Nothing Special   »   [go: up one dir, main page]

SG11201509782TA - Compositions and methods for the treatment of diabetes and pre-diabetes - Google Patents

Compositions and methods for the treatment of diabetes and pre-diabetes

Info

Publication number
SG11201509782TA
SG11201509782TA SG11201509782TA SG11201509782TA SG11201509782TA SG 11201509782T A SG11201509782T A SG 11201509782TA SG 11201509782T A SG11201509782T A SG 11201509782TA SG 11201509782T A SG11201509782T A SG 11201509782TA SG 11201509782T A SG11201509782T A SG 11201509782TA
Authority
SG
Singapore
Prior art keywords
diabetes
compositions
treatment
methods
Prior art date
Application number
SG11201509782TA
Inventor
Mahesh Kandula
Original Assignee
Cellix Bio Private Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2013/059680 external-priority patent/WO2014080307A2/en
Priority claimed from PCT/IB2014/058634 external-priority patent/WO2014195810A2/en
Application filed by Cellix Bio Private Ltd filed Critical Cellix Bio Private Ltd
Publication of SG11201509782TA publication Critical patent/SG11201509782TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • C07C279/265—X and Y being nitrogen atoms, i.e. biguanides containing two or more biguanide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG11201509782TA 2013-06-04 2014-02-12 Compositions and methods for the treatment of diabetes and pre-diabetes SG11201509782TA (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
IN2448CH2013 2013-06-04
PCT/IB2013/059680 WO2014080307A2 (en) 2012-11-21 2013-10-26 Compositions and methods for the treatment of diabetes and pre-diabetes
IN5592CH2013 2013-12-04
IN315CH2014 2014-01-25
PCT/IB2014/058634 WO2014195810A2 (en) 2013-06-04 2014-01-29 Compositions and methods for the treatment of diabetes and pre-diabetes
IN527CH2014 2014-02-05
PCT/IN2014/000089 WO2014195961A1 (en) 2013-06-04 2014-02-12 Compositions and methods for the treatment of diabetes and pre-diabetes

Publications (1)

Publication Number Publication Date
SG11201509782TA true SG11201509782TA (en) 2015-12-30

Family

ID=54850555

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201509782TA SG11201509782TA (en) 2013-06-04 2014-02-12 Compositions and methods for the treatment of diabetes and pre-diabetes

Country Status (6)

Country Link
US (2) US8952068B2 (en)
EP (1) EP3004049B1 (en)
AU (1) AU2014276346A1 (en)
CA (1) CA2914461A1 (en)
SG (1) SG11201509782TA (en)
WO (1) WO2014195961A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
SG11201509782TA (en) * 2013-06-04 2015-12-30 Cellix Bio Private Ltd Compositions and methods for the treatment of diabetes and pre-diabetes
WO2015022613A1 (en) * 2013-08-11 2015-02-19 Mahesh Kandula Compositions and methods for the treatment of diabetes and pre-diabetes
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
NZ736131A (en) 2014-09-26 2019-04-26 Cellix Bio Private Ltd Compositions and methods for the treatment of epilepsy and neurological disorders
EP3201168B1 (en) 2014-09-29 2020-03-18 Cellix Bio Private Limited Compounds and compositions for the treatment of multiple sclerosis
US9932294B2 (en) 2014-12-01 2018-04-03 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
JP6679616B2 (en) 2015-01-06 2020-04-22 セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ Compositions and methods for the treatment of inflammation and pain
US10112890B2 (en) 2015-01-19 2018-10-30 Showa Denko K.K. Compound, salt of compound, external agent for skin, cosmetic, and food additive
US9371276B1 (en) * 2015-03-21 2016-06-21 Mohan Murali Alapati Compositions and methods for the treatment of hyperglycemia and metabolic syndrome
KR102379963B1 (en) 2020-04-20 2022-03-29 (주)아이랩 A process for preparing benzopyranone compound and novel intermediates used for the process
EP4424792A1 (en) 2023-02-28 2024-09-04 Cowa Thermal Solutions AG Phase change material composition

