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SI1783222T1 - Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity. - Google Patents

Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity.

Info

Publication number
SI1783222T1
SI1783222T1 SI9931068T SI9931068T SI1783222T1 SI 1783222 T1 SI1783222 T1 SI 1783222T1 SI 9931068 T SI9931068 T SI 9931068T SI 9931068 T SI9931068 T SI 9931068T SI 1783222 T1 SI1783222 T1 SI 1783222T1
Authority
SI
Slovenia
Prior art keywords
receptor
peptide mimetics
thrombopoietic activity
dimeric
binding
Prior art date
Application number
SI9931068T
Other languages
English (en)
Inventor
Chuan-Fa Liu
Ulrich Feige
Janet Cheetham
Original Assignee
Kirin Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Amgen Inc filed Critical Kirin Amgen Inc
Publication of SI1783222T1 publication Critical patent/SI1783222T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SI9931068T 1998-10-23 1999-10-22 Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity. SI1783222T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10534898P 1998-10-23 1998-10-23
EP20060022333 EP1783222B1 (en) 1998-10-23 1999-10-22 Dimeric thrombopoietin peptide mimetics binding to MPL receptor and having thrombopoietic activity.

Publications (1)

Publication Number Publication Date
SI1783222T1 true SI1783222T1 (en) 2012-09-28

Family

ID=22305310

Family Applications (3)

Application Number Title Priority Date Filing Date
SI9930953T SI1124961T1 (sl) 1998-10-23 1999-10-22 Trombopoetinske spojine
SI9931072T SI2319928T1 (sl) 1998-10-23 1999-10-22 Dimerni trombopoietinski peptidni mimetiki, ki se veĺ˝ejo na receptor mp1 in imajo trombopoietinsko aktivnost
SI9931068T SI1783222T1 (en) 1998-10-23 1999-10-22 Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SI9930953T SI1124961T1 (sl) 1998-10-23 1999-10-22 Trombopoetinske spojine
SI9931072T SI2319928T1 (sl) 1998-10-23 1999-10-22 Dimerni trombopoietinski peptidni mimetiki, ki se veĺ˝ejo na receptor mp1 in imajo trombopoietinsko aktivnost

Country Status (36)

Country Link
US (8) US6835809B1 (sl)
EP (3) EP2319928B9 (sl)
JP (2) JP3820105B2 (sl)
KR (1) KR100719202B1 (sl)
CN (2) CN1810832B (sl)
AR (1) AR020934A1 (sl)
AT (1) ATE348163T1 (sl)
AU (1) AU773891C (sl)
BG (3) BG65663B1 (sl)
BR (1) BRPI9914698B8 (sl)
CA (1) CA2346996C (sl)
CY (4) CY1107526T1 (sl)
CZ (1) CZ302155B6 (sl)
DE (2) DE69934425T2 (sl)
DK (3) DK2319928T3 (sl)
EA (1) EA003998B1 (sl)
ES (3) ES2388341T3 (sl)
FR (1) FR09C0030I2 (sl)
HK (2) HK1042114B (sl)
HU (1) HU228582B1 (sl)
IL (1) IL142023A0 (sl)
LT (1) LTC1124961I2 (sl)
LU (1) LU91598I2 (sl)
ME (2) MEP42108A (sl)
MY (1) MY126795A (sl)
NL (1) NL300398I2 (sl)
NO (2) NO331027B1 (sl)
NZ (1) NZ510529A (sl)
PL (1) PL219605B1 (sl)
PT (3) PT2319928E (sl)
RS (1) RS51237B (sl)
SI (3) SI1124961T1 (sl)
SK (1) SK287737B6 (sl)
TW (2) TWI250988B (sl)
WO (1) WO2000024770A2 (sl)
ZA (1) ZA200102102B (sl)

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