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TR201908447T4 - Tnf aktivitesinin modülatörleri olarak kaynaşık imidazol ve pirazol türevleri. - Google Patents

Tnf aktivitesinin modülatörleri olarak kaynaşık imidazol ve pirazol türevleri. Download PDF

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Publication number
TR201908447T4
TR201908447T4 TR2019/08447T TR201908447T TR201908447T4 TR 201908447 T4 TR201908447 T4 TR 201908447T4 TR 2019/08447 T TR2019/08447 T TR 2019/08447T TR 201908447 T TR201908447 T TR 201908447T TR 201908447 T4 TR201908447 T4 TR 201908447T4
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TR
Turkey
Prior art keywords
disorders
modulators
pyrazole derivatives
fused imidazole
tnf activity
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TR2019/08447T
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English (en)
Inventor
Peter Alexander Rikki
Mark Bentley Jonathan
Neil Brace Gareth
Christopher Brookings Daniel
Tulshi Chovatia Praful
Jean Claude Deboves Hervé
Johnstone Craig
Pearl Jones Elizabeth
Kroeplien Boris
Claude Lecomte Fabien
Madden James
Adrian Miller Craig
Robert Porter John
Duncan Selby Matthew
Alan Shaw Michael
Gunvant Vaidya Darshan
Andrew Yule Ian
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Ucb Biopharma Sprl
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Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl
Publication of TR201908447T4 publication Critical patent/TR201908447T4/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
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  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
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  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Mevcut buluş, kaynaşık imidazol ve pirazol türevlerinin bir sınıfı ile ve bunların tedavide kullanımı ile ilgilidir. Daha özel olarak bu buluş, farmakolojik olarak aktif şekilde substitüe edilmiş benzimidazol, imidazo[1,2-a]piridin ve pirazolo[1,5-a]piridin türevleri ve bunların analogları ile ilgilidir. Bu bileşikler, TNF? sinyal iletiminin modülatörleridir ve dolayısıyla, özellikle advers enflamatuar ve otoimmün bozukluklar, nörolojik ve nörodejeneratif bozukluklar, ağrı ve nosiseptif bozukluklar, kardiyovasküler bozukluklar, metabolik bozukluklar, oküler bozukluklar ve onkolojik bozuklukların tedavisinde farmasötik ajanlar olarak faydalıdır.
TR2019/08447T 2013-12-09 2014-12-08 Tnf aktivitesinin modülatörleri olarak kaynaşık imidazol ve pirazol türevleri. TR201908447T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1321738.5A GB201321738D0 (en) 2013-12-09 2013-12-09 Therapeutic Agents

Publications (1)

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TR201908447T4 true TR201908447T4 (tr) 2019-07-22

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TR2019/08447T TR201908447T4 (tr) 2013-12-09 2014-12-08 Tnf aktivitesinin modülatörleri olarak kaynaşık imidazol ve pirazol türevleri.

Country Status (11)

Country Link
US (1) US9868749B2 (tr)
EP (1) EP3080115B1 (tr)
JP (1) JP6495915B2 (tr)
CN (1) CN105814054B (tr)
BR (1) BR112016011851B1 (tr)
CA (1) CA2932056C (tr)
ES (1) ES2733927T3 (tr)
GB (1) GB201321738D0 (tr)
RU (1) RU2687093C1 (tr)
TR (1) TR201908447T4 (tr)
WO (1) WO2015086506A1 (tr)

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Publication number Publication date
EP3080115A1 (en) 2016-10-19
WO2015086506A1 (en) 2015-06-18
US20160297837A1 (en) 2016-10-13
EP3080115B1 (en) 2019-05-08
ES2733927T3 (es) 2019-12-03
JP2016539961A (ja) 2016-12-22
CA2932056C (en) 2021-10-26
CN105814054B (zh) 2018-09-25
BR112016011851B1 (pt) 2022-07-19
US9868749B2 (en) 2018-01-16
JP6495915B2 (ja) 2019-04-03
RU2687093C1 (ru) 2019-05-07
CA2932056A1 (en) 2015-06-18
GB201321738D0 (en) 2014-01-22
CN105814054A (zh) 2016-07-27
BR112016011851A2 (tr) 2017-08-08

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