Family Cites Families (147)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2807644A (en) 1954-08-20 1957-09-24 Parke Davis & Co Pantethine inhibitors
DE1205972B (en) 1963-08-20 1965-12-02 Merck Ag E Process for the production of a lipoic acid derivative
US4011342A (en) 1971-06-02 1977-03-08 Seperic Method and composition for the treatment of hypertension with ortho-disubstituted arylguanidines
GB1356470A (en) 1971-06-02 1974-06-12 Seperic Ortho-disubstituted aryl-guanidines process for their preparation and applications thereof
AU514991B2 (en) 1976-05-26 1981-03-12 Commonwealth Of Australia, The Pharmaceutical compositions containing antiinflammatory analgesic compounds
JPS5677259A (en) 1979-11-29 1981-06-25 Nippon Chemiphar Co Ltd N-pyridoxyl 5,8,11,14,17-eicosapentaenoic acid amide, and its preparation
WO1981002671A1 (en) 1980-03-20 1981-10-01 Ferring Farma Lab Pharmaceutical composition and method for the treatment of colitis ulcerosa and crohn's disease by oral administration
US4404366A (en) 1980-05-06 1983-09-13 Miles Laboratories, Inc. Beta-galactosyl-umbelliferone-labeled hapten conjugates
US4412992A (en) 1980-07-21 1983-11-01 Biorex Laboratories Limited 2-Hydroxy-5-phenylazobenzoic acid derivatives and method of treating ulcerative colitis therewith
US4440763A (en) 1981-03-18 1984-04-03 Block Drug Company, Inc. Use of 4-aminosalicyclic acid as an anti-inflammatory agent
IT1190727B (en) 1982-03-10 1988-02-24 Ausonia Farma Srl COMPOUND WITH ANALGESIC, ANTI-INFLAMMATORY AND MUCOREGULATING ACTIVITY PROCEDURE FOR ITS PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS
US4564628A (en) 1983-01-03 1986-01-14 Nelson Research & Development Co. Substituted 2-aminotetralins
US5104887A (en) 1983-02-04 1992-04-14 University Of Iowa Research Foundation Topical ophthalmic imino substituted 2-imino-3-methyl-delta4-1,3,4-thiadiazoline-5-sulfonamides carbonic anhydrase inhibitors
DE3379266D1 (en) 1983-08-01 1989-04-06 Astra Laekemedel Ab L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same
JPS6089474A (en) 1983-10-20 1985-05-20 Toyo Pharma- Kk Morphinan derivative, production thereof and antitumor agent containing said compound
IL73293A (en) 1983-11-04 1988-02-29 Abbott Lab Methyl 2-(alkanamidoalkylsulfonic)ethylthiophosphonate derivatives
IT1213132B (en) 1984-02-02 1989-12-14 Yason Srl ANTIBRONCOPNEUMOPATHIC AGENT.
US4550109A (en) 1984-05-31 1985-10-29 The Board Of Regents, The University Of Texas System Lipoidal biopterin compounds
JPS61277618A (en) 1985-06-04 1986-12-08 Suntory Ltd Remedy for autism
YU213587A (en) 1986-11-28 1989-06-30 Orion Yhtymae Oy Process for obtaining new pharmacologic active cateholic derivatives
US4873259A (en) 1987-06-10 1989-10-10 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US5102870A (en) 1989-04-14 1992-04-07 Schering Ag Treatment and prevention of oral mucositis with growth factors
EP0421441B1 (en) 1989-10-06 1995-01-25 Fujirebio Inc. Pantothenic acid derivatives
US5242937A (en) 1990-03-19 1993-09-07 Research Corporation Technologies, Inc. Topically active ocular thiadiazole sulfonamide carbonic anhydrase inhibitors
IT1248702B (en) 1990-06-06 1995-01-26 Yason Srl ANTITUSSIVE AGENT AND MUCOREGULATOR, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS
FR2699077B1 (en) 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application of anticonvulsants in the treatment of neurological lesions linked to trauma.
FR2707637B1 (en) 1993-06-30 1995-10-06 Lafon Labor New acetamide derivatives, their preparation process and their use in therapy.
JPH09511496A (en) 1994-02-18 1997-11-18 セル・セラピューティックス・インコーポレーテッド Intracellular messenger
