RU2372933C1 - Medical product and medicinal composition for manufacturing thereof - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention concerns pharmaceutical industry, particularly medicinal composition for preparing an antiinflammatory and antibacterial medical product. The medicinal composition for preparing the antiinflammatory and antibacterial medical product which contains at least a polyphenol-containing substance of certain catechine concentration, preferentially green tea and/or its extract, and fluoroquinolone, preferentially Ciprofloxacin taken in a certain ratio. The antiinflammatory and antibacterial medical product containing said medicinal composition, and also at least a base, preferentially, lipophilic or hydrophilic, e.g. mixed tri-, di- and monoglycerides and/or saturated fatty acids in amount sufficient to produce the required medicinal form.

EFFECT: said composition and medical product possess effective antiinflammatory and antibacterial action.

25 cl, 1 tbl, 3 ex

Description

The group of inventions relates to medicine, in particular to antimicrobial and anti-inflammatory non-steroidal agents, which also have a cytostatic effect.

From the prior art, a pharmaceutical composition is known that is included in a medicament for the treatment of prostate diseases, containing a complex of bioregulatory peptides of the cattle prostate in the form of a powder with a content of water-soluble peptides of at least 20%, which is made in the form of a suppository and additionally contains a base in the following the ratio of components, g per candle: a complex of bioregulatory peptides of the prostate gland of cattle in the form of a powder - 0.04- 0.06; the basis is a sufficient amount to obtain a candle weighing 1.15-1.35 g (see RU 2112504 C1, 1998.06.10, A61K 9/02, A61K 38/00).

Also known from the prior art is a medicinal composition that is included in a drug made in the form of a suppository, containing interferon, a fat base and an emulsifier, characterized in that lyophilized human leukocyte interferon is also included in the composition, purified from low molecular weight and high molecular weight components with antiviral activity of at least 25,000 IU / g, a mixture of tri-, di- and monoglycerides and saturated fatty acids from coconut and palm oils of the Viteps brand was used as a fat base ol ”H-15 and W-35 in equal proportions, and distilled monoglycerides were used as emulsifier (see RU 2315619 C2, 2008.01.27, A61K 38/21).

Known drug composition included in the drug, made in the form of a vaginal suppository for the treatment of mixed infections of the lower parts of the female genital area, containing chloramphenicol, nystatin, metronidazole, an anti-inflammatory component and a pharmaceutical base, characterized in that the composition contains prednisolone as an anti-inflammatory component, in as a pharmaceutical base, cocoa butter and lanolin (see RU 2320319 C1, 2008.03.27, A61K 9/02).

Known drug for the treatment of urogenital infections, made in the form of a suppository, which contains the following drug composition, mg: antibiotic antibacterial action - erythromycin 50-250, antifungal antibiotic action - nystatin 50-250, antiprotozoal drug - metronidazole 100-500, and the filler is type A solid fat, up to a candle weight of 1.5-3.5 g (RU 2253457 C2, 2005.06.10, A61K 31/7048).

The task to which the present group of inventions is directed is to create an effective combined drug composition and a medicine based on it, having antimicrobial, anti-inflammatory and cytostatic effects and aimed at treating a wide range of diseases, mainly of the anogenital sphere.

The problem in terms of the medicinal composition for the preparation of anti-inflammatory and antibacterial drugs is solved due to the fact that it includes at least a polyphenol-containing substance with a concentration of catechins of at least 70%, preferably green tea and / or its extract, and fluoroquinolone, preferably ciprofloxacin taken in a ratio of 1:20 to 20: 1.

Green tea extract can be made water or water-alcohol.

Also, green tea extract can be a liquid extract, or a thick extract in the form of a viscous mass with a moisture content of not more than 25%, or a dry extract in the form of a granular mass with a moisture content of not more than 5%, and the extract is obtained using methods that ensure the maximum preservation of catechins .

The medicinal composition may be included in the composition of the medicinal product containing a mixture of medicinal and auxiliary substances and made in the form of powder or granules for internal use in the form of grains of round, cylindrical or irregular shape.

