BR9506733A - Proteina de fusão de hematopoiese il-3 multivarian - Google Patents

Proteina de fusão de hematopoiese il-3 multivarian

Info

Publication number: BR9506733A
Authority: BR; Brazil
Prior art keywords: fusion protein; amino acids; given; multivarian; hematopoiesis
Prior art date: 1994-02-04

Application number

BR9506733A

Other languages

English (en)

Inventor

Christopher Bauer

Mark Allen Abrams

Sarah Ruth Braford-Goldberg

Maire Helena Caparon

Alan Michael Easton

Barbara Kure Klein

John Patrick Mckearn

Peter O Olins

Kumnan Paik

John Warren Thomas

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-02-04

Filing date

1995-02-02

Publication date

1997-09-23

1995-02-02 Application filed by Searle & Co filed Critical Searle & Co

1997-09-23 Publication of BR9506733A publication Critical patent/BR9506733A/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Epidemiology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

BR9506733A 1994-02-04 1995-02-02 Proteina de fusão de hematopoiese il-3 multivarian BR9506733A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/192,325 US6057133A (en)	1992-11-24	1994-02-04	Multivariant human IL-3 fusion proteins and their recombinant production
PCT/US1995/001185 WO1995021254A1 (en)	1994-02-04	1995-02-02	Multivariant il-3 hematopoiesis fusion protein

Publications (1)

Publication Number	Publication Date
BR9506733A true BR9506733A (pt)	1997-09-23

Family

ID=22709185

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9506733A BR9506733A (pt)	1994-02-04	1995-02-02	Proteina de fusão de hematopoiese il-3 multivarian

Country Status (17)

