SI1828201T1 - Makrociklični derivati kinazolina in njihova uporaba kot MTKI - Google Patents
Makrociklični derivati kinazolina in njihova uporaba kot MTKIInfo
- Publication number
- SI1828201T1 SI1828201T1 SI200532035T SI200532035T SI1828201T1 SI 1828201 T1 SI1828201 T1 SI 1828201T1 SI 200532035 T SI200532035 T SI 200532035T SI 200532035 T SI200532035 T SI 200532035T SI 1828201 T1 SI1828201 T1 SI 1828201T1
- Authority
- SI
- Slovenia
- Prior art keywords
- mtki
- quinazoline derivatives
- macrocyclic quinazoline
- macrocyclic
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63422804P | 2004-12-08 | 2004-12-08 | |
| EP04106383 | 2004-12-08 | ||
| PCT/EP2005/056609 WO2006061417A2 (en) | 2004-12-08 | 2005-12-08 | Macrocyclic quinazole derivatives and their use as mtki |
| EP05826362.5A EP1828201B1 (en) | 2004-12-08 | 2005-12-08 | Macrocyclic quinazoline derivatives and their use as mtki |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1828201T1 true SI1828201T1 (sl) | 2016-02-29 |
Family
ID=34930015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200532035T SI1828201T1 (sl) | 2004-12-08 | 2005-12-08 | Makrociklični derivati kinazolina in njihova uporaba kot MTKI |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20100152174A1 (sl) |
| EP (1) | EP1828201B1 (sl) |
| JP (1) | JP5140431B2 (sl) |
| KR (1) | KR101320431B1 (sl) |
| CN (2) | CN101072781B (sl) |
| AR (1) | AR051985A1 (sl) |
| AU (1) | AU2005313350B2 (sl) |
| BR (1) | BRPI0518394B8 (sl) |
| CA (1) | CA2588764C (sl) |
| DK (1) | DK1828201T3 (sl) |
| EA (1) | EA013995B1 (sl) |
| ES (1) | ES2559305T3 (sl) |
| HU (1) | HUE027253T2 (sl) |
| JO (1) | JO3088B1 (sl) |
| MX (1) | MX2007006820A (sl) |
| MY (1) | MY148503A (sl) |
| NZ (1) | NZ555496A (sl) |
| PA (1) | PA8654501A1 (sl) |
| SI (1) | SI1828201T1 (sl) |
| TW (2) | TWI511970B (sl) |
| UA (1) | UA91522C2 (sl) |
| WO (1) | WO2006061417A2 (sl) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8603801A1 (es) * | 2003-05-27 | 2004-12-16 | Janssen Pharmaceutica Nv | Derivados de la quinazolina |
| ES2305887T3 (es) | 2003-12-18 | 2008-11-01 | Janssen Pharmaceutica Nv | Derivados de pirido y pirimidopirimidinas como agentes antiproliferativos. |
| NI200700147A (es) | 2004-12-08 | 2019-05-10 | Janssen Pharmaceutica Nv | Derivados de quinazolina inhibidores de cinasas dirigidos a multip |
| US8492377B2 (en) * | 2006-07-13 | 2013-07-23 | Janssen Pharmaceutica Nv | MTKI quinazoline derivatives |
| AU2007310843A1 (en) * | 2006-10-27 | 2008-05-02 | Janssen Pharmaceutica Nv | Macrocyclic quinazoline derivatives as VEGFR3 inhibitors |
| AU2007310845A1 (en) * | 2006-10-27 | 2008-05-02 | Janssen Pharmaceutica Nv | Use of MTKI 1 for treating or preventing bone cancer |
| DK2170827T3 (da) * | 2007-06-21 | 2013-11-18 | Janssen Pharmaceutica Nv | Indolin-2-oner og aza-indolin-2-oner |
| WO2009016132A1 (en) * | 2007-07-27 | 2009-02-05 | Janssen Pharmaceutica Nv | Pyrrolopyrimidines |
| EP2350075B1 (en) | 2008-09-22 | 2014-03-05 | Array Biopharma, Inc. | Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors |
| ES2669581T7 (es) | 2008-10-22 | 2020-07-29 | Array Biopharma Inc | Compuestos de pirazolo[1,5-a]pirimidina como inhibidores de TRK quinasa |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| ES2628418T3 (es) | 2010-05-20 | 2017-08-02 | Array Biopharma, Inc. | Compuestos macrocíclicos como inhibidores de la TRK cinasa |
