Nothing Special   »   [go: up one dir, main page]

SI2642999T1 - Postopki zdravljenja z uporabo selektivnih Bcl-2 inhibitorjev - Google Patents

Postopki zdravljenja z uporabo selektivnih Bcl-2 inhibitorjev

Info

Publication number
SI2642999T1
SI2642999T1 SI201131050A SI201131050A SI2642999T1 SI 2642999 T1 SI2642999 T1 SI 2642999T1 SI 201131050 A SI201131050 A SI 201131050A SI 201131050 A SI201131050 A SI 201131050A SI 2642999 T1 SI2642999 T1 SI 2642999T1
Authority
SI
Slovenia
Prior art keywords
inhibitors
treatment
methods
selective bcl
bcl
Prior art date
Application number
SI201131050A
Other languages
English (en)
Inventor
Steven Elmore
Andrew Souers
Li Chun Wang
Tariq Ghayur
Stuart J. Perper
Original Assignee
Abbvie Ireland Unlimited Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45218888&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2642999(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Ireland Unlimited Company filed Critical Abbvie Ireland Unlimited Company
Publication of SI2642999T1 publication Critical patent/SI2642999T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI201131050A 2010-11-23 2011-11-22 Postopki zdravljenja z uporabo selektivnih Bcl-2 inhibitorjev SI2642999T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41668910P 2010-11-23 2010-11-23
PCT/US2011/061769 WO2012071374A1 (en) 2010-11-23 2011-11-22 Methods of treatment using selective bcl-2 inhibitors
EP11793928.0A EP2642999B1 (en) 2010-11-23 2011-11-22 Methods of treatment using selective bcl-2 inhibitors

Publications (1)

Publication Number Publication Date
SI2642999T1 true SI2642999T1 (sl) 2017-01-31

Family

ID=45218888

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201131050A SI2642999T1 (sl) 2010-11-23 2011-11-22 Postopki zdravljenja z uporabo selektivnih Bcl-2 inhibitorjev

Country Status (36)

