Nothing Special   »   [go: up one dir, main page]

PT670898E - Polipeptidos de multiplas mutacoes de interleucina-3 (il-3) - Google Patents

Polipeptidos de multiplas mutacoes de interleucina-3 (il-3)

Info

Publication number
PT670898E
PT670898E PT94902293T PT94902293T PT670898E PT 670898 E PT670898 E PT 670898E PT 94902293 T PT94902293 T PT 94902293T PT 94902293 T PT94902293 T PT 94902293T PT 670898 E PT670898 E PT 670898E
Authority
PT
Portugal
Prior art keywords
hil
muteins
amino acid
relates
present
Prior art date
Application number
PT94902293T
Other languages
English (en)
Inventor
Mark Allen Abrams
Sarah Ruth Braford-Goldberg
Maire Helena Caparon
Alan Michael Easton
Barbara Kure Klein
John Patrick Mckearn
Peter O Olins
John Warren Thomas
S Christopher Bauer
Kumman Paik
Joseph O Polazzi
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of PT670898E publication Critical patent/PT670898E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT94902293T 1992-11-24 1993-11-22 Polipeptidos de multiplas mutacoes de interleucina-3 (il-3) PT670898E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98104492A 1992-11-24 1992-11-24

Publications (1)

Publication Number Publication Date
PT670898E true PT670898E (pt) 2004-02-27

Family

ID=25528061

Family Applications (2)

Application Number Title Priority Date Filing Date
PT94902293T PT670898E (pt) 1992-11-24 1993-11-22 Polipeptidos de multiplas mutacoes de interleucina-3 (il-3)
PT94901584T PT672145E (pt) 1992-11-24 1993-11-22 Polipeptideos de interleucina-3(il-3) com multiplas mutacoes

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT94901584T PT672145E (pt) 1992-11-24 1993-11-22 Polipeptideos de interleucina-3(il-3) com multiplas mutacoes

Country Status (12)