| JP6382997B2 (ja) * | 2014-02-07 | 2018-08-29 | エクセセーラ ファーマシューティカルズ インコーポレイテッド | 治療用化合物および組成物 |
| MA39823A (fr) | 2014-04-03 | 2018-01-09 | Janssen Pharmaceutica Nv | Dérivés de pyridine macrocyclique |
| MA39822A (fr) | 2014-04-03 | 2018-02-06 | Janssen Pharmaceutica Nv | Dérivés de pyrimidine bicycle |
| TWI746426B (zh) | 2014-11-16 | 2021-11-21 | 美商亞雷生物製藥股份有限公司 | (S)-N-(5-((R)-2-(2,5-二氟苯基)-吡咯啶-1-基)-吡唑并[1,5-a]嘧啶-3-基)-3-羥基吡咯啶-1-甲醯胺硫酸氫鹽結晶型 |
| KR20180102544A (ko) | 2015-10-26 | 2018-09-17 | 더 리전츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코퍼레이트 | Trk 억제제-내성 암에서의 점 돌연변이 및 이의 관련 방법 |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| PE20181888A1 (es) | 2016-04-04 | 2018-12-11 | Loxo Oncology Inc | Formulaciones liquidas de (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida |
| EP3458456B1 (en) | 2016-05-18 | 2020-11-25 | Loxo Oncology Inc. | Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE2423536A1 (de) * | 1974-05-15 | 1975-11-27 | Bayer Ag | 3-amino-phenylessigsaeure-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide |
| US4126687A (en) * | 1976-05-17 | 1978-11-21 | Janssen Pharmaceutica N.V. | Antiemetic, 1-(benzimidazolyl-alkyl)-piperidine derivatives |
| US4442278A (en) * | 1981-12-03 | 1984-04-10 | Hughes Aircraft Company | Ethynyl-substituted s-triazine derivatives, polymers thereof and process for making the same |
| US5721237A (en) * | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
| SG63570A1 (en) * | 1993-12-07 | 1999-03-30 | Lilly Co Eli | Protein kinase c inhibitors |
| US5679683A (en) * | 1994-01-25 | 1997-10-21 | Warner-Lambert Company | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| AU3817595A (en) | 1994-10-31 | 1996-05-23 | Dsm N.V. | Catalyst composition and process for the polymerization of an olefin |
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| EA199800372A1 (ru) * | 1995-11-14 | 1998-10-29 | Дзе Дюпон Мерк Фармасьютикал Компани | Новые макроциклические соединения-ингибиторы |
| DE19608588A1 (de) * | 1996-03-06 | 1997-09-11 | Thomae Gmbh Dr K | Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| SK284073B6 (sk) * | 1996-04-12 | 2004-09-08 | Warner-Lambert Company | Polycyklické zlúčeniny, ich použitie a farmaceutické kompozície na ich báze |
| GB9718972D0 (en) * | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US6288082B1 (en) * | 1998-09-29 | 2001-09-11 | American Cyanamid Company | Substituted 3-cyanoquinolines |
| ES2257313T3 (es) * | 1999-08-27 | 2006-08-01 | BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG | Indolinonas sustituidas en calidad de inhibidores de tirosina quinasa. |
| JP2003511378A (ja) * | 1999-10-07 | 2003-03-25 | アムジエン・インコーポレーテツド | トリアジン系キナーゼ阻害薬 |
| US6864255B2 (en) * | 2001-04-11 | 2005-03-08 | Amgen Inc. | Substituted triazinyl amide derivatives and methods of use |
| EP1395257A1 (en) * | 2001-06-12 | 2004-03-10 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| ES2272737T3 (es) * | 2001-07-16 | 2007-05-01 | Astrazeneca Ab | Derivados de quinolina y su uso como inhibidores de tirosina quinasas. |
| US6924285B2 (en) * | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| AU2003281193A1 (en) * | 2002-07-09 | 2004-01-23 | Astrazeneca Ab | Quinazoline derivatives for use in the treatment of cancer |
