Nothing Special   »   [go: up one dir, main page]

RU2014119897A - Имплантируемое устройство для доставки биоактивного агента - Google Patents

Имплантируемое устройство для доставки биоактивного агента Download PDF

Info

Publication number
RU2014119897A
RU2014119897A RU2014119897/14A RU2014119897A RU2014119897A RU 2014119897 A RU2014119897 A RU 2014119897A RU 2014119897/14 A RU2014119897/14 A RU 2014119897/14A RU 2014119897 A RU2014119897 A RU 2014119897A RU 2014119897 A RU2014119897 A RU 2014119897A
Authority
RU
Russia
Prior art keywords
delivery device
nanostructures
implantable delivery
implantable
microstructures
Prior art date
Application number
RU2014119897/14A
Other languages
English (en)
Inventor
Джереми ОЛЛЕРЕНШО
Эмили РЕЙХАРТ
Расселл Ф. РОСС
Original Assignee
Кимберли-Кларк Ворлдвайд, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кимберли-Кларк Ворлдвайд, Инк. filed Critical Кимберли-Кларк Ворлдвайд, Инк.
Publication of RU2014119897A publication Critical patent/RU2014119897A/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A61F2002/0081—Special surfaces of prostheses, e.g. for improving ingrowth directly machined on the prosthetic surface, e.g. holes, grooves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Prostheses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

1. Имплантируемое устройство для доставки биоактивного агента субъекту включающее:- множество наноструктур, изготовленных на поверхности имплантируемого устройства для доставки и расположенных согласно заданному паттерну;биологически активный агент, находящийся внутри или на поверхности данного имплантируемого устройства для доставки.2. Имплантируемое устройство для доставки по п. 1, отличающееся тем, что биологически активный агент представляет собой компонент композиции, причем эта композиция дополнительно содержит один или несколько фармацевтически приемлемых эксципиентов и/или матрицу с замедленным высвобождением.3. Имплантируемое устройство для доставки по п. 1 или 2, отличающееся тем, что паттерн также содержит микроструктуры, причем поперечный размер наноструктур меньше, чем у микроструктур.4. Имплантируемое устройство для доставки по п. 3, отличающееся тем, что микроструктуры имеют поперечный размер более чем примерно 500 нм, а наноструктуры имеют поперечный размер менее чем примерно 300 нм.5. Имплантируемое устройство для доставки по п. 3, содержащее также вторичные наноструктуры, имеющие размер поперечного сечения меньше, чем размер поперечного сечения микроструктур и больше, чем размер поперечного сечения первичных наноструктур.6. Имплантируемое устройство для доставки по п. 1, в котором, по крайней мере, часть наноструктур имеют одну или более следующих характеристик:а) расстояние между центрами составляет от примерно 50 нм до примерно 1 мкм,б) высота их составляет от примерно 10 нм до примерно 20 мкм,в) соотношение их сторон составляет от примерно 0,15 до примерно 30.7. Имплантируемое устройство для до�

Claims (14)

