剤
WO1995034588A1 (fr) * 1994-06-10 1995-12-21 Geltex Pharmaceuticals, Inc. Polymeres reticules utilises pour eliminer les sels biliaires d'un patient
US20020015690A1 (en) * 2000-06-30 2002-02-07 Green Bernard S. Molecularly imprinted polymers for the treatment and diagnosis of medical conditions

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198395A (en) * 1976-05-25 1980-04-15 Etablissement Viridis Novel hypocholesterolemic resin
WO1993013781A1 (fr) * 1992-01-14 1993-07-22 Hisamitsu Pharmaceutical Co., Inc. Reducteur du taux de cholesterol
JPH07206687A (ja) * 1993-05-20 1995-08-08 Sekisui Chem Co Ltd 経口コレステロール低下剤及びその製造方法
JPH07241463A (ja) * 1994-03-07 1995-09-19 Sekisui Chem Co Ltd 胆汁酸吸着剤
JPH07316061A (ja) * 1994-05-23 1995-12-05 Sekisui Chem Co Ltd コレステロール低下剤
WO1995034588A1 (fr) * 1994-06-10 1995-12-21 Geltex Pharmaceuticals, Inc. Polymeres reticules utilises pour eliminer les sels biliaires d'un patient
US20020015690A1 (en) * 2000-06-30 2002-02-07 Green Bernard S. Molecularly imprinted polymers for the treatment and diagnosis of medical conditions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112472686A (zh) * 2020-12-07 2021-03-12 中国药科大学 一种peg-pla-sn38连接物的脂质纳米粒及其制备方法

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