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SI3116891T1 - Čiščenje imunoglobulina z uporabo predčistilnih stopenj - Google Patents

Čiščenje imunoglobulina z uporabo predčistilnih stopenj

Info

Publication number
SI3116891T1
SI3116891T1 SI201531188T SI201531188T SI3116891T1 SI 3116891 T1 SI3116891 T1 SI 3116891T1 SI 201531188 T SI201531188 T SI 201531188T SI 201531188 T SI201531188 T SI 201531188T SI 3116891 T1 SI3116891 T1 SI 3116891T1
Authority
SI
Slovenia
Prior art keywords
cleaning steps
immunoglobulin purification
immunoglobulin
purification
cleaning
Prior art date
Application number
SI201531188T
Other languages
English (en)
Inventor
Ferenc Felfoldi
Zsuzsa Benko
Melinda Gaspar
Original Assignee
Richter Gedeon Nyrt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU1400131A external-priority patent/HUP1400131A1/hu
Priority claimed from HU1500053A external-priority patent/HUP1500053A1/hu
Application filed by Richter Gedeon Nyrt. filed Critical Richter Gedeon Nyrt.
Publication of SI3116891T1 publication Critical patent/SI3116891T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26—Cation exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SI201531188T 2014-03-10 2015-03-09 Čiščenje imunoglobulina z uporabo predčistilnih stopenj SI3116891T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU1400131A HUP1400131A1 (hu) 2014-03-10 2014-03-10 Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával
HU1500053A HUP1500053A1 (hu) 2015-02-09 2015-02-09 Immunglobulin tisztítása elõtisztítási lépések alkalmazásával
EP15708522.6A EP3116891B1 (en) 2014-03-10 2015-03-09 Immunoglobulin purification using pre-cleaning steps
PCT/EP2015/054862 WO2015135884A1 (en) 2014-03-10 2015-03-09 Immunoglobulin purification using pre-cleaning steps

Publications (1)

Publication Number Publication Date
SI3116891T1 true SI3116891T1 (sl) 2020-07-31

Family

ID=89991731

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201531188T SI3116891T1 (sl) 2014-03-10 2015-03-09 Čiščenje imunoglobulina z uporabo predčistilnih stopenj

Country Status (15)

