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RU2196139C2 - 1,4,5-тризамещенные производные имидазола, способы их получения и фармацевтическая композиция на их основе - Google Patents

1,4,5-тризамещенные производные имидазола, способы их получения и фармацевтическая композиция на их основе Download PDF

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Publication number
RU2196139C2
RU2196139C2 RU97113753/04A RU97113753A RU2196139C2 RU 2196139 C2 RU2196139 C2 RU 2196139C2 RU 97113753/04 A RU97113753/04 A RU 97113753/04A RU 97113753 A RU97113753 A RU 97113753A RU 2196139 C2 RU2196139 C2 RU 2196139C2
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RU
Russia
Prior art keywords
formula
alkyl
imidazole
compound
fluorophenyl
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Application number
RU97113753/04A
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English (en)
Russian (ru)
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RU97113753A (ru
Inventor
Джерри Лерой ЭДАМС (US)
Джерри Лерой ЭДАМС
Тимоти Ф. ГАЛЛАГЕР (US)
Тимоти Ф. ГАЛЛАГЕР
Рави Шанкер ГАРИДЖИПАТИ (IN)
Рави Шанкер ГАРИДЖИПАТИ
Джеффри Чарльз БОЕМ (US)
Джеффри Чарльз БОЕМ
Джозеф СИСКО (US)
Джозеф Сиско
Джон Чеунг-Лун ЛИ (US)
Джон Чеунг-Лун ЛИ
Original Assignee
Смитклайн Бичам Корпорейшн
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Publication of RU97113753A publication Critical patent/RU97113753A/ru
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Publication of RU2196139C2 publication Critical patent/RU2196139C2/ru

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
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  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
RU97113753/04A 1995-01-09 1996-01-11 1,4,5-тризамещенные производные имидазола, способы их получения и фармацевтическая композиция на их основе RU2196139C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36996495A 1995-01-09 1995-01-09
US08/369,964 1995-01-09
US08/472,366 1995-06-07
US08/472,366 US5593992A (en) 1993-07-16 1995-06-07 Compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2002122174/14A Division RU2002122174A (ru) 1995-01-09 2002-08-15 Способ профилактики и лечения заболевания, опосредуемого csbp/rk/p38 киназой, и способ лечения воспаления

Publications (2)

Publication Number Publication Date
RU97113753A RU97113753A (ru) 1999-06-20
RU2196139C2 true RU2196139C2 (ru) 2003-01-10

Family

ID=27004764

Family Applications (2)

Application Number Title Priority Date Filing Date
RU97113753/04A RU2196139C2 (ru) 1995-01-09 1996-01-11 1,4,5-тризамещенные производные имидазола, способы их получения и фармацевтическая композиция на их основе
RU2002122174/14A RU2002122174A (ru) 1995-01-09 2002-08-15 Способ профилактики и лечения заболевания, опосредуемого csbp/rk/p38 киназой, и способ лечения воспаления

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2002122174/14A RU2002122174A (ru) 1995-01-09 2002-08-15 Способ профилактики и лечения заболевания, опосредуемого csbp/rk/p38 киназой, и способ лечения воспаления

Country Status (34)

Country Link
US (5) US5593992A (fr)
EP (2) EP1264827A1 (fr)
JP (2) JP3330952B2 (fr)
CN (1) CN1138546C (fr)
AP (1) AP1270A (fr)
AR (1) AR002267A1 (fr)
AT (1) ATE254613T1 (fr)
AU (1) AU705207C (fr)
BG (1) BG63769B1 (fr)
BR (1) BR9606904A (fr)
CA (1) CA2209938A1 (fr)
CZ (1) CZ215897A3 (fr)
DE (1) DE69630777T2 (fr)
DK (1) DK0809499T3 (fr)
DZ (1) DZ1961A1 (fr)
ES (1) ES2210348T3 (fr)
FI (1) FI972901A (fr)
HK (1) HK1003623A1 (fr)
HU (1) HUP9702409A3 (fr)
ID (3) ID23599A (fr)
IL (7) IL134323A (fr)
IN (3) IN184957B (fr)
MA (1) MA23770A1 (fr)
MX (1) MX9705142A (fr)
NO (3) NO973167L (fr)
NZ (1) NZ301204A (fr)
OA (1) OA10738A (fr)
PL (1) PL322249A1 (fr)
PT (1) PT809499E (fr)
RU (2) RU2196139C2 (fr)
SI (1) SI0809499T1 (fr)
SK (1) SK90297A3 (fr)
TW (1) TW523511B (fr)
WO (1) WO1996021452A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2475483C2 (ru) * 2006-04-20 2013-02-20 Янссен Фармацевтика Н.В. Ингибиторы с-fms киназы
RU2813203C2 (ru) * 2019-08-23 2024-02-07 Мотида Фармасьютикал Ко., Лтд. Способ получения гетероциклиденового ацетамидного производного

