UA119458C2 - Сполуки піридину пладієноліду та способи застосування - Google Patents
Сполуки піридину пладієноліду та способи застосуванняInfo
- Publication number
- UA119458C2 UA119458C2 UAA201612731A UAA201612731A UA119458C2 UA 119458 C2 UA119458 C2 UA 119458C2 UA A201612731 A UAA201612731 A UA A201612731A UA A201612731 A UAA201612731 A UA A201612731A UA 119458 C2 UA119458 C2 UA 119458C2
- Authority
- UA
- Ukraine
- Prior art keywords
- methods
- pyridine compounds
- compounds
- pladienolide pyridine
- useful
- Prior art date
Links
- 150000003222 pyridines Chemical class 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 210000001324 spliceosome Anatomy 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Даний винахід пропонує нові сполуки пладієноліду піридину, фармацевтичні композиції, що містять такі сполуки, та способи застосування сполук як терапевтичних засобів. Ці сполуки можуть бути корисними у лікуванні раку, зокрема раку, при якому відомо, що корисно застосовувати агенти, які націлені на сплайсосому та мутації в ній. 48
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461993423P | 2014-05-15 | 2014-05-15 | |
| PCT/US2015/030464 WO2015175594A1 (en) | 2014-05-15 | 2015-05-13 | Pladienolide pyridine compounds and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA119458C2 true UA119458C2 (uk) | 2019-06-25 |
Family
ID=53284528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201612731A UA119458C2 (uk) | 2014-05-15 | 2015-05-13 | Сполуки піридину пладієноліду та способи застосування |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US9481669B2 (uk) |
| EP (2) | EP3514154B1 (uk) |
| JP (1) | JP6067943B1 (uk) |
| KR (2) | KR102146726B1 (uk) |
| CN (1) | CN107074827B (uk) |
| AR (1) | AR100431A1 (uk) |
| AU (1) | AU2015259237B2 (uk) |
| BR (1) | BR112016026638B1 (uk) |
| CA (1) | CA2947754C (uk) |
| CL (1) | CL2016002835A1 (uk) |
| CY (1) | CY1121550T1 (uk) |
| DK (1) | DK3143016T3 (uk) |
| ES (1) | ES2712401T3 (uk) |
| HR (1) | HRP20190432T1 (uk) |
| HU (1) | HUE041838T2 (uk) |
| IL (1) | IL248529B (uk) |
| JO (1) | JO3668B1 (uk) |
| LT (1) | LT3143016T (uk) |
| MA (1) | MA39915B1 (uk) |
| ME (1) | ME03417B (uk) |
| MX (2) | MX2020004476A (uk) |
| MY (1) | MY195081A (uk) |
| PE (1) | PE20170384A1 (uk) |
| PH (1) | PH12016502249A1 (uk) |
| PL (1) | PL3143016T3 (uk) |
| PT (1) | PT3143016T (uk) |
| RS (1) | RS58400B1 (uk) |
| RU (1) | RU2707730C2 (uk) |
| SG (1) | SG11201609693XA (uk) |
| SI (1) | SI3143016T1 (uk) |
| TR (1) | TR201902328T4 (uk) |
| TW (1) | TWI634115B (uk) |
| UA (1) | UA119458C2 (uk) |
| WO (1) | WO2015175594A1 (uk) |
| ZA (1) | ZA201607354B (uk) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017040526A2 (en) | 2015-09-01 | 2017-03-09 | Eisai R&D Management Co., Ltd. | Splice variants associated with neomorphic sf3b1 mutants |
| JP6312282B2 (ja) | 2015-11-18 | 2018-04-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 固体形態のプラジエノライドピリジン化合物及び使用の方法 |