1. Имплантируемое устройство для доставки биоактивного агента субъекту включающее:
- множество наноструктур, изготовленных на поверхности имплантируемого устройства для доставки и расположенных согласно заданному паттерну;
биологически активный агент, находящийся внутри или на поверхности данного имплантируемого устройства для доставки.
2. Имплантируемое устройство для доставки по п. 1, отличающееся тем, что биологически активный агент представляет собой компонент композиции, причем эта композиция дополнительно содержит один или несколько фармацевтически приемлемых эксципиентов и/или матрицу с замедленным высвобождением.
3. Имплантируемое устройство для доставки по п. 1 или 2, отличающееся тем, что паттерн также содержит микроструктуры, причем поперечный размер наноструктур меньше, чем у микроструктур.
4. Имплантируемое устройство для доставки по п. 3, отличающееся тем, что микроструктуры имеют поперечный размер более чем примерно 500 нм, а наноструктуры имеют поперечный размер менее чем примерно 300 нм.
5. Имплантируемое устройство для доставки по п. 3, содержащее также вторичные наноструктуры, имеющие размер поперечного сечения меньше, чем размер поперечного сечения микроструктур и больше, чем размер поперечного сечения первичных наноструктур.
6. Имплантируемое устройство для доставки по п. 1, в котором, по крайней мере, часть наноструктур имеют одну или более следующих характеристик:
а) расстояние между центрами составляет от примерно 50 нм до примерно 1 мкм,
б) высота их составляет от примерно 10 нм до примерно 20 мкм,
в) соотношение их сторон составляет от примерно 0,15 до примерно 30.
7. Имплантируемое устройство для доставки по п. 1, отличающееся тем, что паттерн имеет фрактальную размерность больше чем примерно 1.
8. Имплантируемое устройство для доставки по п. 1, в котором поверхность микроиглы, содержащая множество наноструктур, имеет среднюю шероховатость поверхности от примерно 10 нм до примерно 200 нм и/или эффективный модуль сжатия от примерно 4 МПа до примерно 320 МПа.
9. Имплантируемое устройство для доставки по п. 1, содержащее резервуар, в котором содержится биоактивный агент.
10. Имплантируемое устройство для доставки по п. 1, включающее канавку на поверхности устройства, причем внутри этой канавки содержится биоактивный агент.
11. Способ формирования имплантируемого устройства для доставки по любому из пп. 1-10, включающий изготовление паттерна наноструктур на поверхности устройства.
12. Способ по п. 11, отличающийся тем, что изготовление паттерна наноструктур проводят при помощи методов, выбранных из группы, включающей фотолитографию, электронно-лучевую литографию, рентгеновскую литографию, методы самосборки, реактивное ионное травление, влажное травление, осаждение пленки, напыление, химическое осаждение из паровой фазы, эпитаксию, электропорацию, а также их комбинации.
13. Способ по п. 11, отличающийся тем, что изготовление паттерна наноструктур проводят на пленке, причем этот способ также включает нанесение пленки на поверхность имплантируемого устройства для доставки.
14. Способ по п. 11, дополнительно включающий помещение биологически активного агента внутрь или снаружи устройства, например в резервуар этого устройства или на поверхность устройства.
RU2014119897/14A 2011-10-27 2012-10-16 Имплантируемое устройство для доставки биоактивного агента RU2014119897A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161552059P 2011-10-27 2011-10-27
US61/552,059 2011-10-27
PCT/IB2012/055622 WO2013061209A1 (en) 2011-10-27 2012-10-16 Implantable devices for delivery of bioactive agents

Publications (1)

Publication Number Publication Date
RU2014119897A true RU2014119897A (ru) 2015-12-10

Family

ID=48167199

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2014119897/14A RU2014119897A (ru) 2011-10-27 2012-10-16 Имплантируемое устройство для доставки биоактивного агента

Country Status (15)

Country Link
US (2) US11110066B2 (ru)
EP (3) EP3542851B1 (ru)
JP (1) JP6535464B2 (ru)
KR (1) KR20140079429A (ru)
CN (1) CN103906549A (ru)
AU (1) AU2012328038B2 (ru)
BR (1) BR112014009712A2 (ru)
CA (1) CA2850931A1 (ru)
DK (1) DK3542851T3 (ru)
ES (1) ES2908653T3 (ru)
HU (1) HUE058275T2 (ru)
MX (1) MX2014004690A (ru)
PL (1) PL3542851T3 (ru)
RU (1) RU2014119897A (ru)
WO (1) WO2013061209A1 (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2636673T3 (es) 2010-04-28 2017-10-06 Kimberly-Clark Worldwide, Inc. Dispositivo para la administración de medicamentos contra la artritis reumatoide
WO2011135533A2 (en) 2010-04-28 2011-11-03 Kimberly-Clark Worldwide, Inc. Nanopatterned medical device with enhanced cellular interaction
WO2012046149A1 (en) 2010-04-28 2012-04-12 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
JP5860033B2 (ja) 2010-04-28 2016-02-16 キンバリー クラーク ワールドワイド インコーポレイテッド ｓｉＲＮＡ送達用の医療デバイス
WO2012082863A1 (en) * 2010-12-15 2012-06-21 Advanced Bionics Ag Protection for implanted gold surfaces
EP3574950B1 (en) 2011-10-27 2021-02-17 Sorrento Therapeutics, Inc. Transdermal delivery of high viscosity bioactive agents
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
KR101985094B1 (ko) * 2017-09-14 2019-05-31 고려대학교 산학협력단 정형외과적인 인공 금속물 및 이의 제조 방법
US20190093150A1 (en) * 2017-09-22 2019-03-28 Uchicago Argonne, Llc Nanotextured materials
CN109173030B (zh) * 2018-10-19 2024-06-25 无锡市第九人民医院 一种可视化肛肠给药装置
TWI832928B (zh) * 2018-11-21 2024-02-21 瑞士商Ｂｖｗ控股公司 微結構化表面
US11766822B2 (en) 2019-08-20 2023-09-26 3M Innovative Properties Company Microstructured surface with increased microorganism removal when cleaned, articles and methods
JP7370283B2 (ja) * 2020-03-10 2023-10-27 テルモ株式会社 投与デバイス及び投与方法

