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TR201910814T4 - Kanser immünoterapisi için cd123 spesifik kimerik antijen reseptörleri. - Google Patents

Kanser immünoterapisi için cd123 spesifik kimerik antijen reseptörleri. Download PDF

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Publication number
TR201910814T4
TR201910814T4 TR2019/10814T TR201910814T TR201910814T4 TR 201910814 T4 TR201910814 T4 TR 201910814T4 TR 2019/10814 T TR2019/10814 T TR 2019/10814T TR 201910814 T TR201910814 T TR 201910814T TR 201910814 T4 TR201910814 T4 TR 201910814T4
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Turkey
Prior art keywords
chimeric antigen
antigen receptors
cancer immunotherapy
specific chimeric
lymphoma
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TR2019/10814T
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English (en)
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Galetto Roman
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Cellectis
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Abstract

Mevcut buluş, immün hücresi spesifitesini ve reaktivitesini seçilen membran antijenlerine yönlendirebilen ve daha özel olarak ekstraselüler ligand bağlamanın bir CD123 monoklonal antikordan türetildiği bir scFV olduğu, CD123 pozitif hücrelere spesifik bağışıklık sağladığı, rekombinant kimerik proteinler olan Kimerik Antijen Reseptörleri (CAR) ile ilgilidir. Bu tür CAR'larla donatılmış geliştirilmiş immün hücreleri, özellikle lenfoma ve löseminin tedavisi için uygundur.
TR2019/10814T 2014-03-19 2015-03-19 Kanser immünoterapisi için cd123 spesifik kimerik antijen reseptörleri. TR201910814T4 (tr)

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DKPA201470137 2014-03-19

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TR201910814T4 true TR201910814T4 (tr) 2019-08-21

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US (3) US9944709B2 (tr)
EP (2) EP3569619B1 (tr)
JP (2) JP6689202B2 (tr)
KR (1) KR102157411B1 (tr)
CN (1) CN106103490B (tr)
AU (1) AU2015233461B2 (tr)
CA (1) CA2943008C (tr)
DK (2) DK3119807T3 (tr)
ES (2) ES2877606T3 (tr)
HU (1) HUE045480T2 (tr)
IL (1) IL247172B (tr)
MX (2) MX370272B (tr)
PL (1) PL3119807T3 (tr)
PT (1) PT3119807T (tr)
RU (1) RU2727290C2 (tr)
TR (1) TR201910814T4 (tr)
WO (1) WO2015140268A1 (tr)

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