Country Link
US (11) US5604116A (pt)
EP (4) EP1283264A3 (pt)
JP (3) JPH08503489A (pt)
KR (1) KR100332139B1 (pt)
AT (2) ATE251669T1 (pt)
AU (3) AU690088B2 (pt)
CA (2) CA2150117A1 (pt)
DE (2) DE69332908T2 (pt)
DK (2) DK0670898T3 (pt)
ES (2) ES2198416T3 (pt)
PT (2) PT670898E (pt)
WO (2) WO1994012639A2 (pt)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413509B1 (en) * 1992-11-24 2002-07-02 S. Christopher Bauer Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 mutant polypeptides with other hematopoietic growth factors
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
EP1283264A3 (en) * 1992-11-24 2004-03-10 G.D. Searle & Co. Interleukin-3 (IL-3) mutant polypeptides
US6436387B1 (en) * 1992-11-24 2002-08-20 G.D. Searle & Co. Methods of ex-vivo expansion of hematopoietic cells using multivariant IL-3 hematopoiesis chimera proteins
US6403076B1 (en) * 1992-11-24 2002-06-11 S. Christopher Bauer Compositions for increasing hematopoiesis with interleukin-3 mutants
US5772992A (en) * 1992-11-24 1998-06-30 G.D. Searle & Co. Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors
US6153183A (en) * 1992-11-24 2000-11-28 G. D. Searle & Company Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production
US6361976B1 (en) * 1992-11-24 2002-03-26 S. Christopher Bauer Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production
US6057133A (en) * 1992-11-24 2000-05-02 G. D. Searle Multivariant human IL-3 fusion proteins and their recombinant production
US7091319B1 (en) 1992-11-24 2006-08-15 Bauer S Christopher IL-3 variant hematopoiesis fusion protein
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
US5501962A (en) * 1993-06-21 1996-03-26 G. D. Searle & Co. Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same
US20050059149A1 (en) * 1993-11-22 2005-03-17 Bauer S. Christopher Methods of ex-vivo expansion of hematopoeitic cells using multivariant IL-3 hematopoiesis chimera proteins
US6465616B1 (en) 1994-04-08 2002-10-15 Bresagen Limited Interleukin-5 antagonist
NL1000332C1 (nl) * 1994-08-31 1996-03-04 Victor Smit Graduele chemische modificatie van biologisch actieve peptiden en eiwitten.
US6017523A (en) * 1995-06-06 2000-01-25 G.D. Searle & Co. Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides
US6066318A (en) * 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6171820B1 (en) 1995-12-07 2001-01-09 Diversa Corporation Saturation mutagenesis in directed evolution
US7495087B2 (en) 1997-07-14 2009-02-24 Bolder Biotechnology, Inc. Cysteine muteins in the C-D loop of human interleukin-11
AU2008203051B2 (en) * 1997-07-14 2011-07-28 Bolder Biotechnology, Inc Derivatives of growth hormone and related proteins
US7153943B2 (en) 1997-07-14 2006-12-26 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins, and methods of use thereof
US20080076706A1 (en) 1997-07-14 2008-03-27 Bolder Biotechnology, Inc. Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
WO1999003887A1 (en) 1997-07-14 1999-01-28 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins
US8288126B2 (en) 1999-01-14 2012-10-16 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US7270984B1 (en) * 1999-06-25 2007-09-18 Basf Aktiengesellschaft Polynucleotides encoding a 6-phosphogluconolactonase polypeptide from corynebacterium glutamicum
WO2001027621A2 (en) * 1999-10-07 2001-04-19 Pharmacia Corporation Competitive inhibition elisa for antibody detection
US6555660B2 (en) * 2000-01-10 2003-04-29 Maxygen Holdings Ltd. G-CSF conjugates
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
US6646110B2 (en) * 2000-01-10 2003-11-11 Maxygen Holdings Ltd. G-CSF polypeptides and conjugates
AU2001289307A1 (en) * 2000-04-06 2001-10-23 Pharmacia Corporation Chemically-modified myelopoietin conjugates
EP1364197B1 (en) * 2001-01-29 2010-04-14 Ivan N. Rich ATP-based assay for the determination of the proliferation status of hematopoietic stem and progenitor cells
US7989178B2 (en) * 2001-01-29 2011-08-02 Hemogenix, Inc. Colony assay miniaturization with enumeration output
US7666615B2 (en) * 2001-01-29 2010-02-23 Hemogenix, Inc. High-throughput assay of hematopoietic stem and progenitor cell proliferation
US7354730B2 (en) * 2002-01-29 2008-04-08 Hemogenix, Inc. High-throughput assay of hematopoietic stem and progenitor cell proliferation
KR100961859B1 (ko) * 2001-07-11 2010-06-09 맥시겐 홀딩스 엘티디 지-씨에스에프 접합체
AU2003208580A1 (en) * 2002-02-05 2003-09-02 Technion Research And Development Foundation Ltd Lineage committed stem cells selected for telomerase promoter activity
IL155783A (en) 2003-05-05 2010-11-30 Technion Res & Dev Foundation Multicellular systems of multi-potential embryonic human stem cells and cancer cells and their use
RU2007149238A (ru) 2005-06-01 2009-07-20 Максиджен Холдингз Лтд. (Ky) Пегилированные полипептиды гксф и способы их получения
US20100209341A1 (en) 2009-02-18 2010-08-19 Csl Limited Treatment of chronic inflammatory conditions
EP3406717B1 (en) 2009-07-17 2019-12-11 Bioatla LLC Simultaneous, integrated selection and evolution of antibody/protein performance and expression in production hosts
ES2741175T3 (es) 2010-07-16 2020-02-10 Bioatla Llc Nuevos métodos de evolución de proteínas
US8895291B2 (en) 2010-10-08 2014-11-25 Terumo Bct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
DK2847231T3 (da) 2012-05-10 2019-10-14 Bioatla Llc Multispecifikke monoklonale antistoffer
DE102012110664A1 (de) * 2012-11-07 2014-05-08 Henkel Ag & Co. Kgaa In Beschichtungsmitteln, Haftvermittlern oder Klebstoffen für oxidische Oberflächen einsetzbare Peptide
KR101510743B1 (ko) 2013-07-23 2015-04-10 (주)케어젠 파골 세포 분화 억제용 펩타이드 및 이의 용도
JP6612227B2 (ja) 2013-11-16 2019-11-27 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
WO2015105888A1 (en) 2014-01-07 2015-07-16 Bioatla, Llc Proteins targeting orthologs
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
CN109415696A (zh) 2016-05-25 2019-03-01 泰尔茂比司特公司 细胞扩增
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
CN117247899A (zh) 2017-03-31 2023-12-19 泰尔茂比司特公司 细胞扩增
GB201819187D0 (en) * 2018-11-26 2019-01-09 Univ Manchester Assay
CH717226B1 (it) * 2020-07-14 2021-09-30 Contrad Swiss Sa Idrogel per applicazione topica efficace nel limitare la degenerazione di tendini e muscoli.
JP2024511064A (ja) 2021-03-23 2024-03-12 テルモ ビーシーティー、インコーポレーテッド 細胞捕獲及び増殖

