PT67164B - Process for the preparation of hydantoin derivatives as therapeutic agents - Google Patents

Process for the preparation of hydantoin derivatives as therapeutic agents

Info

Publication number: PT67164B
Authority: PT; Portugal
Prior art keywords: preparation; therapeutic agents; hydantoin derivatives; hydantoin; derivatives
Prior art date: 1976-10-18

Application number

PT67164A

Other languages

Portuguese (pt)

Other versions

PT67164A (en

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-10-18

Filing date

1977-10-17

Publication date

1979-03-20

1977-02-11 Priority claimed from US05/767,803 external-priority patent/US4117230A/en

1977-10-17 Application filed by Pfizer filed Critical Pfizer

1977-11-01 Publication of PT67164A publication Critical patent/PT67164A/en

1979-03-20 Publication of PT67164B publication Critical patent/PT67164B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

PT67164A 1976-10-18 1977-10-17 Process for the preparation of hydantoin derivatives as therapeutic agents PT67164B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US73306276A	1976-10-18	1976-10-18
US05/767,803 US4117230A (en)	1976-10-18	1977-02-11	Hydantoin derivatives as therapeutic agents

Publications (2)

Publication Number	Publication Date
PT67164A PT67164A (en)	1977-11-01
PT67164B true PT67164B (en)	1979-03-20

Family

ID=27112515

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT67164A PT67164B (en)	1976-10-18	1977-10-17	Process for the preparation of hydantoin derivatives as therapeutic agents

Country Status (29)

Country	Link
JP (3)	JPS5353653A (en)
AR (1)	AR220901A1 (en)
AT (1)	AT356136B (en)
AU (1)	AU504978B2 (en)
BG (1)	BG28847A3 (en)
CA (1)	CA1088945A (en)
CH (1)	CH625511A5 (en)
DD (1)	DD131931A5 (en)
DE (4)	DE2746244C2 (en)
DK (1)	DK150302C (en)
ES (1)	ES463267A1 (en)
FI (1)	FI62307C (en)
FR (1)	FR2367754A1 (en)
GB (1)	GB1566171A (en)
GR (1)	GR70201B (en)
HK (1)	HK53881A (en)
IE (1)	IE45805B1 (en)
IL (1)	IL53094A0 (en)
KE (1)	KE3167A (en)
LU (1)	LU78330A1 (en)
MX (1)	MX4899E (en)
MY (1)	MY8200157A (en)
NL (1)	NL167434C (en)
NO (1)	NO148453C (en)
NZ (1)	NZ185358A (en)
PH (1)	PH15639A (en)
PT (1)	PT67164B (en)
SE (1)	SE437024B (en)
YU (1)	YU40821B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents
US4127665A (en) *	1978-01-18	1978-11-28	Pfizer Inc.	Thienohydantoin derivatives
US4147797A (en) *	1978-08-11	1979-04-03	Pfizer Inc.	Spiro-furanohydantoin derivatives
US4200642A (en) *	1978-08-21	1980-04-29	Pfizer Inc.	Spiro-oxazolidindiones
US4181728A (en) *	1978-11-16	1980-01-01	Pfizer Inc.	Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) *	1979-03-21	1980-01-01	Pfizer Inc.	Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4235911A (en) *	1979-06-13	1980-11-25	Pfizer Inc.	Hydantoin derivatives
US4283409A (en) *	1979-10-29	1981-08-11	Pfizer Inc.	Imidazolone derivatives
US4286098A (en) *	1980-03-28	1981-08-25	Pfizer Inc.	Process for the preparation of chiral hydantoins
JPS5745185A (en) *	1980-07-21	1982-03-13	Eisai Co Ltd	Hydantoin derivative and its preparation
DE3262294D1 (en) *	1981-05-13	1985-03-28	Ici Plc	Pharmaceutical compositions containing spiro succinimide derivatives
JPS58213717A (en) *	1982-01-20	1983-12-12	Eisai Co Ltd	Remedy containing hydantoin derivative
JPS59500617A (en) *	1982-04-15	1984-04-12	アルコン・ラボラトリ−ズ・インコ−ポレ−テッド	Hydantoin therapeutic agent
HU193191B (en) *	1982-12-06	1987-08-28	Pfizer	Process for preparing spiro-hetero-azolones
US4474967A (en) *	1983-04-27	1984-10-02	Pfizer Inc.	8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
HU198051B (en) *	1984-10-30	1989-07-28	Pfizer	Process for producing spiro square brackets open imidazolidine-4,5'(6h)-quinoline square brackets closed-2,5-dione derivatives
JPS61200991A (en) *	1985-03-04	1986-09-05	Sanwa Kagaku Kenkyusho:Kk	Novel spiro-3-heteroazolidine compound, production thereof, preventive and remedy for diabetic complication comprising same as active ingredient
US4575507A (en) *	1985-05-29	1986-03-11	Pfizer Inc.	Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
JPS6357588A (en) *	1986-08-28	1988-03-12	Sanwa Kagaku Kenkyusho Co Ltd	Hydantoin derivative, salt and, production thereof and preventing and treating, agent for diabetic complication
HU204832B (en) *	1987-09-04	1992-02-28	Pfizer	Process for producing spiro-(imidazolidine-4,4'-pyrano/2,3-b/pyridine) derivatives and pharmaceutical compositions comprising same
GB2355264A (en)	1999-09-30	2001-04-18	Merck & Co Inc	Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
WO2003088915A2 (en)	2002-04-18	2003-10-30	University Of Virginia Patent Foundation	Novel sodium channel blockers
FR2955107B1 (en)	2010-01-08	2012-03-02	Servier Lab	NOVEL THIOCHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB818724A (en) *	1956-10-18	1959-08-19	Ici Ltd	Hydantoin derivatives
DE1135915B (en) *	1961-06-29	1962-09-06	Asta Werke Ag Chem Fab	Process for the production of new, anticonvulsant spirohydantoins
US3532744A (en) *	1967-07-28	1970-10-06	American Home Prod	1- and 2-amino substituted indane and tetralene carboxylic acids
US3821383A (en)	1972-07-10	1974-06-28	Ayerst Mckenna & Harrison	Compositions for and a method of treating diabetic complications
DE2449030A1 (en) *	1974-10-11	1976-05-20	Schering Ag	NEW PYRIDINE DERIVATIVES
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents

1977
- 1977-09-30 CA CA287,868A patent/CA1088945A/en not_active Expired
- 1977-10-03 SE SE7711053A patent/SE437024B/en not_active IP Right Cessation
- 1977-10-04 GR GR54503A patent/GR70201B/el unknown
- 1977-10-05 NZ NZ185358A patent/NZ185358A/en unknown
- 1977-10-06 AU AU29431/77A patent/AU504978B2/en not_active Expired
- 1977-10-10 IL IL53094A patent/IL53094A0/en not_active IP Right Cessation
- 1977-10-10 YU YU2442/77A patent/YU40821B/en unknown
- 1977-10-14 PH PH20335A patent/PH15639A/en unknown
- 1977-10-14 FI FI773060A patent/FI62307C/en not_active IP Right Cessation
- 1977-10-14 DE DE2746244A patent/DE2746244C2/en not_active Expired
- 1977-10-14 DE DE2759543A patent/DE2759543C2/en not_active Expired
- 1977-10-14 DE DE2759927A patent/DE2759927C2/en not_active Expired
- 1977-10-14 DE DE2759542A patent/DE2759542C2/de not_active Expired
- 1977-10-15 ES ES463267A patent/ES463267A1/en not_active Expired
- 1977-10-17 CH CH1262677A patent/CH625511A5/en not_active IP Right Cessation
- 1977-10-17 DK DK461377A patent/DK150302C/en not_active IP Right Cessation
- 1977-10-17 NO NO773548A patent/NO148453C/en unknown
- 1977-10-17 FR FR7731216A patent/FR2367754A1/en active Granted
- 1977-10-17 MX MX776490U patent/MX4899E/en unknown
- 1977-10-17 JP JP12437177A patent/JPS5353653A/en active Granted
- 1977-10-17 PT PT67164A patent/PT67164B/en unknown
- 1977-10-17 NL NL7711358.A patent/NL167434C/en not_active IP Right Cessation
- 1977-10-17 IE IE2114/77A patent/IE45805B1/en not_active IP Right Cessation
- 1977-10-17 GB GB43122/77A patent/GB1566171A/en not_active Expired
- 1977-10-17 LU LU78330A patent/LU78330A1/en unknown
- 1977-10-18 BG BG037604A patent/BG28847A3/en unknown
- 1977-10-18 DD DD7700201582A patent/DD131931A5/en unknown
- 1977-10-18 AR AR269623A patent/AR220901A1/en active
- 1977-10-18 AT AT745977A patent/AT356136B/en not_active IP Right Cessation
1978
- 1978-11-25 JP JP53145926A patent/JPS607997B2/en not_active Expired
- 1978-11-25 JP JP53145925A patent/JPS5940388B2/en not_active Expired
1981
- 1981-10-09 KE KE3167A patent/KE3167A/en unknown
- 1981-11-05 HK HK538/81A patent/HK53881A/en unknown
1982
- 1982-12-30 MY MY157/82A patent/MY8200157A/en unknown

