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RO65264A - Procede pour la preparation des derives des 6-aza-3 h-1,4-benzofiazepines - Google Patents

Procede pour la preparation des derives des 6-aza-3 h-1,4-benzofiazepines

Info

Publication number
RO65264A
RO65264A RO7281195A RO8119572A RO65264A RO 65264 A RO65264 A RO 65264A RO 7281195 A RO7281195 A RO 7281195A RO 8119572 A RO8119572 A RO 8119572A RO 65264 A RO65264 A RO 65264A
Authority
RO
Romania
Prior art keywords
benzofiazepines
aza
derivatives
preparation
benzofiazepines derivatives
Prior art date
Application number
RO7281195A
Other languages
English (en)
French (fr)
Inventor
Bebenburg Walter Von
Heribert Offermanns
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of RO65264A publication Critical patent/RO65264A/ro

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57Nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/73Unsubstituted amino or imino radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
RO7281195A 1971-12-09 1972-12-07 Procede pour la preparation des derives des 6-aza-3 h-1,4-benzofiazepines RO65264A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT1060471A AT333284B (de) 1971-12-09 1971-12-09 Verfahren zur herstellung von neuen 6-aza-3h-1,4-benzodiazepinen, deren optischen isomeren und deren salzen

Publications (1)

Publication Number Publication Date
RO65264A true RO65264A (fr) 1979-08-15

Family

ID=3623479

Family Applications (4)

Application Number Title Priority Date Filing Date
RO7281195A RO65264A (fr) 1971-12-09 1972-12-07 Procede pour la preparation des derives des 6-aza-3 h-1,4-benzofiazepines
RO7200073075A RO62312A (fr) 1971-12-09 1972-12-07 Procede pour la preparation des 6-aza-3h-1,4-benzodiazepines
RO7281196A RO65263A (ro) 1971-12-09 1972-12-07 Procedeu pentru prepararea unor derivati ai 6-aza/3h-benzodiazepinelor
RO7281197A RO67345A (ro) 1971-12-09 1972-12-07 Procedeu pentru prepararea 6-aza-1,2-dihioro-3b-1,4-benzodiazepinelor

Family Applications After (3)

Application Number Title Priority Date Filing Date
RO7200073075A RO62312A (fr) 1971-12-09 1972-12-07 Procede pour la preparation des 6-aza-3h-1,4-benzodiazepines
RO7281196A RO65263A (ro) 1971-12-09 1972-12-07 Procedeu pentru prepararea unor derivati ai 6-aza/3h-benzodiazepinelor
RO7281197A RO67345A (ro) 1971-12-09 1972-12-07 Procedeu pentru prepararea 6-aza-1,2-dihioro-3b-1,4-benzodiazepinelor

Country Status (26)

Country Link
JP (4) JPS569509B2 (ro)
AR (3) AR201201A1 (ro)
AT (4) AT332878B (ro)
AU (1) AU473253B2 (ro)
BE (1) BE792541A (ro)
CH (4) CH594665A5 (ro)
CS (1) CS212736B2 (ro)
DD (1) DD105448A5 (ro)
DE (1) DE2259471C2 (ro)
DK (1) DK138425B (ro)
EG (1) EG10918A (ro)
ES (2) ES409089A1 (ro)
FI (1) FI54710C (ro)
FR (1) FR2162482B1 (ro)
GB (1) GB1400755A (ro)
HU (1) HU169468B (ro)
IL (1) IL41034A (ro)
IT (1) IT1035053B (ro)
NL (1) NL171986C (ro)
NO (1) NO137094C (ro)
PL (3) PL89682B1 (ro)
RO (4) RO65264A (ro)
SE (1) SE404803B (ro)
SU (4) SU468423A3 (ro)
YU (2) YU305972A (ro)
ZA (1) ZA728497B (ro)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2364636C2 (de) * 1973-12-24 1982-11-04 Degussa Ag, 6000 Frankfurt Verfahren zur Herstellung von 2-Benzoyl-6-chlor-3-nitro-pyridinen
DE3067662D1 (en) * 1980-01-16 1984-06-07 Lacer Sa New 2-halo-pyridines, their production and pharmaceutical compositions
JPS60132610A (ja) * 1983-12-20 1985-07-15 Japan Organo Co Ltd 汚泥脱水装置
JPS6219221A (ja) * 1985-07-16 1987-01-28 Chiyoda Chem Eng & Constr Co Ltd 原液中の微細粒子を除去する濾過方法と濾過装置

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3314941A (en) * 1964-06-23 1967-04-18 American Cyanamid Co Novel substituted pyridodiazepins
US3523939A (en) * 1967-07-03 1970-08-11 Hoffmann La Roche 5-(2,6-disubstituted phenyl)-1,4-benzodiazepines and methods for their preparation

Also Published As

Publication number Publication date
DE2259471A1 (de) 1973-06-14
ZA728497B (en) 1973-09-26
FI54710B (fi) 1978-10-31
CH594665A5 (ro) 1978-01-13
JPS5744678B2 (ro) 1982-09-22
YU305972A (en) 1982-02-28
FI54710C (fi) 1979-02-12
CS212736B2 (en) 1982-03-26
ATA902074A (de) 1977-01-15
SE404803B (sv) 1978-10-30
SU674675A3 (ru) 1979-07-15
RO67345A (ro) 1980-07-15
AT332878B (de) 1976-10-25
AT338798B (de) 1977-09-12
SU468423A3 (ru) 1975-04-25
JPS4864096A (ro) 1973-09-05
AT332877B (de) 1976-10-25
RO65263B (ro) 1983-06-30
YU116881A (en) 1984-02-29
IL41034A0 (en) 1973-02-28
ATA902174A (de) 1976-02-15
FR2162482A1 (ro) 1973-07-20
NL7216621A (ro) 1973-06-13
JPS5625181A (en) 1981-03-10
IL41034A (en) 1976-10-31
JPS55147282A (en) 1980-11-17
ES409090A1 (es) 1975-10-16
RO65263A (ro) 1983-07-07
DD105448A5 (ro) 1974-04-20
JPS5625180A (en) 1981-03-10
RO62312A (fr) 1977-12-15
CH605946A5 (ro) 1978-10-13
AU4993172A (en) 1974-06-13
PL91828B1 (en) 1977-03-31
NL171986C (nl) 1983-06-16
JPS569509B2 (ro) 1981-03-02
PL91876B1 (en) 1977-03-31
JPS5742639B2 (ro) 1982-09-09
SU564809A3 (ru) 1977-07-05
FR2162482B1 (ro) 1976-03-05
CH603644A5 (ro) 1978-08-31
DE2259471C2 (de) 1982-08-19
CH603645A5 (ro) 1978-08-31
JPS5742638B2 (ro) 1982-09-09
PL89682B1 (en) 1976-12-31
ATA902274A (de) 1976-02-15
BE792541A (fr) 1973-06-08
HU169468B (ro) 1976-11-28
DK138425C (ro) 1979-02-12
EG10918A (en) 1981-12-31
IT1035053B (it) 1979-10-20
NO137094B (no) 1977-09-19
AR203311A1 (es) 1975-08-29
SU574156A3 (ru) 1977-09-25
AR200309A1 (es) 1974-10-31
AT333284B (de) 1976-11-10
NO137094C (no) 1977-12-28
ES409089A1 (es) 1975-10-16
DK138425B (da) 1978-09-04
AU473253B2 (en) 1976-06-17
NL171986B (nl) 1983-01-17
ATA1060471A (de) 1976-03-15
AR201201A1 (es) 1975-02-21
GB1400755A (en) 1975-07-23

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