Nothing Special   »   [go: up one dir, main page]

SG168451A1 - Quarternary ammonium compounds and their use as antimuscarinic agents - Google Patents

Quarternary ammonium compounds and their use as antimuscarinic agents

Info

Publication number
SG168451A1
SG168451A1 SG200905309-1A SG2009053091A SG168451A1 SG 168451 A1 SG168451 A1 SG 168451A1 SG 2009053091 A SG2009053091 A SG 2009053091A SG 168451 A1 SG168451 A1 SG 168451A1
Authority
SG
Singapore
Prior art keywords
ammonium compounds
quarternary ammonium
antimuscarinic agents
trifluoromethyl
compound
Prior art date
Application number
SG200905309-1A
Other languages
English (en)
Inventor
Ivan Richards
Sue K Cammarata
Craig D Wegner
Michael Hawley
Mark P Warchol
Mark Kontny
Walter Morozowich
Karen P Kolbasa
Malcolm W Moon
Dominique Bonafoux
Sergey G Wolfson
Patrick J Lennon
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of SG168451A1 publication Critical patent/SG168451A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/66Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with quaternised amino groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Cephalosporin Compounds (AREA)
SG200905309-1A 2001-10-26 2002-10-25 Quarternary ammonium compounds and their use as antimuscarinic agents SG168451A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34893001P 2001-10-26 2001-10-26
US36197902P 2002-03-06 2002-03-06
US39152102P 2002-06-25 2002-06-25

Publications (1)

Publication Number Publication Date
SG168451A1 true SG168451A1 (en) 2011-02-28

Family

ID=27407868

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200905309-1A SG168451A1 (en) 2001-10-26 2002-10-25 Quarternary ammonium compounds and their use as antimuscarinic agents

Country Status (16)

