TW350772B - Tablets with improved bioavailability of the active material clodronic acid - Google Patents

Tablets with improved bioavailability of the active material clodronic acid

Info

Publication number: TW350772B
Authority: TW; Taiwan
Prior art keywords: tablet; clodronic acid; improved bioavailability; tablets; active material
Prior art date: 1993-05-15

Application number

TW082106635A

Other languages

English (en)

Inventor

Walter Preis

Bernd Muesel

Guenter Neugebauer

Rolf-Dieter Gabel

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-15

Filing date

1993-09-10

Publication date

1999-01-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25927331&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW350772(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-05-15 Priority claimed from DE9307393U external-priority patent/DE9307393U1/de

1993-07-02 Priority claimed from DE19934322057 external-priority patent/DE4322057A1/de

1993-09-10 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1999-01-21 Application granted granted Critical

1999-01-21 Publication of TW350772B publication Critical patent/TW350772B/zh

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

TW082106635A 1993-05-15 1993-09-10 Tablets with improved bioavailability of the active material clodronic acid TW350772B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE9307393U DE9307393U1 (de)	1993-05-15	1993-05-15	Tablette mit verbesserter Bioverfügbarkeit, enthaltend Dichlormethylendiphosphonsäure als Wirkstoff
DE19934322057 DE4322057A1 (de)	1993-07-02	1993-07-02	Tablette mit verbesserter Bioverfügbarkeit enthaltend Dichlormethylendiphosphonsäure als Wirkstoff

Publications (1)

Publication Number	Publication Date
TW350772B true TW350772B (en)	1999-01-21

Family

ID=25927331

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW082106635A TW350772B (en)	1993-05-15	1993-09-10	Tablets with improved bioavailability of the active material clodronic acid

Country Status (25)

Country	Link
US (1)	US5650168A (zh)
EP (2)	EP0697890A1 (zh)
JP (1)	JP3699110B2 (zh)
KR (1)	KR100263284B1 (zh)
CN (1)	CN1041797C (zh)
AT (2)	ATE128363T1 (zh)
AU (1)	AU687744B2 (zh)
BR (1)	BR9307859A (zh)
CA (1)	CA2162470C (zh)
CZ (1)	CZ287984B6 (zh)
DE (1)	DE59300688D1 (zh)
DK (1)	DK0625355T5 (zh)
ES (1)	ES2065313T5 (zh)
FI (1)	FI111519B (zh)
GR (2)	GR940300095T1 (zh)
HU (1)	HU220872B1 (zh)
IL (1)	IL106743A (zh)
NO (1)	NO307548B1 (zh)
NZ (1)	NZ254765A (zh)
PL (1)	PL173026B1 (zh)
RU (1)	RU2134103C1 (zh)
SK (1)	SK281193B6 (zh)
TW (1)	TW350772B (zh)
UA (1)	UA39884C2 (zh)
WO (1)	WO1994026310A1 (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI94926C (fi) *	1993-11-12	1995-11-27	Leiras Oy	Menetelmä klodronaattivalmisteen valmistamiseksi
DE19615812A1 (de) *	1996-04-20	1997-10-23	Boehringer Mannheim Gmbh	Pharmazeutische Zubereitung enthaltend Diphosphonsäuren zur oralen Applikation
DE19719680A1 (de)	1997-05-09	1998-11-19	Boehringer Mannheim Gmbh	Verwendung von Diphosphonsäuren zur präventiven Behandlung von Spätfolgen bei Harnblasenerweiterung oder Harnblasenersatz
FI109088B (fi) *	1997-09-19	2002-05-31	Leiras Oy	Tabletti ja menetelmä sen valmistamiseksi
EP0998932A1 (de)	1998-10-09	2000-05-10	Boehringer Mannheim Gmbh	Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung
SE9901272D0 (sv) *	1999-04-09	1999-04-09	Astra Ab	New improved formulation
CZ289261B6 (cs) *	2000-07-11	2001-12-12	Léčiva, A.S.	Tableta vyrobitelná přímým tabletováním, obsahující aktivní látku kyselinu 4-amino-1-hydroxybutyliden-1,1-bisfosfonovou, a způsob její výroby
US10213387B2 (en)	2003-09-19	2019-02-26	Sun Pharma Advanced Research Company Ltd.	Oral drug delivery system
ATE551051T1 (de) *	2003-09-19	2012-04-15	Sun Pharma Advanced Res Co Ltd	Orales arzneimittelabgabesystem
US10226428B2 (en)	2003-09-19	2019-03-12	Sun Pharma Advanced Research Company Ltd.	Oral drug delivery system
US7151400B2 (en) *	2004-07-13	2006-12-19	Taiwan Semiconductor Manufacturing Company, Ltd.	Boost-biased level shifter
CN100370972C (zh) *	2006-01-10	2008-02-27	北京申科联华科技有限公司	一种具有益气养阴、活血复脉功效的片剂及制备方法
JPWO2009017222A1 (ja) *	2007-08-02	2010-10-21	帝人ファーマ株式会社	骨代謝異常に起因する疾患の予防剤又は治療剤
EP2242485A4 (en) *	2008-02-15	2013-05-08	Sun Pharma Advanced Res Co Ltd	ORAL TABLET WITH CONTROLLED RELEASE
CN118370733B (zh) *	2024-06-21	2024-10-01	山东新时代药业有限公司	一种钙代谢调节药物氯膦酸二钠片及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2813121A1 (de) *	1977-03-29	1978-10-12	Procter & Gamble	Verwendung von dichlormethan-diphosphonatverbindungen bei der bekaempfung von collagen-erkrankungen und zur wundheilung
US4634691A (en) *	1980-10-07	1987-01-06	The Procter & Gamble Company	Method for inhibiting tumor metastasis
US4517179A (en) *	1983-04-29	1985-05-14	Pennwalt Corporation	Rapid dissolving, uniform drug compositions and their preparation
SE457326B (sv) *	1986-02-14	1988-12-19	Lejus Medical Ab	Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa
ATE60711T1 (de) *	1986-12-20	1991-02-15	Boehringer Mannheim Gmbh	Clodronat-haltige arzneimittel und verfahren zur herstellung derselben.
DE3804686A1 (de) *	1988-02-15	1989-08-24	Henkel Kgaa	Arzneimittel mit einer kombination von cytostatika bzw. hormontherapeutika und phosphonoderivaten
FR2629716B1 (fr) *	1988-04-07	1991-07-19	Sanofi Sa	Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique
FI83421C (fi) †	1989-06-21	1991-07-10	Huhtamaeki Oy	Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.
JP3727332B2 (ja) *	1991-02-26	2005-12-14	ノーウィッチ、イートン、ファーマスーティカルズ、インコーポレーテッド	骨粗鬆症の治療方法
SE501389C2 (sv) *	1992-04-24	1995-01-30	Leiras Oy	Farmaceutiskt preparat och förfarande för dess framställning
JPH08505142A (ja) *	1992-12-23	1996-06-04	メルクエンドカンパニーインコーポレーテッド	骨損失を治療及び予防するためのビスホスホネート／エストロゲン療法