Family Cites Families (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US4051840A (en) 1976-01-05 1977-10-04 Sinai Hospital Of Detroit Dynamic aortic patch
US4698062A (en) 1985-10-30 1987-10-06 Alza Corporation Medical device for pulsatile transdermal delivery of biologically active agents
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
WO1999009149A1 (en) * 1997-08-01 1999-02-25 Massachusetts Institute Of Technology Three-dimensional polymer matrices
GB9805214D0 (en) * 1998-03-11 1998-05-06 Univ Glasgow Cell adhesion
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US20020095134A1 (en) 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
SE515607C2 (sv) 1999-12-10 2001-09-10 Obducat Ab Anordning och metod vid tillverkning av strukturer
AU2001228987A1 (en) 2000-01-21 2001-07-31 Obducat Aktiebolag A mold for nano imprinting
JP2001238964A (ja) * 2000-02-29 2001-09-04 Japan Lifeline Co Ltd ステント
KR20080023768A (ko) 2000-03-30 2008-03-14 화이트헤드 인스티튜트 포 바이오메디칼 리서치 Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체
SE516194C2 (sv) 2000-04-18 2001-12-03 Obducat Ab Substrat för samt process vid tillverkning av strukturer
SE516414C2 (sv) 2000-05-24 2002-01-15 Obducat Ab Metod vid tillverkning av en mall, samt mallen tillverkad därav
AU2001275138A1 (en) 2000-06-02 2001-12-17 The University Of Utah Research Foundation Active needle devices with integrated functionality
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US6656147B1 (en) 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
WO2002030506A2 (en) 2000-10-12 2002-04-18 Ink Jet Technology Ltd. Transdermal method
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US6979347B1 (en) 2000-10-23 2005-12-27 Advanced Cardiovascular Systems, Inc. Implantable drug delivery prosthesis
NL1016779C2 (nl) 2000-12-02 2002-06-04 Cornelis Johannes Maria V Rijn Matrijs, werkwijze voor het vervaardigen van precisieproducten met behulp van een matrijs, alsmede precisieproducten, in het bijzonder microzeven en membraanfilters, vervaardigd met een dergelijke matrijs.
KR100991573B1 (ko) 2000-12-11 2010-11-04 프레지던트 앤드 펠로우즈 오브 하버드 칼리지 나노센서
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
CA2451882A1 (en) 2001-03-14 2002-09-19 University Of Massachusetts Nanofabrication
US6767341B2 (en) 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
SE519573C2 (sv) 2001-07-05 2003-03-11 Obducat Ab Stamp med antividhäftningsskikt samt sätt att framställa och sätt att reparera en sådan stamp
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US20040087992A1 (en) 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
WO2003024508A2 (en) 2001-09-21 2003-03-27 Biovalve Technologies, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US6746825B2 (en) 2001-10-05 2004-06-08 Wisconsin Alumni Research Foundation Guided self-assembly of block copolymer films on interferometrically nanopatterned substrates
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
WO2003092785A1 (en) 2002-04-30 2003-11-13 Morteza Shirkhanzadeh Arrays of microneedles comprising porous calcium phosphate coating and bioactive agents
EP1513688B1 (en) 2002-06-20 2006-11-29 Obducat AB Mold tool method of manufacturing a mold tool and storage medium formed by use of the mold tool
US7252492B2 (en) 2002-06-20 2007-08-07 Obducat Ab Devices and methods for aligning a stamp and a substrate
WO2004009978A2 (en) 2002-07-24 2004-01-29 Koch Kenneth W Methods and compositions for on-line gas turbine cleaning
EP1546804A1 (en) 2002-08-27 2005-06-29 Obducat AB Device for transferring a pattern to an object
US20040063100A1 (en) 2002-09-30 2004-04-01 Wang Chung Lin Nanoneedle chips and the production thereof
AU2003277306A1 (en) 2002-10-07 2004-05-04 Biovalve Technologies, Inc. Microneedle array patch
IL152912A0 (en) 2002-11-18 2003-06-24 Nanopass Ltd Micro needle systems
