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TR200001050T2 - Çözünmez insülin bileşimleri - Google Patents

Çözünmez insülin bileşimleri

Info

Publication number
TR200001050T2
TR200001050T2 TR2000/01050T TR200001050T TR200001050T2 TR 200001050 T2 TR200001050 T2 TR 200001050T2 TR 2000/01050 T TR2000/01050 T TR 2000/01050T TR 200001050 T TR200001050 T TR 200001050T TR 200001050 T2 TR200001050 T2 TR 200001050T2
Authority
TR
Turkey
Prior art keywords
insulin
nph
unopened
blood sugar
acylated
Prior art date
Application number
TR2000/01050T
Other languages
English (en)
Inventor
Laurence Brader Mark
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of TR200001050T2 publication Critical patent/TR200001050T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Bulus açillenmis insülin, açillenmis analog insülin ve açillenmis proinsülinlerin olusturdugu grup içinden seçilen protein ihtiva eden çözünmez bilesimlerle ilgilidir. Bilesim formülleri diabet hastalarinin kan sekeri seviyelerini düzenlemek için kullanilir. Bilesim civa, protamin ve bir fenolik terkip ile kompleks hale gelmis açillenmis proteinden olusur ve elde edilen mikro kristal NPH insülin kristallerine benzer fakat deri altina uygulandiginda daha uzun ve etkin bir kan sekeri düzenleme özelligine sahiptir. Ayrica NPH gibi tekrar süspansiyon haline getirilebilir ve diger çözülebilir insülinlerle de karistirilabilir.
TR2000/01050T 1997-10-24 1998-10-22 Çözünmez insülin bileşimleri TR200001050T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6310497P 1997-10-24 1997-10-24
US8893098P 1998-06-11 1998-06-11

Publications (1)

Publication Number Publication Date
TR200001050T2 true TR200001050T2 (tr) 2000-08-21

Family

ID=26743043

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/01050T TR200001050T2 (tr) 1997-10-24 1998-10-22 Çözünmez insülin bileşimleri

Country Status (21)

Country Link
US (3) US6268335B1 (tr)
EP (1) EP1039920A4 (tr)
JP (2) JP2001521006A (tr)
KR (1) KR20010024556A (tr)
CN (1) CN1276731A (tr)
AR (1) AR020047A1 (tr)
AU (2) AU747926B2 (tr)
BR (1) BR9813111A (tr)
CA (2) CA2306905A1 (tr)
CO (1) CO4970769A1 (tr)
EA (1) EA200000453A1 (tr)
HR (1) HRP20000236A2 (tr)
HU (1) HUP0004169A3 (tr)
ID (1) ID24890A (tr)
IL (1) IL134901A0 (tr)
NO (1) NO20002038L (tr)
PE (1) PE123799A1 (tr)
PL (1) PL340255A1 (tr)
SV (1) SV1998000125A (tr)
TR (1) TR200001050T2 (tr)
WO (2) WO1999021573A1 (tr)

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AU1111799A (en) 1999-05-17
AR020047A1 (es) 2002-04-10
EP1039920A1 (en) 2000-10-04
BR9813111A (pt) 2000-08-15
PE123799A1 (es) 1999-12-13
EP1039920A4 (en) 2003-05-28
US6268335B1 (en) 2001-07-31
NO20002038L (no) 2000-06-26
WO1999021573A1 (en) 1999-05-06
HUP0004169A3 (en) 2001-06-28
CA2306905A1 (en) 1999-05-06
SV1998000125A (es) 1999-05-24
PL340255A1 (en) 2001-01-29
ID24890A (id) 2000-08-31
AU747926B2 (en) 2002-05-30
US20010036916A1 (en) 2001-11-01
IL134901A0 (en) 2001-05-20
HRP20000236A2 (en) 2001-02-28
JP2001521006A (ja) 2001-11-06
US6465426B2 (en) 2002-10-15
WO1999021578A1 (en) 1999-05-06
US20020082199A1 (en) 2002-06-27
EA200000453A1 (ru) 2000-10-30
JP2001521004A (ja) 2001-11-06
HUP0004169A2 (hu) 2001-05-28
AU1116699A (en) 1999-05-17
KR20010024556A (ko) 2001-03-26
CA2306877A1 (en) 1999-05-06
NO20002038D0 (no) 2000-04-18
CO4970769A1 (es) 2000-11-07
CN1276731A (zh) 2000-12-13

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