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EA200701233A1 - Производные хиназолина в качестве mtki - Google Patents

Производные хиназолина в качестве mtki

Info

Publication number
EA200701233A1
EA200701233A1 EA200701233A EA200701233A EA200701233A1 EA 200701233 A1 EA200701233 A1 EA 200701233A1 EA 200701233 A EA200701233 A EA 200701233A EA 200701233 A EA200701233 A EA 200701233A EA 200701233 A1 EA200701233 A1 EA 200701233A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
hydrogen
het
optionally substituted
alkyloxy group
Prior art date
Application number
EA200701233A
Other languages
English (en)
Other versions
EA013995B1 (ru
Inventor
Эдди Жан Эдгар Фрейн
Марк Виллемс
Петер Тен Холтэ
Александра Папаникос
Вернер Констант Йохан Эмбрехтс
Пьер Анри Сторк
Виржини Софи Понселе
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200701233A1 publication Critical patent/EA200701233A1/ru
Publication of EA013995B1 publication Critical patent/EA013995B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Настоящее изобретение относится к соединениям формулы (I), их N-оксидным формам, фармацевтически приемлемым аддитивным солям и стереохимически изомерным формам, где Z означает NH; Y означает -С-алкил-, -С-алкил-NR-С-алкил-, -C-алкил-NR-CO-C-алкил-, -С-алкил-NR-Н-СО-NH-С-алкил- или -C-алкил-NR-CO-CRR-NH-; Xозначает О или -О-С-алкил-; Xозначает прямую связь, C-алкил, -CO-C-алкил- или NR-C-алкил; Rозначает водород или галоген; Rозначает галоген, ацетилен или Het; Rозначает водород или цианогруппу; Rозначает Ar-С-алкилоксигруппу, C-алкилоксигруппу или C-алкилоксигруппу, замещенную одним или, в тех случаях, когда это возможно, двумя или более заместителями, выбранными из Het, NRR, гидроксигруппы и С-алкилокси-С-алкилоксигруппы; Rозначает водород или C-алкил; Rозначает C-алкил, замещенный NRRили C-алкилсульфонилом; Rозначает водород или C-алкил-; Rозначает Ar-сульфонил или C-алкилоксикарбонил, необязательно замещенный фенилом; Rи Rозначают водород, C-алкил или Rи R, вместе взятые с атомом углерода, с котором они связаны, образуют С-циклоалкил; Rозначает C-алкил и Rозначает водород в том случае, когда Rи R, вместе взятые с атомом углерода, с котором они связаны, образуют С-циклоалкил; R, R, Rи R, каждый независимо, означают водород или C-алкилкарбонил; Hetозначает 2-бора-1,3-диоксоланил; Hetозначает пиперидинил, пиперазинил, морфолинил, тиоморфолинил или 1,1-диоксотиоморфолинил, при этом указанный Hetнеобязательно замещен C-алкилоксикарбонилом или NRR-С-алкилом; Arи Arозначают фенил; Arозначает фенил, необязательно замещенный нитрогруппой.
EA200701233A 2004-12-08 2005-12-08 Производные хиназолина в качестве mtki EA013995B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63422804P 2004-12-08 2004-12-08
EP04106383 2004-12-08
PCT/EP2005/056609 WO2006061417A2 (en) 2004-12-08 2005-12-08 Macrocyclic quinazole derivatives and their use as mtki

Publications (2)

Publication Number Publication Date
EA200701233A1 true EA200701233A1 (ru) 2007-10-26
EA013995B1 EA013995B1 (ru) 2010-08-30

Family

ID=34930015

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701233A EA013995B1 (ru) 2004-12-08 2005-12-08 Производные хиназолина в качестве mtki

Country Status (22)

Country Link
US (1) US20100152174A1 (ru)
EP (1) EP1828201B1 (ru)
JP (1) JP5140431B2 (ru)
KR (1) KR101320431B1 (ru)
CN (2) CN101072781B (ru)
AR (1) AR051985A1 (ru)
AU (1) AU2005313350B2 (ru)
BR (1) BRPI0518394B8 (ru)
CA (1) CA2588764C (ru)
DK (1) DK1828201T3 (ru)
EA (1) EA013995B1 (ru)
ES (1) ES2559305T3 (ru)
HU (1) HUE027253T2 (ru)
JO (1) JO3088B1 (ru)
MX (1) MX2007006820A (ru)
MY (1) MY148503A (ru)
NZ (1) NZ555496A (ru)
PA (1) PA8654501A1 (ru)
SI (1) SI1828201T1 (ru)
TW (2) TWI511970B (ru)
UA (1) UA91522C2 (ru)
WO (1) WO2006061417A2 (ru)

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Also Published As

Publication number Publication date
ES2559305T3 (es) 2016-02-11
CA2588764A1 (en) 2006-06-15
EP1828201B1 (en) 2015-11-11
KR101320431B1 (ko) 2013-10-30
CN101072781B (zh) 2012-07-18
CN102532163B (zh) 2016-06-01
BRPI0518394B8 (pt) 2021-05-25
BRPI0518394B1 (pt) 2020-12-15
HUE027253T2 (en) 2016-08-29
CN101072781A (zh) 2007-11-14
SI1828201T1 (sl) 2016-02-29
TW200635933A (en) 2006-10-16
JP2008523034A (ja) 2008-07-03
WO2006061417A2 (en) 2006-06-15
CN102532163A (zh) 2012-07-04
TW201410684A (zh) 2014-03-16
AU2005313350B2 (en) 2012-05-31
TWI432440B (zh) 2014-04-01
PA8654501A1 (es) 2006-09-08
NZ555496A (en) 2011-04-29
WO2006061417A3 (en) 2006-08-03
KR20070086030A (ko) 2007-08-27
AR051985A1 (es) 2007-02-21
EA013995B1 (ru) 2010-08-30
MY148503A (en) 2013-04-30
EP1828201A2 (en) 2007-09-05
US20100152174A1 (en) 2010-06-17
MX2007006820A (es) 2007-07-24
AU2005313350A1 (en) 2006-06-15
CA2588764C (en) 2016-11-29
BRPI0518394A2 (pt) 2008-11-18
JP5140431B2 (ja) 2013-02-06
DK1828201T3 (en) 2016-02-01
JO3088B1 (ar) 2017-03-15
UA91522C2 (en) 2010-08-10
TWI511970B (zh) 2015-12-11

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