Or the drug composition may be included in the composition of the medicinal product containing a mixture of medicinal and auxiliary substances and made in the form of capsules for oral administration, as well as for rectal and vaginal routes of administration.

The medicinal composition may be included in the composition of the medicinal product, made in the form of tablets, obtained by compressing medicinal products or a mixture of medicinal and auxiliary substances and intended for internal, external, sublingual, implantation or parenteral use, and binders and / or diluents are used as auxiliary substances, and / or disintegrants, and / or glidants and lubricants, and / or colorants, flavoring agents.

The drug composition may be part of the coated drug.

Or the drug composition may be included in the composition of the medicinal product containing at least a mixture of drugs and excipients and made in the form of a solution, suspension or emulsion for internal, external and parenteral use, and substances that increase the viscosity of the dispersion medium are used as auxiliary substances, and / or surfactants and buffers, reducing agents, and / or flavoring agents, and / or preservatives, and / or antioxidants, and / or dyes, and for the preparation of the emulsion use emulsifiers are used.

In this case, in a drug having the form of an emulsion, peach, and / or olive, and / or sunflower, and / or tomato, and / or pumpkin, and / or flax, and / or castor, and / or petrolatum can be used and essential oils, as well as fish oil, balms, and non-ionic or anionic surfactants, for example soaps, hydrophilic natural substances, for example gelatose or pectin, semi-synthetic substances, for example methyl cellulose, sodium carboxymethyl cellulose, synthetic substances, are used as emulsifier.

Also in the drug, having the form of an emulsion, an auxiliary substance can be used - a preservative, for example nipagin, nipazole, sorbic acid.

The medicinal composition may be included in the composition of the medicinal product containing a base and a mixture of medicinal and auxiliary substances and made in the form of an ointment, preferably a paste, cream, gel or liniment, having a homogeneous, suspension, emulsion or combined dispersion system, while as a basis for preparation ointments, a base approved for medical use is used, preferably lipophilic, or hydrophilic, or hydrophilic-lipophilic, and as an auxiliary substance, it is used zovany preservatives, surfactants.

Moreover, as a lipophilic base for ointment, it is advisable to use petroleum jelly, and / or hydrocarbon alloys, and / or natural hydrogenated fats and their alloy with vegetable oils and fat-like substances, or silicone fat.

As a hydrophilic base for ointment, it is recommended to use gels of high molecular weight carbohydrates and proteins, for example cellulose ethers and / or starch, and / or gelatin, and / or agar, or gels of inorganic substances, for example bentonite, or gels of synthetic high molecular weight compounds, for example polyethylene oxide, polyvinylpyrrolidone, polyacrylamide.

As an hydrophilic-lipophilic base for ointment, anhydrous alloys of lipophilic bases with emulsifiers, for example, an alloy of petrolatum with lanolin or with other emulsifiers, as well as emulsion bases of the water / oil type, for example an alloy of petrolatum with water lanolin, a water / petroleum jelly-based emulsion, can preferably be used. , or emulsion bases such as oil / water, where sodium, potassium, triethanolamine salts of fatty acids are used as emulsifiers.

The medicinal composition may be part of a medicinal product containing a base and a mixture of medicinal and auxiliary substances and made in the form of a suppository, made rectal, shaped like a cone, a cylinder with a pointed end or another shape with a maximum diameter of 1.5 cm, or made vaginal, having spherical, ovoid, or in the form of a flat body with a rounded end, or made in the form of a rod, having the shape of a cylinder with a pointed end and a diameter of not more than 1 cm, and suppositories zgotovleny pouring the molten mass into molds, compression overrun events or special equipment.

As a basis for the manufacture of a suppository, a base approved for medical use, preferably lipophilic, or hydrophilic, or hydrophilic-lipophilic, can be used.

As a lipophilic base for the manufacture of a suppository, cocoa butter and / or cocoa butter alloys with paraffin and hydrogenated fats, and / or vegetable and animal hydrogenated fats, solid fat, and / or lanol, and / or hydrogenated fat alloys with wax can be used hard paraffin.

As a hydrophilic base, it is advisable to use gelatin-glycerin gels, alloys of polyethylene oxides with different molecular weights, moreover, the gelatin-glycerin gel is made from medical gelatin, glycerin and water.