Country Link
US (5) US20120129853A1 (sl)
EP (2) EP3028702B1 (sl)
JP (2) JP5876067B2 (sl)
KR (3) KR20180030257A (sl)
CN (2) CN105664164B (sl)
AR (1) AR083946A1 (sl)
AU (2) AU2011332000B2 (sl)
BR (1) BR112013012854B1 (sl)
CA (1) CA2820618C (sl)
CL (1) CL2013001458A1 (sl)
CR (1) CR20130268A (sl)
CY (1) CY1118442T1 (sl)
DK (1) DK2642999T3 (sl)
DO (1) DOP2017000056A (sl)
EC (1) ECSP13012710A (sl)
ES (2) ES2603129T3 (sl)
GT (1) GT201300136A (sl)
HR (1) HRP20161762T1 (sl)
HU (1) HUE031267T2 (sl)
IL (2) IL226490A (sl)
LT (1) LT2642999T (sl)
MX (1) MX346201B (sl)
MY (2) MY165884A (sl)
NZ (2) NZ610746A (sl)
PH (1) PH12016500939A1 (sl)
PL (1) PL2642999T3 (sl)
PT (1) PT2642999T (sl)
RS (1) RS55545B1 (sl)
RU (1) RU2593231C2 (sl)
SG (2) SG190399A1 (sl)
SI (1) SI2642999T1 (sl)
TW (2) TWI620736B (sl)
UA (2) UA113157C2 (sl)
UY (1) UY33746A (sl)
WO (1) WO2012071374A1 (sl)
ZA (1) ZA201303589B (sl)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
BR112012030625A2 (pt) 2010-06-03 2017-06-27 Pharmacyclics Inc uso de inibidores de tirosina quinase de bruton (btk)
KR20180059560A (ko) 2010-10-29 2018-06-04 애브비 인코포레이티드 아폽토시스―유도제를 포함하는 고체 분산체
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
SI2642999T1 (sl) 2010-11-23 2017-01-31 Abbvie Ireland Unlimited Company Postopki zdravljenja z uporabo selektivnih Bcl-2 inhibitorjev
WO2012071336A1 (en) 2010-11-23 2012-05-31 Abbott Laboratories Salts and crystalline forms of an apoptosis-inducing agent
EP2790725A4 (en) 2011-12-13 2015-11-04 Buck Inst For Res On Aging METHOD FOR IMPROVING MEDICAL THERAPIES
EP2877598A1 (en) 2012-07-24 2015-06-03 Pharmacyclics, Inc. Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk)
KR20200110711A (ko) 2012-09-07 2020-09-24 제넨테크, 인크. Ii형 항-cd20 항체와 선택적 bcl-2 억제제와의 병용 치료요법
US20150241429A1 (en) * 2012-09-11 2015-08-27 Hospital For Special Surgery Irhom2 inhibition for the treatment of complement mediated disorders
BR122021025062B1 (pt) 2013-03-13 2022-04-19 Abbvie Inc Compostos agentes indutores de apoptose e processos para a preparação dos mesmos
US20140275082A1 (en) * 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US10328058B2 (en) 2014-01-28 2019-06-25 Mayo Foundation For Medical Education And Research Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques
WO2015116735A1 (en) 2014-01-28 2015-08-06 Mayo Foundation For Medical Education And Research Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders
CN106163557B (zh) 2014-01-28 2020-07-14 巴克老龄化研究所 用于杀死衰老细胞和用于治疗衰老相关疾病和病症的方法和组合物
EP3119910A4 (en) 2014-03-20 2018-02-21 Pharmacyclics LLC Phospholipase c gamma 2 and resistance associated mutations
EP3139942B1 (en) * 2014-05-05 2019-12-18 Bioventures, Llc COMPOSITIONS AND METHODS FOR INHIBITING ANTIAPOPTOTIC Bcl-2 PROTEINS AS ANTI-AGING AGENTS
LT3179991T (lt) 2014-08-11 2021-11-10 Acerta Pharma B.V. Terapiniai btk inhibitoriaus ir bcl-2 inhibitoriaus deriniai
US10195213B2 (en) 2015-03-13 2019-02-05 Unity Biotechnology, Inc. Chemical entities that kill senescent cells for use in treating age-related disease