SE9401727D0 (en) 1994-05-18 1994-05-18 Astra Ab New compounds I
FR2722199B3 (en) 1994-07-11 1996-09-06 Univ Picardie Jules Verne Etab VALPROIC ACID DERIVATIVES AND THEIR APPLICATIONS AS MEDICAMENTS
US6156777A (en) 1994-12-15 2000-12-05 Pharmacia & Upjohn Company Use of pramipexole as a neuroprotective agent
NZ334389A (en) 1996-08-28 2001-05-25 Ube Industries Cyclic amine derivatives
CN1238760A (en) 1996-11-22 1999-12-15 伊兰药品公司 N- (aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions containing such compounds, and methods of inhibiting beta-amyloid peptide release and or synthesis using such compounds
US6414008B1 (en) 1997-04-29 2002-07-02 Boehringer Ingelheim Pharma Kg Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions
GB9710351D0 (en) 1997-05-20 1997-07-16 Scotia Holdings Plc Glucosamine fatty acids
NZ333474A (en) 1998-01-02 1999-06-29 Mcneil Ppc Inc A chewable tablet containing ibuprofen, fumaric acid and a non hydrocolloid binder e.g. a wax or a fat
DK1063230T3 (en) 1998-02-27 2003-07-14 Sankyo Co Cyclic amino compounds
JP3761324B2 (en) 1998-05-15 2006-03-29 ヤンマー農機株式会社 Passenger rice transplanter
US6846495B2 (en) 1999-01-11 2005-01-25 The Procter & Gamble Company Compositions having improved delivery of actives
EP2133325A1 (en) 1999-04-06 2009-12-16 Sepracor Inc. Derivatives of venlafaxine and methods of preparing and using the same
US6262118B1 (en) 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
WO2001022967A1 (en) 1999-09-29 2001-04-05 The Procter & Gamble Company Compositions having improved stability
US20020049155A1 (en) 2000-05-31 2002-04-25 Hogenkamp Henricus P.C. Cobalamin compounds useful as cardiovascular agents and as imaging agents
US6429223B1 (en) 2000-06-23 2002-08-06 Medinox, Inc. Modified forms of pharmacologically active agents and uses therefor
WO2002009769A2 (en) 2000-07-27 2002-02-07 Rutgers, The State University Of New Jersey Therapeutic azo-compounds for drug delivery
WO2002034713A1 (en) 2000-10-24 2002-05-02 Ajinomoto Co.,Inc. Process for producing b-form nateglinide crystal
DE10103506A1 (en) 2001-01-26 2002-08-14 Ingo S Neu Pharmaceutical composition for the treatment of multiple sclerosis
UA81224C2 (en) 2001-05-02 2007-12-25 Euro Celtic S A Dosage form of oxycodone and use thereof
FR2827517B1 (en) 2001-07-23 2003-10-24 Bioalliance Pharma EXTENDED RELEASE BIOADHESIVE THERAPEUTIC SYSTEMS
CN1612732A (en) 2001-08-29 2005-05-04 恩德制药公司 Analgesics and methods of use
US7138133B2 (en) 2001-10-10 2006-11-21 The Procter & Gamble Company Orally administered liquid compositions
US20040010038A1 (en) 2002-02-27 2004-01-15 Eran Blaugrund Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors
US20030220344A1 (en) 2002-04-04 2003-11-27 Luiz Belardinelli Method of treating arrhythmias
CN1304366C (en) 2002-04-15 2007-03-14 诺瓦提斯公司 Crystal forms of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine
WO2003086391A1 (en) 2002-04-16 2003-10-23 Fujisawa Pharmaceutical Co., Ltd. New use
US7060725B2 (en) 2002-05-13 2006-06-13 Janssen Pharmaceutica N.V. Substituted sulfamate anticonvulsant derivatives
GB0223224D0 (en) 2002-10-07 2002-11-13 Novartis Ag Organic compounds
WO2004052841A1 (en) 2002-12-06 2004-06-24 Xenoport, Inc. Carbidopa prodrugs and uses thereof
CA2510455C (en) 2002-12-19 2013-03-12 The Scripps Research Institute Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
WO2004075886A1 (en) 2003-02-14 2004-09-10 Pierre Fabre Medicament Use of the enantiomer (1s, 2r) of milnacipran for the preparation of a medicament
UA81657C2 (en) 2003-03-04 2008-01-25 Орто-Макнейл Фармасьютикел, Инк. Normal;heading 1;heading 2;PROCESS FOR THE PREPARATION OF ANTICONVULSANT DERIVATIVES OF TOPIRAMATE