The problem in terms of anti-inflammatory and antibacterial drugs is solved by the fact that it includes the above-described drug composition, as well as at least a base, preferably lipophilic or hydrophilic, for example a mixture of tri-, di- and monoglycerides and / or saturated fatty acids in an amount sufficient to obtain the desired dosage form.

In this case, tri-, di- and monoglycerides and saturated fatty acids can be obtained from coconut and / or palm oil.

As a base, vitepsol, preferably Witepsol brand H-15, or Witepsol brand W-35, or a mixture thereof can be used.

The drug may further comprise at least an excipient.

The drug may be a dosage form - an ointment or cream, or a suppository having a torpedo shape or a cone shape, or a cylinder shape with a pointed end, or another shape with a maximum diameter of 1.5 cm.

The drug can be a dosage form - a suppository weighing 1 g, while the content of its components should be:

green tea and / or its extract 25 ÷ 500 mg ciprofloxacin 25 ÷ 500 mg the basis rest.

The drug can be a dosage form - a suppository weighing 2 g, while the content of its components should be:

green tea and / or its extract 25 ÷ 500 mg ciprofloxacin 25 ÷ 500 mg the basis rest.

The technical result provided by the given set of signs is to create an effective combined medicinal composition and a medicine based on it, having antimicrobial, anti-inflammatory and cytostatic effects and aimed at treating a wide range of diseases, mainly diseases of the anogenital sphere, while achieving a faster and more complete in comparison with other means, the disappearance of painful sensations, provides an effective therapeutic, profile tactical and therapeutic and prophylactic actions due to improved pharmacokinetic characteristics and an optimally selected ratio of two medicinal components, the action of at least one of which enhances the effect of the other, the most pronounced of which are anti-inflammatory, antibacterial and cytostatic effects.

A medicinal composition for the preparation of an anti-inflammatory and antibacterial drug, comprising at least a polyphenol-containing substance with a concentration of catechins of at least 70%, preferably green tea and / or its extract, and fluoroquinolone, preferably ciprofloxacin, is fundamentally new, unknown from the previous level, although the separate use of polyphenols and fluoroquinolones in medicine is known.

Recently, an increased interest in polyphenol-containing substances in the medical environment is due to the popularity of their strong anti-inflammatory and antioxidant effects due to the high biological activity of catechins, the largest amount of which is found in young shoots and leaves of a tea plant. Green tea polyphenols are capable of exerting a cytostatic effect mediated by such subcellular formations as Ah-, k (kappa) B- and other matrix cell receptors. Catechins regulate the permeability of capillaries and increase the elasticity of their walls, and also contribute to a more efficient use of ascorbic acid by the body. Therefore, catechins are classified as substances with P-vitamin activity and are used in the treatment of diseases associated with impaired capillary function, edema of vascular origin, etc. Green tea extract contains up to 95% polyphenols, of which 75% are catechins.

Among catechins, the main one in terms of quantity and bioeffects is epigallocatechin-3-gallate, which accounts for 50% of the total number of catechins in green tea. Epigallocatechin-3-gallate inhibits neoangiogenesis or the formation of new vessels, which leads to the stopping of an important link in the development of diseases such as tumor growth, endometriosis, uterine fibroids, combined uterine pathology and adenomyosis, and also inhibits endometrial cell invasion, which stops the key mechanism of endometriosis and adenomyosis. The total amount of polyphenols in green tea is determined spectrophotometrically, and the catechins are determined using high performance liquid chromatography with witnesses.

Fluoroquinolones belonging to the quinolone class have a wide spectrum of antimicrobial activity, including staphylococci, high bactericidal activity and good pharmacokinetics, which allows them to be used to treat infections of different localization. They are characterized by high activity against gram-positive bacteria, intracellular pathogens, anaerobes. Fluoroquinolones have a bactericidal effect, inhibiting two vital microbial cell enzymes — DNA gyrase and topoisomerase, and thereby disrupting DNA synthesis. Fluoroquinolones are well distributed in tissues and body fluids: they penetrate well into bones, intraocular fluid, bronchial secretions, saliva, skin, muscles, pleura, peritoneum, and lymph. The drug, which is part of the pharmacological group of fluoroquinolones, is ciprofloxacin.