Country Link
US (1) US10487138B2 (sl)
EP (2) EP3674310A1 (sl)
JP (1) JP6293907B2 (sl)
KR (1) KR101921552B1 (sl)
CN (1) CN106103465B (sl)
CA (1) CA2930350C (sl)
DK (1) DK3116891T3 (sl)
ES (1) ES2784749T3 (sl)
HR (1) HRP20200711T1 (sl)
HU (1) HUE048782T2 (sl)
LT (1) LT3116891T (sl)
PL (1) PL3116891T3 (sl)
PT (1) PT3116891T (sl)
SI (1) SI3116891T1 (sl)
WO (1) WO2015135884A1 (sl)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3116891T1 (sl) 2014-03-10 2020-07-31 Richter Gedeon Nyrt. Čiščenje imunoglobulina z uporabo predčistilnih stopenj
GB2539420B (en) * 2015-06-16 2021-01-13 Cytiva Sweden Ab Determination of chromatography conditions
JP6851109B2 (ja) * 2016-06-16 2021-03-31 Jsr株式会社 抗体を精製する方法及び担体を洗浄する方法
CN109563124A (zh) * 2016-06-17 2019-04-02 豪夫迈·罗氏有限公司 多特异性抗体的纯化
WO2018051348A1 (en) * 2016-09-14 2018-03-22 Insight Biopharmaceutical Ltd. Methods of purifying and qualifying antibodies
EP3601332A1 (en) * 2017-03-24 2020-02-05 Council of Scientific and Industrial Research A process for the purification of recombinant antibody fragments
WO2019040671A1 (en) * 2017-08-22 2019-02-28 Biogen Ma Inc. METHODS OF PURIFYING ANTIBODIES HAVING REDUCED AGGREGATES OF HIGH MOLECULAR WEIGHT
KR20190047376A (ko) 2017-10-27 2019-05-08 주식회사 녹십자 개선된 면역글로불린의 정제방법
EP3762120A4 (en) * 2018-03-08 2021-09-01 Bio-Rad Laboratories, Inc. MIXED MODE ANIONIC-HYDROPHOBIC EXCHANGE CHROMATOGRAPHY RESIN
US11155575B2 (en) 2018-03-21 2021-10-26 Waters Technologies Corporation Non-antibody high-affinity-based sample preparation, sorbent, devices and methods
GB201805142D0 (en) * 2018-03-29 2018-05-16 Ge Healthcare Bioprocess R&D Ab Separation method
WO2020016417A1 (en) * 2018-07-19 2020-01-23 Ichnos Sciences S.A. Liquid antibody formulation
KR102209790B1 (ko) * 2018-12-20 2021-02-01 에이치케이이노엔 주식회사 친화성 크로마토그래피를 이용한 백신용 바이러스 정제방법
JP7241888B2 (ja) * 2018-12-30 2023-03-17 エフ． ホフマン－ラ ロシュ アーゲー ｐＨ勾配ＳＰＲに基づく結合アッセイ
SG11202107870RA (en) * 2019-03-21 2021-08-30 Agency Science Tech & Res A method of capturing and/or purifying a target
HU231498B1 (hu) * 2019-04-04 2024-05-28 Richter Gedeon Nyrt Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelőző flokkulálás alkalmazásával
MX2021015302A (es) * 2019-06-10 2022-01-18 Takeda Pharmaceuticals Co Metodos de purificacion de anticuerpos y composiciones de estos.
CN114040815B (zh) 2019-09-05 2024-06-28 生物辐射实验室股份有限公司 阴离子交换-疏水混合模式色谱树脂
WO2022071990A1 (en) * 2020-04-10 2022-04-07 Plasma Technologies, Llc Compositions and methods for simplified high efficiency isolation of proteins
CN113563469A (zh) * 2020-04-28 2021-10-29 江苏中新医药有限公司 高回收率纯化阿达木单抗的方法
WO2021220252A1 (en) * 2020-05-01 2021-11-04 Kashiv Biosciences, Llc An improved process of purification of protein
AU2022361768A1 (en) * 2021-10-08 2024-05-02 Kashiv Biosciences, Llc Separation of pre-peak and post-peak in fusion protein sample by using size exclusion high performance liquid chromatography
EP4412747A1 (en) * 2021-10-08 2024-08-14 Kashiv Biosciences, LLC Separation of pre-peak in fusion protein sample by using size exclusion high performance liquid chromatography
CN114133446A (zh) * 2021-12-31 2022-03-04 方坦思(上海)生物医药有限公司 单克隆抗体的纯化方法
CN115304673B (zh) * 2022-06-24 2024-10-01 上海赛伦生物技术股份有限公司 一种马抗破伤风特异性免疫球蛋白F(ab’)2的纯化方法及其应用