CN108137550A (zh) 2015-08-10 2018-06-08 达纳-法伯癌症研究所有限公司 对bet溴结构域抑制剂的抗性的机理
MA43170A (fr) 2015-11-03 2018-09-12 Univ Texas Association d'un inhibiteur de bcl-2 et d'un inhibiteur de mek pour le traitement du cancer
US10807977B2 (en) 2016-04-21 2020-10-20 Bioventures, Llc Compounds that induce degradation of anti-apoptotic Bcl-2 family proteins and the uses thereof
KR102376764B1 (ko) 2016-08-05 2022-03-18 더 리젠츠 오브 더 유니버시티 오브 미시건 Bcl-2 억제제로서의 n-(페닐설포닐)벤즈아미드 및 관련 화합물
EP3626241A4 (en) * 2017-06-26 2020-05-27 Shenzhen Targetrx, Inc. N-BENZOLSULFONYLBENZAMIDE COMPOUND FOR INHIBITING BCL-2 PROTEIN AND COMPOSITION AND USE THEREOF
US11480568B2 (en) * 2017-09-28 2022-10-25 Yeda Research And Development Co. Ltd. Diagnosis of autoimmune diseases
JP2021510165A (ja) 2018-01-10 2021-04-15 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー ベンズアミド化合物
EP3743069A4 (en) 2018-01-22 2021-06-09 BioVentures, LLC DEGRADER OF BCL-2 PROTEIN FOR CANCER TREATMENT
US10285998B1 (en) 2018-04-04 2019-05-14 The Menopause Method, Inc. Composition and method to aid in hormone replacement therapy
JP7058345B2 (ja) 2018-07-31 2022-04-21 アセンテージ ファーマ(スーチョウ)カンパニー,リミティド Bcl-2阻害剤及びMDM2阻害剤の組合せ製品並びに疾患の予防及び/又治療におけるその使用
KR20200139139A (ko) 2018-07-31 2020-12-11 어센테지 파마 (쑤저우) 컴퍼니 리미티드 리툭시맙 및/또는 벤다무스틴과 병용된 Bcl-2 억제제 또는 CHOP와 병용된 Bcl-2 억제제의 시너지적 항종양 효과
CN114522167A (zh) 2018-07-31 2022-05-24 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
CA3095699A1 (en) 2018-07-31 2020-02-06 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases
EP3852766B1 (en) 2018-09-18 2024-05-08 SignalChem Lifesciences Corporation Combination therapy for treating blood cancer
CN112888687B (zh) 2018-10-29 2023-01-24 正大天晴药业集团股份有限公司 三氟甲基取代的磺酰胺类选择性bcl-2抑制剂
EP3978494A4 (en) 2019-05-24 2023-04-19 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. METHYL AND TRFLUOROMETHYL CONTAINING DISUBSTITUTED SULFONAMIDE SELECTIVE BCL-2 INHIBITORS
CN112707900B (zh) * 2019-10-24 2022-06-10 上海科技大学 蛋白降解剂及其在疾病治疗中的应用
CN113444078B (zh) * 2020-03-25 2023-07-07 中国科学院上海有机化学研究所 抗凋亡蛋白Bcl-2抑制剂及其制备方法和应用
TW202206111A (zh) 2020-04-24 2022-02-16 美商建南德克公司 使用抗cd79b免疫結合物之方法
EP4129998A4 (en) 2020-04-29 2024-05-01 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. CRYSTAL OF A TRIFLUOROMETHYL/CHLORODISUBSTITUTED SULFONAMIDE SELECTIVE BCL-2 INHIBITOR
CN114073707A (zh) * 2020-08-21 2022-02-22 苏州亚盛药业有限公司 治疗系统性红斑狼疮的组合物和方法
EP4319800A1 (en) 2021-04-07 2024-02-14 Dana-Farber Cancer Institute, Inc. Compositions and methods for the treatment of cancer
US20240287110A1 (en) 2021-06-04 2024-08-29 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Phosphate of trifluoromethyl-substituted sulfonamide compound
IT202100025976A1 (it) 2021-10-06 2023-04-06 Univ Degli Studi Di Perugia Combinazione di principi attivi per il trattamento della leucemia acuta mieloide (LAM) con mutazione della nucleofosmina (NPM1)
WO2024102890A2 (en) * 2022-11-11 2024-05-16 The Board Of Regents Of The University Of Texas System Amino acid-benzoic acid oligomers and methods of use thereof for treating cancer

