AT356136B - METHOD FOR PRODUCING NEW SPIRO-HYDANTOINES - Google Patents

METHOD FOR PRODUCING NEW SPIRO-HYDANTOINES

Info

Publication number: AT356136B
Authority: AT; Austria
Prior art keywords: hydantoines; producing new; new spiro; spiro; producing
Prior art date: 1976-10-18

Application number

AT745977A

Other languages

German (de)

Other versions

ATA745977A (en

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-10-18

Filing date

1977-10-18

Publication date

1980-04-10

1977-02-11 Priority claimed from US05/767,803 external-priority patent/US4117230A/en

1977-10-18 Application filed by Pfizer filed Critical Pfizer

1979-09-15 Publication of ATA745977A publication Critical patent/ATA745977A/en

1980-04-10 Application granted granted Critical

1980-04-10 Publication of AT356136B publication Critical patent/AT356136B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT745977A 1976-10-18 1977-10-18 METHOD FOR PRODUCING NEW SPIRO-HYDANTOINES AT356136B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US73306276A	1976-10-18	1976-10-18
US05/767,803 US4117230A (en)	1976-10-18	1977-02-11	Hydantoin derivatives as therapeutic agents

Publications (2)

Publication Number	Publication Date
ATA745977A ATA745977A (en)	1979-09-15
AT356136B true AT356136B (en)	1980-04-10

Family

ID=27112515

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT745977A AT356136B (en)	1976-10-18	1977-10-18	METHOD FOR PRODUCING NEW SPIRO-HYDANTOINES

Country Status (29)

Country	Link
JP (3)	JPS5353653A (en)
AR (1)	AR220901A1 (en)
AT (1)	AT356136B (en)
AU (1)	AU504978B2 (en)
BG (1)	BG28847A3 (en)
CA (1)	CA1088945A (en)
CH (1)	CH625511A5 (en)
DD (1)	DD131931A5 (en)
DE (4)	DE2759542C2 (en)
DK (1)	DK150302C (en)
ES (1)	ES463267A1 (en)
FI (1)	FI62307C (en)
FR (1)	FR2367754A1 (en)
GB (1)	GB1566171A (en)
GR (1)	GR70201B (en)
HK (1)	HK53881A (en)
IE (1)	IE45805B1 (en)
IL (1)	IL53094A0 (en)
KE (1)	KE3167A (en)
LU (1)	LU78330A1 (en)
MX (1)	MX4899E (en)
MY (1)	MY8200157A (en)
NL (1)	NL167434C (en)
NO (1)	NO148453C (en)
NZ (1)	NZ185358A (en)
PH (1)	PH15639A (en)
PT (1)	PT67164B (en)
SE (1)	SE437024B (en)
YU (1)	YU40821B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents
US4127665A (en) *	1978-01-18	1978-11-28	Pfizer Inc.	Thienohydantoin derivatives
US4147797A (en) *	1978-08-11	1979-04-03	Pfizer Inc.	Spiro-furanohydantoin derivatives
US4200642A (en) *	1978-08-21	1980-04-29	Pfizer Inc.	Spiro-oxazolidindiones
US4181728A (en) *	1978-11-16	1980-01-01	Pfizer Inc.	Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) *	1979-03-21	1980-01-01	Pfizer Inc.	Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4235911A (en) *	1979-06-13	1980-11-25	Pfizer Inc.	Hydantoin derivatives
US4283409A (en) *	1979-10-29	1981-08-11	Pfizer Inc.	Imidazolone derivatives
US4286098A (en) *	1980-03-28	1981-08-25	Pfizer Inc.	Process for the preparation of chiral hydantoins
JPS5745185A (en) *	1980-07-21	1982-03-13	Eisai Co Ltd	Hydantoin derivative and its preparation
DE3262294D1 (en) *	1981-05-13	1985-03-28	Ici Plc	Pharmaceutical compositions containing spiro succinimide derivatives
JPS58213717A (en) *	1982-01-20	1983-12-12	Eisai Co Ltd	Remedy containing hydantoin derivative
JPS59500617A (en) *	1982-04-15	1984-04-12	アルコン・ラボラトリ−ズ・インコ−ポレ−テッド	Hydantoin therapeutic agent
ZA839023B (en) *	1982-12-06	1985-07-31	Pfizer	Spiro-3-hetero-azolones for treatment of diabetic complications
US4474967A (en) *	1983-04-27	1984-10-02	Pfizer Inc.	8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
HU198051B (en) *	1984-10-30	1989-07-28	Pfizer	Process for producing spiro square brackets open imidazolidine-4,5'(6h)-quinoline square brackets closed-2,5-dione derivatives
JPS61200991A (en) *	1985-03-04	1986-09-05	Sanwa Kagaku Kenkyusho:Kk	Novel spiro-3-heteroazolidine compound, production thereof, preventive and remedy for diabetic complication comprising same as active ingredient
US4575507A (en) *	1985-05-29	1986-03-11	Pfizer Inc.	Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
JPS6357588A (en) *	1986-08-28	1988-03-12	Sanwa Kagaku Kenkyusho Co Ltd	Hydantoin derivative, salt and, production thereof and preventing and treating, agent for diabetic complication
HU204832B (en) *	1987-09-04	1992-02-28	Pfizer	Process for producing spiro-(imidazolidine-4,4'-pyrano/2,3-b/pyridine) derivatives and pharmaceutical compositions comprising same
GB2355264A (en)	1999-09-30	2001-04-18	Merck & Co Inc	Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
CA2482035A1 (en)	2002-04-18	2003-10-30	University Of Virginia Patent Foundation	Novel sodium channel blockers
FR2955107B1 (en)	2010-01-08	2012-03-02	Servier Lab	NOVEL THIOCHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB818724A (en) *	1956-10-18	1959-08-19	Ici Ltd	Hydantoin derivatives
DE1135915B (en) *	1961-06-29	1962-09-06	Asta Werke Ag Chem Fab	Process for the production of new, anticonvulsant spirohydantoins
US3532744A (en) *	1967-07-28	1970-10-06	American Home Prod	1- and 2-amino substituted indane and tetralene carboxylic acids
US3821383A (en) *	1972-07-10	1974-06-28	Ayerst Mckenna & Harrison	Compositions for and a method of treating diabetic complications
DE2449030A1 (en) *	1974-10-11	1976-05-20	Schering Ag	NEW PYRIDINE DERIVATIVES
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents

1977
- 1977-09-30 CA CA287,868A patent/CA1088945A/en not_active Expired
- 1977-10-03 SE SE7711053A patent/SE437024B/en not_active IP Right Cessation
- 1977-10-04 GR GR54503A patent/GR70201B/el unknown
- 1977-10-05 NZ NZ185358A patent/NZ185358A/en unknown
- 1977-10-06 AU AU29431/77A patent/AU504978B2/en not_active Expired
- 1977-10-10 YU YU2442/77A patent/YU40821B/en unknown
- 1977-10-10 IL IL53094A patent/IL53094A0/en not_active IP Right Cessation
- 1977-10-14 PH PH20335A patent/PH15639A/en unknown
- 1977-10-14 DE DE2759542A patent/DE2759542C2/de not_active Expired
- 1977-10-14 FI FI773060A patent/FI62307C/en not_active IP Right Cessation
- 1977-10-14 DE DE2759543A patent/DE2759543C2/en not_active Expired
- 1977-10-14 DE DE2759927A patent/DE2759927C2/en not_active Expired
- 1977-10-14 DE DE2746244A patent/DE2746244C2/en not_active Expired
- 1977-10-15 ES ES463267A patent/ES463267A1/en not_active Expired
- 1977-10-17 NL NL7711358.A patent/NL167434C/en not_active IP Right Cessation
- 1977-10-17 MX MX776490U patent/MX4899E/en unknown
- 1977-10-17 NO NO773548A patent/NO148453C/en unknown
- 1977-10-17 LU LU78330A patent/LU78330A1/en unknown
- 1977-10-17 CH CH1262677A patent/CH625511A5/en not_active IP Right Cessation
- 1977-10-17 DK DK461377A patent/DK150302C/en not_active IP Right Cessation
- 1977-10-17 PT PT67164A patent/PT67164B/en unknown
- 1977-10-17 IE IE2114/77A patent/IE45805B1/en not_active IP Right Cessation
- 1977-10-17 FR FR7731216A patent/FR2367754A1/en active Granted
- 1977-10-17 JP JP12437177A patent/JPS5353653A/en active Granted
- 1977-10-17 GB GB43122/77A patent/GB1566171A/en not_active Expired
- 1977-10-18 AR AR269623A patent/AR220901A1/en active
- 1977-10-18 BG BG037604A patent/BG28847A3/en unknown
- 1977-10-18 DD DD7700201582A patent/DD131931A5/en unknown
- 1977-10-18 AT AT745977A patent/AT356136B/en not_active IP Right Cessation
1978
- 1978-11-25 JP JP53145925A patent/JPS5940388B2/en not_active Expired
- 1978-11-25 JP JP53145926A patent/JPS607997B2/en not_active Expired
1981
- 1981-10-09 KE KE3167A patent/KE3167A/en unknown
- 1981-11-05 HK HK538/81A patent/HK53881A/en unknown
1982
- 1982-12-30 MY MY157/82A patent/MY8200157A/en unknown