A concentration of catechins in a polyphenol-containing substance of less than 70% reduces the anti-inflammatory, antioxidant and cytostatic properties of the composition, since it is catechins that have a strong effect on these properties.

The revealed ratio of the components included in the medicinal composition - polyphenol-containing substance with a concentration of catechins of at least 70%, preferably green tea and / or its extract, and fluoroquinolone, preferably ciprofloxacin, is optimal, since only in the stated range of ratios the maximum enhancement of the effects of the composition is achieved components that provide the necessary antimicrobial, anti-inflammatory and cytostatic effects.

Composition outside declared concentration limits may have side effects.

The following are examples confirming the possibility of implementing the present invention.

Example 1

Using the claimed composition, a drug was obtained in the form of rectal suppositories with green tea and ciprofloxacin in the range of concentrations from 25 to 500 mg of each component per suppository. These suppositories were used in the treatment of patients with prostate diseases in the period December 2004 - March 2005.

Monotherapy with suppositories with various concentrations of green tea extract and ciprofloxacin in six patients aged 21 to 64 years with prostate diseases was carried out on an outpatient basis: four patients with chronic prostatitis and two with exacerbation of chronic prostatitis with prostate adenoma. Irritative symptoms predominated in all patients. Patients complained of pain during urination, discomfort and pain in the perineum. Complaints such as decreased libido and potency were also noted. Given that this category of patients previously received repeated courses of conservative therapy for chronic prostatitis with a temporary positive effect (antibacterial, immunostimulating drugs, physiotherapy, prostate massage, etc.), the last complaints were regarded as psychogenic and were not organic.

In addition to examination and history taking, all patients underwent the following types of diagnostics: sperm diagnostics using the method of polymerase chain reaction, ultrasound examination of the kidneys, prostate, scrotum, blood test for prostate-specific antigen.

The treatment was carried out in a course of one suppository at night for 10 days.

results

Regardless of the dose used, in all patients after the first dose a complete disappearance of pain in the perineum and dysuria was noted.

findings

This drug is a fairly promising drug for the treatment of patients with chronic prostatitis and prostate adenoma. The disappearance of pain and dysuria indicates a strong anti-inflammatory effect of suppositories with green tea, which can be used not only in the conservative treatment of chronic prostatitis and prostate adenoma, but also in the early postoperative period in patients after transurethral resection of the prostate and transvesical adenomectomy.

Example 2

Using the claimed composition, a drug was obtained in the form of rectal suppositories with green tea and ciprofloxacin in the range of concentrations from 25 to 500 mg of each component per suppository. These suppositories were used in the treatment of patients with urological diseases in the period from June 2005 to November 2005.

Methods

The study group included patients operated on in the Urology Research Institute on the upper and lower urinary tract, in the postoperative period who developed a clinic of urethritis, acute prostatitis and epididymitis.

Patient D., 6 years old (and / b 1084). September 12, 2005, the patient underwent Holtsov's surgery (urethroanastomosis). On the 9th day after the operation, against the background of the urethral catheter, the patient developed epididymitis on the right. Along with the antibacterial therapy that he received earlier, the patient was prescribed three suppositories with green tea and ciprofloxacin (200 mg of each component per suppository). After the first suppository intake, a sharp positive dynamics was observed from the side of the appendage of the right testicle - after 6 hours, a significant decrease in the size of the appendage, normalization of body temperature and the disappearance of pain were noted.

Patient S., 19 years old, was operated on in October 2005. The patient underwent percutaneous nephrolitholapaxia on the right due to the coral calculus. After removal of the urethral catheter in the early postoperative period, the patient experienced a clinic of urethritis. Positive dynamics was noted 30 minutes after taking the first suppository with green tea and ciprofloxacin.