Country	Link
US (3)	US6057133A (pt)
EP (2)	EP0742826B1 (pt)
JP (1)	JPH10502801A (pt)
KR (1)	KR100370264B1 (pt)
CN (1)	CN1227604A (pt)
AT (1)	ATE302275T1 (pt)
BR (1)	BR9506733A (pt)
CA (1)	CA2182484A1 (pt)
CZ (1)	CZ289904B6 (pt)
DE (1)	DE69534381T2 (pt)
FI (1)	FI963072A (pt)
MX (1)	MX9603205A (pt)
NO (1)	NO963225L (pt)
NZ (2)	NZ330060A (pt)
PL (1)	PL315791A1 (pt)
RO (1)	RO118016B1 (pt)
WO (1)	WO1995021254A1 (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5581476A (en)	1993-01-28	1996-12-03	Amgen Inc.	Computer-based methods and articles of manufacture for preparing G-CSF analogs
CA2212006A1 (en)	1995-02-03	1996-08-08	G.D. Searle & Co.	Novel c-mpl ligands
CA2234045A1 (en) *	1995-10-05	1997-04-10	G.D. Searle & Co.	Interleuken-3 (il-3) receptor agonists
US6066318A (en)	1995-10-05	2000-05-23	G.D. Searle & Co.	Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
PL184424B1 (pl) *	1995-10-05	2002-10-31	Searle & Co	Agoniści krwiotwórczych receptorów wieloczynnościowych
WO1997023639A1 (fr) *	1995-12-22	1997-07-03	Toray Industries, Inc.	Procede de production de proteines fusionnees biologiquement actives
RO120919B1 (ro) *	1996-10-25	2006-09-29	G.D. Searle & Co.	Proteină hematopoietină, moleculă de acid nucleiccare o codifică, compoziţie farmaceutică şi utilizarea proteinei
US6967092B1 (en)	1996-10-25	2005-11-22	Mc Kearn John P	Multi-functional chimeric hematopoietic receptor agonists
DE19900743A1 (de) *	1999-01-12	2000-07-13	Aventis Pharma Gmbh	Neue komplexbildende Proteine
AU7645700A (en) *	1999-10-07	2001-05-10	Maxygen Aps	Single-chain antagonist polypeptides
US6831158B2 (en) *	2000-01-10	2004-12-14	Maxygen Holdings Ltd.	G-CSF conjugates
US6646110B2 (en) *	2000-01-10	2003-11-11	Maxygen Holdings Ltd.	G-CSF polypeptides and conjugates
WO2001076639A2 (en) *	2000-04-06	2001-10-18	Pharmacia Corporation	Chemically-modified myelopoietin conjugates
US7572436B1 (en)	2000-09-11	2009-08-11	Therapro Technologies, Inc.	Thionin as an antineoplastic and immunostimulant
KR100961859B1 (ko) *	2001-07-11	2010-06-09	맥시겐 홀딩스 엘티디	지-씨에스에프 접합체
PT1567641E (pt)	2001-08-24	2012-08-21	Uvic Industry Partnerships Inc	Proaerolisina contendo sequência de activação de proteases e métodos de uso para o tratamento do cancro da próstata
DK1450786T3 (da) *	2002-06-29	2006-04-18	Aquanova Ger Solubilisate Tech	Isoflavonkoncentrater samt fremgangsmåde til fremstilling deraf
US8227411B2 (en) *	2002-08-20	2012-07-24	BioSurface Engineering Technologies, Incle	FGF growth factor analogs
US7166574B2 (en)	2002-08-20	2007-01-23	Biosurface Engineering Technologies, Inc.	Synthetic heparin-binding growth factor analogs
US7598224B2 (en)	2002-08-20	2009-10-06	Biosurface Engineering Technologies, Inc.	Dual chain synthetic heparin-binding growth factor analogs
US7414028B1 (en) *	2004-02-04	2008-08-19	Biosurface Engineering Technologies, Inc.	Growth factor analogs
US20060024347A1 (en) *	2004-02-10	2006-02-02	Biosurface Engineering Technologies, Inc.	Bioactive peptide coatings
US20080227696A1 (en) *	2005-02-22	2008-09-18	Biosurface Engineering Technologies, Inc.	Single branch heparin-binding growth factor analogs
US7671012B2 (en)	2004-02-10	2010-03-02	Biosurface Engineering Technologies, Inc.	Formulations and methods for delivery of growth factor analogs
US7528105B1 (en)	2004-02-10	2009-05-05	Biosurface Engineering Technologies	Heterodimeric chain synthetic heparin-binding growth factor analogs
ATE482228T1 (de) *	2004-02-20	2010-10-15	Biosurface Eng Tech Inc	Positiver modulator des knochenmorphogenetisches protein-2 (bmp-2)
JP2008505650A (ja) *	2004-07-12	2008-02-28	ソリン・グループ・イタリア・ソシエタ・ア・レスポンサビリタ・リミタータ	ヒト細胞を増殖させるための装置及び方法
US7597884B2 (en)	2004-08-09	2009-10-06	Alios Biopharma, Inc.	Hyperglycosylated polypeptide variants and methods of use
CN101193658B (zh)	2005-06-01	2011-08-31	马克西根控股公司	聚乙二醇化g-csf多肽及其产生方法
WO2007056867A1 (en)	2005-11-21	2007-05-24	Protox Therapeutics Incorporated	Modified pore-forming protein toxins and use thereof
US7820172B1 (en)	2006-06-01	2010-10-26	Biosurface Engineering Technologies, Inc.	Laminin-derived multi-domain peptides
EP2046350A4 (en)	2006-06-22	2011-09-14	Biosurface Eng Tech Inc	COMPOSITIONS AND METHOD FOR THE RELEASE OF A BMP-2 AMPLIFIER / COACTIVATOR FOR REINFORCED OSTEOGENESIS
CN101139399B (zh) *	2007-08-13	2011-01-26	重庆医科大学附属第二医院	重组靶向杀伤白血病细胞的融合蛋白及其制备方法和用途
EP2498795B1 (en)	2009-10-12	2016-12-07	The United States Of America, As Represented By The Secretary, Department of Health and Human Services	Granulysin in immunotherapy
RU2573909C2 (ru)	2010-03-04	2016-01-27	Пфенекс Инк.	Способ получения растворимого рекомбинантного белка интерферона без денатурирования
PL2552949T3 (pl)	2010-04-01	2017-01-31	Pfenex Inc.	Sposoby wytwarzania G-CSF w komórce gospodarza Pseudomonas
AU2011377617B2 (en)	2011-09-23	2018-03-08	Bluebird Bio, Inc.	Improved gene therapy methods
WO2019073299A1 (en)	2017-10-10	2019-04-18	Medicenna Therapeutics, Inc.	IL-4 FUSION FORMULATIONS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) TUMORS
US11795203B2 (en)	2018-07-30	2023-10-24	Jinyu Zhang	Protein heterodimer and use thereof