WO2004068553A2 (en) 2003-01-29 2004-08-12 The Regents Of The University Of Michigan Method for forming nanoscale features
WO2005029179A2 (en) 2003-02-13 2005-03-31 The Regents Of The University Of Michigan Combined nanoimprinting and photolithography for micro and nano devices fabrication
US7578954B2 (en) 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US20050038498A1 (en) * 2003-04-17 2005-02-17 Nanosys, Inc. Medical device applications of nanostructured surfaces
US7972616B2 (en) * 2003-04-17 2011-07-05 Nanosys, Inc. Medical device applications of nanostructured surfaces
WO2004093818A2 (en) 2003-04-21 2004-11-04 Stratagent Life Sciences Apparatus and methods for repetitive microjet drug delivery
US7803574B2 (en) 2003-05-05 2010-09-28 Nanosys, Inc. Medical device applications of nanostructured surfaces
US7572405B2 (en) 2003-06-02 2009-08-11 Corium International Inc. Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation
US20050112636A1 (en) 2003-09-23 2005-05-26 Atom Sciences Polymeric nucleic acid hybridization probes
US7862849B2 (en) 2003-10-17 2011-01-04 Massachusetts Institute Of Technology Nanocontact printing
DE10353629A1 (de) 2003-11-17 2005-06-16 Lts Lohmann Therapie-Systeme Ag Vorrichtung zur transdermalen Verabreichung von Wirkstoffen
JP4050219B2 (ja) 2003-11-18 2008-02-20 アルプス電気株式会社 接続装置の製造方法
US20050119723A1 (en) * 2003-11-28 2005-06-02 Medlogics Device Corporation Medical device with porous surface containing bioerodable bioactive composites and related methods
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2005075016A1 (ja) 2004-02-03 2005-08-18 Hisamitsu Pharmaceutical Co., Inc. 経皮薬物投与装置用インタフェース
WO2005082593A1 (en) 2004-02-17 2005-09-09 Avery Dennison Corporation Method of making microneedles
US8915957B2 (en) * 2004-03-11 2014-12-23 Alcatel Lucent Drug delivery stent
US7611481B2 (en) 2004-03-24 2009-11-03 Corium International, Inc. Transdermal delivery device
US20070249552A1 (en) 2004-05-12 2007-10-25 Kamel Khalili Compositions and Methods for Sirna Inhibition of Primate Polyomavirus Genes
EP1759245B1 (en) 2004-05-28 2008-11-05 Obducat AB Modified metal mold for use in imprinting processes
US7315758B2 (en) 2004-06-03 2008-01-01 Lynntech, Inc. Transdermal delivery of therapeutic agent
US20060025848A1 (en) * 2004-07-29 2006-02-02 Jan Weber Medical device having a coating layer with structural elements therein and method of making the same
US7537590B2 (en) 2004-07-30 2009-05-26 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
WO2006016364A2 (en) 2004-08-10 2006-02-16 Hellman De Picciotto, Tania Drug delivery devices
EP1790375A4 (en) 2004-08-12 2009-06-17 Hisamitsu Pharmaceutical Co TRANSDERMAL MEDICINE ADMINISTRATION WITH MICRONADEL
DE102004041813A1 (de) 2004-08-26 2006-03-02 Siemens Ag Oberfläche mit einer haftungsvermindernden Mikrostruktur und Verfahren zu deren Herstellung
SE0402100D0 (sv) 2004-08-30 2004-08-30 Bonsens Ab Molded micro-needles
KR101224257B1 (ko) 2004-11-18 2013-01-18 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로니들 어레이를 코팅하기 위한 마스킹 방법
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
AU2005314151B2 (en) 2004-12-07 2011-09-08 3M Innovative Properties Company Method of molding a microneedle
AU2005314289A1 (en) 2004-12-10 2006-06-15 3M Innovative Properties Company Medical device
WO2006075689A1 (ja) 2005-01-14 2006-07-20 Fujikura Ltd. 医薬物運搬用器具とその製造方法
US20070112548A1 (en) 2005-02-18 2007-05-17 Georgia Tech Research Corporation Methods for fabricating micro-to-nanoscale devices via biologically-induced solid formation on biologically-derived templates, and micro-to-nanoscale structures and micro-to-nanoscale devices made thereby
US7855046B2 (en) 2005-04-07 2010-12-21 The University Of North Carolina At Charlotte Method and apparatus for fabricating shaped structures and shaped structures including one- , two- or three-dimensional patterns incorporated therein