Patient G., 66 years old (and / b 1562). September 7, 2005, the patient underwent cystolithotripsy, transurethral resection (TUR) of the prostate for prostate adenoma. After removal of the urethral catheter, the patient exacerbated chronic prostatitis. Normalization of the condition was noted after three times the appointment of suppositories with green tea and ciprofloxacin.

findings

The prospect of using suppositories with green tea and ciprofloxacin in the claimed dosages, not only in the treatment of chronic prostatitis and prostate adenoma, but also as an emergency drug for acute inflammatory diseases of the prostate, urethra and scrotum organs is obvious.

Example 3

Using the claimed composition, a drug was obtained in the form of rectal-vaginal suppositories with green tea (100 and 200 mg) and ciprofloxacin (100 and 200 mg). These suppositories were used in the treatment of patients in the gynecological clinic.

During January-February 2007, rectal-vaginal suppositories containing ciprofloxacin 100 or 200 mg per suppository and green tea extract with a concentration of flavonoid catechins also 100 or 200 mg per suppository were tested on an outpatient basis. Suppositories were used topically (vaginally) in the course of monotherapy of gynecological pathology: cervicitis, ectopia with inflammation, endomyometritis, vulvitis, vaginitis of various etiologies. The study voluntarily involved 8 sick women who were examined before and after one or two courses of treatment with suppositories with ciprofloxacin and green tea with the above concentration of components. One course was 10 suppositories (two suppositories per day). The infectious nature of the inflammation was confirmed by a special laboratory analysis. In all cases, a positive effect was obtained during one or two courses (depending on the concentration of the components) of vaginal suppository treatment.

In three groups of laboratory animals sick with tuberculosis, different medicinal compositions were tested for 2 weeks. The first group was treated with a polyphenol-containing substance, the second group with fluoroquinolone, the third with a composition of a polyphenol-containing substance and fluoroquinolone taken in the studied ratios. At the end of the studies, analyzes were taken showing that in all three experimental groups microbiological cultures showed reduced bacterial growth, and the condition of the animals improved. However, the best results were obtained in the groups treated with fluoroquinolone and a composition of a polyphenol-containing substance and fluoroquinolone taken in a ratio of 1:20 to 20: 1. Moreover, when comparing histological analyzes of these groups, the best results were noted in the group receiving the composition of a polyphenol-containing substance and fluoroquinolone, which allowed us to conclude that the composition is highly effective and the components are synergistic with respect to each other.

Similar studies were carried out using the drugs indicated in the table, with similar results.

Medicines based on a medicinal composition. Key Features and Application Features No. Active components Dosage form Mode of application Treatment results one Ofloxacin 500 mg, green tea extract 25 mg Tab. 0.75 g In the treatment of chronic bronchitis, an intake of 0.75 g every 12 hours for 3 days was prescribed. The most active fluoroquinolone against most gram-negative bacteria, enhanced by the action of green tea catechins, surpasses other drugs in activity against P. aeruginosa 2 Ofloxacin 25 mg, oolong tea 500 mg Eye ointment 0.3% In case of eye infection, a topical ointment was placed 3-5 times a day for the lower eyelid of the affected eye The most active fluoroquinolone of the second generation in relation to chlamydia and pneumococci in effective combination with a polyphenol-containing substance - oolong tea, provides the highest therapeutic effect and shortens the duration of treatment. 3 Norfloxacin 25 mg, liquid extracts of white and green tea 500 mg Eye / ear drops 0.3% In case of eye infection, eye drops were instilled in 1-2 drops. in the affected eye every 4 hours, in severe cases - every hour until improvement. Ear drops were instilled in 2-3 drops. in the affected ear 4-6 times a day, in severe cases - every 2-3 hours, gradually trimming as it improves Eye drops based on the proposed medicinal composition are well tolerated with frequent installation in the acute period and are more effective in treating infections of the eyes and outer ear compared to known compositions. four Levofloxacin
200 mg, green tea 50 mg and thick extract of green tea 50 mg, base - cocoa butter Rectal suppositories weighing 1 g Composed of
complex treatment of chlamydia is prescribed 2 courses of one suppository at night for 10 days with an interval of 7 days. Composition application
of the levorotatory isomer ofloxacin - levofloxacin and a polyphenol-containing substance - a mixture of green tea and a thick extract of green tea, showed a high antibacterial and anti-inflammatory effect in the treatment of chlamydia as part of complex therapy. The drug is easily tolerated and does not have pronounced side effects. 5 Moxifloxacin 400 mg, oolong tea 100 mg and dry extract of green tea 50 mg, the base is gelatin-glycerin gel Vaginal suppositories weighing 2 g As part of the complex treatment of mycoplasmosis, 1 course is prescribed, one suppository per night for 14 days. The use of a moxifloxacin composition and a mixture of oolong tea and a dry extract of green tea in a medicinal product showed excellent results in the treatment of mycoplasmosis as part of complex therapy due to the high antibacterial and anti-inflammatory effect of the composition.