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4877729A (en) * 1986-07-14 1989-10-31 Genetics Institute, Inc. Recombinant DNA encoding novel family of primate hematopoietic growth factors
US4959455A (en) * 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
GR871029B (en) * 1986-07-14 1987-11-02 Genetics Inst Novel osteoinductive factors
US5032395A (en) * 1986-07-14 1991-07-16 Genetics Institute, Inc. Method of inducing leukocytosis with a combination of IL-3 and GM-CSF
DE3752158T2 (de) * 1986-12-16 1998-05-20 Gist Brocades Nv Molekulare Klonierung und Expression von menschlichem IL-3
EP0790307A1 (en) * 1986-12-16 1997-08-20 Gist-Brocades B.V. Molecular cloning and expression of human IL-3
JPH02501925A (ja) * 1987-01-20 1990-06-28 イミュネックス・コーポレーション ヒト　インターロイキン‐３　蛋白質
OA09736A (en) * 1987-02-18 1993-11-30 Schering Biotech Corp "Human interleukin-3 and muteins thereof".
GB2210883B (en) * 1987-10-08 1992-01-02 British Bio Technology Synthetic interleukin-3 gene
JPH04500508A (ja) * 1988-07-20 1992-01-30 イミュネックス・コーポレーション 非グリコシル化　ヒト　インターロイキン―３　組成物
NZ232913A (en) * 1989-03-15 1992-08-26 Gist Brocades Nv Il-3 produced recombinantly and purified to homogeneity; vectors and pharmaceutical preparations
US5166322A (en) * 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5128450A (en) * 1989-06-30 1992-07-07 Urdal David L Nonglycosylated human interleukin-3 analog proteins
US5516512A (en) * 1989-08-14 1996-05-14 Gist-Brocades, N.V. N- and C-terminal truncation and deletion mutants of human interleukin-3
EP0413383B1 (en) * 1989-08-14 1997-06-18 Gist-Brocades N.V. Mutants of human interleukin-3
JP3115318B2 (ja) * 1989-08-22 2000-12-04 イミュネックス・コーポレーション Ｇｍ―ｃｓｆ及びｉｌ―３を含む融合タンパク質
IL96477A0 (en) * 1989-12-01 1991-08-16 Amgen Inc Megakaryocyte production
JPH03236400A (ja) * 1990-02-09 1991-10-22 Kirin Brewery Co Ltd 化学修飾ポリペプチド及びその用途
JPH0463595A (ja) * 1990-04-03 1992-02-28 Kirin Brewery Co Ltd ヒトインターロイキン３誘導体
EP0503050A4 (en) * 1990-09-28 1994-07-06 Ortho Pharma Corp Hybrid growth factors
US5116322A (en) * 1990-11-23 1992-05-26 Colgate-Palmolive Company Method and apparatus for gluing closure flaps of a carton on a continuously moving conveyor
US5199942A (en) * 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
ES2133329T3 (es) * 1991-10-07 1999-09-16 Medvet Science Pty Ltd Variantes de il-3 humana.
EP1283264A3 (en) * 1992-11-24 2004-03-10 G.D. Searle & Co. Interleukin-3 (IL-3) mutant polypeptides
JP3236400B2 (ja) 1993-04-07 2001-12-10 旭化成株式会社 非水二次電池