US20080269666A1 (en) * 2005-05-25 2008-10-30 Georgia Tech Research Corporation Microneedles and Methods for Microinfusion
ES2317159T3 (es) 2005-06-10 2009-04-16 Obducat Ab Replicacion de modelo con sello intermedio.
EP1904158B1 (en) 2005-06-24 2013-07-24 3M Innovative Properties Company Collapsible patch with microneedle array
JP2009502261A (ja) 2005-07-25 2009-01-29 ナノテクノロジー ビクトリア ピーティーワイ リミテッド マイクロアレイデバイス
US8118753B2 (en) 2005-08-18 2012-02-21 Seoul National University Industry Foundation Barb-wired micro needle made of single crystalline silicon and biopsy method and medicine injecting method using the same
EP1928537B1 (en) 2005-09-02 2015-01-21 Intercell USA, Inc. Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs
US7659252B2 (en) 2005-09-15 2010-02-09 Novomed Technologies, Inc. (Shanghai) Transdermal delivery peptides and method of use thereof
US20070066934A1 (en) 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
EP1928539A1 (en) 2005-09-30 2008-06-11 Tti Ellebeau, Inc. Functionalized microneedles transdermal drug delivery systems, devices, and methods
US20070112309A1 (en) 2005-11-17 2007-05-17 Jerry Zucker Withdrawal syringe
ATE549294T1 (de) 2005-12-09 2012-03-15 Obducat Ab Vorrichtung und verfahren zum transfer von mustern mit zwischenstempel
WO2007081876A2 (en) 2006-01-04 2007-07-19 Liquidia Technologies, Inc. Nanostructured surfaces for biomedical/biomaterial applications and processes thereof
US7658728B2 (en) 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
EP1992386B1 (en) 2006-02-10 2011-11-09 Hisamitsu Pharmaceutical Co., Inc. Transdermal drug administration apparatus having microneedles
EP1998844A4 (en) 2006-03-24 2017-03-01 3M Innovative Properties Company Process for making microneedles, microneedle arrays, masters, and replication tools
US20070224235A1 (en) * 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
JP5049268B2 (ja) 2006-04-07 2012-10-17 久光製薬株式会社 マイクロニードルデバイスおよびマイクロニードル付き経皮薬物投与装置
CA2650197A1 (en) 2006-05-09 2008-02-28 Apogee Technology, Inc. Nanofiber structures on asperities for sequestering, carrying and transferring substances
CA2651982C (en) * 2006-05-17 2014-07-15 Debiotech S.A. Anisotropic nanoporous coating for medical implants
DE102006031506A1 (de) 2006-07-07 2008-01-17 Robert Bosch Gmbh Verfahren zur Herstellung von Mikronadeln in einem Si-Halbleitersubstrat
WO2008020632A1 (fr) * 2006-08-18 2008-02-21 Toppan Printing Co., Ltd. Micro-aiguille et timbre à micro-aiguilles
DE102006040642A1 (de) 2006-08-30 2008-03-13 Robert Bosch Gmbh Mikronadeln zur Platzierung in der Haut zwecks transdermaler Applikation von Pharmazeutika
CA2663003C (en) 2006-09-08 2018-02-13 Justin Hanes Compositions and methods for enhancing transport through mucus
US20080097352A1 (en) 2006-09-12 2008-04-24 Beck Patricia A Methods of fabricating microneedles with bio-sensory functionality
GB0620617D0 (en) 2006-10-17 2006-11-29 Glaxo Group Ltd Novel device
EP2083876A4 (en) 2006-10-25 2012-09-19 Revalesio Corp WOUND CARE AND TREATMENT METHOD
US8238995B2 (en) * 2006-12-08 2012-08-07 General Electric Company Self-adhering electrodes and methods of making the same
EP2601883A1 (en) * 2006-12-22 2013-06-12 Medingo Ltd. Fluid delivery with in vivo electrochemical analyte sensing
WO2008115883A1 (en) * 2007-03-16 2008-09-25 The Regents Of The University Of California Nanostructure surface coated medical implants and methods of using the same
ES2817249T3 (es) 2007-04-16 2021-04-06 Corium Inc Matrices de microagujas obtenidas mediante disolución y colada que contienen un principio activo
US20080311172A1 (en) 2007-04-25 2008-12-18 Schapira Jay N Programmed-release, nanostructured biological construct
CA2695731C (en) 2007-08-06 2018-04-03 Transderm, Inc. Microneedle arrays formed from polymer films