When combination 1 exceeds the ratio of active components in the direction of increasing the proportion of fluoroquinolone by more than 20 times compared with the polyphenol-containing substance, a statistical increase in the number of side effects caused by fluoroquinolones, in particular heartburn, epigastric pain, loss of appetite, nausea, vomiting, diarrhea .

When combinations of 2 and 3 exceeded the ratio of active components in the direction of increasing the proportion of polyphenol-containing substances by more than 20 times compared with fluoroquinolone, a slowdown in the decrease in the number of bacteria and a statistical increase in the treatment time were observed.

Claims (25)

1. A medicinal composition for preparing an anti-inflammatory and antibacterial drug, characterized in that it comprises at least a polyphenol-containing substance with a concentration of catechins of at least 70%, preferably green tea and / or its extract, and fluoroquinolone, preferably ciprofloxacin, taken in ratio from 1:20 to 20: 1. 2. The drug composition according to claim 1, where the green tea extract is made aqueous or hydroalcoholic. 3. The drug composition according to claim 1, where the green tea extract is made with a liquid extract or a thick extract in the form of a viscous mass with a moisture content of not more than 25%, or a dry extract in the form of a granular mass with a moisture content of not more than 5%, and the extract obtained with using methods that maximize the preservation of catechins. 4. The drug composition according to claim 1, where it is part of a medicinal product containing a mixture of medicinal and auxiliary substances and made in the form of powder or granules for internal use in the form of grains of round, cylindrical or irregular shape. 5. The drug composition according to claim 1, where it is part of a medicinal product containing a mixture of medicinal and auxiliary substances and made in the form of capsules for oral administration, as well as for rectal and vaginal routes of administration. 6. The drug composition according to claim 1, where it is included in the composition of the medicinal product, made in the form of tablets, obtained by compressing medicinal products or a mixture of medicinal and auxiliary substances and intended for internal, external, sublingual, implantation or parenteral use, and used as auxiliary binders, and / or diluents, and / or disintegrants, and / or glidants and lubricants, and / or colorants, flavoring agents. 7. The drug composition according to claim 1, where it is part of the coated drug. 8. The drug composition according to claim 1, where it is part of a medicinal product containing at least a mixture of drugs and excipients and made in the form of a solution, suspension or emulsion for internal, external and parenteral use, and used as auxiliary substances that increase the viscosity of the dispersion medium and / or surfactants and buffers, reducing agents, and / or flavoring agents, and / or preservatives, and / or antioxidants, and / or dyes, and for preparing the emulsion emulsifiers used. 9. The drug composition of claim 8, where in the drug, having the form of an emulsion, used peach, and / or olive, and / or sunflower, and / or tomato, and / or pumpkin, and / or flax, and / or castor and / or liquid paraffin and essential oils, as well as fish oil, balms, and nonionic or anionic surfactants, for example soaps, hydrophilic natural substances, for example gelatose or pectin, semi-synthetic substances, for example methyl cellulose, sodium carboxymethyl cellulose, synthetic substances, are used as emulsifier. 10. The drug composition of claim 8, where in the drug, having the form of an emulsion, an auxiliary substance is used - a preservative, for example nipagin, nipazole, sorbic acid. 11. The drug composition according to claim 1, where it is part of a medicinal product containing a base and a mixture of medicinal and auxiliary substances and made in the form of an ointment, preferably a paste, cream, gel or liniment, having a homogeneous, suspension, emulsion or combined dispersion system moreover, as the basis for the preparation of ointments, a base approved for medical use is used, preferably lipophilic, or hydrophilic, or hydrophilic-lipophilic, and as an auxiliary substance Twa used preservatives, surfactants. 