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SG11201502589YA - Acylaminopyrimidine derivatives for the treatment of viral infections and further diseases - Google Patents

Acylaminopyrimidine derivatives for the treatment of viral infections and further diseases

Info

Publication number
SG11201502589YA
SG11201502589YA SG11201502589YA SG11201502589YA SG11201502589YA SG 11201502589Y A SG11201502589Y A SG 11201502589YA SG 11201502589Y A SG11201502589Y A SG 11201502589YA SG 11201502589Y A SG11201502589Y A SG 11201502589YA SG 11201502589Y A SG11201502589Y A SG 11201502589YA
Authority
SG
Singapore
Prior art keywords
treatment
viral infections
further diseases
acylaminopyrimidine
derivatives
Prior art date
Application number
SG11201502589YA
Other languages
English (en)
Inventor
Gowan David Craig Mc
Serge Maria Aloysius Pieters
Werner EMBRECHTS
Stefaan Julien Last
Tim Hugo Maria Jonckers
Pierre Jean-Marie Bernard Raboisson
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of SG11201502589YA publication Critical patent/SG11201502589YA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG11201502589YA 2012-10-05 2013-10-03 Acylaminopyrimidine derivatives for the treatment of viral infections and further diseases SG11201502589YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12187519 2012-10-05
PCT/EP2013/070619 WO2014053595A1 (en) 2012-10-05 2013-10-03 Acylaminopyrimidine derivatives for the treatment of viral infections and further diseases

Publications (1)

Publication Number Publication Date
SG11201502589YA true SG11201502589YA (en) 2015-04-29

Family

ID=47049003

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201502589YA SG11201502589YA (en) 2012-10-05 2013-10-03 Acylaminopyrimidine derivatives for the treatment of viral infections and further diseases

Country Status (21)

Country Link
US (1) US9790191B2 (es)
EP (1) EP2903967B3 (es)
JP (1) JP6283033B2 (es)
KR (2) KR102252649B1 (es)
CN (2) CN104884434B (es)
AU (1) AU2013326486B2 (es)
BR (1) BR112015007366A2 (es)
CA (1) CA2882786C (es)
CL (1) CL2015000784A1 (es)
DK (1) DK2903967T6 (es)
EA (1) EA034650B1 (es)
ES (1) ES2701098T7 (es)
HK (1) HK1210463A1 (es)
IL (1) IL237760B (es)
MX (1) MX369803B (es)
NZ (1) NZ705360A (es)
PH (1) PH12015500713B1 (es)
SG (1) SG11201502589YA (es)
UA (1) UA118018C2 (es)
WO (1) WO2014053595A1 (es)
ZA (1) ZA201502238B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013025987B1 (pt) 2011-04-08 2021-04-06 Janssen Sciences Ireland Uc Derivados de pirimidina para o tratamento de infecções virais, composição farmacêutica que os compreende e uso dos mesmos
EA033830B1 (ru) 2011-11-09 2019-11-29 Janssen Sciences Ireland Uc Производные аденина в качестве активаторов толл-подобных рецепторов tlr7
MY167797A (en) 2012-07-13 2018-09-26 Janssen Sciences Ireland Uc Macrocyclic purines for the treatment of viral infections
KR102252649B1 (ko) 2012-10-05 2021-05-17 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 바이러스 감염 및 추가 질환의 치료를 위한 아실아미노피리미딘 유도체
SI2906563T1 (en) 2012-10-10 2018-06-29 Janssen Sciences Ireland Uc Derivatives of pyrrolo (3,2-d) pyrimidine for the treatment of viral infections and other diseases
WO2014076221A1 (en) 2012-11-16 2014-05-22 Janssen R&D Ireland Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections
EP2958900B1 (en) 2013-02-21 2019-04-10 Janssen Sciences Ireland Unlimited Company 2-aminopyrimidine derivatives for the treatment of viral infections
MX366481B (es) 2013-03-29 2019-07-09 Janssen Sciences Ireland Uc Deaza-purinonas macrociclicas para el tratamiento de infecciones virales.
CN105377833B (zh) 2013-05-24 2018-11-06 爱尔兰詹森科学公司 用于治疗病毒感染和另外的疾病的吡啶酮衍生物
SG10201803331PA (en) 2013-06-27 2018-06-28 Janssen Sciences Ireland Uc Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
ES2836881T3 (es) 2013-07-30 2021-06-28 Janssen Sciences Ireland Unlimited Co Derivados de tieno[3,2-d]pirimidinas para el tratamiento de infecciones virales
CA3027471A1 (en) 2016-07-01 2018-01-04 Janssen Sciences Ireland Unlimited Company Dihydropyranopyrimidines for the treatment of viral infections
CN109790154B (zh) * 2016-09-29 2023-06-23 爱尔兰詹森科学公司 用于治疗病毒感染和另外的疾病的嘧啶前药
TW202415645A (zh) 2018-03-01 2024-04-16 愛爾蘭商健生科學愛爾蘭無限公司 2,4-二胺基喹唑啉衍生物及其醫學用途
WO2020162705A1 (ko) 2019-02-08 2020-08-13 성균관대학교산학협력단 톨-유사 수용체 7 또는 8 작용자와 콜레스테롤의 결합체 및 그 용도
CN115666637A (zh) 2020-03-02 2023-01-31 蛋白科技先锋 基于病原体细胞壁骨架的模拟活病原体的纳米粒子及其制备方法
EP4194008A1 (en) 2020-08-04 2023-06-14 Progeneer Inc. Kinetically acting adjuvant ensemble
WO2022031057A1 (ko) 2020-08-04 2022-02-10 성균관대학교산학협력단 활성화 부위가 일시적으로 비활성화된 톨-유사 수용체 7 또는 8 작용자와 기능성 약물의 결합체 및 그 용도
CN116322751A (zh) 2020-08-04 2023-06-23 蛋白科技先锋 包含能够动力学控制的佐剂的mRNA疫苗