US20100121307A1 (en) 2007-08-24 2010-05-13 Microfabrica Inc. Microneedles, Microneedle Arrays, Methods for Making, and Transdermal and/or Intradermal Applications
US20090093879A1 (en) * 2007-10-04 2009-04-09 Debra Wawro Micro- and nano-patterned surface features to reduce implant fouling and regulate wound healing
US20090093871A1 (en) * 2007-10-08 2009-04-09 Medtronic Vascular, Inc. Medical Implant With Internal Drug Delivery System
MX2010006699A (es) 2007-12-17 2010-11-30 New World Pharmaceuticals Llc Sistema integrado de entrega, diagnostico y comunicacion intradermicos.
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
EP2100850A1 (en) 2008-03-11 2009-09-16 Stichting Voor De Technische Wetenschappen Microneedle array and a method for manufacturing microneedles
WO2009114719A2 (en) 2008-03-13 2009-09-17 Richmond Chemical Corporation Apparatus and method of retaining and releasing molecules from nanostructures by an external stimulus
US20100004733A1 (en) * 2008-07-02 2010-01-07 Boston Scientific Scimed, Inc. Implants Including Fractal Structures
KR101028584B1 (ko) 2008-08-27 2011-04-12 주식회사 바이오프로테크 일회용 유도전극 및 이에 접속되는 리드선
CN101347652B (zh) 2008-09-09 2011-01-12 南京大学 一种空心微针阵列注射器的制备方法
US9566256B2 (en) 2008-09-22 2017-02-14 Biochemics, Inc. Transdermal drug delivery using an osmolyte and vasoactive agent
US8784385B2 (en) 2008-10-31 2014-07-22 The Invention Science Fund I, Llc Frozen piercing implements and methods for piercing a substrate
US20100130958A1 (en) 2008-11-26 2010-05-27 David Kang Device and Methods for Subcutaneous Delivery of High Viscosity Fluids
KR101039078B1 (ko) 2009-08-04 2011-06-07 (주)마이티시스템 이동되는 약물 저장 캡슐이 있는 미세바늘 약물 전달 시스템
WO2010070628A1 (en) 2008-12-19 2010-06-24 Janisys Limited A fluid transfer device and an active substance cartridge for the fluid transfer device, and a method for controlling the pressure at which an active substance is delivered to a subject from a fluid transfer device
KR101087088B1 (ko) * 2008-12-29 2011-11-25 한국과학기술연구원 나노 구조 패턴을 갖는 약물 방출용 스텐트의 제조방법 및 이로부터 제조된 약물 방출용 스텐트
KR101033513B1 (ko) 2009-01-20 2011-05-09 (주)마이티시스템 미세바늘을 이용한 유용성분 피부전달용 용기
AU2010242010B2 (en) * 2009-02-12 2015-06-18 Trustees Of Tufts College Nanoimprinting of silk fibroin structures for biomedical and biophotonic applications
EP2421595A1 (en) 2009-04-23 2012-02-29 National University of Singapore An apparatus that includes nano-sized projections and a method for manufacture thereof
US8389205B2 (en) 2009-06-11 2013-03-05 International Business Machines Corporation Patterning nano-scale patterns on a film comprising unzipping polymer chains
DE102009035795A1 (de) * 2009-07-31 2011-02-03 Leibniz-Institut Für Neue Materialien Gemeinnützige Gmbh Struktuierte Oberflächen für Implantate
US20110144591A1 (en) 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
WO2011116388A1 (en) 2010-03-19 2011-09-22 Nanostar Health Corporation Body fluid sampling/fluid delivery device
JP5860033B2 (ja) 2010-04-28 2016-02-16 キンバリー クラーク ワールドワイド インコーポレイテッド ｓｉＲＮＡ送達用の医療デバイス
WO2012046149A1 (en) 2010-04-28 2012-04-12 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
ES2636673T3 (es) 2010-04-28 2017-10-06 Kimberly-Clark Worldwide, Inc. Dispositivo para la administración de medicamentos contra la artritis reumatoide
WO2011135533A2 (en) 2010-04-28 2011-11-03 Kimberly-Clark Worldwide, Inc. Nanopatterned medical device with enhanced cellular interaction
US20130211310A1 (en) 2010-10-28 2013-08-15 3M Innovative Properties Company Engineered surfaces for reducing bacterial adhesion
US9017289B2 (en) 2010-11-03 2015-04-28 Covidien Lp Transdermal fluid delivery device
EP2665504A4 (en) 2011-01-18 2017-01-25 Massachusetts Institute of Technology Deployable barbed microneedle array and uses thereof
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles

Also Published As

Publication number Publication date
JP6535464B2 (ja) 2019-06-26
EP3995172B1 (en) 2024-08-21
US20140287019A1 (en) 2014-09-25
MX2014004690A (es) 2014-06-05
EP2771058B1 (en) 2019-05-01
US11925712B2 (en) 2024-03-12
EP3995172A1 (en) 2022-05-11
EP3542851B1 (en) 2021-12-15
CN103906549A (zh) 2014-07-02
AU2012328038A1 (en) 2014-04-10
EP2771058A4 (en) 2015-06-17
KR20140079429A (ko) 2014-06-26
PL3542851T3 (pl) 2022-04-25
BR112014009712A2 (pt) 2017-04-18
US20210401764A1 (en) 2021-12-30
ES2908653T3 (es) 2022-05-03
WO2013061209A1 (en) 2013-05-02
CA2850931A1 (en) 2013-05-02
AU2012328038B2 (en) 2016-11-17
EP3542851A1 (en) 2019-09-25
EP2771058A1 (en) 2014-09-03
HUE058275T2 (hu) 2022-07-28
JP2014530733A (ja) 2014-11-20
US11110066B2 (en) 2021-09-07
DK3542851T3 (da) 2022-03-14

Similar Documents

Publication Publication Date Title
RU2014119897A (ru) Имплантируемое устройство для доставки биоактивного агента
RU2014119898A (ru) Трансдермальная доставка высоковязких биоактивных агентов
Ball et al. Drug-eluting fibers for HIV-1 inhibition and contraception
ES2557303T3 (es) Agente terapéutico para la estenosis del canal espinal
ES2631980T3 (es) Formas de dosificación orales farmacéuticas que comprenden dabigatrán etexilato y sus sales farmacéuticamente aceptables
JP2015143257A (ja) 多孔質シリコン薬物溶出粒子
JP2010179112A5 (ru)
UY31698A (es) Preparacion solida de desintegracion oral
JP2008228958A (ja) 針状体および針状体製造方法
JP2014505018A (ja) 二重剥離層を用いる機能性ナノ粒子のナノインプリントリソグラフィ形成
JP2019511582A (ja) 治療剤の送達のためのケイ酸金属塩を含むポーラスシリコン物質
PE20060160A1 (es) Formulaciones de tableta recubierta que comprenden peliglitazar o muraglitazar y procedimiento
Xu et al. One-step large-scale nanotexturing of nonplanar PTFE surfaces to induce bactericidal and anti-inflammatory properties
WO2010118298A2 (en) Compositions and methods for bioactive coatings to improve allograft incorporation
ES2563632T3 (es) Composición de micropartículas biocompatibles de ácido algínico para la liberación controlada de principios activos por vía intravenosa
JP2013535239A5 (ru)
CO6270216A2 (es) Formulaciones galenicas de alisquireno
RU2019108058A (ru) Покрытие для имплантата
AR063330A1 (es) Nanoparticulas micelares incrustadas
RU2012150730A (ru) Медицинское устройство с наноузором с улучшенным взаимодействием с клеткой
Lee et al. 3-Dimensional coating polymer microneedles for economical and efficient transdermal drug delivery
Furuhashi et al. Influence of titanium surface topography on peri-implant soft tissue integration
TWI565484B (zh) 皮膚覆蓋物及其製造方法
Gokce et al. A Novel Alternative for the Treatment of Diabetic Foot Wounds: A Three Dimensional Porous Dermal Matrix
KR20240102765A (ko) 두창 백신 패치의 조성물 및 이의 제조 방법

Legal Events

Date Code Title Description
FA94 Acknowledgement of application withdrawn (non-payment of fees)

Effective date: 20180403