NZ541516A (en) * 2003-03-18 2008-05-30 Novartis Ag Compositions comprising fatty acids and amino acids
EP1643999B8 (en) 2003-06-20 2012-03-14 NephroGenex, Inc. Pyridoxamine for use in the treatment of diabetic nephropathy in type ii diabetes
CN101123878A (en) 2003-07-29 2008-02-13 信号研发控股有限责任公司 L-threonine derivatives of high therapeutic index
WO2005037784A2 (en) 2003-10-14 2005-04-28 Xenoport, Inc. Crystalline form of gamma-aminobutyric acid analog
US7470435B2 (en) 2003-11-17 2008-12-30 Andrx Pharmaceuticals, Llc Extended release venlafaxine formulation
CA2547472A1 (en) 2003-11-28 2005-06-09 Sankyo Company Limited Cyclic amine derivative having heteroaryl ring
DE10361259A1 (en) 2003-12-24 2005-07-28 Schwarz Pharma Ag Use of Rotigotine in Early Stage Parkinson's Disease to Prevent Further Neuronal Loss
CN1248690C (en) 2004-03-25 2006-04-05 华中师范大学 Oral preparation containing ranolazine hydrochloride for treating cardiovascular disease
EA200601648A1 (en) 2004-04-07 2007-04-27 Зе Юниверсити Оф Джорджия Рисерч Фаундейшн, Инк. GLUCOSAMINE AND GENERAL PROCEDURES GLUCOSAMINE / ANTI-INFLAMMATORY AGENT, COMPOSITIONS AND METHODS
CN1976689A (en) 2004-04-29 2007-06-06 考德威尔·盖勒公司 Topical methadone compositions and methods for using the same
CN1672678A (en) 2004-05-03 2005-09-28 深圳微芯生物科技有限责任公司 Separation and extraction of natural active long-chain fatty acid component for preventing and treating prostatosis and the prepn and application of its medicine prepn
US7342131B2 (en) 2004-06-04 2008-03-11 Xenoport, Inc. Levodopa prodrugs, and compositions and uses thereof
CN100455560C (en) 2004-06-09 2009-01-28 中国人民解放军军事医学科学院放射医学研究所 Medicine precursor containing long chain fatty acyl group substituted venlafaxine and its prepn and use
PL1848403T3 (en) 2005-01-14 2010-09-30 Camurus Ab Topical bioadhesive formulations
WO2006096996A1 (en) 2005-03-18 2006-09-21 Ripped Formulations Ltd. Compositions and methods for increasing metabolism, thermogenesis and/or muscular definition
EP1940392A2 (en) 2005-05-11 2008-07-09 Nycomed GmbH Combination of the pde4 inhibitor and a tetrahydrobiopterin derivative
DE102005022276A1 (en) 2005-05-13 2006-11-16 Ellneuroxx Ltd. Derivatives of dihydroxyphenylalanine
US20060270635A1 (en) 2005-05-27 2006-11-30 Wallace John L Derivatives of 4- or 5-aminosalicylic acid
WO2006125293A1 (en) 2005-05-27 2006-11-30 Antibe Therapeutics Inc. Derivatives of 4- or 5-aminosalicylic acid
BRPI0610311A2 (en) 2005-05-27 2010-06-15 Daiichi Sankyo Co Ltd cyclically amine derivative having substituted alkyl group
JP2009511618A (en) 2005-10-18 2009-03-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Use of pramipexole to treat moderate to severe restless legs syndrome (RLS)
EP1980271A4 (en) 2006-01-27 2012-04-25 Asahi Kasei Pharma Corp Medicine for transnasal administration
US20070259930A1 (en) 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
EP1870395A1 (en) 2006-06-19 2007-12-26 KRKA, D.D., Novo Mesto Process for preparation of o-desmethylvenlafaxine and its analogue
US7943666B2 (en) 2006-07-24 2011-05-17 Trinity Laboratories, Inc. Esters of capsaicin for treating pain
US7645767B2 (en) 2006-08-31 2010-01-12 Trinity Laboratories, Inc. Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy
TW200817048A (en) 2006-09-08 2008-04-16 Wyeth Corp Dry powder compound formulations and uses thereof
EP2101766B1 (en) 2006-12-14 2016-09-21 Knopp Biosciences LLC Compositions and methods of using (r)-pramipexole
CN100573950C (en) 2006-12-14 2009-12-23 财团法人工业技术研究院 Phase change memory apparatus and manufacture method thereof
