Nothing Special   »   [go: up one dir, main page]

TW200616953A - Indole, indazole or indoline derivatives - Google Patents

Indole, indazole or indoline derivatives

Info

Publication number
TW200616953A
TW200616953A TW094126127A TW94126127A TW200616953A TW 200616953 A TW200616953 A TW 200616953A TW 094126127 A TW094126127 A TW 094126127A TW 94126127 A TW94126127 A TW 94126127A TW 200616953 A TW200616953 A TW 200616953A
Authority
TW
Taiwan
Prior art keywords
indazole
indole
indoline derivatives
compounds
indoline
Prior art date
Application number
TW094126127A
Other languages
English (en)
Inventor
Aurelia Conte-Mayweg
Holger Kuehne
Thomas Luebbers
Cyrille Maugeais
Werner Mueller
Philippe Pflieger
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of TW200616953A publication Critical patent/TW200616953A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
TW094126127A 2004-08-05 2005-08-02 Indole, indazole or indoline derivatives TW200616953A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04103762 2004-08-05

Publications (1)

Publication Number Publication Date
TW200616953A true TW200616953A (en) 2006-06-01

Family

ID=35448129

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094126127A TW200616953A (en) 2004-08-05 2005-08-02 Indole, indazole or indoline derivatives

Country Status (13)

Country Link
US (1) US7259183B2 (zh)
EP (1) EP1776338A1 (zh)
JP (1) JP4787254B2 (zh)
KR (1) KR100854864B1 (zh)
CN (1) CN1993323B (zh)
AR (1) AR050281A1 (zh)
AU (1) AU2005268893B2 (zh)
BR (1) BRPI0514133A (zh)
CA (1) CA2575329A1 (zh)
MX (1) MX2007001431A (zh)
RU (1) RU2007106180A (zh)
TW (1) TW200616953A (zh)
WO (1) WO2006013048A1 (zh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7951973B2 (en) * 2005-11-22 2011-05-31 Bayer Cropscience Ag N-(1-methyl-2Phenylethyl)benzamide derivatives
US7674815B2 (en) * 2006-02-07 2010-03-09 Hoffmann-La Roche Inc. Heteroaryl and benzyl amide compounds
US7572823B2 (en) * 2006-02-07 2009-08-11 Hoffmann-La Roche Inc. Heteroaryl carboxamide compounds
US7745477B2 (en) * 2006-02-07 2010-06-29 Hoffman-La Roche Inc. Heteroaryl and benzyl amide compounds
EP2049493B1 (en) 2006-07-31 2012-03-21 Cadila Healthcare Limited Compounds suitable as modulators of hdl
WO2008068185A1 (en) 2006-12-07 2008-06-12 F. Hoffmann-La Roche Ag Spiro-piperidine derivatives as via receptor antagonists
CA2673307A1 (en) 2006-12-22 2008-07-03 F. Hoffman-La Roche Ag Spiro-piperidine derivatives
EP2011783A1 (en) * 2007-07-06 2009-01-07 F. Hoffmann-La Roche Ag Process for the preparation of an indole derivative
US20090325717A1 (en) * 2008-06-26 2009-12-31 Marlon John Lee-Him Video Game Controller Holder
WO2010059711A1 (en) * 2008-11-18 2010-05-27 Wisconsin Alumni Research Foundation Sigma-1 receptor ligands and methods of use
KR20230165366A (ko) * 2009-07-17 2023-12-05 니뽄 다바코 산교 가부시키가이샤 트리아졸로피리딘 화합물, 그리고 그 프롤릴 수산화효소 저해제 및 에리트로포이에틴 생성 유도제로서의 작용
BR112012030657A2 (pt) 2010-05-31 2015-09-29 Kyorin Seiyaku Kk método para produzir derivado de 3-substituído-4-fluoropirrolidina
RU2563030C2 (ru) 2011-03-16 2015-09-20 Мицубиси Танабе Фарма Корпорейшн Сульфонамидные соединения, обладающие антагонистической активностью в отношении trpm8
AU2012255690B2 (en) 2011-05-16 2015-06-11 Bionomics Limited Amine derivatives as potassium channel blockers
US9688630B2 (en) 2013-10-10 2017-06-27 Merck Sharp & Dohme Corp. 3,3′-disubstituted indolines as inhibitors of cholesterol ester transfer protein
KR20160110357A (ko) * 2013-11-15 2016-09-21 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 Ｅｂｎａ１ 억제제 및 그의 사용 방법
MX2017014550A (es) 2015-05-14 2018-02-26 Wistar Inst Inhibidores del antigeno nuclear epstein-barr 1 (ebna1) y metodos que los utilizan.
US11242338B2 (en) 2018-05-17 2022-02-08 The Wistar Institute EBNA1 inhibitor crystalline forms, and methods of preparing and using same
WO2020124206A1 (en) 2018-12-18 2020-06-25 University Of Manitoba Metal complexes, methods of making the same, and uses thereof
CN113045475A (zh) * 2019-12-27 2021-06-29 上海泓博智源医药股份有限公司 一种5-溴-7-甲基吲哚的制备方法
CN113943238B (zh) 2020-07-17 2022-11-01 沈阳中化农药化工研发有限公司 一种取代的苯硫醚类化合物及其应用
WO2024050408A1 (en) * 2022-08-30 2024-03-07 The Wistar Institute Of Anatomy And Biology Development of a novel ebna-1 degrader targeting through mdm2
CN115417781B (zh) * 2022-09-30 2023-08-29 西安凯立新材料股份有限公司 一种制备氯虫苯甲酰胺中间体k胺的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2345118C (en) * 1998-09-25 2010-04-27 Monsanto Company Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
US7879893B2 (en) * 2001-09-14 2011-02-01 Novo Nordisk A/S Ligands for the HisB10 Zn2 + sites of the R-state insulin hexamer
WO2004020393A1 (ja) * 2002-08-30 2004-03-11 Japan Tobacco Inc. ジベンジルアミン化合物及びその医薬用途
CA2497979A1 (en) * 2002-09-06 2004-03-18 Elan Pharmaceuticals, Inc. 1, 3-diamino-2-hydroxypropane prodrug derivatives

