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RU95102323A - Производные 5,6,7,8-тетрагидро-имидазо [1,2-a]-пиридина, способ их получения, содержащая их композиция и способ ее получения - Google Patents

Производные 5,6,7,8-тетрагидро-имидазо [1,2-a]-пиридина, способ их получения, содержащая их композиция и способ ее получения

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Publication number
RU95102323A
RU95102323A RU95102323/04A RU95102323A RU95102323A RU 95102323 A RU95102323 A RU 95102323A RU 95102323/04 A RU95102323/04 A RU 95102323/04A RU 95102323 A RU95102323 A RU 95102323A RU 95102323 A RU95102323 A RU 95102323A
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RU
Russia
Prior art keywords
preparation
derivatives
composition
tetrahydroimidazo
pyridine derivatives
Prior art date
Application number
RU95102323/04A
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English (en)
Inventor
Юрашик Хорст
De]
Генте Йоахим
Вурцигер Ханнс
Бернотат-Данеловски Сабине
Мельцер Гвидо
At]
Original Assignee
Мерк Патент ГмбХ (DE)
Мерк Патент Гмбх
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Application filed by Мерк Патент ГмбХ (DE), Мерк Патент Гмбх filed Critical Мерк Патент ГмбХ (DE)
Publication of RU95102323A publication Critical patent/RU95102323A/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Соединения формулыа также соответствующие производные 5,6,7,8-тетрагидроимидазо[1,2-а] пиридина, их физиологически приемлемые соли и/или сольваты, подавляют связывание фибриногена с соответствующим рецептором и могут применяться для лечения тромбозов, остеопрозов, опухолевых заболеваний, апоплексии, инфаркта сердца, воспалений, артериосклероза и остеолитических заболеваний.

Claims (1)

  1. Соединения формулы
    Figure 00000001

    а также соответствующие производные 5,6,7,8-тетрагидроимидазо[1,2-а] пиридина, их физиологически приемлемые соли и/или сольваты, подавляют связывание фибриногена с соответствующим рецептором и могут применяться для лечения тромбозов, остеопрозов, опухолевых заболеваний, апоплексии, инфаркта сердца, воспалений, артериосклероза и остеолитических заболеваний.
RU95102323/04A 1994-02-19 1995-02-17 Производные 5,6,7,8-тетрагидро-имидазо [1,2-a]-пиридина, способ их получения, содержащая их композиция и способ ее получения RU95102323A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4405378A DE4405378A1 (de) 1994-02-19 1994-02-19 Adhäsionsrezeptor-Antagonisten
DEP4405378.9 1994-02-19

Publications (1)

Publication Number Publication Date
RU95102323A true RU95102323A (ru) 1997-03-20

Family

ID=6510687

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95102323/04A RU95102323A (ru) 1994-02-19 1995-02-17 Производные 5,6,7,8-тетрагидро-имидазо [1,2-a]-пиридина, способ их получения, содержащая их композиция и способ ее получения

Country Status (15)

Country Link
US (1) US5614531A (ru)
EP (1) EP0668278A1 (ru)
JP (1) JPH07252254A (ru)
KR (1) KR950032197A (ru)
CN (1) CN1111630A (ru)
AU (1) AU1230795A (ru)
CA (1) CA2142741A1 (ru)
CZ (1) CZ42495A3 (ru)
DE (1) DE4405378A1 (ru)
HU (1) HUT71806A (ru)
NO (1) NO950606L (ru)
PL (1) PL307328A1 (ru)
RU (1) RU95102323A (ru)
SK (1) SK22195A3 (ru)
ZA (1) ZA951345B (ru)

Families Citing this family (21)