EP2063867A2 (en) 2006-12-22 2009-06-03 Combinatorx, Incorporated Pharmaceutical compositions for treatment of parkinson's disease and related disorders
EP2114944A2 (en) 2007-01-12 2009-11-11 BioMarin Pharmaceutical Inc. Tetrahydrobiopterin prodrugs
ES2319024B1 (en) 2007-02-13 2009-12-11 Quimica Sintetica, S.A. PROCEDURE FOR OBTAINING ENTACAPONA SUBSTANTIALLY FREE OF ISOMERO Z, ITS SYNTHESIS INTERMEDIATES AND NEW CRYSTAL FORM.
JP2010521496A (en) 2007-03-14 2010-06-24 ノップ ニューロサイエンシーズ、インク． Synthesis of chiral purified substituted benzothiazolediamine
ES2381317T3 (en) 2007-05-01 2012-05-25 Concert Pharmaceuticals Inc. Morphinan compounds
EP1997493A1 (en) 2007-05-28 2008-12-03 Laboratorios del Dr. Esteve S.A. Combination of a 5-HT7 receptor ligand and an opioid receptor ligand
CA2690776A1 (en) 2007-06-22 2008-12-31 Gluconova Llc Halide-free glucosamine-acidic drug complexes
US20090075942A1 (en) 2007-09-13 2009-03-19 Protia, Llc Deuterium-enriched fosamprenavir
CN101390854A (en) 2007-09-21 2009-03-25 北京德众万全药物技术开发有限公司 Medical composition containing riluzole
WO2009056791A1 (en) 2007-11-02 2009-05-07 Pliva Hrvatska D.O.O. Processes for preparing pharmaceutical compounds
WO2009061934A1 (en) 2007-11-06 2009-05-14 Xenoport, Inc. Use of prodrugs of gaba b agonists for treating neuropathic and musculoskeletal pain
CN101186583B (en) 2007-12-20 2011-05-11 吉林大学 Methyl 2-(2-(2,6-dichlorophenylamino)phenyl)acetate and its synthesizing method and application
US20100081713A1 (en) 2008-03-19 2010-04-01 CombinatoRx, (Singapore) Pte. Ltd. Compositions and methods for treating viral infections
CN101569618B (en) 2008-04-30 2011-11-09 上海医药工业研究院 Application of long-chain fatty acid derivative or plant extracts containing same in inhibiting the activity of aromatizing enzyme
KR100990949B1 (en) 2008-06-09 2010-10-29 엔자이텍 주식회사 Method for Preparing Clopidogrel and Derivatives Thereof
CN102149673B (en) 2008-07-08 2014-07-09 凯特贝希制药公司 Fatty acid acetylated salicylates and their uses
CA2806444C (en) 2008-08-19 2016-02-23 Xenoport, Inc. Prodrugs of methyl hydrogen fumarate
CA2734972C (en) 2008-08-22 2017-03-28 Wockhardt Research Centre An extended release pharmaceutical composition of entacapone or salts thereof
EP2165706A1 (en) 2008-09-18 2010-03-24 BioAlliance Pharma Treating Inflammatory Pain in Mucosa of the Oral Cavity Using Mucosal Prolonged Release Bioadhesive Therapeutic Carriers.
US20110313176A1 (en) 2008-12-26 2011-12-22 Actavis Group Ptc Ehf Processes for preparing highly pure rotigotine or a pharmaceutically acceptable salt thereof
BRPI0901298A2 (en) 2009-04-06 2011-01-04 Ems Sa phthalimide derivatives of nonsteroidal antiinflammatory compounds and / or modulators of tnf- (alpha), process for obtaining them, pharmaceutical compositions containing them and their uses in the treatment of inflammatory diseases
NZ720946A (en) 2009-04-29 2017-09-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
WO2010147666A1 (en) 2009-06-19 2010-12-23 Memorial Sloan-Kettering Cancer Center Compounds useful as carbonic anhydrase modulators and uses thereof
CA2768877A1 (en) 2009-08-10 2011-02-17 Bellus Health Inc. Methods, compounds, and compositions for delivering 1,3-propanedisulfonic acid
CN102002053A (en) 2009-09-02 2011-04-06 陕西合成药业有限公司 Tetrahydro thienopyridine derivative for treating
CN101717392A (en) 2009-10-09 2010-06-02 苏州凯达生物医药技术有限公司 Method for preparing rotigotine and derivative thereof
CN102050815B (en) 2009-11-06 2014-04-02 北京美倍他药物研究有限公司 Dabigatran ester derivatives as prodrug
CN101724934B (en) 2009-11-10 2012-07-04 东华大学 Medicinal fibre used for treating cutaneous inflammation and pain, preparation and application thereof
