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FR2812875B1 - Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation - Google Patents

Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation

Info

Publication number
FR2812875B1
FR2812875B1 FR0010427A FR0010427A FR2812875B1 FR 2812875 B1 FR2812875 B1 FR 2812875B1 FR 0010427 A FR0010427 A FR 0010427A FR 0010427 A FR0010427 A FR 0010427A FR 2812875 B1 FR2812875 B1 FR 2812875B1
Authority
FR
France
Prior art keywords
casr
preparation
modulating activity
novel diamines
diamines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0010427A
Other languages
English (en)
Other versions
FR2812875A1 (fr
Inventor
Philippe Marcel Dauban
Robert Dodd
Helene Veronique Faure
Martial Ruat
Pierre Jean Paul Potier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR0010427A priority Critical patent/FR2812875B1/fr
Priority to EP20010963065 priority patent/EP1409453A1/fr
Priority to PCT/FR2001/002562 priority patent/WO2002012181A1/fr
Priority to AU2001284113A priority patent/AU2001284113A1/en
Priority to US10/344,146 priority patent/US7157498B2/en
Priority to JP2002518159A priority patent/JP4896350B2/ja
Publication of FR2812875A1 publication Critical patent/FR2812875A1/fr
Application granted granted Critical
Publication of FR2812875B1 publication Critical patent/FR2812875B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/36Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D203/00Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/26Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR0010427A 2000-08-08 2000-08-08 Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation Expired - Fee Related FR2812875B1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR0010427A FR2812875B1 (fr) 2000-08-08 2000-08-08 Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation
EP20010963065 EP1409453A1 (fr) 2000-08-08 2001-08-07 Diamines possedant une activite modulatrice des casr
PCT/FR2001/002562 WO2002012181A1 (fr) 2000-08-08 2001-08-07 Nouvelles diamines possedant une activite modulatrice des casr
AU2001284113A AU2001284113A1 (en) 2000-08-08 2001-08-07 Novel diamines having a casr modulating activity
US10/344,146 US7157498B2 (en) 2000-08-08 2001-08-07 Diamines having a CaSR modulating activity
JP2002518159A JP4896350B2 (ja) 2000-08-08 2001-08-07 Casr調節活性を有する新規ジアミン

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0010427A FR2812875B1 (fr) 2000-08-08 2000-08-08 Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation

Publications (2)

Publication Number Publication Date
FR2812875A1 FR2812875A1 (fr) 2002-02-15
FR2812875B1 true FR2812875B1 (fr) 2003-12-12

Family

ID=8853394

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0010427A Expired - Fee Related FR2812875B1 (fr) 2000-08-08 2000-08-08 Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation

Country Status (6)