Also Published As

Publication number Publication date
MX2007001431A (es) 2007-04-02
AU2005268893B2 (en) 2011-10-13
US7259183B2 (en) 2007-08-21
US20060030613A1 (en) 2006-02-09
KR20070035096A (ko) 2007-03-29
WO2006013048A1 (en) 2006-02-09
CA2575329A1 (en) 2006-02-09
AU2005268893A1 (en) 2006-02-09
AR050281A1 (es) 2006-10-11
BRPI0514133A (pt) 2008-05-27
CN1993323A (zh) 2007-07-04
JP2008508334A (ja) 2008-03-21
JP4787254B2 (ja) 2011-10-05
KR100854864B1 (ko) 2008-08-28
EP1776338A1 (en) 2007-04-25
CN1993323B (zh) 2011-04-20
RU2007106180A (ru) 2008-09-10

Similar Documents

Publication Publication Date Title
TW200616953A (en) Indole, indazole or indoline derivatives
MX2008013196A (es) 5-amido-2-carboxiamida-indoles.
TW200612936A (en) Indole derivatives
MY143367A (en) Substituted indole derivatives for pharmaceutical compositions for treating respiratory diseases
ATE430744T1 (de) Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren
UA96785C2 (uk) Заміщені похідні оксиндолу та їх застосування як лігандів рецептора вазопресину
ATE467632T1 (de) Pyrroloä2,3-büpyridinderivate als modulatoren des h3-rezeptors
PT1940839E (pt) Inibidores de piridopirimidinona pi3k alfa
MX2009003157A (es) Pirazoliltienopiridinas terapeuticas.
TW200736233A (en) Cyclohexyl piperazinyl methanone derivatives
ATE449776T1 (de) Pyrroloä2,3-cüpyridinderivate
TW200738651A (en) Cyclohexyl sulfonamide derivatives
MX2007011698A (es) Derivados de oxindol sustituido, medicamentos que contienen dichos derivados y uso de los mismos.
TW200637817A (en) 5-aminoindole derivatives
UA99787C2 (en) Lactams as beta secretase inhibitors
MX2010006206A (es) Derivados de oxindol substituidos por 5-halogeno y el uso de los mismos para el tratamiento de enfermedades dependientes de la vasopresina.
MX2010006108A (es) Inhibidores de estearoil-coa-desaturasa.
MX2008002539A (es) Derivados de (indol-3-il)-heterociclo como agonistas del receptor canabinoide cb1.
IL195016A0 (en) 1h-indol-5-yl-piperazin-1-yl-methanone derivatives
TW200732304A (en) Piperidine derivatives
GEP20135805B (en) 1-(ARYLSULFONYL)-4-(PIPERAZIN-1-YL)-1H-BENZIMIDAZOLES AS δ-HYDROXYTRYPTAMINE-6 LIGANDS
ATE466007T1 (de) 5-substituierte indol-2-carbonsäureamidderivate
TW200626158A (en) Naphthaline derivatives
MY157425A (en) Substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses
MX2007006387A (es) Derivados de piridina 3-substituidos como antagonistas h3.