1993
- 1993-07-24 EP EP93917636A patent/EP0697890A1/de not_active Withdrawn
- 1993-07-24 CZ CZ1995100A patent/CZ287984B6/cs not_active IP Right Cessation
- 1993-07-24 DE DE59300688T patent/DE59300688D1/de not_active Expired - Lifetime
- 1993-07-24 SK SK48-95A patent/SK281193B6/sk not_active IP Right Cessation
- 1993-07-24 BR BR9307859A patent/BR9307859A/pt not_active Application Discontinuation
- 1993-07-24 ES ES93111827T patent/ES2065313T5/es not_active Expired - Lifetime
- 1993-07-24 CA CA002162470A patent/CA2162470C/en not_active Expired - Lifetime
- 1993-07-24 NZ NZ254765A patent/NZ254765A/en not_active IP Right Cessation
- 1993-07-24 JP JP51843194A patent/JP3699110B2/ja not_active Expired - Fee Related
- 1993-07-24 HU HU9403160A patent/HU220872B1/hu unknown
- 1993-07-24 RU RU95121748A patent/RU2134103C1/ru active
- 1993-07-24 WO PCT/EP1993/001967 patent/WO1994026310A1/de not_active Application Discontinuation
- 1993-07-24 EP EP93111827A patent/EP0625355B2/de not_active Expired - Lifetime
- 1993-07-24 AU AU47020/93A patent/AU687744B2/en not_active Expired
- 1993-07-24 DK DK93111827T patent/DK0625355T5/da active
- 1993-07-24 UA UA95114854A patent/UA39884C2/uk unknown
- 1993-07-24 US US08/537,853 patent/US5650168A/en not_active Expired - Lifetime
- 1993-07-24 AT AT93111827T patent/ATE128363T1/de active
- 1993-07-24 KR KR1019950705094A patent/KR100263284B1/ko not_active IP Right Cessation
- 1993-07-24 PL PL93307133A patent/PL173026B1/pl unknown
- 1993-08-19 IL IL10674393A patent/IL106743A/en not_active IP Right Cessation
- 1993-09-10 TW TW082106635A patent/TW350772B/zh not_active IP Right Cessation
- 1993-09-23 CN CN93118149A patent/CN1041797C/zh not_active Expired - Lifetime
1994
- 1994-05-13 AT AT0007494U patent/AT128U1/de not_active IP Right Cessation
- 1994-11-11 FI FI945313A patent/FI111519B/fi not_active IP Right Cessation
- 1994-11-17 NO NO944405A patent/NO307548B1/no not_active IP Right Cessation
1995
- 1995-01-31 GR GR940300095T patent/GR940300095T1/el unknown
- 1995-09-28 GR GR950402574T patent/GR3017547T3/el unknown

