PT710109E - Metodo para identificar um inibidor de pde iv - Google Patents
Metodo para identificar um inibidor de pde ivInfo
- Publication number
- PT710109E PT710109E PT94920760T PT94920760T PT710109E PT 710109 E PT710109 E PT 710109E PT 94920760 T PT94920760 T PT 94920760T PT 94920760 T PT94920760 T PT 94920760T PT 710109 E PT710109 E PT 710109E
- Authority
- PT
- Portugal
- Prior art keywords
- pde
- inhibitor
- identifying
- value
- binds rolipram
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8003493A | 1993-06-18 | 1993-06-18 | |
US8037793A | 1993-06-21 | 1993-06-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT710109E true PT710109E (pt) | 2005-01-31 |
Family
ID=26762985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT94920760T PT710109E (pt) | 1993-06-18 | 1994-06-17 | Metodo para identificar um inibidor de pde iv |
Country Status (12)
Country | Link |
---|---|
US (1) | US6143782A (pt) |
EP (2) | EP1466598A3 (pt) |
JP (1) | JPH08511805A (pt) |
AT (1) | ATE275951T1 (pt) |
AU (1) | AU7174794A (pt) |
DE (1) | DE69433997T2 (pt) |
DK (1) | DK0710109T3 (pt) |
ES (1) | ES2229221T3 (pt) |
HK (1) | HK1012255A1 (pt) |
PT (1) | PT710109E (pt) |
SI (1) | SI0710109T1 (pt) |
WO (1) | WO1995000139A1 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996027384A2 (en) * | 1995-03-08 | 1996-09-12 | Parfums Christian Dior | Composition for treating skin conditions comprising an inhibitor of skin iso-phosphodiesterase |
WO1998030718A1 (en) * | 1997-01-09 | 1998-07-16 | Merck Frosst Canada Co. | System for stably expressing a high-affinity camp phosphodiesterase and use thereof |
US5922557A (en) * | 1997-01-09 | 1999-07-13 | Merck & Co., Inc. | System for stably expressing a high-affinity camp phosphodiesterase and use thereof |
DZ3019A1 (fr) | 1999-03-01 | 2005-05-20 | Smithkline Beecham Corp | Utilisation d'un inhibiteur de pde4 dans la préparation d'un médicament contre la copd. |
DE19928412C2 (de) * | 1999-06-22 | 2002-03-21 | Agilent Technologies Inc | Versorgungselement für einen Labor-Mikrochip |
ECSP003747A (es) * | 1999-11-02 | 2002-05-23 | Smithkline Beecham Corp | Metodo y composiciones para el tratamiento de las enfermedades pulmonares |
EP1265861A2 (en) | 2000-03-16 | 2002-12-18 | Inflazyme Pharmaceuticals, Ltd. | Benzylated pde4 inhibitors |
US7250518B2 (en) | 2001-01-31 | 2007-07-31 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
BR0116850A (pt) | 2001-01-31 | 2004-02-25 | Pfizer Prod Inc | Derivados de amida de ácido tiazolil-, oxazolil-, pirrolil- e imidazolil- úteis como inibidores de isoenzimas de pde4 |
SK8792003A3 (en) | 2001-01-31 | 2004-09-08 | Pfizer Prod Inc | Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes and pharmaceutical composition containing them |
ATE305467T1 (de) | 2001-01-31 | 2005-10-15 | Pfizer Prod Inc | Als inhibitoren von pde4-isozymen geeignete etherderivate |
EP1370211A4 (en) * | 2001-03-02 | 2005-02-09 | Bristol Myers Squibb Co | SIMULTANEOUS ADMINISTRATION OF MELANOCORTIN RECEPTOR AGONISTS AND A PHOSPHODIESTERASE HEMMER FOR THE TREATMENT OF DISEASES RELATED TO CYCLIC AMP |
WO2004067006A1 (en) * | 2003-01-27 | 2004-08-12 | Pharmacia Corporation | Combination of a pde iv inhibitor and a tnf-alpha antagonist |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4109926A (en) * | 1976-04-09 | 1978-08-29 | Lane Gilbert M | Utility cart |
US4795757A (en) * | 1984-09-04 | 1989-01-03 | Rorer Pharmaceutical Corporation | Bisarylamines |
US5128358A (en) * | 1988-01-19 | 1992-07-07 | Pfizer Inc. | Aryl substituted nitrogen heterocyclic antidepressants |
JPH06501679A (ja) * | 1990-07-10 | 1994-02-24 | スミスクライン・ビーチャム・コーポレイション | オキサミド |
PT100441A (pt) * | 1991-05-02 | 1993-09-30 | Smithkline Beecham Corp | Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso |
WO1993019751A1 (en) * | 1992-04-02 | 1993-10-14 | Smithkline Beecham Corporation | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor |
JP3192424B2 (ja) * | 1992-04-02 | 2001-07-30 | スミスクライン・ビーチャム・コーポレイション | アレルギーまたは炎症疾患の治療用化合物 |
AU3803593A (en) * | 1992-04-02 | 1993-11-08 | Smithkline Beecham Corporation | Compounds |
EP0633776B1 (en) * | 1992-04-02 | 2001-05-09 | Smithkline Beecham Corporation | Compounds useful for treating allergic and inflammatory diseases |
US5576329A (en) * | 1992-07-24 | 1996-11-19 | Hennessey; Richard K. | Method for treating tendon or joint inflammation with papaverine HCL |
GB9404706D0 (en) * | 1994-03-11 | 1994-04-27 | Smithkline Beecham Corp | Compounds |
-
1994
- 1994-06-17 AU AU71747/94A patent/AU7174794A/en not_active Abandoned
- 1994-06-17 JP JP7502974A patent/JPH08511805A/ja not_active Ceased
- 1994-06-17 EP EP04076173A patent/EP1466598A3/en not_active Withdrawn
- 1994-06-17 AT AT94920760T patent/ATE275951T1/de not_active IP Right Cessation
- 1994-06-17 DE DE69433997T patent/DE69433997T2/de not_active Expired - Fee Related
- 1994-06-17 WO PCT/US1994/006861 patent/WO1995000139A1/en active IP Right Grant
- 1994-06-17 ES ES94920760T patent/ES2229221T3/es not_active Expired - Lifetime
- 1994-06-17 SI SI9430469T patent/SI0710109T1/xx unknown
- 1994-06-17 PT PT94920760T patent/PT710109E/pt unknown
- 1994-06-17 EP EP94920760A patent/EP0710109B1/en not_active Expired - Lifetime
- 1994-06-17 DK DK94920760T patent/DK0710109T3/da active
-
1995
- 1995-05-31 US US08/456,274 patent/US6143782A/en not_active Expired - Fee Related
-
1998
- 1998-12-15 HK HK98113514A patent/HK1012255A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0710109B1 (en) | 2004-09-15 |
EP1466598A2 (en) | 2004-10-13 |
EP0710109A4 (en) | 1999-01-20 |
EP1466598A3 (en) | 2007-06-27 |
JPH08511805A (ja) | 1996-12-10 |
US6143782A (en) | 2000-11-07 |
HK1012255A1 (en) | 1999-07-30 |
EP0710109A1 (en) | 1996-05-08 |
SI0710109T1 (en) | 2005-02-28 |
DK0710109T3 (da) | 2005-01-03 |
ES2229221T3 (es) | 2005-04-16 |
ATE275951T1 (de) | 2004-10-15 |
DE69433997D1 (de) | 2004-10-21 |
WO1995000139A1 (en) | 1995-01-05 |
DE69433997T2 (de) | 2005-01-27 |
AU7174794A (en) | 1995-01-17 |
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