ES2364011B1 (en) 2009-11-20 2013-01-24 Gp Pharm, S.A. CAPSULES OF PHARMACEUTICAL ACTIVE AND ESTERS OF POLYINSATURATED FATTY ACIDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES.
CN102821602B (en) 2010-01-08 2016-04-20 凯特贝希制药公司 Fatty Acid Fumarate Derivative and uses thereof
US9062094B2 (en) 2010-01-22 2015-06-23 Ascendis Pharma As Dipeptide-based prodrug linkers for aliphatic amine-containing drugs
RU2436772C2 (en) 2010-01-28 2011-12-20 Закрытое акционерное общество "НПК ЭХО" 4[(4'-nicotinoylamino)butyroylamino]butanoic acid, exhibiting nootropic activity, and method of producing said compound
US20130190327A1 (en) 2010-02-26 2013-07-25 Catabasis Pharmaceuticals Inc Bis-fatty acid conjugates and their uses
JP5412340B2 (en) 2010-03-19 2014-02-12 本田技研工業株式会社 Vehicle viewing window
BR112012031194A2 (en) 2010-06-08 2018-05-29 Krisani Biosciences P Ltd cysteamine derivatives and their use in the treatment of ehna
CN103052384B (en) 2010-07-12 2017-04-05 贝林格尔.英格海姆国际有限公司 Aquo-composition comprising bromhexine
AR082499A1 (en) 2010-08-23 2012-12-12 Gruenenthal Gmbh USEFUL COMPOUNDS FOR NERVOUS SYSTEM, INFLAMMATORY, STOMACH AND AS ANALGESIC DISORDERS
WO2012027543A1 (en) 2010-08-25 2012-03-01 Teva Pharmaceuticals Usa, Inc. Solid state forms of dabigatran etexilate, dabigatran etexilate mesylate and processes for preparation thereof
CN101921245B (en) 2010-08-30 2012-04-18 中国人民解放军军事医学科学院卫生学环境医学研究所 Sulfonamide compound for inhibiting carbonic anhydrase II, and synthesis method and application thereof
WO2012055567A2 (en) 2010-10-29 2012-05-03 Algiax Pharmaceuticals Gmbh Use of malononitrilamides in neuropathic pain
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
US20120178813A1 (en) * 2011-01-12 2012-07-12 Thetis Pharmaceuticals Llc Lipid-lowering antidiabetic agent
WO2012115695A1 (en) 2011-02-25 2012-08-30 Catabasis Pharmaceuticals, Inc. Bis-fatty acid conjugates and their uses
WO2013008182A1 (en) 2011-07-10 2013-01-17 Mahesh Kandula Prodrugs of gaba analogs
CN102336767A (en) 2011-07-11 2012-02-01 华东理工大学 Method for preparing high-purity chiral alpha-substituted-6,7-thiaindan[3,2-c]pyridine derivative
WO2013017974A1 (en) 2011-07-30 2013-02-07 Mahesh Kandula Compositions and methods for the treatment of neuromuscular disorders and neurodegenerative diseases
WO2013024376A1 (en) 2011-08-16 2013-02-21 Mahesh Kandula Compositions and methods for the treatment of atherothrombosis
WO2013027150A1 (en) 2011-08-21 2013-02-28 Mahesh Kandula Compositions and methods for the treatment of parkinson's disease
CN102633799B (en) 2012-04-10 2014-06-25 凯莱英医药集团（天津）股份有限公司 Method for synthesizing sapropterin dihydrochloride from racemate intermediate separation route
US9434704B2 (en) 2012-05-08 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of neurological degenerative disorders
WO2013168022A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for treating atherothrombosis
WO2013167988A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of cough
JP2015521184A (en) 2012-05-10 2015-07-27 セリックスビオ プライヴェート リミテッド Compositions and treatments for the treatment of metabolic syndrome
CA2873104A1 (en) 2012-05-23 2013-11-28 Cellixbio Private Limited Compositions and methods for the treatment of mucositis
WO2014080307A2 (en) * 2012-11-21 2014-05-30 Mahesh Kandula Compositions and methods for the treatment of diabetes and pre-diabetes
WO2014174425A2 (en) 2013-04-24 2014-10-30 Mahesh Kandula Compositions and methods for the treatment of orthostasis and neurological diseases
SG11201509782TA (en) * 2013-06-04 2015-12-30 Cellix Bio Private Ltd Compositions and methods for the treatment of diabetes and pre-diabetes