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR930007430B1 (ko) * 1987-07-16 1993-08-10 쉐링 코포레이션 크로마토그래피 단계에 의한 과립구-대식세포 콜로니-자극 인자의 정제방법
CA1341235C (en) 1987-07-24 2001-05-22 Randy R. Robinson Modular assembly of antibody genes, antibodies prepared thereby and use
US4983722A (en) 1988-06-08 1991-01-08 Miles Inc. Removal of protein A from antibody preparations
AU8001291A (en) * 1990-05-31 1991-12-31 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Method for purifying hiv reverse transcriptase
ES2289997T3 (es) 1991-03-18 2008-02-16 New York University Anticuerpos monoclonales y quimericos especificos para el factor de necrosis tumoral humano.
EP0940468A1 (en) 1991-06-14 1999-09-08 Genentech, Inc. Humanized antibody variable domain
RU2139731C1 (ru) 1992-11-13 1999-10-20 Айдек Фармасьютикалс Корпорейшн (US Способ лечения, антитела, гибридома
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
MX336813B (es) 1996-02-09 2016-02-02 Abbvie Biotechnology Ltd Anticuerpos humanos que ligan el tnfa humano.
CN100480269C (zh) 1997-04-07 2009-04-22 基因技术股份有限公司 抗-血管内皮生长因子的抗体
EP1222572A2 (en) 1999-08-26 2002-07-17 Symtec Limited Methods and devices for selecting data files
CN1547486A (zh) 2001-06-26 2004-11-17 抗opgl抗体
WO2003016909A1 (en) * 2001-08-16 2003-02-27 Ludwig Institute For Cancer Research Method for determining protein component in a biological sample
DE10155984A1 (de) 2001-11-15 2003-05-28 Boehringer Ingelheim Pharma Verfahren zur Reduktion des Liganden-leakage von Affinitätschromatographie-Matrices
JP4319979B2 (ja) 2002-04-26 2009-08-26 ジェネンテック・インコーポレーテッド タンパク質の非アフィニティ精製
PT1601697E (pt) 2003-02-28 2007-09-04 Lonza Biologics Plc Purificação de anticorpos através de proteína a e cromatografia de troca iónica.
WO2004087761A1 (ja) 2003-03-31 2004-10-14 Kirin Beer Kabushiki Kaisha ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製
EP3095793B1 (en) * 2003-07-28 2020-03-25 Genentech, Inc. Reducing protein a leaching during protein a affinity chromatography
AU2004291341B2 (en) * 2003-11-05 2010-08-05 Ares Trading S.A. Process for the purification of IL-18 binding protein
EP1718386A1 (en) * 2004-02-27 2006-11-08 GE Healthcare Bio-Sciences AB A process for the purification of antibodies
EP1685161A1 (en) 2004-08-30 2006-08-02 Lonza Biologics plc Affinity- plus ion exchange-chromatography for purifying antibodies
BRPI0817182A2 (pt) 2007-10-30 2015-03-17 Genentech Inc Método para purificar um anticorpo e composições
CN103396480A (zh) 2008-05-15 2013-11-20 诺沃—诺迪斯克有限公司 抗体纯化方法
TWI610936B (zh) 2008-10-20 2018-01-11 艾伯維有限公司 使用蛋白質ａ親和性層析進行抗體之分離及純化
US8497358B2 (en) 2008-12-19 2013-07-30 Takeda Pharmaceutical Company Limited Antibody purification method
MX2012000841A (es) * 2009-07-24 2012-02-28 Hoffmann La Roche Optimizacion de la produccion de anticuerpos.
EP2462157B1 (en) 2009-08-07 2020-06-17 EMD Millipore Corporation Methods for purifying a target protein from one or more impurities in a sample
JP5787891B2 (ja) * 2009-09-01 2015-09-30 ジェネンテック， インコーポレイテッド 改変されたプロテインａ溶離による向上したタンパク質精製
WO2011049798A1 (en) 2009-10-20 2011-04-28 Merck Sharp & Dohme Corp. Use of mixed mode chromatography for the capture and purification of basic antibody products
EP2519537A4 (en) 2009-12-29 2013-07-10 Reddys Lab Ltd Dr CLEANING PROTEINS
AU2011258254B2 (en) 2010-05-25 2016-01-07 Genentech, Inc. Methods of purifying polypeptides
EP2627425A4 (en) * 2010-10-11 2014-11-05 Abbvie Inc METHODS OF PURIFYING PROTEINS
DK2731677T3 (en) * 2011-07-11 2018-06-18 Glenmark Pharmaceuticals Sa ANTIBODIES. BINDING TO OX40 AND THEIR USES
US20140288278A1 (en) 2011-10-31 2014-09-25 Joseph Nti-Gyabaah Chromatography process for resolving heterogeneous antibody aggregates
LT3257564T (lt) 2011-11-02 2019-04-10 F. Hoffmann-La Roche Ag Perkrovos ir eliuentinė chromatografija
WO2013180647A1 (en) * 2012-05-31 2013-12-05 Agency For Science, Technology And Research Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities
US9845338B2 (en) * 2012-06-21 2017-12-19 Synthon Biopharmaceuticals Bv Method of purifying an antibody
SI3116891T1 (sl) 2014-03-10 2020-07-31 Richter Gedeon Nyrt. Čiščenje imunoglobulina z uporabo predčistilnih stopenj

Also Published As

Publication number Publication date
EP3116891B1 (en) 2020-02-12
JP6293907B2 (ja) 2018-03-14
EP3674310A1 (en) 2020-07-01
US10487138B2 (en) 2019-11-26
CN106103465B (zh) 2021-01-08
PT3116891T (pt) 2020-05-18
US20170058019A1 (en) 2017-03-02
WO2015135884A1 (en) 2015-09-17
KR101921552B1 (ko) 2018-11-23
ES2784749T3 (es) 2020-09-30
PL3116891T3 (pl) 2020-07-27
EP3116891A1 (en) 2017-01-18
CN106103465A (zh) 2016-11-09
JP2017507907A (ja) 2017-03-23
CA2930350C (en) 2021-04-06
CA2930350A1 (en) 2015-09-17
HRP20200711T1 (hr) 2020-07-24
KR20160124107A (ko) 2016-10-26
HUE048782T2 (hu) 2020-08-28
LT3116891T (lt) 2020-03-25
DK3116891T3 (da) 2020-05-04

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