Country Link
US (2) US6890920B2 (es)
EP (1) EP1461306B1 (es)
JP (1) JP3981357B2 (es)
AT (1) ATE418534T1 (es)
BR (1) BR0206207A (es)
CA (1) CA2464223C (es)
CY (1) CY1109898T1 (es)
DE (1) DE60230546D1 (es)
DK (1) DK1461306T3 (es)
ES (1) ES2315425T3 (es)
MX (1) MXPA04003865A (es)
MY (1) MY130316A (es)
NO (1) NO20032938L (es)
PT (1) PT1461306E (es)
SG (1) SG168451A1 (es)
WO (1) WO2003035599A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957073A1 (en) 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
MY130316A (en) * 2001-10-26 2007-06-29 Pharmacia & Upjohn Co Llc Quaternary ammonium compounds
US7754242B2 (en) * 2002-03-20 2010-07-13 Alkermes, Inc. Inhalable sustained therapeutic formulations
JP2006511449A (ja) * 2002-04-29 2006-04-06 シャイア ラボラトリーズ,インコーポレイテッド 改良されたバイオアベイラビリティーを有する薬学的処方物
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
WO2004091607A1 (en) * 2003-04-15 2004-10-28 Pharmacia & Upjohn Company Llc Quaternary ammonium compounds and their use as antimuscarinic agents
WO2004091597A2 (en) * 2003-04-15 2004-10-28 Pharmacia & Upjohn Company Llc Method of treating irritable bowel syndrome (ibs)
BRPI0409492A (pt) * 2003-04-18 2006-05-02 Pharmacia & Up John Company Ll terapias de combinação
CA2523226A1 (en) 2003-04-25 2004-11-11 Pharmacia & Upjohn Company Llc Halogen substituted 3,3-diphenylpropylamines (tolterodine) having antimuscarinic activity
ATE493981T1 (de) * 2003-11-04 2011-01-15 Supernus Pharmaceuticals Inc Einmal tägliche dosierformen von trospium
WO2005046663A1 (en) 2003-11-04 2005-05-26 Shire Laboratories, Inc. Compositions of quaternary ammonium containing bioavailability enhancers
ES2235648B1 (es) * 2003-12-22 2006-11-01 Ragactives, S.L. Procedimiento para la obtencion de tolterodina.
EP1701932B1 (en) 2003-12-24 2012-07-18 Cipla Ltd. Tolterodine, compositions and uses thereof, and preparation of the same
WO2005086873A2 (en) * 2004-03-11 2005-09-22 Glaxo Group Limited Novel m3 muscarinic acetylcholine receptor antagonists
EP1838659B1 (en) * 2004-12-24 2015-07-15 LEK Pharmaceuticals d.d. Process for preparation of n,n-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine
EP2029126A1 (en) * 2006-05-24 2009-03-04 Boehringer Ingelheim International GmbH Novel medicament combinations for the treatment of respiratory diseases
EP1908502A1 (en) * 2006-10-02 2008-04-09 Koninklijke Philips Electronics N.V. Interactive modular tile system
US7731604B2 (en) * 2006-10-31 2010-06-08 Taylor Made Golf Company, Inc. Golf club iron head
US20100112061A1 (en) * 2006-12-13 2010-05-06 William Baker Monophosphates as Mutual Prodrugs of Muscarinic Receptor Antagonists and Beta-Agonists for the Treatment of COPD And Chronic Bronchitis
CA2675942C (en) 2007-02-23 2016-04-12 Theravance, Inc. Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists
WO2008133900A1 (en) * 2007-04-24 2008-11-06 Theravance, Inc. Quaternary ammonium compounds useful as muscarinic receptor antagonists
US20090246146A1 (en) * 2008-01-25 2009-10-01 Botond Banfi Halides in the treatment of pathogenic infection
WO2009152171A1 (en) * 2008-06-10 2009-12-17 Gilead Sciences, Inc. Corticosteroid linked beta-agonist compounds for use in therapy
WO2010010464A2 (en) * 2008-07-21 2010-01-28 Actavis Group Ptc Ehf Fesoterodine substantially free of dehydroxy impurity
JP5801997B2 (ja) 2009-07-07 2015-10-28 ファイザー・リミテッドPfizer Limited 薬品の組合せを吸入するための投薬ユニット、投薬ユニットのパック、および吸入器
CN110372571B (zh) 2018-04-12 2022-11-15 中国科学院大连化学物理研究所 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物
CN110845357B (zh) * 2019-11-22 2022-09-30 华东理工大学 季铵盐型酰肼化合物及由其制备的季铵盐型腙类化合物与应用
WO2021260441A1 (en) 2020-06-26 2021-12-30 Mylan Pharma Uk Limited Formulations including 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2592191A (en) * 1949-09-16 1952-04-08 Sterling Drug Inc Quaternary ammonium salts of nu-(3, 3-diphenylpropyl) pyrrolidine
US5382600A (en) * 1988-01-22 1995-01-17 Pharmacia Aktiebolag 3,3-diphenylpropylamines and pharmaceutical compositions thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE106643C (es)
NL267508A (es) 1960-07-26
NL6717123A (es) * 1966-12-29 1968-07-01
US3505337A (en) * 1967-12-22 1970-04-07 Boehringer Sohn Ingelheim N - hydrocarbyl-substituted noratropinium,haloalkylates and o-acyl derivatives thereof
IL91377A (en) * 1988-09-14 1996-09-12 Nippon Shinyaku Co Ltd Derivatives of botinylamine glycolate
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
SE9203318D0 (sv) * 1992-11-06 1992-11-06 Kabi Pharmacia Ab Novel 3,3-diphenylpropylamines, their use and preparation
US5492933A (en) 1993-10-08 1996-02-20 Sepracor, Inc. Methods and compositions for treating urinary incontinence and other disorders using optically pure R-terodiline and hydroxylated derivatives thereof
AU7971394A (en) 1993-10-08 1995-05-04 Sepracor, Inc. Method for treating urinary incontinence using optically pure s-terodiline
KR20000057548A (ko) 1996-12-13 2000-09-25 알프레드 엘. 미첼슨 광학적 전송물질 및 결합재
SE9701144D0 (sv) * 1997-03-27 1997-03-27 Pharmacia & Upjohn Ab Novel compounds, their use and preparation
PE20020547A1 (es) * 2000-10-24 2002-06-12 Upjohn Co Uso de la tolterodina en tratamientos del asma
WO2002035245A1 (en) 2000-10-26 2002-05-02 Koninklijke Philips Electronics N.V. Electronic device
MY130316A (en) * 2001-10-26 2007-06-29 Pharmacia & Upjohn Co Llc Quaternary ammonium compounds
WO2004091607A1 (en) * 2003-04-15 2004-10-28 Pharmacia & Upjohn Company Llc Quaternary ammonium compounds and their use as antimuscarinic agents
CA2523226A1 (en) * 2003-04-25 2004-11-11 Pharmacia & Upjohn Company Llc Halogen substituted 3,3-diphenylpropylamines (tolterodine) having antimuscarinic activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2592191A (en) * 1949-09-16 1952-04-08 Sterling Drug Inc Quaternary ammonium salts of nu-(3, 3-diphenylpropyl) pyrrolidine
US5382600A (en) * 1988-01-22 1995-01-17 Pharmacia Aktiebolag 3,3-diphenylpropylamines and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
MXPA04003865A (es) 2004-07-08
NO20032938D0 (no) 2003-06-26
CA2464223A1 (en) 2003-05-01
CA2464223C (en) 2009-05-26
JP3981357B2 (ja) 2007-09-26
EP1461306B1 (en) 2008-12-24
DE60230546D1 (de) 2009-02-05
EP1461306A1 (en) 2004-09-29
PT1461306E (pt) 2009-04-01
US20030158176A1 (en) 2003-08-21
NO20032938L (no) 2003-08-25
MY130316A (en) 2007-06-29
ATE418534T1 (de) 2009-01-15
US7439397B2 (en) 2008-10-21
ES2315425T3 (es) 2009-04-01
DK1461306T3 (da) 2009-03-09
CY1109898T1 (el) 2014-09-10
US6890920B2 (en) 2005-05-10
US20050148672A1 (en) 2005-07-07
BR0206207A (pt) 2003-12-23
WO2003035599A1 (en) 2003-05-01
JP2005524605A (ja) 2005-08-18