| CA3056389A1 (en) | 2017-03-15 | 2018-09-20 | Eisai R&D Management Co., Ltd. | Spliceosome mutations and uses thereof |
| AU2018360559B2 (en) | 2017-10-31 | 2024-08-22 | Eisai R&D Management Co., Ltd. | Combination comprising at least one spliceosome modulator and at least one inhibitor chosen from BCL2 inhibitors, BCL2/BCLXL inhibitors, and BCLXL inhibitors and methods of use |
| AU2019251096B2 (en) * | 2018-04-09 | 2023-04-20 | Eisai R&D Management Co., Ltd. | Pladienolide compounds and their use |
| BR112020020956A2 (pt) * | 2018-04-12 | 2021-03-02 | Eisai R&D Management Co., Ltd. | derivados de pladienolida como spliceossoma que tem como alvo agentes para tratar câncer |
| EP3801523B1 (en) * | 2018-06-01 | 2024-09-11 | Eisai R&D Management Co., Ltd. | Splicing modulators |
| IL262658A (en) * | 2018-10-28 | 2020-04-30 | Memorial Sloan Kettering Cancer Center | Prevention of age related clonal hematopoiesis and diseases associated therewith |
| BR112022024833A2 (pt) * | 2020-06-05 | 2023-02-14 | Eisai R&D Man Co Ltd | Conjugados anticorpo anti-bcma-fármaco e métodos de uso |
| TW202233187A (zh) | 2020-11-04 | 2022-09-01 | 日商衛材R&D企管股份有限公司 | 骨髓發育不良症候群（ｍｄｓ）之生物標記物及其使用方法 |
| WO2022263702A1 (es) * | 2021-06-18 | 2022-12-22 | Universidad de Córdoba | Compuesto para el tratamiento del glioblastoma |
| CN113876771B (zh) * | 2021-11-12 | 2022-09-23 | 中国医学科学院基础医学研究所 | 一种靶向pabpc1的小分子药物及其在慢性髓系白血病中的应用 |
| WO2023131866A1 (en) | 2022-01-05 | 2023-07-13 | Eisai R&D Management Co., Ltd. | Biomarkers for myelodysplastic syndrome (mds) and methods of using the same |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI311558B (en) | 2001-02-01 | 2009-07-01 | Mercian Corporatio | Novel physiologically active substance |
| TWI334866B (en) | 2002-05-29 | 2010-12-21 | Mercian Corp | Novel physiologically active substances |
| CN1671856B (zh) | 2002-07-31 | 2010-05-12 | 卫材R&D管理株式会社 | 生理活性物质 |
| JP4459051B2 (ja) | 2002-07-31 | 2010-04-28 | メルシャン株式会社 | 新規生理活性物質 |
| WO2004037212A2 (en) | 2002-10-24 | 2004-05-06 | Sepracor, Inc. | Compositions comprising zopiclone derivatives and methods of making and using the same |
| WO2004050890A1 (ja) | 2002-11-29 | 2004-06-17 | Mercian Corporation | マクロライド系化合物の製造方法 |
| KR20060110865A (ko) | 2003-11-27 | 2006-10-25 | 에자이 가부시키가이샤 | 매크로라이드계 화합물의 수산화에 관여하는 ｄｎａ |
| ATE466937T1 (de) | 2003-11-28 | 2010-05-15 | Kanagawa Kagaku Gijutsu Akad | Verfahren zum nachweis von leberkrebs, diagnostikum für leberkrebs sowie heilmittel gegen krebs |
| US20070199741A1 (en) | 2004-07-02 | 2007-08-30 | Kenji Noumi | Combined Weighing Apparatus |
| AU2005265443B2 (en) | 2004-07-20 | 2008-09-04 | Eisai R & D Management Co., Ltd | DNA coding for polypeptide participating in biosynthesis of pladienolide |
| TW200716744A (en) * | 2005-05-26 | 2007-05-01 | Eisai R&D Man Co Ltd | Genetically modified microorganism and process for production of macrolide compound using the microorganism |