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TR199900781T2 (xx) * 1996-07-25 1999-07-21 Biogen, Inc. H�cre yap��ma inhibit�rleri
DE19653646A1 (de) * 1996-12-20 1998-06-25 Hoechst Ag Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung
AR011057A1 (es) * 1997-01-08 2000-08-02 Smithkline Beecham Corp Uso de bis-acridinas sustituidas y compuestos afines para la preparacion de medicamentos y dichos compuestos
US5902797A (en) * 1997-11-10 1999-05-11 Beth Israel Deaconess Medical Center Nutritional supplement for use in the treatment of attention deficit
ATE322290T1 (de) 1998-12-23 2006-04-15 Searle Llc Verwendung von cyclooxygenase-2 inhibitor celecoxib und capecitabine zur kombinationsbehandlung von neoplasia
DE10117184A1 (de) * 2001-04-05 2002-10-17 Gruenenthal Gmbh Substituierte Imidazol[1,2-a]-pyridin-3-yl-amid- und -aminverbindungen
DE10117183A1 (de) * 2001-04-05 2002-10-10 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]-pyridinverbindungen als Arzneimittel
ATE551060T1 (de) 2004-06-04 2012-04-15 Scripps Research Inst Zusammensetzungen und verfahren zur behandlung von neovaskulären erkrankungen
WO2006029258A2 (en) * 2004-09-07 2006-03-16 Archemix Corp. Aptamer medicinal chemistry
US7566701B2 (en) * 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
CA2579374A1 (en) 2004-09-07 2006-03-30 Archemix Corp. Aptamers to von willebrand factor and their use as thrombotic disease therapeutics
US7919519B2 (en) * 2005-11-23 2011-04-05 Epix Pharmaceuticals Inc. S1P receptor modulating compounds and use thereof
US7855193B2 (en) * 2005-11-23 2010-12-21 Epix Pharmaceuticals, Inc. S1P receptor modulating compounds and use thereof
CA2631259A1 (en) * 2005-11-28 2007-06-07 Mallinckrodt Inc. Improved method of preparation for imidazolepyridines
JP2009530389A (ja) * 2006-03-21 2009-08-27 エピックス デラウェア， インコーポレイテッド Ｓ１ｐ受容体調節化合物及びその使用
US7563797B2 (en) * 2006-08-28 2009-07-21 Forest Laboratories Holding Limited Substituted imidazo(1,2-A)pyrimidines and imidazo(1,2-A) pyridines as cannabinoid receptor ligands
EP1964840A1 (en) 2007-02-28 2008-09-03 sanofi-aventis Imidazo[1,2-a]pyridines and their use as pharmaceuticals
AU2007227278B2 (en) * 2007-03-21 2014-09-11 Epix Pharmaceuticals, Inc. SIP receptor modulating compounds and use thereof
WO2008150495A2 (en) * 2007-06-01 2008-12-11 Archemix Corp. Vwf aptamer formulations and methods for use
MX2010002885A (es) * 2007-09-20 2010-04-01 Amgen Inc Derivados de acido 1-(4-(bencilbenzamido)-bencil)-azetidin-3-carbo xilico y compuestos relacionados como moduladores de receptores de s1p para el tratamiento de trastornos inmunitarios.
US7868001B2 (en) * 2007-11-02 2011-01-11 Hutchison Medipharma Enterprises Limited Cytokine inhibitors

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DE3769333D1 (de) * 1986-01-22 1991-05-23 Synthelabo Acylaminomethylimidazo(1,2-a)pyrimidinderivate, ihre herstellung und therapeutische verwendung.
US4990506A (en) * 1986-02-05 1991-02-05 Synthelabo 3-(acylaminomethyl)imidazo[1,2-a]pyridine derivatives and their application in therapy
US4791117A (en) * 1986-09-22 1988-12-13 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their use as calcium channel blockers
FR2606410B1 (fr) * 1986-11-07 1989-02-24 Synthelabo Imidazopyridines, leur preparation et leur application en therapeutique
US5053393A (en) * 1988-07-20 1991-10-01 Monsanto Company Novel platelet-aggregation inhibitor
US5256812A (en) * 1989-01-31 1993-10-26 Hoffmann-La Roche Inc. Carboxamides and sulfonamides
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
DE4017211A1 (de) * 1990-05-29 1991-12-05 Merck Patent Gmbh Oxazolidinone
WO1992019595A1 (en) * 1991-05-07 1992-11-12 Merck & Co., Inc. Fibrinogen receptor antagonists
US5321034A (en) * 1991-05-07 1994-06-14 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4129603A1 (de) * 1991-09-06 1993-03-11 Thomae Gmbh Dr K Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
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DE4327027A1 (de) * 1993-02-15 1994-08-18 Bayer Ag Imidazoazine

Also Published As

Publication number Publication date
SK22195A3 (en) 1995-09-13
US5614531A (en) 1997-03-25
DE4405378A1 (de) 1995-08-24
HUT71806A (en) 1996-02-28
CZ42495A3 (en) 1995-10-18
CA2142741A1 (en) 1995-08-20
PL307328A1 (en) 1995-08-21
CN1111630A (zh) 1995-11-15
ZA951345B (en) 1995-10-24
KR950032197A (ko) 1995-12-20
NO950606L (no) 1995-08-21
AU1230795A (en) 1995-08-31
JPH07252254A (ja) 1995-10-03
EP0668278A1 (de) 1995-08-23
NO950606D0 (no) 1995-02-17
HU9500479D0 (en) 1995-04-28

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