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GB1356470A - Ortho-disubstituted aryl-guanidines process for their preparation and applications thereof - Google Patents

Ortho-disubstituted aryl-guanidines process for their preparation and applications thereof

Info

Publication number
GB1356470A
GB1356470A GB1851071*[A GB1851071A GB1356470A GB 1356470 A GB1356470 A GB 1356470A GB 1851071 A GB1851071 A GB 1851071A GB 1356470 A GB1356470 A GB 1356470A
Authority
GB
United Kingdom
Prior art keywords
preparation
dichlorophenyl
guanidines
ortho
applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1851071*[A
Inventor
J Schwartz
C G Wermuth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seperic SA
Original Assignee
Seperic SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seperic SA filed Critical Seperic SA
Priority to GB1851071*[A priority Critical patent/GB1356470A/en
Priority to IE690/72A priority patent/IE36383B1/en
Priority to CH755872A priority patent/CH554319A/en
Priority to ZA723523A priority patent/ZA723523B/en
Priority to DK265372AA priority patent/DK129987B/en
Priority to OA54584A priority patent/OA04093A/en
Priority to NL7207269A priority patent/NL7207269A/xx
Priority to JP5255972A priority patent/JPS5521740B2/ja
Priority to FR7219188A priority patent/FR2140060B1/fr
Priority to AT463372A priority patent/AT314555B/en
Priority to SE7207080A priority patent/SE375524B/xx
Priority to LU65442D priority patent/LU65442A1/xx
Priority to DE19722226590 priority patent/DE2226590A1/en
Priority to BE784259A priority patent/BE784259A/en
Priority to AU43059/72A priority patent/AU462814B2/en
Priority to CA143,747A priority patent/CA970391A/en
Publication of GB1356470A publication Critical patent/GB1356470A/en
Priority to US05/553,155 priority patent/US4011342A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1356470 Arylguanidines SEPERIC 23 May 1972 [2 June 1971] 18510/71 Heading C2C The invention comprises compounds of formula and their acid addition salts with pharmaceutically acceptable acids, wherein R and R<SP>1</SP> are each H or Me. These compounds are prepared by reacting with RNH 2 N-(2,6-dichlorophenyl)- S - methylisothiourea or N - (2,6 - dichlorophenyl) - N<SP>1</SP>, S - dimethylisothiourea (preferably in the form of hydroiodide). Details are also given for the preparation of N-(2,6-dichlorophenyl)-N<SP>1</SP>-methylthiourea. Therapeutic compositions for oral or parenteral administration comprise compounds of the above formula, which have hypotensive activity.
GB1851071*[A 1971-06-02 1971-06-02 Ortho-disubstituted aryl-guanidines process for their preparation and applications thereof Expired GB1356470A (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
GB1851071*[A GB1356470A (en) 1971-06-02 1971-06-02 Ortho-disubstituted aryl-guanidines process for their preparation and applications thereof
IE690/72A IE36383B1 (en) 1971-06-02 1972-05-23 Improvements in or relating to ortho-disubstituted arylguanidines process for their preparation and applications thereof
CH755872A CH554319A (en) 1971-06-02 1972-05-23 PROCESS FOR THE PREPARATION OF ORTHO-DISUBSTITUTED ARYL-GUANIDINES.
ZA723523A ZA723523B (en) 1971-06-02 1972-05-23 Ortho-disubstituted aryl guanidines,process for their preparation and applications thereof
DK265372AA DK129987B (en) 1971-06-02 1972-05-26 Analogous process for the preparation of guanidines.
OA54584A OA04093A (en) 1971-06-02 1972-05-27 Process for the preparation of ortho-disubstituted aryl-guanidines.
AT463372A AT314555B (en) 1971-06-02 1972-05-29 Process for the production of new guanidines
JP5255972A JPS5521740B2 (en) 1971-06-02 1972-05-29
FR7219188A FR2140060B1 (en) 1971-06-02 1972-05-29
NL7207269A NL7207269A (en) 1971-06-02 1972-05-29
SE7207080A SE375524B (en) 1971-06-02 1972-05-30
LU65442D LU65442A1 (en) 1971-06-02 1972-05-31
DE19722226590 DE2226590A1 (en) 1971-06-02 1972-05-31 Ortho-disubstituted arylguanidines, process for their preparation and their use
BE784259A BE784259A (en) 1971-06-02 1972-06-01 ORTHO-DISUBSTITUTED ARYL-GUANIDINES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS
AU43059/72A AU462814B2 (en) 1971-06-02 1972-06-02 Ortho-disubstituted aryl-guanidines process for their preparation and applications thereof
CA143,747A CA970391A (en) 1971-06-02 1972-06-02 Process of preparation of ortho-disubstituted aryl-guanidines
US05/553,155 US4011342A (en) 1971-06-02 1975-02-26 Method and composition for the treatment of hypertension with ortho-disubstituted arylguanidines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1851071*[A GB1356470A (en) 1971-06-02 1971-06-02 Ortho-disubstituted aryl-guanidines process for their preparation and applications thereof