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2128208A (en) 1937-02-27 1938-08-23 Du Pont Alkoxy derivatives of methacrylic acid esters and method of producing them
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
FR2736550B1 (fr) 1995-07-14 1998-07-24 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
ATE257829T1 (de) 1995-09-15 2004-01-15 Upjohn Co Aminoaryl oxazolidinone n-oxide
HU221984B1 (hu) 1996-02-09 2003-03-28 Basf Ag Humán TNFalfa-t kötő antitestek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
AU767456B2 (en) 1998-07-06 2003-11-13 Bristol-Myers Squibb Company Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
WO2000004901A1 (en) * 1998-07-21 2000-02-03 Thomas Jefferson University Small molecule inhibitors of bcl-2 proteins
DE19913692A1 (de) 1999-03-25 2000-09-28 Basf Ag Mechanisch stabile pharmazeutische Darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive Substanzen
DE19929361A1 (de) 1999-06-25 2001-01-04 Basf Ag Mechanisch stabile pharmazeutische Darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive Substanzen
US20030236236A1 (en) 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
GB9918037D0 (en) 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
US6787534B2 (en) 1999-12-28 2004-09-07 Eisai Co., Ltd. Sulfonamide-containing heterocyclic compounds
AR031130A1 (es) 2000-09-20 2003-09-10 Abbott Lab N-acilsulfonamidas promotoras de la apoptosis
US20020055631A1 (en) 2000-09-20 2002-05-09 Augeri David J. N-acylsulfonamide apoptosis promoters
US6720338B2 (en) 2000-09-20 2004-04-13 Abbott Laboratories N-acylsulfonamide apoptosis promoters
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
BR0210078A (pt) 2001-06-06 2004-06-22 Lilly Co Eli Composto, uso do mesmo, e, formulação farmacêutica
GB0123400D0 (en) 2001-09-28 2001-11-21 Novartis Ag Organic compounds
US20090247613A1 (en) 2002-02-20 2009-10-01 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF B-CELL CLL/LYMPHOMA-2 (BCL2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
DK1480679T3 (da) 2002-02-26 2007-09-03 Astrazeneca Ab Farmaceutisk formulering af iressa, der omfatter et vandoplöseligt cellulosederivat
KR20040086452A (ko) 2002-02-26 2004-10-08 아스트라제네카 아베 항암 화합물 zd1839의 신규한 결정질 형태
FR2836914B1 (fr) 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
TWI262077B (en) 2002-04-29 2006-09-21 Merck & Co Inc Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
WO2005024636A1 (ja) 2003-09-04 2005-03-17 Hitachi Ulsi Systems Co., Ltd. 半導体装置
US7642260B2 (en) 2003-11-13 2010-01-05 Abbott Laboratories, Inc. Apoptosis promoters
US8614318B2 (en) 2003-11-13 2013-12-24 Abbvie Inc. Apoptosis promoters
US7973161B2 (en) 2003-11-13 2011-07-05 Abbott Laboratories Apoptosis promoters
WO2005049593A2 (en) * 2003-11-13 2005-06-02 Abbott Laboratories N-acylsulfonamide apoptosis promoters
US7767684B2 (en) 2003-11-13 2010-08-03 Abbott Laboratories Apoptosis promoters
US7790190B2 (en) 2004-03-20 2010-09-07 Yasoo Health, Inc. Aqueous emulsions of lipophile solubilized with vitamin E TPGS and linoleic acid
US7307163B2 (en) 2004-04-19 2007-12-11 Symed Labs Limited Process for the preparation of linezolid and related compounds
DE602004020812D1 (de) 2004-07-20 2009-06-04 Symed Labs Ltd Neue zwischenprodukte für linezolid und verwandte verbindungen
ES2306216T3 (es) 2004-08-27 2008-11-01 Bayer Pharmaceuticals Corporation Composiciones farmaceuticas en forma de dispersiones solidas para el tratamiento de cancer.
JP2008514702A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
US8624027B2 (en) 2005-05-12 2014-01-07 Abbvie Inc. Combination therapy for treating cancer and diagnostic assays for use therein
SI1888550T1 (sl) 2005-05-12 2014-10-30 Abbvie Bahamas Limited Promotorji apoptoze
EP1896470B1 (en) 2005-05-16 2010-05-26 Irm Llc Pyrrolopyridine derivatives as protein kinase inhibitors
TW200716636A (en) 2005-05-31 2007-05-01 Speedel Experimenta Ag Heterocyclic spiro-compounds
SI2395004T1 (sl) 2005-06-22 2016-05-31 Plexxikon Inc. Derivati piro (2,3-b) piridina kot inhibitorji proteinske kinaze
US7514068B2 (en) 2005-09-14 2009-04-07 Concert Pharmaceuticals Inc. Biphenyl-pyrazolecarboxamide compounds
ATE552837T1 (de) 2005-12-02 2012-04-15 Univ Johns Hopkins Verwendung von hochdosierten oxazaphosphorin- arzneimitteln zur behandlung von immunstörungen
