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RS59172B1 - Supstituisana jedinjenja hromana kao modulatori receptora osetljivog na kalcijum - Google Patents

Supstituisana jedinjenja hromana kao modulatori receptora osetljivog na kalcijum

Info

Publication number
RS59172B1
RS59172B1 RSP20191101A RS59172B1 RS 59172 B1 RS59172 B1 RS 59172B1 RS P20191101 A RSP20191101 A RS P20191101A RS 59172 B1 RS59172 B1 RS 59172B1
Authority
RS
Serbia
Prior art keywords
receptor modulators
sensing receptor
calcium sensing
chroman compounds
substituted chroman
Prior art date
Application number
Other languages
English (en)
Inventor
Manojkumar Ramprasad Shukla
Ankush Gangaram Sarde
Rajeshkumar Maganlal Loriya
Vipul Dilip Pachpute
Navnath Bajirao Walke
Talha Hussain Khan
Sanjeev Anant Kulkarni
Venkata P Palle
Rajender Kumar Kamboj
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of RS59172B1 publication Critical patent/RS59172B1/sr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RSP20191101 2012-02-24 2013-02-22 Supstituisana jedinjenja hromana kao modulatori receptora osetljivog na kalcijum RS59172B1 (sr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN178KO2012 2012-02-24
IN1030KO2012 2012-09-07
PCT/IB2013/051445 WO2013124828A1 (en) 2012-02-24 2013-02-22 Substituted chroman compounds as calcium sensing receptor modulators
EP13712928.4A EP2817299B1 (en) 2012-02-24 2013-02-22 Substituted chroman compounds as calcium sensing receptor modulators

Publications (1)

Publication Number Publication Date
RS59172B1 true RS59172B1 (sr) 2019-10-31

Family

ID=54261188

Family Applications (1)

Application Number Title Priority Date Filing Date
RSP20191101 RS59172B1 (sr) 2012-02-24 2013-02-22 Supstituisana jedinjenja hromana kao modulatori receptora osetljivog na kalcijum

Country Status (44)

Country Link
US (3) US9163001B2 (sr)
EP (1) EP2817299B1 (sr)
JP (1) JP6114316B2 (sr)
KR (1) KR102041154B1 (sr)
CN (1) CN104350047B (sr)
AP (1) AP2014007919A0 (sr)
AR (1) AR090135A1 (sr)
AU (1) AU2013223715B2 (sr)
BR (1) BR112014021133B1 (sr)
CA (1) CA2864332C (sr)
CL (1) CL2014002218A1 (sr)
CO (1) CO7160018A2 (sr)
CR (1) CR20140424A (sr)
CU (1) CU24325B1 (sr)
CY (1) CY1122017T1 (sr)
DK (1) DK2817299T3 (sr)
DO (1) DOP2014000193A (sr)
EA (1) EA026940B9 (sr)
ES (1) ES2743492T3 (sr)
GE (1) GEP20186911B (sr)
GT (1) GT201400179A (sr)
HK (1) HK1205117A1 (sr)
HR (1) HRP20191606T1 (sr)
HU (1) HUE046172T2 (sr)
IL (1) IL234252A (sr)
IN (1) IN2014MN01672A (sr)
LT (1) LT2817299T (sr)
MA (1) MA35937B1 (sr)
MX (1) MX355670B (sr)
MY (1) MY171374A (sr)
NI (1) NI201400094A (sr)
NZ (1) NZ628627A (sr)
PE (1) PE20142281A1 (sr)
PH (1) PH12014501891A1 (sr)
PL (1) PL2817299T3 (sr)
PT (1) PT2817299T (sr)
RS (1) RS59172B1 (sr)
SG (1) SG11201405117SA (sr)
SI (1) SI2817299T1 (sr)
TN (1) TN2014000352A1 (sr)
TW (1) TWI617549B (sr)
UA (1) UA112679C2 (sr)
WO (1) WO2013124828A1 (sr)
ZA (1) ZA201405990B (sr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU24325B1 (es) * 2012-02-24 2018-03-13 Lupin Atlantis Holdings Sa Compuestos de cromano sustituidos como modulares del receptor sensible al calcio para tratar enfermedades o desórdenes asociados con estos moduladores
JP2015528462A (ja) * 2012-08-27 2015-09-28 ルピン・リミテッドLupin Limited カルシウム感知受容体モジュレーターとしてのアリールアルキルアミン化合物
TW201602062A (zh) 2013-08-12 2016-01-16 魯賓有限公司 取代聯苯基化合物作為鈣敏感受體調節劑
US9493396B2 (en) 2013-08-28 2016-11-15 Lupin Atlantis Holdings Sa Substituted naphthalene compounds as calcium sensing receptor modulators
WO2015162538A1 (en) 2014-04-21 2015-10-29 Lupin Limited Heterocyclic compounds as calcium sensing receptor modulators for the treatment of hyperparathyroidism, chronic renal failure and chronic kidney disease
WO2017037616A1 (en) 2015-08-31 2017-03-09 Lupin Limited Arylalkylamine compounds as calcium sensing receptor modulators
WO2021100059A1 (en) * 2019-11-19 2021-05-27 Lupin Limited Process for preparing chroman compounds
EP4081210A1 (en) 2019-12-27 2022-11-02 Lupin Limited Pharmaceutical composition of casr modulators and methods and uses thereof
US20230140054A1 (en) * 2020-01-17 2023-05-04 Lupin Limited Methods, processes and intermediates for preparing chroman compounds