Similar Documents

Publication Publication Date Title
SG168451A1 (en) Quarternary ammonium compounds and their use as antimuscarinic agents
BR0212733A (pt) Composto, composição farmacêutica, uso de um composto, e, método para o tratamento de um distúrbio afetivo
AR047551A1 (es) Compuestos activos antritranspirantes de aluminio/ zirconio / glicina, estabilizados con betaina
MXPA05012286A (es) Mezclas fungicidas para combatir patogenos de arroz.
ATE289750T1 (de) Fungizide wirkstoffkombinationen
HK1090293A1 (en) Topical stabilized prostaglandin e compound dosage forms
DE60035639D1 (de) Hydroxydiphenyletherverbindungen
MX2009007094A (es) Mezclas fungicidas a partir de 1-metilpirazol-4-ilcarboxanilidas y azolopirimidinilaminas.
EA200000975A1 (ru) 6-(2-гало-4-алкоксифенил)триазолпиримидины с фунгицидным действием
WO2006043149A3 (en) Novel dicarboxylic acid derivatives
TR199901017A2 (xx) B�cek ilac� terkibi.
ES2183709A1 (es) Composicion para el control de artropodos.
BR9707356A (pt) Composto processo para preparação do mesmo composição fingicida e processo para combater fungos
AU2002361185A1 (en) Use of (+)-(1s,2s)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol as anti-emetic agent
BR0312308A (pt) Mistura fungicida, agente fungicida, processo para combater fungos nocivos, e, uso dos compostos
BR0311809A (pt) Mistura fungicida, agente fungicida, e, processo para combater fungos nocivos
RS20050875A (en) Fungicidal mixtures
BRPI0614104A2 (pt) compostos, processo para preparar compostos, agente fungicida, semente, e, processo para combater fungos nocivos fitopatogênicos
MY112982A (en) Para-hydroxyphenylacetic acid for reducing the repellency of insecticides
BR0312828A (pt) Mistura fungicida, agente fungicida, processo para combater fungos nocivos, e, uso de compostos
BR0312307A (pt) Mistura fungicida, agente fungicida, processo para combater fungos nocivos, e, uso dos compostos
BRPI0418836A (pt) misturas fungicidas, agente fungicida, processo para combater fungos nocivos fitopatogênicos, semente, e, uso de compostos
BRPI0408647A (pt) composto, composição farmacêutica, uso de um composto, e, método para o tratamento de um distúrbio afetivo
TW200605790A (en) Fungicidal mixtures
PT1237850E (pt) Glioxilamidas, processo para a sua preparacao e sua utilizacao para o combate de organismos prejudiciais