| EP1935893A4 (en) | 2005-10-13 | 2009-07-22 | Eisai R&D Man Co Ltd | TOTAL SYNTHESIS OF PLADIENOLIDE B AND PLADIENOLIDE D |
| US20100021918A1 (en) * | 2007-03-05 | 2010-01-28 | Eisai R&D Management Co., Ltd. | Method for assaying action of antitumor agent using splicing defects as index |
| US20080312317A1 (en) | 2007-04-12 | 2008-12-18 | Eisai R&D Management Co., Ltd. | 12 membered-ring macrolactam derivatives |
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2015
- 2015-05-13 AU AU2015259237A patent/AU2015259237B2/en active Active
- 2015-05-13 ME MEP-2019-81A patent/ME03417B/me unknown
- 2015-05-13 RU RU2016148887A patent/RU2707730C2/ru active
- 2015-05-13 PL PL15727125T patent/PL3143016T3/pl unknown
- 2015-05-13 HU HUE15727125A patent/HUE041838T2/hu unknown
- 2015-05-13 US US14/710,687 patent/US9481669B2/en active Active
- 2015-05-13 UA UAA201612731A patent/UA119458C2/uk unknown
- 2015-05-13 EP EP18210019.8A patent/EP3514154B1/en active Active
- 2015-05-13 CA CA2947754A patent/CA2947754C/en active Active
- 2015-05-13 RS RS20190233A patent/RS58400B1/sr unknown
- 2015-05-13 SG SG11201609693XA patent/SG11201609693XA/en unknown
- 2015-05-13 DK DK15727125.5T patent/DK3143016T3/en active
- 2015-05-13 KR KR1020177004442A patent/KR102146726B1/ko active IP Right Grant
- 2015-05-13 TW TW104115293A patent/TWI634115B/zh active
- 2015-05-13 MY MYPI2016001944A patent/MY195081A/en unknown
- 2015-05-13 JO JOP/2015/0113A patent/JO3668B1/ar active
- 2015-05-13 WO PCT/US2015/030464 patent/WO2015175594A1/en active Application Filing
- 2015-05-13 KR KR1020167016648A patent/KR101710318B1/ko active IP Right Grant
- 2015-05-13 JP JP2016526218A patent/JP6067943B1/ja active Active
- 2015-05-13 AR ARP150101485A patent/AR100431A1/es unknown
- 2015-05-13 CN CN201580025344.0A patent/CN107074827B/zh active Active
- 2015-05-13 LT LTEP15727125.5T patent/LT3143016T/lt unknown
- 2015-05-13 ES ES15727125T patent/ES2712401T3/es active Active
- 2015-05-13 PT PT15727125T patent/PT3143016T/pt unknown
- 2015-05-13 MX MX2020004476A patent/MX2020004476A/es unknown
- 2015-05-13 TR TR2019/02328T patent/TR201902328T4/tr unknown
- 2015-05-13 BR BR112016026638-2A patent/BR112016026638B1/pt active IP Right Grant
- 2015-05-13 EP EP15727125.5A patent/EP3143016B1/en active Active
- 2015-05-13 SI SI201530641T patent/SI3143016T1/sl unknown
- 2015-05-13 MA MA39915A patent/MA39915B1/fr unknown
- 2015-05-13 PE PE2016002233A patent/PE20170384A1/es unknown
- 2015-05-13 MX MX2016014997A patent/MX2016014997A/es active IP Right Grant
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2016
- 2016-10-25 ZA ZA2016/07354A patent/ZA201607354B/en unknown
- 2016-10-26 IL IL24852916A patent/IL248529B/en active IP Right Grant
- 2016-11-08 CL CL2016002835A patent/CL2016002835A1/es unknown
- 2016-11-11 PH PH12016502249A patent/PH12016502249A1/en unknown
-
2019
- 2019-02-22 CY CY20191100228T patent/CY1121550T1/el unknown
- 2019-03-04 HR HRP20190432TT patent/HRP20190432T1/hr unknown
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