12. The drug composition according to claim 11, where vaseline and / or hydrocarbon alloys and / or natural hydrogenated fats and their alloy with vegetable oils and fat-like substances, or silicone fat, are used as the lipophilic base for the ointment. 13. The drug composition according to claim 11, where gels of high molecular weight carbohydrates and proteins, for example cellulose ethers and / or starch, and / or gelatin, and / or agar, or gels of inorganic substances, for example bentonite, are used as the hydrophilic base for the ointment, or gels of synthetic macromolecular compounds, for example polyethylene oxide, polyvinylpyrrolidone, polyacrylamide. 14. The drug composition according to claim 11, where anhydrous alloys of lipophilic bases with emulsifiers, for example, an alloy of petrolatum with lanolin or with other emulsifiers, as well as emulsion bases of the water / oil type, for example an alloy of petrolatum and water, are used as the hydrophilic-lipophilic base for the ointment. lanolin, a consistent emulsion of water / petroleum jelly, or emulsion bases of the type oil / water, where sodium, potassium, triethanolamine salts of fatty acids are used as emulsifiers. 15. The drug composition according to claim 1, where it is part of a medicinal product containing a base and a mixture of medicinal and auxiliary substances and made in the form of a suppository, made rectal, having the shape of a cone, a cylinder with a pointed end or another shape with a maximum diameter of 1, 5 cm, or made vaginal, having a spherical, ovoid shape, or in the form of a flat body with a rounded end, or made in the form of a rod, having the shape of a cylinder with a pointed end and a diameter of not more than 1 cm, and the suppo The halls are made by pouring molten mass into molds, rolling out or pressing on special equipment. 16. The drug composition according to clause 15, where the basis for the manufacture of a suppository is used approved for medical use, preferably lipophilic, or hydrophilic, or hydrophilic-lipophilic. 17. The drug composition according to clause 16, where as a lipophilic base for the manufacture of a suppository used cocoa butter and / or cocoa butter alloys with paraffin and hydrogenated fats, and / or vegetable and animal hydrogenated fats, solid fat, and / or lanol, and / or alloys of hydrogenated fats with wax, paraffin wax. 18. The drug composition according to clause 16, where the gelatin-glycerin gels, alloys of polyethylene oxides with different molecular weights, the gelatin-glycerin gel made from medical gelatin, glycerin and water, are used as the hydrophilic base. 19. An anti-inflammatory and antibacterial drug, characterized in that it includes the drug composition according to claim 1, as well as at least a base, preferably lipophilic or hydrophilic, for example a mixture of tri-, di- and monoglycerides and / or saturated fatty acids in an amount sufficient to obtain the desired dosage form. 20. The anti-inflammatory and antibacterial drug of claim 19, wherein the tri-, di- and monoglycerides and saturated fatty acids are derived from coconut and / or palm oil. 21. The anti-inflammatory and antibacterial drug according to claim 19, wherein vitepsol is used as a base, preferably vitepsol brand H-15, or vitepsol brand W-35, or a mixture thereof. 22. The anti-inflammatory and antibacterial drug according to claim 19, where it further comprises at least an auxiliary substance. 23. The anti-inflammatory and antibacterial drug according to claim 19, where it is a dosage form - an ointment or cream, or a suppository, which has a torpedo shape or a cone shape, or a cylinder shape with a pointed end, or another shape with a maximum diameter of 1.5 cm. 24. The anti-inflammatory and antibacterial drug according to item 23, where it is a dosage form - a suppository weighing 1 g, while the content of its components is, mg:
green tea and / or its extract 25 ÷ 500 ciprofloxacin 25 ÷ 500 the basis rest 25. The anti-inflammatory and antibacterial drug according to item 23, where it is a dosage form - a suppository weighing 2 g, while the content of its components is, mg:
green tea and / or its extract 25 ÷ 500 ciprofloxacin 25 ÷ 500 the basis rest