PT88204A - New 2-piperidinyl:methyl-1,2,3,4-tetra:hydro-isoquinoline derivs. - with selective action on HT one A serotoninergic receptors, e.g. for treating depression and cardiovascular disease
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New 2-piperidinyl:methyl-1,2,3,4-tetra:hydro-isoquinoline derivs. - with selective action on HT one A serotoninergic receptors, e.g. for treating depression and cardiovascular disease
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Priority claimed from FR8711288Aexternal-prioritypatent/FR2619110B1/en
Priority claimed from FR8718342Aexternal-prioritypatent/FR2625504B2/en
Priority claimed from FR8805130Aexternal-prioritypatent/FR2630114B2/en
Application filed by SynthelabofiledCriticalSynthelabo
Publication of PT88204ApublicationCriticalpatent/PT88204A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Ni(piperidinylmethyl) -tetrahydroisoquinoline derivs. of formula (I) and their pharmaceutically acceptable acid addn. salts are new: R = (a) H; (b) 1-6C alkyl, allyl, 3-6C cycloalkylmethyl, benzyl (opt. substd. by 1-3 of halo, CF3, NO2, NH2, NMe2, CN, CONH2, or 1-3C alkyl, alkoxy or alkylthio), 2-phenylethyl, 3-phenylpropyl, 3-phenylpropen-2-yl, phenylcarbonylmethyl, naphthylmethyl, pyridylmethyl, furanylmethyl, or thienylmethyl; (c) 2-6C alkanoyl, 3-6C cycloalkylcarbonyl, CF3CO, phenylcarbonyl (opt. substd. by halo, CF3, NO2 or 1-3C alkyl, alkoxy or alkylthio), 1-oxo-3-phenylpropen-2-yl, naphthylcarbonyl, pyridinylcarbonyl, furancarbonyl, thienylcarbonyl or 2- or 5-indolylcarbonyl.
PT8820488A1987-08-071988-08-05New 2-piperidinyl:methyl-1,2,3,4-tetra:hydro-isoquinoline derivs. - with selective action on HT one A serotoninergic receptors, e.g. for treating depression and cardiovascular disease
PT88204A
(en)
New 2-piperidinyl:methyl-1,2,3,4-tetra:hydro-isoquinoline derivs. - with selective action on HT one A serotoninergic receptors, e.g. for treating depression and cardiovascular disease
The combination of (a) dextromethorphan or a pharmaceutically acceptable salt thereof, precursors or derivatives, e.g. dextromethorphan hydrobromide and in particular dextromethorphan hydrobromide monohydrate; and (b) quinidine or a pharmaceutically acceptable salt thereof, precursors or derivatives, e.g. quinidine sulfate and in particular quinidine sulfate dihydrate
New 2-piperidinyl:methyl-1,2,3,4-tetra:hydro-isoquinoline derivs. - with selective action on HT one A serotoninergic receptors, e.g. for treating depression and cardiovascular disease
PHARMACEUTICAL COMPOSITIONS, FOR TOPICAL USE, CONTAINING "SCAVENGERS" OF FREE OXYGEN RADICALS AND ANTIBACTERIALS, INDICATED IN THE THERAPY OF SURFACE TISSUES.