DK0710109T3 - Fremgangsmåde til identifikation af en PDE IV inhibitor - Google Patents
Fremgangsmåde til identifikation af en PDE IV inhibitorInfo
- Publication number
- DK0710109T3 DK0710109T3 DK94920760T DK94920760T DK0710109T3 DK 0710109 T3 DK0710109 T3 DK 0710109T3 DK 94920760 T DK94920760 T DK 94920760T DK 94920760 T DK94920760 T DK 94920760T DK 0710109 T3 DK0710109 T3 DK 0710109T3
- Authority
- DK
- Denmark
- Prior art keywords
- pde
- inhibitor
- identifying
- value
- binds rolipram
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8003493A | 1993-06-18 | 1993-06-18 | |
US8037793A | 1993-06-21 | 1993-06-21 | |
PCT/US1994/006861 WO1995000139A1 (en) | 1993-06-18 | 1994-06-17 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0710109T3 true DK0710109T3 (da) | 2005-01-03 |
Family
ID=26762985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94920760T DK0710109T3 (da) | 1993-06-18 | 1994-06-17 | Fremgangsmåde til identifikation af en PDE IV inhibitor |
Country Status (12)
Country | Link |
---|---|
US (1) | US6143782A (da) |
EP (2) | EP0710109B1 (da) |
JP (1) | JPH08511805A (da) |
AT (1) | ATE275951T1 (da) |
AU (1) | AU7174794A (da) |
DE (1) | DE69433997T2 (da) |
DK (1) | DK0710109T3 (da) |
ES (1) | ES2229221T3 (da) |
HK (1) | HK1012255A1 (da) |
PT (1) | PT710109E (da) |
SI (1) | SI0710109T1 (da) |
WO (1) | WO1995000139A1 (da) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11501311A (ja) * | 1995-03-08 | 1999-02-02 | パルファン、クリスチャン、ディオール | 皮膚イソホスホジエステラーゼの阻害剤を含んでなる皮膚疾患を治療するための組成物 |
CA2277430A1 (en) * | 1997-01-09 | 1998-07-16 | Merck Frosst Canada & Co. | System for stably expressing a high-affinity camp phosphodiesterase and use thereof |
US5922557A (en) * | 1997-01-09 | 1999-07-13 | Merck & Co., Inc. | System for stably expressing a high-affinity camp phosphodiesterase and use thereof |
DZ3019A1 (fr) | 1999-03-01 | 2005-05-20 | Smithkline Beecham Corp | Utilisation d'un inhibiteur de pde4 dans la préparation d'un médicament contre la copd. |
DE19928412C2 (de) * | 1999-06-22 | 2002-03-21 | Agilent Technologies Inc | Versorgungselement für einen Labor-Mikrochip |
AR029189A1 (es) * | 1999-11-02 | 2003-06-18 | Smithkline Beecham Corp | Uso de un inhibidor de fosfodiesterasa 4 y un corticoesteroide antiinflamatorio en forma combinada, separadamente o separadamente secuencial para la preparacion de un medicamento |
US6555572B2 (en) | 2000-03-16 | 2003-04-29 | Inflazyme Pharmaceuticals Ltd. | Benzylated PDE4 inhibitors |
US7250518B2 (en) | 2001-01-31 | 2007-07-31 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
ES2248231T3 (es) | 2001-01-31 | 2006-03-16 | Pfizer Products Inc. | Derivados de eteres utiles como inhibidores de las isozimas pde4. |
BR0116850A (pt) | 2001-01-31 | 2004-02-25 | Pfizer Prod Inc | Derivados de amida de ácido tiazolil-, oxazolil-, pirrolil- e imidazolil- úteis como inibidores de isoenzimas de pde4 |
BR0116852A (pt) | 2001-01-31 | 2004-02-25 | Pfizer Prod Inc | Derivados biarilados de nicotinamida úteis como inibidores de isozimas pde4 |
