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TR200100286T2 - (1H)-Benzo[C]kuinolizin-3-on türevlerinin sentezi için proses. - Google Patents

(1H)-Benzo[C]kuinolizin-3-on türevlerinin sentezi için proses.

Info

Publication number
TR200100286T2
TR200100286T2 TR2001/00286T TR200100286T TR200100286T2 TR 200100286 T2 TR200100286 T2 TR 200100286T2 TR 2001/00286 T TR2001/00286 T TR 2001/00286T TR 200100286 T TR200100286 T TR 200100286T TR 200100286 T2 TR200100286 T2 TR 200100286T2
Authority
TR
Turkey
Prior art keywords
quinolizine
benzo
derivatives
synthesis
compounds
Prior art date
Application number
TR2001/00286T
Other languages
English (en)
Inventor
Guarna Antonio
Serio Mario
Giovanni Occhiato Ernesto
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of TR200100286T2 publication Critical patent/TR200100286T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Carbon And Carbon Compounds (AREA)

Abstract

Mevcut bulus, ticari olarak piyasada bulunan veya kolayca hazirlanabilen bilesiklerin baslangiç ürünleri olarak, üç asama ve kullanim içeren genel formül (I)'deki (1H)-benzo[c]kuinolizin-3-on türevlerinin hazirlanmasi için bir proses ile ilgilidir. Formül (I)'in bilesikleri 5alfa-redüktazlarin inhibitörleri olarak yararlidirlar.
TR2001/00286T 1998-08-03 1999-07-23 (1H)-Benzo[C]kuinolizin-3-on türevlerinin sentezi için proses. TR200100286T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98114524 1998-08-03

Publications (1)

Publication Number Publication Date
TR200100286T2 true TR200100286T2 (tr) 2001-07-23

Family

ID=8232396

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/00286T TR200100286T2 (tr) 1998-08-03 1999-07-23 (1H)-Benzo[C]kuinolizin-3-on türevlerinin sentezi için proses.

Country Status (29)

Country Link
US (1) US6723850B1 (tr)
EP (1) EP1102765B1 (tr)
JP (1) JP2002522435A (tr)
KR (1) KR100624239B1 (tr)
CN (1) CN1128148C (tr)
AT (1) ATE250057T1 (tr)
AU (1) AU751873B2 (tr)
BG (1) BG65062B1 (tr)
BR (1) BR9912870A (tr)
CA (1) CA2338498C (tr)
CZ (1) CZ291648B6 (tr)
DE (1) DE69911430T2 (tr)
DK (1) DK1102765T3 (tr)
EA (1) EA003997B1 (tr)
EE (1) EE04642B1 (tr)
ES (1) ES2203169T3 (tr)
HK (1) HK1037368A1 (tr)
HU (1) HUP0103241A3 (tr)
IL (2) IL141212A0 (tr)
NO (1) NO20010559D0 (tr)
NZ (1) NZ509243A (tr)
PL (1) PL198963B1 (tr)
PT (1) PT1102765E (tr)
SI (1) SI1102765T1 (tr)
SK (1) SK285438B6 (tr)
TR (1) TR200100286T2 (tr)
UA (1) UA67787C2 (tr)
WO (1) WO2000008019A1 (tr)
ZA (1) ZA200100365B (tr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
MX365890B (es) * 2004-06-24 2019-06-19 Vertex Pharma Moduladores de transportadores con casete de unión con atp.
US8354427B2 (en) * 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
AU2006331614A1 (en) * 2005-12-24 2007-07-05 Vertex Pharmaceuticals Incorporated Quinolin- 4 - one derivatives as modulators of ABC transporters
RS55940B1 (sr) 2005-12-28 2017-09-29 Vertex Pharma Čvrsti oblici n-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksohinolin-3-karboksamida
SG174410A1 (en) 2009-03-20 2011-11-28 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
DK2651890T3 (en) * 2010-12-14 2014-11-24 Syngenta Participations Ag STRIGOLACTAM DERIVATIVES AND THEIR USE AS PLANT GROWTH REGULATORS
RU2692779C2 (ru) 2012-02-27 2019-06-27 Вертекс Фармасьютикалз Инкорпорейтед Фармацевтическая композиция и ее введения
EP3204358B1 (en) 2014-10-07 2018-09-19 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
CN105001216B (zh) * 2015-07-08 2017-03-01 中国科学院兰州化学物理研究所 一种喹嗪酮的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5064961A (en) * 1989-12-18 1991-11-12 E. R. Squibb & Sons, Inc. Process for preparing an optically active cyclobutane nucleoside
FR2696465B1 (fr) * 1992-10-02 1994-12-23 Adir Nouveaux dérivés d'ellipticine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
IT1286545B1 (it) 1996-02-09 1998-07-15 Antonio Guarna Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi
JPH09316076A (ja) * 1996-05-24 1997-12-09 Nippon Paper Ind Co Ltd ９−置換プリン誘導体及びその抗ウイルス剤としての用途

Also Published As

Publication number Publication date
DE69911430T2 (de) 2004-07-22
EA200100213A1 (ru) 2001-08-27
SI1102765T1 (en) 2003-12-31
PL198963B1 (pl) 2008-08-29
CA2338498A1 (en) 2000-02-17
AU751873B2 (en) 2002-08-29
WO2000008019A1 (en) 2000-02-17
US6723850B1 (en) 2004-04-20
IL141212A0 (en) 2002-03-10
EP1102765A1 (en) 2001-05-30
AU6312399A (en) 2000-02-28
CZ291648B6 (cs) 2003-04-16
HK1037368A1 (en) 2002-02-08
HUP0103241A2 (hu) 2002-01-28
BR9912870A (pt) 2001-10-16
SK285438B6 (sk) 2007-01-04
EE200100060A (et) 2002-06-17
DE69911430D1 (de) 2003-10-23
HUP0103241A3 (en) 2002-10-28
CN1311788A (zh) 2001-09-05
JP2002522435A (ja) 2002-07-23
PL345802A1 (en) 2002-01-02
ATE250057T1 (de) 2003-10-15
ZA200100365B (en) 2001-07-26
BG105198A (en) 2001-12-29
DK1102765T3 (da) 2004-02-02
BG65062B1 (bg) 2007-01-31
EE04642B1 (et) 2006-06-15
PT1102765E (pt) 2003-12-31
CA2338498C (en) 2009-05-19
KR20010074684A (ko) 2001-08-09
NO20010559L (no) 2001-02-01
EP1102765B1 (en) 2003-09-17
KR100624239B1 (ko) 2006-09-13
NO20010559D0 (no) 2001-02-01
CN1128148C (zh) 2003-11-19
CZ2001434A3 (cs) 2001-08-15
EA003997B1 (ru) 2003-12-25
IL141212A (en) 2006-12-31
UA67787C2 (uk) 2004-07-15
SK1672001A3 (en) 2001-08-06
ES2203169T3 (es) 2004-04-01
NZ509243A (en) 2002-11-26

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