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TR201819138T4 - FGFR Kinaz Modülatörleri Olarak Faydalı Kinoksalin Türevleri - Google Patents

FGFR Kinaz Modülatörleri Olarak Faydalı Kinoksalin Türevleri Download PDF

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Publication number
TR201819138T4
TR201819138T4 TR2018/19138T TR201819138T TR201819138T4 TR 201819138 T4 TR201819138 T4 TR 201819138T4 TR 2018/19138 T TR2018/19138 T TR 2018/19138T TR 201819138 T TR201819138 T TR 201819138T TR 201819138 T4 TR201819138 T4 TR 201819138T4
Authority
TR
Turkey
Prior art keywords
derivatives useful
quinoxaline derivatives
fgfr kinase
kinase modulators
compounds
Prior art date
Application number
TR2018/19138T
Other languages
English (en)
Inventor
Vermeulen Wim
Anna HOSTYN Steven
Albert Celine Cuyckens Filip
MARK JONES Russell
Fernando Domenico Broggini Diego
Original Assignee
Astex Therapeutics Ltd
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50389854&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR201819138(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of TR201819138T4 publication Critical patent/TR201819138T4/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Buluş, formülün (I) yeni kinoksalin türevi bileşikleri, söz konusu bileşikleri içeren farmasötik bileşimler, söz konusu bileşiklerin hazırlanışına yönelik prosesler ve söz konusu bileşiklerin, örneğin kanser olmak üzere hastalıkların tedavisindeki kullanımı ile ilgilidir.
TR2018/19138T 2014-03-26 2015-03-26 FGFR Kinaz Modülatörleri Olarak Faydalı Kinoksalin Türevleri TR201819138T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14161820 2014-03-26

Publications (1)

Publication Number Publication Date
TR201819138T4 true TR201819138T4 (tr) 2019-01-21

Family

ID=50389854

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2018/19138T TR201819138T4 (tr) 2014-03-26 2015-03-26 FGFR Kinaz Modülatörleri Olarak Faydalı Kinoksalin Türevleri

Country Status (37)

Country Link
US (2) US9902714B2 (tr)
EP (1) EP3122742B1 (tr)
JP (1) JP6625551B2 (tr)
KR (1) KR102469506B1 (tr)
CN (1) CN106459010B (tr)
AP (1) AP2016009536A0 (tr)
AR (1) AR099854A1 (tr)
AU (1) AU2015238300C1 (tr)
BR (1) BR112016022060B1 (tr)
CA (1) CA2943683A1 (tr)
CL (1) CL2016002382A1 (tr)
CR (1) CR20160501A (tr)
CY (1) CY1120969T1 (tr)
DK (1) DK3122742T3 (tr)
EA (1) EA032145B1 (tr)
ES (1) ES2702450T3 (tr)
HR (1) HRP20182073T1 (tr)
HU (1) HUE041738T2 (tr)
IL (1) IL247658B (tr)
JO (1) JO3512B1 (tr)
LT (1) LT3122742T (tr)
MA (1) MA39783B1 (tr)
MX (1) MX2016012446A (tr)
MY (1) MY194074A (tr)
NI (1) NI201600144A (tr)
NZ (1) NZ724907A (tr)
PH (1) PH12016501898B1 (tr)
PL (1) PL3122742T3 (tr)
PT (1) PT3122742T (tr)
RS (1) RS58088B1 (tr)
SG (1) SG11201607961QA (tr)
SI (1) SI3122742T1 (tr)
TR (1) TR201819138T4 (tr)
TW (1) TWI686391B (tr)
UA (1) UA117958C2 (tr)
WO (1) WO2015144803A1 (tr)
ZA (1) ZA201606942B (tr)

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