US20030069169A1 (en) * | 2001-03-02 | 2003-04-10 | Macor John E. | Co-administration of melanocortin receptor agonist and phosphodiesterase inhibitor for treatment of cyclic-AMP associated disorders |
US20060083714A1 (en) * | 2003-01-27 | 2006-04-20 | Warner James M | Combination of a pde iv inhibitor and a tnf-alpha antagonist |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4109926A (en) * | 1976-04-09 | 1978-08-29 | Lane Gilbert M | Utility cart |
US4795757A (en) * | 1984-09-04 | 1989-01-03 | Rorer Pharmaceutical Corporation | Bisarylamines |
US5128358A (en) * | 1988-01-19 | 1992-07-07 | Pfizer Inc. | Aryl substituted nitrogen heterocyclic antidepressants |
WO1992000968A1 (en) * | 1990-07-10 | 1992-01-23 | Smithkline Beecham Corporation | Oxamides |
PT100441A (pt) * | 1991-05-02 | 1993-09-30 | Smithkline Beecham Corp | Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso |
US5605923A (en) * | 1992-04-02 | 1997-02-25 | Smithkline Beecham Corporation | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor |
CA2133439C (en) * | 1992-04-02 | 2005-07-26 | Siegfried Benjamin Christensen, Iv | Compounds useful for treating allergic and inflammatory diseases |
WO1993019750A1 (en) * | 1992-04-02 | 1993-10-14 | Smithkline Beecham Corporation | Compounds useful for treating allergic or inflammatory diseases |
AU3803593A (en) * | 1992-04-02 | 1993-11-08 | Smithkline Beecham Corporation | Compounds |
US5576329A (en) * | 1992-07-24 | 1996-11-19 | Hennessey; Richard K. | Method for treating tendon or joint inflammation with papaverine HCL |
GB9404706D0 (en) * | 1994-03-11 | 1994-04-27 | Smithkline Beecham Corp | Compounds |
-
1994
- 1994-06-17 EP EP94920760A patent/EP0710109B1/en not_active Expired - Lifetime
- 1994-06-17 DK DK94920760T patent/DK0710109T3/da active
- 1994-06-17 AU AU71747/94A patent/AU7174794A/en not_active Abandoned
- 1994-06-17 DE DE69433997T patent/DE69433997T2/de not_active Expired - Fee Related
- 1994-06-17 WO PCT/US1994/006861 patent/WO1995000139A1/en active IP Right Grant
- 1994-06-17 ES ES94920760T patent/ES2229221T3/es not_active Expired - Lifetime
- 1994-06-17 EP EP04076173A patent/EP1466598A3/en not_active Withdrawn
- 1994-06-17 JP JP7502974A patent/JPH08511805A/ja not_active Ceased
- 1994-06-17 PT PT94920760T patent/PT710109E/pt unknown
- 1994-06-17 SI SI9430469T patent/SI0710109T1/xx unknown
- 1994-06-17 AT AT94920760T patent/ATE275951T1/de not_active IP Right Cessation
-
1995
- 1995-05-31 US US08/456,274 patent/US6143782A/en not_active Expired - Fee Related
-
1998
- 1998-12-15 HK HK98113514A patent/HK1012255A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1995000139A1 (en) | 1995-01-05 |
DE69433997D1 (de) | 2004-10-21 |
ATE275951T1 (de) | 2004-10-15 |
US6143782A (en) | 2000-11-07 |
EP1466598A2 (en) | 2004-10-13 |
EP0710109B1 (en) | 2004-09-15 |
SI0710109T1 (en) | 2005-02-28 |
PT710109E (pt) | 2005-01-31 |
EP0710109A4 (en) | 1999-01-20 |
DE69433997T2 (de) | 2005-01-27 |
JPH08511805A (ja) | 1996-12-10 |
ES2229221T3 (es) | 2005-04-16 |
EP1466598A3 (en) | 2007-06-27 |
HK1012255A1 (en) | 1999-07-30 |
AU7174794A (en) | 1995-01-17 |
EP0710109A1 (en) | 1996-05-08 |
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