Also Published As

Publication number Publication date
US5677149A (en) 1997-10-14
WO1994012639A3 (en) 1994-07-21
EP1283264A3 (en) 2004-03-10
US5817486A (en) 1998-10-06
WO1994012639A2 (en) 1994-06-09
US20050244372A1 (en) 2005-11-03
JPH08503706A (ja) 1996-04-23
US20030103936A1 (en) 2003-06-05
PT672145E (pt) 2003-08-29
WO1994012638A2 (en) 1994-06-09
DK0672145T3 (da) 2003-08-11
US6479261B1 (en) 2002-11-12
JPH08503489A (ja) 1996-04-16
US6458931B1 (en) 2002-10-01
AU690088B2 (en) 1998-04-23
DK0670898T3 (da) 2004-02-09
AU5670994A (en) 1994-06-22
ATE251669T1 (de) 2003-10-15
CA2150117A1 (en) 1994-06-09
EP0672145A1 (en) 1995-09-20
US20030220472A1 (en) 2003-11-27
EP0670898B1 (en) 2003-10-08
WO1994012638A3 (en) 1994-09-01
EP1361273A3 (en) 2004-02-11
US6051217A (en) 2000-04-18
JP2003259886A (ja) 2003-09-16
ES2211875T3 (es) 2004-07-16
EP0672145B1 (en) 2003-04-23
KR950704490A (ko) 1995-11-20
EP1283264A2 (en) 2003-02-12
DE69332908D1 (de) 2003-05-28
DE69333243D1 (de) 2003-11-13
DE69333243T2 (de) 2004-08-19
DE69332908T2 (de) 2003-12-24
EP0670898A1 (en) 1995-09-13
US6440407B1 (en) 2002-08-27
CA2150116A1 (en) 1994-06-09
KR100332139B1 (ko) 2002-11-30
US5604116A (en) 1997-02-18
ES2198416T3 (es) 2004-02-01
AU5612594A (en) 1994-06-22
EP1361273A2 (en) 2003-11-12
ATE238421T1 (de) 2003-05-15
US20040018618A1 (en) 2004-01-29
AU6078398A (en) 1998-06-18

Similar Documents

Publication Publication Date Title
PT670898E (pt) Polipeptidos de multiplas mutacoes de interleucina-3 (il-3)
BR9506733A (pt) Proteina de fusão de hematopoiese il-3 multivarian
UA48105C2 (uk) ФРАГМЕНТ ДНК, ЯКИЙ КОДУЄ БІЛОК РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), РЕКОМБІНАНТНА МОЛЕКУЛА ДНК (ВАРІАНТИ), КЛІТИНА-ХАЗЯЇН (ВАРІАНТИ), СПОСІБ ОДЕРЖАННЯ БІЛКУ РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), БІЛОК РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ (ВАРІАНТИ), АНТИТІЛО АБО ФРАГМЕНТ АНТИТІЛА (ВАРІАНТИ), МОЛЕКУЛА КДНК (ВАРІАНТИ)
PT751957E (pt) Fragmentos peptidicos de proteinas de stress microbianas e composicao farmaceutica a base destes fragmentos para o tratamento e a prevencao de doencas inflamatorias
HUT69169A (en) T-cell-suppressive peptide fragments of human myelin basic protein (hmbp) and pharmaceutical compositions containing them
ES2156862T3 (es) Metodo para seleccionar proteinas morfogenicas.
ATE154638T1 (de) Mutanten von interleukin-3
AU2676399A (en) Novel cystine knot protein and materials and methods for making it
ATE103979T1 (de) Menschliches lymphotoxin.
Seyer et al. Covalent structure of collagen: Amino acid sequence of three cyanogen bromide-derived peptides from human α1 (V) collagen chain
ATE425988T1 (de) Peptide mit affinitat fur ein phospholipid und deren verwendung
Braford-Goldberg et al. Therapeutic methods using interleukin-3 (IL-3) human/murine hybrid polypeptides