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5434157A (en) 1979-03-19 1995-07-18 The Upjohn Company 6-aryl pyrimidine compounds and method for treating viral infections and inducing interferon production
EP1110951B1 (en) * 1998-08-27 2004-05-19 Sumitomo Pharmaceuticals Company, Limited Pyrimidine derivatives
TW200628463A (en) * 2004-11-10 2006-08-16 Synta Pharmaceuticals Corp Heteroaryl compounds
WO2008104472A1 (en) * 2007-02-28 2008-09-04 F. Hoffmann-La Roche Ag 2, 4 -diaminopyrimidine derivatives and their use as p2x antagonists or as prodrugs thereof
PE20091236A1 (es) 2007-11-22 2009-09-16 Astrazeneca Ab Derivados de pirimidina como immunomoduladores de tlr7
EP2432768B1 (en) * 2009-05-21 2017-07-05 Sumitomo Dainippon Pharma Co., Ltd. Novel pyrimidine derivatives and their use in the treatment of cancer and further diseases
BR112013025987B1 (pt) 2011-04-08 2021-04-06 Janssen Sciences Ireland Uc Derivados de pirimidina para o tratamento de infecções virais, composição farmacêutica que os compreende e uso dos mesmos
KR102252649B1 (ko) 2012-10-05 2021-05-17 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 바이러스 감염 및 추가 질환의 치료를 위한 아실아미노피리미딘 유도체

Also Published As

Publication number Publication date
MX369803B (es) 2019-11-21
PH12015500713A1 (en) 2015-05-18
CN111606861A (zh) 2020-09-01
CN104884434A (zh) 2015-09-02
IL237760B (en) 2018-06-28
DK2903967T3 (da) 2019-01-02
KR20210002129A (ko) 2021-01-06
EP2903967A1 (en) 2015-08-12
JP2015534559A (ja) 2015-12-03
CA2882786C (en) 2020-10-20
NZ705360A (en) 2018-11-30
EA034650B1 (ru) 2020-03-03
KR102198128B1 (ko) 2021-01-05
KR20150064729A (ko) 2015-06-11
WO2014053595A1 (en) 2014-04-10
JP6283033B2 (ja) 2018-02-21
UA118018C2 (uk) 2018-11-12
BR112015007366A2 (pt) 2017-07-04
CN104884434B (zh) 2020-05-12
US9790191B2 (en) 2017-10-17
EP2903967B3 (en) 2020-04-15
EP2903967B1 (en) 2018-09-12
ES2701098T7 (es) 2021-02-03
US20150274676A1 (en) 2015-10-01
ZA201502238B (en) 2017-01-25
PH12015500713B1 (en) 2015-05-18
MX2015004288A (es) 2015-08-06
HK1210463A1 (en) 2016-04-22
CL2015000784A1 (es) 2015-06-12
KR102252649B1 (ko) 2021-05-17
EA201590667A1 (ru) 2015-07-30
DK2903967T6 (da) 2020-07-13
AU2013326486B2 (en) 2017-09-14
AU2013326486A1 (en) 2015-03-19
CA2882786A1 (en) 2014-04-10
ES2701098T3 (es) 2019-02-20

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