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SI2635586T1 - Metoda za izdelavo naltreksona - Google Patents

Metoda za izdelavo naltreksona

Info

Publication number
SI2635586T1
SI2635586T1 SI201131131A SI201131131A SI2635586T1 SI 2635586 T1 SI2635586 T1 SI 2635586T1 SI 201131131 A SI201131131 A SI 201131131A SI 201131131 A SI201131131 A SI 201131131A SI 2635586 T1 SI2635586 T1 SI 2635586T1
Authority
SI
Slovenia
Prior art keywords
naltrexone
manufacturing
Prior art date
Application number
SI201131131A
Other languages
English (en)
Inventor
Faveri Carla De
Florian Anton Martin Huber
Mariano Stivanello
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of SI2635586T1 publication Critical patent/SI2635586T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08Oxygen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI201131131A 2010-11-05 2011-11-04 Metoda za izdelavo naltreksona SI2635586T1 (sl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US41040510P 2010-11-05 2010-11-05
DKPA201001007 2010-11-05
US201161489701P 2011-05-25 2011-05-25
DKPA201100396 2011-05-25
EP11785301.0A EP2635586B1 (en) 2010-11-05 2011-11-04 Method for the manufacturing of naltrexone
PCT/DK2011/000128 WO2012059103A1 (en) 2010-11-05 2011-11-04 Method for the manufacturing of naltrexone

Publications (1)

Publication Number Publication Date
SI2635586T1 true SI2635586T1 (sl) 2017-07-31

Family

ID=45001588

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201131131A SI2635586T1 (sl) 2010-11-05 2011-11-04 Metoda za izdelavo naltreksona

Country Status (19)

Country Link
EP (1) EP2635586B1 (sl)
JP (2) JP6246589B2 (sl)
AP (1) AP3415A (sl)
AU (1) AU2011325563B2 (sl)
CA (1) CA2815093C (sl)
CY (1) CY1118742T1 (sl)
DK (1) DK2635586T3 (sl)
EA (1) EA022266B1 (sl)
ES (1) ES2620660T3 (sl)
HR (1) HRP20170379T1 (sl)
HU (1) HUE033596T2 (sl)
LT (1) LT2635586T (sl)
ME (1) ME02621B (sl)
MX (1) MX2013005009A (sl)
PL (1) PL2635586T3 (sl)
PT (1) PT2635586T (sl)
RS (1) RS55777B1 (sl)
SI (1) SI2635586T1 (sl)
WO (1) WO2012059103A1 (sl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140005217A1 (en) 2012-06-27 2014-01-02 H. Lundbeck A/S Nalmefene for reduction of alcohol consumption in specific target populations
AR096851A1 (es) 2013-07-11 2016-02-03 H Lundbeck As Sales que no forman hidratos ni solvatos de nalmefeno
US10376506B2 (en) 2013-12-20 2019-08-13 H. Lundbeck A/S Use of an opioid receptor antagonist with kappa-activity and vortioxetine for treatment of depressive disorder with melancholic features
SG10201809280PA (en) 2014-04-22 2018-11-29 Otsuka Pharma Co Ltd Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders
US9701688B2 (en) * 2014-05-05 2017-07-11 Noramco, Inc. Process for the preparation of opioid compounds
US9701687B2 (en) * 2014-05-05 2017-07-11 Noramco, Inc. Process for the preparation of opioid compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535157A (en) * 1983-11-01 1985-08-13 Key Pharmaceuticals, Inc. Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone
US4751307A (en) 1985-01-17 1988-06-14 Mallinckrodt, Inc. Wittig-reaction processes
CA2067200C (en) * 1989-10-16 1998-06-30 Kenner C. Rice Total synthesis of northebaine, normorphine, noroxymorphone enantiomers and derivatives via n-nor intermediates
FR2906252B1 (fr) 2006-09-21 2008-11-28 Sanofi Aventis Sa Procede de preparation d'halogenures de n-aklyl naltrexone
WO2008138383A1 (de) 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
EP2344506B1 (en) * 2008-09-30 2016-02-10 Mallinckrodt LLC Processes for the alkylation of secondary amine groups of morphinan derivatives
US8598352B2 (en) 2009-05-25 2013-12-03 H. Lundbeck A/S Preparation of nalmefene hydrochloride from naltrexone

Also Published As

Publication number Publication date
CA2815093A1 (en) 2012-05-10
CY1118742T1 (el) 2017-07-12
EP2635586A1 (en) 2013-09-11
PT2635586T (pt) 2017-03-30
PL2635586T3 (pl) 2017-06-30
AP2013006897A0 (en) 2013-05-31
ES2620660T3 (es) 2017-06-29
JP6246589B2 (ja) 2017-12-13
EP2635586B1 (en) 2017-02-08
ME02621B (me) 2017-06-20
HRP20170379T1 (hr) 2017-05-05
EA022266B1 (ru) 2015-11-30
DK2635586T3 (en) 2017-03-27
WO2012059103A1 (en) 2012-05-10
AU2011325563B2 (en) 2015-08-20
HUE033596T2 (hu) 2017-12-28
CA2815093C (en) 2019-08-06
EA201390658A1 (ru) 2013-11-29
LT2635586T (lt) 2017-04-10
JP2013541564A (ja) 2013-11-14
JP2016199566A (ja) 2016-12-01
JP6215399B2 (ja) 2017-10-18
RS55777B1 (sr) 2017-07-31
AU2011325563A1 (en) 2013-05-02
MX2013005009A (es) 2013-08-01
AP3415A (en) 2015-09-30

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