EP1880715A1 (en) 2006-07-19 2008-01-23 Abbott GmbH & Co. KG Pharmaceutically acceptable solubilizing composition and pharmaceutical dosage form containing same
EP2061560A2 (en) 2006-09-05 2009-05-27 Abbott Laboratories Bcl inhibitors for treating platelet excess
US8796267B2 (en) 2006-10-23 2014-08-05 Concert Pharmaceuticals, Inc. Oxazolidinone derivatives and methods of use
US20080182845A1 (en) 2006-11-16 2008-07-31 Abbott Laboratories Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection
CN101616902B (zh) 2007-02-15 2013-03-27 弗·哈夫曼-拉罗切有限公司 作为taar1配体的2-氨基*唑啉类化合物
US8536157B2 (en) 2007-04-13 2013-09-17 The University Of Melbourne Non-steroidal compounds
EP2148867B1 (en) 2007-04-19 2014-09-10 Concert Pharmaceuticals Inc. Deuterated morpholinyl compounds
US7531685B2 (en) 2007-06-01 2009-05-12 Protia, Llc Deuterium-enriched oxybutynin
WO2009035598A1 (en) 2007-09-10 2009-03-19 Concert Pharmaceuticals, Inc. Deuterated pirfenidone
US20090118238A1 (en) 2007-09-17 2009-05-07 Protia, Llc Deuterium-enriched alendronate
US20090082471A1 (en) 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched fingolimod
US20090088416A1 (en) 2007-09-26 2009-04-02 Protia, Llc Deuterium-enriched lapaquistat
AU2007359392A1 (en) * 2007-09-27 2009-04-02 The Walter And Eliza Hall Institute Of Medical Research Benzothiazole compounds
WO2009045464A1 (en) * 2007-10-01 2009-04-09 The Johns Hopkins University Methods of treating neurological autoimmune disorders with cyclophosphamide
JP5973132B2 (ja) 2007-10-01 2016-08-23 アーケマ・インコーポレイテッド 生分解性ポリマーとアクリル系共重合体とのブレンド
EP2209774A1 (en) 2007-10-02 2010-07-28 Concert Pharmaceuticals Inc. Pyrimidinedione derivatives
WO2009051782A1 (en) 2007-10-18 2009-04-23 Concert Pharmaceuticals Inc. Deuterated etravirine
US20090105338A1 (en) 2007-10-18 2009-04-23 Protia, Llc Deuterium-enriched gabexate mesylate
AU2008311827A1 (en) * 2007-10-19 2009-04-23 Burnham Institute For Medical Research Naphthalene-based inhibitors of anti-apoptotic proteins
AU2008317375B2 (en) 2007-10-26 2013-02-28 Concert Pharmaceuticals, Inc. Deuterated darunavir
RU2526201C2 (ru) 2007-11-16 2014-08-20 Эббви Инк. Способ лечения артрита
CN101939008A (zh) 2007-12-06 2011-01-05 雅培制药有限公司 用于治疗癌症的abt-263经口组合物
CN101481363B (zh) * 2008-01-10 2011-05-04 江苏豪森药业股份有限公司 一种制备瑞格列奈的方法
KR20100113112A (ko) 2008-01-15 2010-10-20 아보트 러보러터리즈 개선된 포유동물 발현 벡터 및 이의 용도
US20090258914A1 (en) * 2008-04-15 2009-10-15 Burnham Institute For Medical Research Inhibitor of Anti-Apoptotic Proteins
MY160340A (en) 2008-10-07 2017-02-28 Astrazeneca Uk Ltd Pharmaceutical formulation 514
US8557983B2 (en) 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
UA108193C2 (uk) * 2008-12-04 2015-04-10 Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань
US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US8586754B2 (en) * 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
EP3101019A1 (en) * 2008-12-05 2016-12-07 AbbVie Inc. Sulfonamide derivatives as bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
WO2010077740A2 (en) 2008-12-09 2010-07-08 Cytokine Pharmasciences, Inc. Novel antiviral compounds, compositions, and methods of use
US20120094963A1 (en) 2008-12-23 2012-04-19 of Queen Elizabeth near Dublin Targeting prodrugs and compositions for the treatment of gastrointestinal diseases
NZ593593A (en) 2009-01-19 2013-11-29 Abbvie Inc Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
JP5613177B2 (ja) 2009-01-19 2014-10-22 アッヴィ・インコーポレイテッド 癌並びに免疫及び自己免疫疾患の治療用アポトーシス誘導剤
US20100297194A1 (en) 2009-04-30 2010-11-25 Nathaniel Catron Formulation for oral administration of apoptosis promoter
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
PT2435432E (pt) 2009-05-26 2015-10-13 Abbvie Bahamas Ltd Agentes indutores de apoptose para o tratamento de cancro e doenças imunes e autoimunes
TWI471321B (zh) 2009-06-08 2015-02-01 Abbott Gmbh & Co Kg Bcl-2族群抑制劑之口服醫藥劑型
TWI520960B (zh) 2010-05-26 2016-02-11 艾伯維有限公司 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑
KR20180059560A (ko) 2010-10-29 2018-06-04 애브비 인코포레이티드 아폽토시스―유도제를 포함하는 고체 분산체
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
WO2012071336A1 (en) 2010-11-23 2012-05-31 Abbott Laboratories Salts and crystalline forms of an apoptosis-inducing agent
SI2642999T1 (sl) 2010-11-23 2017-01-31 Abbvie Ireland Unlimited Company Postopki zdravljenja z uporabo selektivnih Bcl-2 inhibitorjev

