SI2442809T1 - Inhibitorji replikacije virusov gripe - Google Patents

Inhibitorji replikacije virusov gripe

Info

Publication number: SI2442809T1
Authority: SI; Slovenia
Prior art keywords: inhibitors; influenza viruses; viruses replication; replication; influenza
Prior art date: 2009-06-17

Application number

SI201031307A

Other languages

English (en)

Inventor

Paul Charifson

Michael P. Clark

Upul K. Bandarage

Randy S. Bethiel

John J. Court

Hongbo Deng

Ioana Drutu

John P. Duffy

Luc Farmer

Huai Gao

Wenxin Gu

Dylan H. Jacobs

Joseph M. Kennedy

Mark W. Ledeboer

Brian Ledford

Francois Maltais

Emanuele Perola

Tiansheng Wang

M. Woods Wannamaker

Randal Byrn

Yi Zhou

Chao Lin

Min Jiang

Ursula A. Germann

Steven Jones

Francesco G. Salituro

Ann Dak-Yee Kwong

Original Assignee

Vertex Pharmaceuticals Incorporated

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-06-17

Filing date

2010-06-17

Publication date

2017-01-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42537408&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2442809(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-06-17 Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated

2017-01-31 Publication of SI2442809T1 publication Critical patent/SI2442809T1/sl

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Virology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

SI201031307A 2009-06-17 2010-06-17 Inhibitorji replikacije virusov gripe SI2442809T1 (sl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US18771309P	2009-06-17	2009-06-17
US28778109P	2009-12-18	2009-12-18
EP10726760.1A EP2442809B1 (en)	2009-06-17	2010-06-17	Inhibitors of influenza viruses replication
PCT/US2010/038988 WO2010148197A1 (en)	2009-06-17	2010-06-17	Inhibitors of influenza viruses replication

Publications (1)

Publication Number	Publication Date
SI2442809T1 true SI2442809T1 (sl)	2017-01-31

Family

ID=42537408

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SI201031779T SI3141252T1 (sl)	2009-06-17	2010-06-17	Inhibitorji replikacije virusov influence
SI201031307A SI2442809T1 (sl)	2009-06-17	2010-06-17	Inhibitorji replikacije virusov gripe

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
SI201031779T SI3141252T1 (sl)	2009-06-17	2010-06-17	Inhibitorji replikacije virusov influence

Country Status (38)

Country	Link
US (7)	US20120171245A1 (sl)
EP (3)	EP3427738B1 (sl)
JP (6)	JP5721706B2 (sl)
KR (3)	KR101702609B1 (sl)
CN (5)	CN104922128B (sl)
AP (1)	AP3631A (sl)
AR (1)	AR077130A1 (sl)
AU (1)	AU2010262905B2 (sl)
BR (1)	BRPI1011993A2 (sl)
CA (1)	CA2764177C (sl)
CL (1)	CL2011003192A1 (sl)
CO (1)	CO6491048A2 (sl)
CY (2)	CY1118246T1 (sl)
DK (2)	DK2442809T3 (sl)
EA (3)	EA037529B1 (sl)
EC (1)	ECSP12011610A (sl)
ES (2)	ES2604667T3 (sl)
GE (3)	GEP20227397B (sl)
HK (4)	HK1215675A1 (sl)
HR (2)	HRP20161577T1 (sl)
HU (1)	HUE031048T2 (sl)
IL (2)	IL216980B (sl)
LT (2)	LT2442809T (sl)
ME (1)	ME02558B (sl)
MX (2)	MX348066B (sl)
NZ (2)	NZ619259A (sl)
PE (2)	PE20160127A1 (sl)
PH (1)	PH12015501678A1 (sl)
PL (2)	PL2442809T3 (sl)
PT (2)	PT2442809T (sl)
RS (2)	RS57869B1 (sl)
SG (3)	SG176722A1 (sl)
SI (2)	SI3141252T1 (sl)
TR (1)	TR201815272T4 (sl)
TW (4)	TWI639596B (sl)
UY (1)	UY32717A (sl)
WO (1)	WO2010148197A1 (sl)
ZA (2)	ZA201109127B (sl)