Publications (1)

Publication Number Publication Date
GB1356470A true GB1356470A (en) 1974-06-12

Family

ID=10113667

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1851071*[A Expired GB1356470A (en) 1971-06-02 1971-06-02 Ortho-disubstituted aryl-guanidines process for their preparation and applications thereof

Country Status (16)

Country Link
JP (1) JPS5521740B2 (en)
AT (1) AT314555B (en)
AU (1) AU462814B2 (en)
BE (1) BE784259A (en)
CA (1) CA970391A (en)
CH (1) CH554319A (en)
DE (1) DE2226590A1 (en)
DK (1) DK129987B (en)
FR (1) FR2140060B1 (en)
GB (1) GB1356470A (en)
IE (1) IE36383B1 (en)
LU (1) LU65442A1 (en)
NL (1) NL7207269A (en)
OA (1) OA04093A (en)
SE (1) SE375524B (en)
ZA (1) ZA723523B (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014091384A2 (en) * 2012-12-12 2014-06-19 Mahesh Kandula Compositions and methods for the treatment of mucositis
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
US9102649B1 (en) 2014-09-29 2015-08-11 Mahesh Kandula Compositions and methods for the treatment of multiple sclerosis
US9174931B2 (en) 2013-06-04 2015-11-03 Cellix Bio Private Limited Compositions for the treatment of diabetes and pre-diabetes
US9206111B1 (en) 2014-12-17 2015-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
US9403793B2 (en) 2012-07-03 2016-08-02 Cellix Bio Private Limited Compositions and methods for the treatment of moderate to severe pain
US9725404B2 (en) 2014-10-27 2017-08-08 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9771355B2 (en) 2014-09-26 2017-09-26 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy and neurological disorders
US9932294B2 (en) 2014-12-01 2018-04-03 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US10343994B2 (en) 2015-01-06 2019-07-09 Mahesh Kandula Compositions and methods for the treatment of inflammation and pain

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0117190Y2 (en) * 1979-04-20 1989-05-18
FR2549049B1 (en) * 1983-07-13 1986-06-20 Chauvin Blache Lab NEW AMIDINES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
WO2013175377A2 (en) * 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of mucositis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1542792B2 (en) * 1965-11-09 1974-08-01 Bayer Ag, 5090 Leverkusen Use of monoarylguanidines to repel birds, rodents and rabbit-like animals
DE1619538B1 (en) * 1967-08-04 1971-06-24 Bayer Ag Process for dyeing fiber materials made of polyacrylonitrile or acrylonitrile-containing copolymers

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9403793B2 (en) 2012-07-03 2016-08-02 Cellix Bio Private Limited Compositions and methods for the treatment of moderate to severe pain
WO2014091384A3 (en) * 2012-12-12 2014-12-24 Mahesh Kandula Compositions and methods for the treatment of mucositis
WO2014091384A2 (en) * 2012-12-12 2014-06-19 Mahesh Kandula Compositions and methods for the treatment of mucositis
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
US9174931B2 (en) 2013-06-04 2015-11-03 Cellix Bio Private Limited Compositions for the treatment of diabetes and pre-diabetes
US9840472B2 (en) 2013-12-07 2017-12-12 Cellix Bio Private Limited Compositions and methods for the treatment of mucositis
US9771355B2 (en) 2014-09-26 2017-09-26 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy and neurological disorders
US9102649B1 (en) 2014-09-29 2015-08-11 Mahesh Kandula Compositions and methods for the treatment of multiple sclerosis
US9988340B2 (en) 2014-09-29 2018-06-05 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9725404B2 (en) 2014-10-27 2017-08-08 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9932294B2 (en) 2014-12-01 2018-04-03 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9206111B1 (en) 2014-12-17 2015-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
US10343994B2 (en) 2015-01-06 2019-07-09 Mahesh Kandula Compositions and methods for the treatment of inflammation and pain

Also Published As

Publication number Publication date
OA04093A (en) 1979-10-30
FR2140060B1 (en) 1975-10-17
NL7207269A (en) 1972-12-05
IE36383B1 (en) 1976-10-27
JPS5521740B2 (en) 1980-06-12
LU65442A1 (en) 1972-08-24
FR2140060A1 (en) 1973-01-12
BE784259A (en) 1972-10-02
AU4305972A (en) 1973-12-13
CA970391A (en) 1975-07-01
AU462814B2 (en) 1975-06-23
ZA723523B (en) 1973-03-28
IE36383L (en) 1972-12-02
DK129987C (en) 1975-06-02
DE2226590A1 (en) 1972-12-14
SE375524B (en) 1975-04-21
CH554319A (en) 1974-09-30
AT314555B (en) 1974-04-10
JPS4828434A (en) 1973-04-14
DK129987B (en) 1974-12-09

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Legal Events

Date Code Title Description
PS Patent sealed
435 Patent endorsed 'licences of right' on the date specified (sect. 35/1949)
PCNP Patent ceased through non-payment of renewal fee