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CA2171982C (fr) * 1993-09-17 2000-02-01 John Cheung-Lun Lee Proteine de liaison de medicament
US6203803B1 (en) 1994-12-14 2001-03-20 Societe L'oreal S.A. Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained
WO1996021654A1 (fr) * 1995-01-12 1996-07-18 Smithkline Beecham Corporation Nouveaux composes
EP0737471A3 (fr) * 1995-04-10 2000-12-06 L'oreal Utilisation d'un sel d'une métal alcalino-terreux comme inhibiteur de TNF-alpha dans une composition unique et composition obtenue
US6369068B1 (en) 1995-06-07 2002-04-09 Smithkline Beecham Corporation Amino substituted pyrimidine containing compounds
IL118544A (en) 1995-06-07 2001-08-08 Smithkline Beecham Corp History of imidazole, the process for their preparation and the pharmaceutical preparations containing them
US5739143A (en) * 1995-06-07 1998-04-14 Smithkline Beecham Corporation Imidazole compounds and compositions
FR2740341B1 (fr) * 1995-10-26 1997-12-19 Oreal Utilisation de sel de lanthanide, d'etain, de zinc, de manganese, d'yttrium, de cobalt, de baryum, de strontium dans une composition pour la peau
ZA9610687B (en) 1995-12-22 1997-09-29 Smithkline Beecham Corp Novel synthesis.
AP9700912A0 (en) * 1996-01-11 1997-01-31 Smithkline Beecham Corp Novel cycloalkyl substituted imidazoles
CA2242327A1 (fr) * 1996-01-11 1997-07-17 Smithkline Beecham Corporation Nouveaux composes d'imidazole substitues
ZA97175B (en) * 1996-01-11 1997-11-04 Smithkline Beecham Corp Novel substituted imidazole compounds.
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
EP1005343A1 (fr) * 1996-03-08 2000-06-07 Smithkline Beecham Corporation Utilisations de composes csaid?tm en tant qu'inhibiteurs de l'angiogenese
EP0889888A4 (fr) * 1996-03-25 2003-01-08 Smithkline Beecham Corp Nouveau traitement des lesions du systeme nerveux central
EP0956018A4 (fr) * 1996-08-21 2000-01-12 Smithkline Beecham Corp Composes d'imidazole, compositions les contenant et leur utilisation
JP2001506980A (ja) 1996-11-19 2001-05-29 アムジエン・インコーポレーテツド アリールおよびヘテロアリール置換縮合ピロール抗炎症剤
US6410729B1 (en) 1996-12-05 2002-06-25 Amgen Inc. Substituted pyrimidine compounds and methods of use
US6096753A (en) 1996-12-05 2000-08-01 Amgen Inc. Substituted pyrimidinone and pyridone compounds and methods of use
AP999A (en) * 1997-01-10 2001-08-11 Smithkline Beecham Corp Novel substituted imidazole compounds.
US5929076A (en) * 1997-01-10 1999-07-27 Smithkline Beecham Corporation Cycloalkyl substituted imidazoles
US6432947B1 (en) * 1997-02-19 2002-08-13 Berlex Laboratories, Inc. N-heterocyclic derivatives as NOS inhibitors
US5965583A (en) 1997-04-24 1999-10-12 Ortho-Mcneil Pharmaceutical, Inc. Substituted imidazoles useful in the treatment of inflammatory disease
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