Also Published As

Publication number Publication date
NZ610746A (en) 2015-06-26
CA2820618A1 (en) 2012-05-31
US20150150870A1 (en) 2015-06-04
PH12016500939B1 (en) 2017-06-14
PL2642999T3 (pl) 2017-04-28
GT201300136A (es) 2014-08-05
ZA201303589B (en) 2014-07-30
DOP2017000056A (es) 2017-03-31
US20180369250A1 (en) 2018-12-27
BR112013012854B1 (pt) 2019-08-06
AU2011332000B2 (en) 2016-07-07
AU2016204396A1 (en) 2016-07-14
KR20140004659A (ko) 2014-01-13
TW201302705A (zh) 2013-01-16
US9872861B2 (en) 2018-01-23
BR112013012854A2 (pt) 2016-08-23
EP2642999B1 (en) 2016-09-28
IL226490A0 (en) 2013-07-31
UA113157C2 (xx) 2016-12-26
UA119150C2 (uk) 2019-05-10
SG190399A1 (en) 2013-06-28
CA2820618C (en) 2020-04-21
PT2642999T (pt) 2017-01-05
US20160235760A1 (en) 2016-08-18
TW201630885A (zh) 2016-09-01
EP3028702B1 (en) 2018-09-12
CN105664164B (zh) 2020-05-05
ECSP13012710A (es) 2013-08-30
HUE031267T2 (en) 2017-06-28
ES2701603T3 (es) 2019-02-25
CR20130268A (es) 2013-10-17
KR20180030257A (ko) 2018-03-21
JP2016117744A (ja) 2016-06-30
AU2011332000A1 (en) 2013-06-06
CN103402521A (zh) 2013-11-20
LT2642999T (lt) 2017-01-25
EP3028702A1 (en) 2016-06-08
WO2012071374A1 (en) 2012-05-31
JP5876067B2 (ja) 2016-03-02
SG10201509631SA (en) 2015-12-30
MY191300A (en) 2022-06-14
US9345702B2 (en) 2016-05-24
BR112013012854A8 (pt) 2018-01-16
RU2013128544A (ru) 2014-12-27
PH12016500939A1 (en) 2017-06-14
JP6215368B2 (ja) 2017-10-18
AR083946A1 (es) 2013-04-10
US20170232000A9 (en) 2017-08-17
KR20190109590A (ko) 2019-09-25
US20120129853A1 (en) 2012-05-24
UY33746A (es) 2012-06-29
CN105664164A (zh) 2016-06-15
TWI620736B (zh) 2018-04-11
CN103402521B (zh) 2016-01-20
CL2013001458A1 (es) 2013-10-04
JP2013543896A (ja) 2013-12-09
KR101841084B1 (ko) 2018-03-23
MX2013005849A (es) 2013-07-05
IL251845B (en) 2019-06-30
AU2016204396B2 (en) 2017-10-26
DK2642999T3 (en) 2017-01-09
IL226490A (en) 2017-05-29
RS55545B1 (sr) 2017-05-31
NZ708508A (en) 2016-06-24
US20200222413A1 (en) 2020-07-16
MX346201B (es) 2017-03-09
MY165884A (en) 2018-05-18
EP2642999A1 (en) 2013-10-02
HRP20161762T1 (hr) 2017-02-24
IL251845A0 (en) 2017-06-29
RU2593231C2 (ru) 2016-08-10
TWI535701B (zh) 2016-06-01
ES2603129T3 (es) 2017-02-23
CY1118442T1 (el) 2017-06-28

Similar Documents

Publication Publication Date Title
IL251845A0 (en) Treatment methods using selective bcl-2 inhibitors
IL261768B (en) Devices and methods for tissue treatment
EP2720623A4 (en) METHOD AND DEVICES FOR TREATING FISTLES
GB201110095D0 (en) Method of treatment
EP2773754A4 (en) Methods of Treatment
EP2717855A4 (en) PROCESSING METHODS
EP2771030A4 (en) COMPOSITIONS AND METHOD FOR THE TREATMENT OF PROTEINOPATHIES
EP2686094A4 (en) ACOUSTIC PROCESSING CONTAINER AND METHOD FOR ACOUSTIC PROCESSING
IL226352A0 (en) שקיטה@לטיפול@עם@מעקב@braf
EP2720625A4 (en) DEVICES FOR THE TREATMENT OF FISTLES AND CORRESPONDING METHODS
PL3581199T3 (pl) Sposoby leczenia lub zmniejszania panikulopatii obrzękowo- zwłóknieniowo-stwardnieniowej
GB201018147D0 (en) Method of treatment
IL256026B (en) Treatment methods
GB201003920D0 (en) Method of treatment
EP2539220A4 (en) METHOD AND DEVICE FOR TREATING WATER
EP2755668A4 (en) COMPOSITIONS OF HYR1 AND TREATMENT PROCEDURES THEREWITH
EP2696693A4 (en) COMPOSITION AND METHOD FOR THE PROTECTION OF POLYMERS THAT PREVENT AGROPRIATION
EP2585103A4 (en) METHOD OF TREATMENT
GB201018149D0 (en) Method of treatment
GB201020015D0 (en) Method of treatment
EP2791324A4 (en) PROCESSING METHOD
GB201005071D0 (en) Method of treatment
GB201003917D0 (en) Method of treatment
GB201000318D0 (en) Method of treatment
EP2643269A4 (en) PROCESS FOR PRE-TREATMENT OF LIZARDITE