Also Published As

Publication number	Publication date
NO944405L (no)	1994-11-24
DE59300688D1 (de)	1995-11-02
DK0625355T3 (da)	1995-12-27
FI111519B (fi)	2003-08-15
ES2065313T3 (es)	1995-12-01
AT128U1 (de)	1995-03-27
NZ254765A (en)	1997-02-24
AU4702093A (en)	1994-12-12
EP0625355B2 (de)	2003-06-25
PL307133A1 (en)	1995-05-02
ES2065313T1 (es)	1995-02-16
CZ10095A3 (en)	1995-10-18
AU687744B2 (en)	1998-03-05
ATE128363T1 (de)	1995-10-15
CN1095267A (zh)	1994-11-23
DK0625355T5 (da)	2003-12-01
CZ287984B6 (cs)	2001-03-14
HU220872B1 (en)	2002-06-29
CA2162470C (en)	1998-06-16
GR3017547T3 (en)	1995-12-31
GR940300095T1 (en)	1995-01-31
CA2162470A1 (en)	1994-11-24
SK281193B6 (sk)	2001-01-18
KR100263284B1 (ko)	2000-08-01
PL173026B1 (pl)	1998-01-30
FI945313A0 (fi)	1994-11-11
SK4895A3 (en)	1997-01-08
UA39884C2 (uk)	2001-07-16
NO307548B1 (no)	2000-04-25
EP0625355A1 (de)	1994-11-23
ES2065313T5 (es)	2004-01-01
WO1994026310A1 (de)	1994-11-24
EP0625355B1 (de)	1995-09-27
CN1041797C (zh)	1999-01-27
NO944405D0 (no)	1994-11-17
IL106743A (en)	1999-11-30
DK0625355T4 (da)	2003-10-06
BR9307859A (pt)	1996-01-09
HU9403160D0 (en)	1995-02-28
US5650168A (en)	1997-07-22
EP0697890A1 (de)	1996-02-28
HUT70214A (en)	1995-09-28
FI945313A (fi)	1994-12-13
JPH08509697A (ja)	1996-10-15
IL106743A0 (en)	1993-12-08
KR960702322A (ko)	1996-04-27
RU2134103C1 (ru)	1999-08-10
JP3699110B2 (ja)	2005-09-28

Publication	Publication Date	Title
TW350772B (en)	1999-01-21	Tablets with improved bioavailability of the active material clodronic acid
AU668375B2 (en)	1996-05-02	Pharmaceutical preparation in the form of an effervescent and/or disintegrating tablet or an instant granulate, and process for producing it
GR3031135T3 (en)	1999-12-31	Compositions containing S(+)-Ibuprofen.
TW272942B (zh)	1996-03-21
HU9300700D0 (en)	1993-05-28	Concentrated solid dosing forms with high active agent content such as pills, granular powders and pellets
MD872G2 (ro)	1998-08-31	Compoziţie farmaceutică efervescentă şi preparat pe baza ei, procedeu de fabricare a preparatului
EP0525389A3 (en)	1993-12-08	Process for preparing mechanically stable, well disintegrating tablets from small active agent containing solid forms
MY104772A (en)	1994-05-31	Dispersible granules of fungicidal products.
CA2149362A1 (en)	1995-11-18	Pharmaceutical composition based on guar gum coated with simethicone, inassociation with a neutralizing antacid
NZ337418A (en)	2000-05-26	Paracetamol composition with improved rate of absorption
CA2211325A1 (en)	1996-08-01	Extended release clonidine formulation
IE810036L (en)	1981-07-11	Sustained release compositions
FR2774291B1 (fr)	2000-04-21	Specialite pharmaceutique sous forme galenique unitaire de comprimes a croquer ou a sucer, comprenant comme principe actif du fer element
AU2508801A (en)	2001-06-04	Detergent compositions
MY107183A (en)	1995-09-30	Pharmaceutical compositions
CA2344686A1 (en)	2000-04-27	High purity composition comprising (7.alpha.,17.alpha.)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-one
CA2038637A1 (en)	1991-09-22	Pharmaceutical iodine compositions
IT1189379B (it)	1988-02-04	Composizione farmaceutica contenente un agente fibrinolitico ed un fattore di diffusione,utile per il trattamento dell'infarto miocardico
DE2963545D1 (en)	1982-10-07	Pharmaceutical composition containing all-e- or 13-z-7,8-dehydro-retinoic acid and process for its preparation
CA2122478A1 (en)	1993-05-27	Unit Dose Form of Bismuth Subsalicylate
EP0175377A3 (en)	1988-07-06	An ether compound, its production and an insecticidal and acaricidal composition containing it as an active ingredient
ES1005500U (es)	1988-11-16	Dispositivo limpiador de reserva para lavavajillas industriales.
JPS5344617A (en)	1978-04-21	Drug composition
GB1449441A (en)	1976-09-15	Agnets for lowering the lipid level in plasma
ES2184285T3 (es)	2003-04-01	Compuestos farmaceuticos que contienen diclorhidrato de cinconina.

Legal Events

Date	Code	Title	Description
2013-10-21	MK4A	Expiration of patent term of an invention patent