Also Published As

Publication number Publication date
CA2914461A1 (en) 2014-12-11
AU2014276346A1 (en) 2015-12-24
US9174931B2 (en) 2015-11-03
US20140357680A1 (en) 2014-12-04
US8952068B2 (en) 2015-02-10
EP3004049B1 (en) 2018-09-05
US20150183728A1 (en) 2015-07-02
WO2014195961A1 (en) 2014-12-11
EP3004049A1 (en) 2016-04-13

Similar Documents

Publication Publication Date Title
IL273090B (en) Methods and compositions for the treatment of cancer
HK1225654A1 (en) Compositions and methods for the treatment of presbyopia
HK1216175A1 (en) Therapeutic compounds and compositions
SG11201509782TA (en) Compositions and methods for the treatment of diabetes and pre-diabetes
GB201320723D0 (en) Composition and methods of treatment
HK1220324A1 (en) Methods, compounds, and compositions for the treatment of angiotensin-related diseases
GB201301626D0 (en) Composition comprising 15-OHEPA and methods of using the same
EP2867239A4 (en) Oxabicycloheptanes and oxabicycloheptenes for the treatment of diabetes
EP3068387A4 (en) Compounds and methods for the treatment of malaria
HK1220374A1 (en) Compositions and methods for the treatment of carboxyhemoglobinemia
HRP20190219T1 (en) Compounds for the treatment of obesity and methods of use thereof
EP2964750A4 (en) Methods and compositions for the treatment and/or prevention of type 1 diabetes
GB201307082D0 (en) Pharmaceutical composition comprising 15-HETrE and methods of using the same
ZA201408065B (en) Compositions and methods for the treatment of diabetes
HRP20181445T1 (en) Compositions and methods for treatment of type 1 diabetes
HK1212587A1 (en) Formulation for prevention or treatment of diabetes
GB201317555D0 (en) The procedure of restoration of metabolism