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SG11201903825SA - Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion - Google Patents

Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion

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Publication number
SG11201903825SA
SG11201903825SA SG11201903825SA SG11201903825SA SG11201903825SA SG 11201903825S A SG11201903825S A SG 11201903825SA SG 11201903825S A SG11201903825S A SG 11201903825SA SG 11201903825S A SG11201903825S A SG 11201903825SA SG 11201903825S A SG11201903825S A SG 11201903825SA
Authority
SG
Singapore
Prior art keywords
international
rule
aapcs
myeloid cell
presenting cells
Prior art date
Application number
SG11201903825SA
Other languages
English (en)
Inventor
Anand Veerapathran
Aishwarya Gokuldass
Brian Rabinovich
Michael Lotze
Original Assignee
Iovance Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iovance Biotherapeutics Inc filed Critical Iovance Biotherapeutics Inc
Publication of SG11201903825SA publication Critical patent/SG11201903825SA/en

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/20—Cytokines; Chemokines
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SG11201903825SA 2016-10-31 2017-10-31 Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion SG11201903825SA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662415274P 2016-10-31 2016-10-31
US201662438600P 2016-12-23 2016-12-23
US201762475053P 2017-03-22 2017-03-22
US201762481831P 2017-04-05 2017-04-05
PCT/US2017/059271 WO2018081789A1 (en) 2016-10-31 2017-10-31 Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion

Publications (1)

Publication Number Publication Date
SG11201903825SA true SG11201903825SA (en) 2019-05-30

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ID=60702946

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Application Number Title Priority Date Filing Date
SG11201903825SA SG11201903825SA (en) 2016-10-31 2017-10-31 Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion

Country Status (14)

Country Link
US (4) US10415015B2 (ja)
EP (1) EP3532608A1 (ja)
JP (2) JP7576912B2 (ja)
KR (2) KR20240013295A (ja)
CN (2) CN110312790A (ja)
AU (2) AU2017347942A1 (ja)
BR (1) BR112019008560A2 (ja)
CA (1) CA3041673A1 (ja)
IL (1) IL266221A (ja)
MA (1) MA46668A (ja)
MX (2) MX2019004708A (ja)
SG (1) SG11201903825SA (ja)
TW (1) TWI788307B (ja)
WO (1) WO2018081789A1 (ja)

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US11254913B1 (en) 2017-03-29 2022-02-22 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
WO2018204761A1 (en) * 2017-05-05 2018-11-08 H. Lee Moffitt Cancer Center And Research Institute, Inc. Rapid method for the culture of tumor infiltrating lymphocytes
EP3635097A1 (en) 2017-06-05 2020-04-15 Iovance Biotherapeutics, Inc. Methods of using tumor infiltrating lymphocytes in double-refractory melanoma
US11713446B2 (en) 2018-01-08 2023-08-01 Iovance Biotherapeutics, Inc. Processes for generating TIL products enriched for tumor antigen-specific T-cells
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BR112020018658A2 (pt) 2018-03-15 2020-12-29 KSQ Therapeutics, Inc. Composições de regulação gênica e métodos para imu-noterapia aprimorada
AU2019257749A1 (en) 2018-04-27 2020-10-22 Iovance Biotherapeutics, Inc. Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
TW202031273A (zh) * 2018-08-31 2020-09-01 美商艾歐凡斯生物治療公司 抗ｐｄ－１抗體難治療性之非小細胞肺癌（ｎｓｃｌｃ）病患的治療
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