Also Published As

Publication number	Publication date
IL53094A0 (en)	1977-12-30
ES463267A1 (en)	1978-07-16
KE3167A (en)	1981-11-06
FI62307C (en)	1982-12-10
NO148453B (en)	1983-07-04
LU78330A1 (en)	1979-06-01
JPS5495570A (en)	1979-07-28
MY8200157A (en)	1982-12-31
BG28847A3 (en)	1980-07-15
FR2367754B1 (en)	1982-07-09
MX4899E (en)	1982-12-14
IE45805B1 (en)	1982-12-01
DE2759542C2 (en)	1988-07-07
GB1566171A (en)	1980-04-30
DE2759543C2 (en)	1987-04-09
AR220901A1 (en)	1980-12-15
JPS5495575A (en)	1979-07-28
FR2367754A1 (en)	1978-05-12
JPS5940388B2 (en)	1984-09-29
JPS5353653A (en)	1978-05-16
NZ185358A (en)	1979-06-08
NL167434C (en)	1981-12-16
PH15639A (en)	1983-03-11
DD131931A5 (en)	1978-08-09
FI773060A (en)	1978-04-19
HK53881A (en)	1981-11-13
ATA745977A (en)	1979-09-15
JPS607997B2 (en)	1985-02-28
JPS5534132B2 (en)	1980-09-04
NO773548L (en)	1978-04-19
DE2759927C2 (en)	1986-12-04
AU504978B2 (en)	1979-11-01
DE2746244A1 (en)	1978-04-20
NO148453C (en)	1983-10-12
DK461377A (en)	1978-04-19
DK150302B (en)	1987-02-02
CA1088945A (en)	1980-11-04
AU2943177A (en)	1979-04-12
SE7711053L (en)	1978-04-19
YU244277A (en)	1982-08-31
CH625511A5 (en)	1981-09-30
NL7711358A (en)	1978-04-20
NL167434B (en)	1981-07-16
IE45805L (en)	1978-04-18
AT356136B (en)	1980-04-10
YU40821B (en)	1986-06-30
DK150302C (en)	1987-09-28
SE437024B (en)	1985-02-04
PT67164A (en)	1977-11-01
GR70201B (en)	1982-08-31
DE2746244C2 (en)	1983-05-19
FI62307B (en)	1982-08-31

Publication	Publication Date	Title
ZA775907B (en)	1978-05-30	Hydantoin derivatives as therapeutic agents
PT67164B (en)	1979-03-20	Process for the preparation of hydantoin derivatives as therapeutic agents
PT66445B (en)	1979-03-09	Process for the preparation of novel anthelmintic agents
PT68071B (en)	1979-10-26	Process for preparing hydantoin therapeutic agents
HRP940703B1 (en)	1997-02-28	Process for the preparation of heterocyclic phenyleters
HRP931392B1 (en)	1996-04-30	Process for the preparation of new alkyloxyme derivatives of 7-aminothiazolyl-acetamido-cephalosporicycloprn acid
RO83052B (en)	1984-02-28	Process for the preparation of phenetanoleamine derivatives
PT70571A (en)	1980-01-01	Process for the preparation of imidazole derivatives
GB1535291A (en)	1978-12-13	Process for the preparation of amoxycillin
DE3064993D1 (en)	1983-11-03	Process for the preparation of hexahydronaphthacene derivatives
PT67096B (en)	1979-02-23	Process for the preparation of n-substituted bis-carbamoylsulfide compounds
GR63697B (en)	1979-11-29	Process for derivatives preparation of phenyl-alamine
PT71582A (en)	1980-08-01	Process for the preparation of 3-methyleneazetidine derivatives
CY1176A (en)	1983-06-10	Process for the preparation of benzopyrane derivatives
GR63658B (en)	1979-11-28	Process for derivatives preparation of naphyridine
GR65298B (en)	1980-08-01	Process for the preparation of benzimidazole derivatives
DE2860746D1 (en)	1981-09-10	Process for the preparation of 3-bromomethyl-3-cephem-sulphoxide derivatives
IL54206A0 (en)	1978-06-15	Process for the preparation of , -dialkoxycarboxylic acid derivatives
GB1519931A (en)	1978-08-02	Process for the preparation of ethyl aminocyanoacetate
HU172137B (en)	1978-06-28	Process for preparing substituted derivatives of the phenoxy-propanolamine
PT66889B (en)	1979-01-25	Process for the preparation of derivatives of the d-threo-1-phenyl
GB1543317A (en)	1979-04-04	Process for the preparation of sodium amoxycillin
DE3066857D1 (en)	1984-04-12	Process for the preparation of benzimidazole derivatives
ZA767468B (en)	1977-11-30	Process for the preparation of 2-aminoindante derivatives
PT67266B (en)	1979-04-18	Process for the preparation of new phenilformamidine derivatives