Country Link
US (1) US7157498B2 (fr)
EP (1) EP1409453A1 (fr)
JP (1) JP4896350B2 (fr)
AU (1) AU2001284113A1 (fr)
FR (1) FR2812875B1 (fr)
WO (1) WO2002012181A1 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8362274B2 (en) * 2004-05-28 2013-01-29 Mitsubishi Tanabe Pharma Corporation Arylalkylamine compound and process for preparing the same
US7361789B1 (en) 2004-07-28 2008-04-22 Amgen Inc. Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis
FR2885129B1 (fr) * 2005-04-29 2007-06-15 Proskelia Sas Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation.
WO2007060026A1 (fr) * 2005-11-25 2007-05-31 Galapagos Sas Dérivés de l'urée utiles comme modulateurs des récepteurs du calcium
WO2007124465A2 (fr) * 2006-04-20 2007-11-01 Amgen Inc. Formules d'émulsions stables
JP5470653B2 (ja) * 2006-10-26 2014-04-16 アムジエン・インコーポレーテツド カルシウム受容体調節剤
ES2449340T3 (es) 2007-03-30 2014-03-19 Amgen Inc. Compuestos calcimiméticos para su uso en el tratamiento de trastornos intestinales
ES2476391T3 (es) * 2007-10-15 2014-07-14 Amgen Inc. Agentes moduladores de receptor de calcio
US8791147B2 (en) * 2008-10-08 2014-07-29 Amgen Inc. Calcium receptor modulating agents
WO2010104882A1 (fr) 2009-03-10 2010-09-16 Amgen Inc. Procédés de modulation de la motilité des spermatozoïdes
US8765676B2 (en) 2009-05-27 2014-07-01 Leo Pharma A/S Calcium sensing receptor modulating compounds and pharmaceutical use thereof
EP2435400A2 (fr) 2009-05-27 2012-04-04 Leo Pharma A/S Composés inédits modulant les récepteurs du calcium et leur utilisation pharmaceutique
CN102958908A (zh) 2010-06-30 2013-03-06 利奥制药有限公司 钙敏感受体激动化合物的新多晶型
JP5968880B2 (ja) 2010-06-30 2016-08-10 レオ ファーマ アクティーゼルスカブ カルシウム模倣化合物の新規多形
RU2013128968A (ru) 2010-11-26 2015-01-10 Лео Фарма А/С Соединения, активные в отношении кальций-чувствительного рецептора
JP2014500882A (ja) 2010-11-26 2014-01-16 レオ ファーマ アクティーゼルスカブ カルシウム感知受容体活性化合物
JP2014508104A (ja) 2010-11-26 2014-04-03 レオ ファーマ アクティーゼルスカブ カルシウム感知受容体活性化合物
US20130245084A1 (en) 2010-11-26 2013-09-19 Leo Pharma A/S Calcium-sensing receptor-active compounds
CA2828415A1 (fr) 2011-03-10 2012-09-13 Lupin Limited Morpholines substituees en tant que modulateurs pour le recepteur de calcium
WO2012127385A1 (fr) 2011-03-18 2012-09-27 Lupin Limited Dérivés benzo[b][1,4]oxazine en tant que modulateurs de récepteurs de détection de calcium
RS59172B1 (sr) 2012-02-24 2019-10-31 Lupin Ltd Supstituisana jedinjenja hromana kao modulatori receptora osetljivog na kalcijum
WO2013136288A1 (fr) 2012-03-16 2013-09-19 Lupin Limited Composés de type 3,4-dihydro-2h-benzo[b] [1,4]oxazine substituée utilisés en tant que modulateurs des récepteurs sensibles au calcium
WO2014033604A1 (fr) 2012-08-27 2014-03-06 Lupin Limited Composés d'arylalkylamine jouant le rôle de modulateurs des récepteurs sensibles au calcium
GB201217330D0 (en) 2012-09-28 2012-11-14 Univ Cardiff Therapeutic for treating inflammatory lung disorders
TW201602062A (zh) 2013-08-12 2016-01-16 魯賓有限公司 取代聯苯基化合物作為鈣敏感受體調節劑
US9493396B2 (en) 2013-08-28 2016-11-15 Lupin Atlantis Holdings Sa Substituted naphthalene compounds as calcium sensing receptor modulators
WO2015162538A1 (fr) 2014-04-21 2015-10-29 Lupin Limited Composés hétérocycliques en tant que modulateurs des récepteurs de détection du calcium pour le traitement de l'hyperparathyroïdie, de l'insuffisance rénale chronique et de la néphropathie chronique
WO2017037616A1 (fr) 2015-08-31 2017-03-09 Lupin Limited Composés d'arylalkylamine comme modulateurs des récepteurs sensibles au calcium
JP2023512754A (ja) 2019-12-27 2023-03-29 ルピン・リミテッド CaSRモジュレーターの医薬組成物ならびにその方法および使用
JP2023512918A (ja) 2020-01-17 2023-03-30 ルピン・リミテッド クロマン化合物を調製するための方法、プロセスおよび中間体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3262977A (en) * 1962-03-10 1966-07-26 Chinoin Gyogyszer Es Vegyeszet N-aralkyl-1, 1-diphenyl-propylamine derivatives
CA2173747C (fr) * 1991-08-23 2006-05-23 Edward F. Nemeth Arylalkylamines agissant sur les recepteurs du calcium
DK1281702T3 (da) * 1991-08-23 2006-04-18 Nps Pharma Inc Calciumreceptoraktive molekyler
EA002984B1 (ru) 1996-04-09 2002-12-26 Эн Пи Эс Фармасьютикалз, Инк. Кальцилитические соединения, фармацевтические композиции и способ скрининга кальцилитических соединений
EP0907631B1 (fr) * 1996-05-01 2003-06-18 Nps Pharmaceuticals, Inc. Composes servant a declencher l'activite d'un recepteur d'ions inorganiques
CA2285556A1 (fr) 1997-04-04 1998-10-15 Smithkline Beecham Corporation Composes calcilytiques
UY24949A1 (es) 1997-04-08 2001-04-30 Smithkline Beecham Corp Compuestos calcilíticos
AR014975A1 (es) 1998-04-08 2001-04-11 Nps Pharma Inc Compuestos calciliticos, una composicion farmaceutica que los comprende, y el uso de los mismos para la fabricacion de un medicamento
MY121054A (en) 1998-04-08 2005-12-30 Smithkline Beecham Corp Calcilytic compounds as calcium receptor antagonists.

Also Published As

Publication number Publication date
US20050192317A1 (en) 2005-09-01
JP4896350B2 (ja) 2012-03-14
AU2001284113A1 (en) 2002-02-18
FR2812875A1 (fr) 2002-02-15
JP2004505949A (ja) 2004-02-26
WO2002012181A1 (fr) 2002-02-14
US7157498B2 (en) 2007-01-02
EP1409453A1 (fr) 2004-04-21

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Effective date: 20150430