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DE3063585D1 (en) * 1979-05-19 1983-07-07 Beecham Group Plc Chroman derivatives, processes for their preparation and pharmaceutical compositions containing them
US5387587A (en) * 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
US6133277A (en) 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
FR2809396B1 (fr) 2000-05-24 2005-10-14 Centre Nat Rech Scient Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation
FR2812875B1 (fr) 2000-08-08 2003-12-12 Centre Nat Rech Scient Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation
US7105537B2 (en) 2003-01-28 2006-09-12 Bristol-Myers Squibb Company 2-substituted cyclic amines as calcium sensing receptor modulators
CA2527203C (en) 2003-05-28 2010-08-17 Japan Tobacco Inc. Casr antagonist
KR101335050B1 (ko) 2005-05-19 2013-11-29 아스텔라스세이야쿠 가부시키가이샤 피롤리딘 유도체 또는 그의 염
TW200815388A (en) 2006-04-18 2008-04-01 Wyeth Corp Chromane and chromene derivatives and uses thereof
CA2663436A1 (en) 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
MX2009003981A (es) * 2006-10-26 2009-04-27 Amgen Inc Agentes moduladores del receptor de calcio.
WO2008059854A1 (fr) 2006-11-16 2008-05-22 Astellas Pharma Inc. Dérivés de pipéridine ou sels de ceux-ci
JP5478496B2 (ja) * 2007-10-15 2014-04-23 アムジエン・インコーポレーテツド カルシウム受容体調節剤
EP2234961A2 (en) 2007-11-23 2010-10-06 Leo Pharma A/S Novel cyclic hydrocarbon compounds for the treatment of diseases
WO2010038895A1 (ja) 2008-10-03 2010-04-08 味の素株式会社 CaSRアゴニスト
WO2010042642A1 (en) 2008-10-08 2010-04-15 Amgen Inc. Calcium receptor modulating agents
CA2762137A1 (en) 2009-05-27 2010-12-02 Leo Pharma A/S Novel calcium sensing receptor modulating compounds and pharmaceutical use thereof
WO2010150837A1 (ja) 2009-06-25 2010-12-29 第一三共株式会社 インドリン誘導体
WO2012069419A1 (en) 2010-11-26 2012-05-31 Leo Pharma A/S Calcium-sensing receptor-active compounds
EP2643298A1 (en) 2010-11-26 2013-10-02 Leo Pharma A/S Substituted cyclopentyl - azines as casr- active compounds
CN103391920A (zh) 2010-11-26 2013-11-13 利奥制药有限公司 钙敏感受体激活化合物
US9382216B2 (en) 2011-03-10 2016-07-05 Lupin Limited Substituted morpholines as modulators for the calcium sensing receptor
EP2686306B1 (en) 2011-03-18 2017-01-04 Lupin Atlantis Holdings SA Benzo[b][1,4]oxazin derivatives as calcium sensing receptor modulators
CU24325B1 (es) * 2012-02-24 2018-03-13 Lupin Atlantis Holdings Sa Compuestos de cromano sustituidos como modulares del receptor sensible al calcio para tratar enfermedades o desórdenes asociados con estos moduladores

Also Published As

Publication number Publication date
US9598391B2 (en) 2017-03-21
CN104350047B (zh) 2017-05-24
IL234252A (en) 2017-02-28
US20150368222A1 (en) 2015-12-24
BR112014021133B1 (pt) 2022-06-28
UA112679C2 (uk) 2016-10-10
AR090135A1 (es) 2014-10-22
EA026940B9 (ru) 2017-11-30
HK1205117A1 (en) 2015-12-11
EA026940B1 (ru) 2017-06-30
AP2014007919A0 (en) 2014-09-30
PH12014501891B1 (en) 2015-02-09
CU24325B1 (es) 2018-03-13
PL2817299T3 (pl) 2019-12-31
NZ628627A (en) 2017-02-24
CN104350047A (zh) 2015-02-11
CU20140103A7 (es) 2015-01-29
ES2743492T3 (es) 2020-02-19
US9987249B2 (en) 2018-06-05
EP2817299B1 (en) 2019-06-12
DOP2014000193A (es) 2017-01-15
CL2014002218A1 (es) 2015-03-06
TW201336831A (zh) 2013-09-16
CR20140424A (es) 2015-01-13
EP2817299A1 (en) 2014-12-31
TN2014000352A1 (en) 2015-12-21
DK2817299T3 (da) 2019-09-16
MX355670B (es) 2018-04-25
LT2817299T (lt) 2019-09-25
AU2013223715A1 (en) 2014-08-28
US9163001B2 (en) 2015-10-20
JP2015508097A (ja) 2015-03-16
EA201491582A1 (ru) 2014-12-30
SG11201405117SA (en) 2014-09-26
US20170209410A1 (en) 2017-07-27
PE20142281A1 (es) 2015-01-16
JP6114316B2 (ja) 2017-04-12
TWI617549B (zh) 2018-03-11
PT2817299T (pt) 2019-09-23
SI2817299T1 (sl) 2019-10-30
US20150038546A1 (en) 2015-02-05
CO7160018A2 (es) 2015-01-15
CY1122017T1 (el) 2020-10-14
MY171374A (en) 2019-10-10
CA2864332C (en) 2020-08-25
BR112014021133A2 (pt) 2018-09-11
MA35937B1 (fr) 2014-12-01
NI201400094A (es) 2015-03-27
HUE046172T2 (hu) 2020-02-28
CA2864332A1 (en) 2013-08-29
KR102041154B1 (ko) 2019-11-07
ZA201405990B (en) 2015-11-25
IN2014MN01672A (sr) 2015-05-29
AU2013223715B2 (en) 2017-09-14
GEP20186911B (en) 2018-10-25
GT201400179A (es) 2016-03-01
WO2013124828A1 (en) 2013-08-29
PH12014501891A1 (en) 2015-02-09
MX2014010139A (es) 2015-09-04
KR20140135731A (ko) 2014-11-26
HRP20191606T1 (hr) 2019-12-13

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