Also Published As

Publication number	Publication date
FI62307B (en)	1982-08-31
NL167434C (en)	1981-12-16
NL7711358A (en)	1978-04-20
AR220901A1 (en)	1980-12-15
JPS5495575A (en)	1979-07-28
LU78330A1 (en)	1979-06-01
ES463267A1 (en)	1978-07-16
GB1566171A (en)	1980-04-30
DD131931A5 (en)	1978-08-09
FR2367754B1 (en)	1982-07-09
AU504978B2 (en)	1979-11-01
DK150302B (en)	1987-02-02
JPS5940388B2 (en)	1984-09-29
JPS5495570A (en)	1979-07-28
FI62307C (en)	1982-12-10
JPS5534132B2 (en)	1980-09-04
IE45805B1 (en)	1982-12-01
JPS607997B2 (en)	1985-02-28
CA1088945A (en)	1980-11-04
YU244277A (en)	1982-08-31
DK461377A (en)	1978-04-19
JPS5353653A (en)	1978-05-16
NO773548L (en)	1978-04-19
MY8200157A (en)	1982-12-31
GR70201B (en)	1982-08-31
PH15639A (en)	1983-03-11
NZ185358A (en)	1979-06-08
FI773060A (en)	1978-04-19
MX4899E (en)	1982-12-14
NO148453B (en)	1983-07-04
DE2759542C2 (en)	1988-07-07
NO148453C (en)	1983-10-12
IL53094A0 (en)	1977-12-30
SE7711053L (en)	1978-04-19
SE437024B (en)	1985-02-04
HK53881A (en)	1981-11-13
IE45805L (en)	1978-04-18
KE3167A (en)	1981-11-06
DE2759927C2 (en)	1986-12-04
DE2746244A1 (en)	1978-04-20
ATA745977A (en)	1979-09-15
YU40821B (en)	1986-06-30
AU2943177A (en)	1979-04-12
DK150302C (en)	1987-09-28
PT67164B (en)	1979-03-20
DE2746244C2 (en)	1983-05-19
DE2759543C2 (en)	1987-04-09
FR2367754A1 (en)	1978-05-12
NL167434B (en)	1981-07-16
CH625511A5 (en)	1981-09-30
BG28847A3 (en)	1980-07-15
PT67164A (en)	1977-11-01

Publication	Publication Date	Title
AT356827B (en)	1980-05-27	METHOD FOR PRODUCING NEW SPIROL ACTONES
AT355571B (en)	1980-03-10	METHOD FOR PRODUCING NEW BIS -PYRIDINIUM COMPOUNDS
AT358727B (en)	1980-09-25	METHOD FOR PRODUCING NEW CEPHALOS PORINANTIBIOTICS
AT356136B (en)	1980-04-10	METHOD FOR PRODUCING NEW SPIRO-HYDANTOINES
AT363478B (en)	1981-08-10	METHOD FOR PRODUCING NEW OXEPANDERIVATIVES
AT359187B (en)	1980-10-27	METHOD FOR PRODUCING NEW 7-BETA- (2- -OXYIMINO-2-ARYLACETAMIDO) -CEPHALOSPORINES
AT370110B (en)	1983-03-10	METHOD FOR PRODUCING NEW 4-ANDROST-3-ONES
AT360185B (en)	1980-12-29	METHOD FOR PRODUCING NEW DEHYDRODIGOPEPTIDES
AT353987B (en)	1979-12-10	METHOD FOR PRODUCING NEW SPIROOXAZOLIDE INDIONS
AT362786B (en)	1981-06-10	METHOD FOR PRODUCING NEW 1-ACYL-2-IMIDAZOLINES
AT358726B (en)	1980-09-25	METHOD FOR PRODUCING NEW CEPHALOS PORINANTIBIOTICS
AT360037B (en)	1980-12-10	METHOD FOR PRODUCING NEW SUBSTITUTED PHENYLGUANIDINES
AT360647B (en)	1981-01-26	METHOD FOR PRODUCING NEW CEPHALOS PORINE COMPOUNDS
AT351191B (en)	1979-07-10	METHOD FOR PRODUCING NEW D-HOMOSTEROIDS
AT375931B (en)	1984-09-25	METHOD FOR PRODUCING NEW AMINOALKYLFURANDERIVATIVES
AT364364B (en)	1981-10-12	METHOD FOR PRODUCING NEW THIEPINES
AT343623B (en)	1978-06-12	METHOD FOR PRODUCING NEW N-ALKYL -4-NITRO-2-TRIFLUORMETHYLDIPHENYLAMINES
AT360646B (en)	1981-01-26	METHOD FOR PRODUCING NEW CEPHALOS PORINES
ATA175879A (en)	1980-02-15	METHOD FOR PRODUCING NEW ANTITUM ORGLYCOSIDES
ATA656076A (en)	1979-09-15	METHOD FOR PRODUCING NEW D-HOMOSTEROIDS
AT351515B (en)	1979-07-25	METHOD FOR PRODUCING NEW POLYEN COMPOUNDS
AT355210B (en)	1980-02-25	METHOD FOR PRODUCING NEW 1-OXA DETHIACEPHALOSPORINES
AT355039B (en)	1980-02-11	METHOD FOR PRODUCING NEW EATHED HYDROXY-BENZIMIDAZOLONES, - BENZOXAZOLONES, -BENZOXAZINONS, - CHINA-ZOLINONES AND -CHINOXAZOLINONES
AT364367B (en)	1981-10-12	METHOD FOR PRODUCING NEW OXEPINES
ATA570179A (en)	1980-08-15	METHOD FOR PRODUCING NEW D-HOMOSTEROIDS

Legal Events

Date	Code	Title	Description
1994-06-15	ELJ	Ceased due to non-payment of the annual fee