| DE10239042A1 (de) * | 2002-08-21 | 2004-03-04 | Schering Ag | Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel |
| US20050021480A1 (en) * | 2003-05-16 | 2005-01-27 | Hyperspace Communications, Inc. | Method and apparatus for creating and validating an encrypted digital receipt for third-party electronic commerce transactions |
| PA8603801A1 (es) * | 2003-05-27 | 2004-12-16 | Janssen Pharmaceutica Nv | Derivados de la quinazolina |
| ES2305887T3 (es) * | 2003-12-18 | 2008-11-01 | Janssen Pharmaceutica Nv | Derivados de pirido y pirimidopirimidinas como agentes antiproliferativos. |
| ES2335216T3 (es) * | 2003-12-18 | 2010-03-23 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-quinolina con actividad antiproliferativa. |
| MY169441A (en) * | 2004-12-08 | 2019-04-11 | Janssen Pharmaceutica Nv | 2,4, (4,6) pyrimidine derivatives |
| WO2007003525A2 (en) * | 2005-06-30 | 2007-01-11 | Janssen Pharmaceutica N.V. | Cyclic anilino-pyridinotriazines as gsk-3 inhibitors |
| KR101513492B1 (ko) * | 2005-11-16 | 2015-04-20 | 에스*바이오 피티이 리미티드 | 헤테로알킬이 결합된 피리미딘 유도체 |
| US8492377B2 (en) * | 2006-07-13 | 2013-07-23 | Janssen Pharmaceutica Nv | MTKI quinazoline derivatives |
| DK2170827T3 (da) * | 2007-06-21 | 2013-11-18 | Janssen Pharmaceutica Nv | Indolin-2-oner og aza-indolin-2-oner |
| WO2009016132A1 (en) * | 2007-07-27 | 2009-02-05 | Janssen Pharmaceutica Nv | Pyrrolopyrimidines |
| JP5480824B2 (ja) * | 2008-03-10 | 2014-04-23 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｐｌｋキナーゼ阻害剤としての４−アリール−２−アニリノ−ピリミジン |
-
2005
- 2005-11-28 JO JOP/2005/0188A patent/JO3088B1/ar active
- 2005-12-05 PA PA20058654501A patent/PA8654501A1/es unknown
- 2005-12-06 MY MYPI20055704A patent/MY148503A/en unknown
- 2005-12-07 TW TW102141302A patent/TWI511970B/zh active
- 2005-12-07 TW TW094143060A patent/TWI432440B/zh active
- 2005-12-07 AR ARP050105124A patent/AR051985A1/es not_active Application Discontinuation
- 2005-12-08 BR BRPI0518394A patent/BRPI0518394B8/pt active IP Right Grant
- 2005-12-08 JP JP2007544918A patent/JP5140431B2/ja active Active
- 2005-12-08 EP EP05826362.5A patent/EP1828201B1/en active Active
- 2005-12-08 WO PCT/EP2005/056609 patent/WO2006061417A2/en active Application Filing
- 2005-12-08 CA CA2588764A patent/CA2588764C/en active Active
- 2005-12-08 MX MX2007006820A patent/MX2007006820A/es active IP Right Grant
- 2005-12-08 CN CN2005800420435A patent/CN101072781B/zh active Active
- 2005-12-08 DK DK05826362.5T patent/DK1828201T3/en active
- 2005-12-08 CN CN201110392750.4A patent/CN102532163B/zh active Active
- 2005-12-08 US US11/720,693 patent/US20100152174A1/en not_active Abandoned
- 2005-12-08 HU HUE05826362A patent/HUE027253T2/en unknown
- 2005-12-08 AU AU2005313350A patent/AU2005313350B2/en active Active
- 2005-12-08 UA UAA200705396A patent/UA91522C2/ru unknown
- 2005-12-08 KR KR1020077013133A patent/KR101320431B1/ko active IP Right Grant
- 2005-12-08 ES ES05826362.5T patent/ES2559305T3/es active Active
- 2005-12-08 EA EA200701233A patent/EA013995B1/ru not_active IP Right Cessation
- 2005-12-08 SI SI200532035T patent/SI1828201T1/sl unknown
- 2005-12-08 NZ NZ555496A patent/NZ555496A/en unknown
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