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Also Published As

Publication number	Publication date
PT3141252T (pt)	2018-11-14
CA2764177C (en)	2018-06-05
EP3141252A1 (en)	2017-03-15
JP2012530713A (ja)	2012-12-06
CA2764177A1 (en)	2010-12-23
TWI574963B (zh)	2017-03-21
KR20120097471A (ko)	2012-09-04
TW201925196A (zh)	2019-07-01
CL2011003192A1 (es)	2013-01-04
HK1215530A1 (zh)	2016-09-02
WO2010148197A1 (en)	2010-12-23
CY1118246T1 (el)	2017-06-28
LT2442809T (lt)	2016-12-12
KR101702609B1 (ko)	2017-02-03
TWI483941B (zh)	2015-05-11
IL262734B (en)	2020-11-30
JP6030619B2 (ja)	2016-11-24
SG176722A1 (en)	2012-01-30
UY32717A (es)	2011-01-31
RS57869B1 (sr)	2018-12-31
JP2015034177A (ja)	2015-02-19
CN104922128B (zh)	2019-12-20
CO6491048A2 (es)	2012-07-31
ECSP12011610A (es)	2012-02-29
EA201270032A1 (ru)	2012-07-30
KR20180108856A (ko)	2018-10-04
IL216980B (en)	2018-11-29
US20140142119A1 (en)	2014-05-22
EP2442809A1 (en)	2012-04-25
PL2442809T3 (pl)	2017-02-28
HUE031048T2 (en)	2017-06-28
PE20120508A1 (es)	2012-05-09
AP3631A (en)	2016-03-08
BRPI1011993A2 (pt)	2021-07-06
CN104940202A (zh)	2015-09-30
EA037529B1 (ru)	2021-04-08
EP3427738A1 (en)	2019-01-16
HK1169326A1 (en)	2013-01-25
NZ619259A (en)	2015-07-31
JP6348939B2 (ja)	2018-06-27
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PE20160127A1 (es)	2016-02-24
CY1120778T1 (el)	2019-12-11
HK1204322A1 (en)	2015-11-13
JP5721706B2 (ja)	2015-05-20
JP2018002747A (ja)	2018-01-11
CN104940202B (zh)	2018-10-16
IL262734A (en)	2018-12-31
CN104151312A (zh)	2014-11-19
US10039762B2 (en)	2018-08-07
LT3141252T (lt)	2018-11-12
JP6620135B2 (ja)	2019-12-11
TR201815272T4 (tr)	2018-11-21
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DK2442809T3 (en)	2016-12-19
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ZA201109127B (en)	2015-07-29
KR20170015551A (ko)	2017-02-08
ZA201500820B (en)	2016-05-25
PT2442809T (pt)	2016-12-06
NZ597059A (en)	2014-01-31
US20160152614A1 (en)	2016-06-02
CN110540538A (zh)	2019-12-06
TW201520211A (zh)	2015-06-01
SG10201405826RA (en)	2014-12-30
RS55341B1 (sr)	2017-03-31
US20190151314A1 (en)	2019-05-23
AU2010262905A1 (en)	2012-01-12
CN104922128A (zh)	2015-09-23
JP2015038146A (ja)	2015-02-26
MX348066B (es)	2017-05-26
GEP20227397B (en)	2022-07-25
US10874673B2 (en)	2020-12-29
TW201103935A (en)	2011-02-01
CN104151312B (zh)	2016-06-15
SG10201405827PA (en)	2014-11-27
TWI639596B (zh)	2018-11-01
MX2011013475A (es)	2012-03-14
KR102050712B1 (ko)	2019-12-02
EP3141252B8 (en)	2019-03-13
EA030188B1 (ru)	2018-07-31
EP2442809B1 (en)	2016-08-31
JP2016204390A (ja)	2016-12-08
AU2010262905B2 (en)	2015-04-16
ME02558B (me)	2017-02-20
US20140296201A1 (en)	2014-10-02
HRP20181715T1 (hr)	2019-04-05
JP2020011990A (ja)	2020-01-23
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AP2012006067A0 (en)	2012-02-29
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CN102458408A (zh)	2012-05-16
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US9808459B2 (en)	2017-11-07
EP3141252B1 (en)	2018-07-25
PH12015501678A1 (en)	2020-06-22
EP3427738B1 (en)	2021-12-01
EA201500266A1 (ru)	2015-10-30
CN102458408B (zh)	2015-06-03
HRP20161577T1 (hr)	2017-01-27
SI3141252T1 (sl)	2018-12-31
DK3141252T3 (en)	2018-11-19
ES2692396T3 (es)	2018-12-03
TWI666209B (zh)	2019-07-21
IL216980A0 (en)	2012-02-29
GEP20207129B (en)	2020-07-10
US8829007B2 (en)	2014-09-09
EA201500871A8 (ru)	2019-02-28
US9518056B2 (en)	2016-12-13
AR077130A1 (es)	2011-08-03
TW201728584A (zh)	2017-08-16
US20180078553A1 (en)	2018-03-22
EA201500871A1 (ru)	2016-11-30
US20120171245A1 (en)	2012-07-05

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HRP20181715T1 (hr)	2019-04-05	Inhibitori replikacije virusa gripe
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HUS1700002I1 (hu)	2017-02-28	Hepatitis C vírus replikációjának inhibitorai
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