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4438032A (en) *	1981-01-30	1984-03-20	The Regents Of The University Of California	Unique T-lymphocyte line and products derived therefrom
UA39161C2 (uk) *	1984-07-06	2001-06-15	Новартіс Аг	Рекомбінантний білок gm-csf для збільшення продукції гранулоцитів і макрофагів у пацієнтів, вектор і кднк, що його кодують
AU588819B2 (en) *	1984-10-29	1989-09-28	Immunex Corporation	Cloning of human granulocyte-macrophage colony stimulating factor gene
US4810643A (en) *	1985-08-23	1989-03-07	Kirin- Amgen Inc.	Production of pluripotent granulocyte colony-stimulating factor
JPS63500636A (ja) *	1985-08-23	1988-03-10	麒麟麦酒株式会社	多分化能性顆粒球コロニー刺激因子をコードするｄｎａ
US5032395A (en) *	1986-07-14	1991-07-16	Genetics Institute, Inc.	Method of inducing leukocytosis with a combination of IL-3 and GM-CSF
US4959455A (en) *	1986-07-14	1990-09-25	Genetics Institute, Inc.	Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US4877729A (en) *	1986-07-14	1989-10-31	Genetics Institute, Inc.	Recombinant DNA encoding novel family of primate hematopoietic growth factors
EP0790307A1 (en) *	1986-12-16	1997-08-20	Gist-Brocades B.V.	Molecular cloning and expression of human IL-3
EP0342206A4 (en) *	1987-01-20	1990-09-19	Immunex Corporation	Human interleukin-3 proteins
WO1990001039A1 (en) *	1988-07-20	1990-02-08	Immunex Corporation	Nonglycosylated human interleukin-3 compositions
US5218092A (en) *	1988-09-29	1993-06-08	Kyowa Hakko Kogyo Co., Ltd.	Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
AU5355790A (en) *	1989-04-19	1990-11-16	Cetus Corporation	Multifunctional m-csf proteins and genes encoding therefor
US5516512A (en) *	1989-08-14	1996-05-14	Gist-Brocades, N.V.	N- and C-terminal truncation and deletion mutants of human interleukin-3
DK0413383T3 (da) *	1989-08-14	1997-07-07	Gist Brocades Nv	Mutanter af humant interleukin-3.
US5073627A (en) *	1989-08-22	1991-12-17	Immunex Corporation	Fusion proteins comprising GM-CSF and IL-3
EP0489116B1 (en) *	1989-08-22	1994-04-06	Immunex Corporation	Fusion proteins comprising gm-csf and il-3
US5108910A (en) *	1989-08-22	1992-04-28	Immunex Corporation	DNA sequences encoding fusion proteins comprising GM-CSF and IL-3
DE3939703C2 (de) *	1989-12-01	1998-07-02	Boehringer Ingelheim Kg	Verbesserte transdermale Applikation von pharmakologisch aktiven Verbindungen
JPH0463595A (ja) *	1990-04-03	1992-02-28	Kirin Brewery Co Ltd	ヒトインターロイキン３誘導体
AU651152B2 (en) *	1990-08-29	1994-07-14	Genetics Institute, Llc	Multidomain hematopoiesis stimulators
AU8735991A (en) *	1990-09-28	1992-04-28	Ortho Pharmaceutical Corporation	Hybrid growth factors
DE4030850A1 (de) *	1990-09-29	1992-04-02	Henkel Kgaa	Bleichmittelzubereitung
US5199942A (en) *	1991-06-07	1993-04-06	Immunex Corporation	Method for improving autologous transplantation
EP0609280B1 (en) *	1991-10-07	1999-04-21	Medvet Science Pty. Ltd.	Human il-3 variants
US5376367A (en) *	1991-11-22	1994-12-27	Immunex Corporation	Fusion proteins comprising MGF and IL-3
DE69332908T2 (de) *	1992-11-24	2003-12-24	G.D. Searle & Co., Chicago	Interleukin-3 (il-3)-polypeptide mith mehreren mutationen
US5501962A (en) *	1993-06-21	1996-03-26	G. D. Searle & Co.	Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same

1994
- 1994-02-04 US US08/192,325 patent/US6057133A/en not_active Expired - Fee Related
1995
- 1995-02-02 CN CN95192254A patent/CN1227604A/zh active Pending
- 1995-02-02 EP EP95910141A patent/EP0742826B1/en not_active Expired - Lifetime
- 1995-02-02 CA CA002182484A patent/CA2182484A1/en not_active Abandoned
- 1995-02-02 RO RO96-01594A patent/RO118016B1/ro unknown
- 1995-02-02 BR BR9506733A patent/BR9506733A/pt not_active Application Discontinuation
- 1995-02-02 WO PCT/US1995/001185 patent/WO1995021254A1/en active IP Right Grant
- 1995-02-02 JP JP7520671A patent/JPH10502801A/ja not_active Ceased
- 1995-02-02 CZ CZ19962298A patent/CZ289904B6/cs not_active IP Right Cessation
- 1995-02-02 MX MX9603205A patent/MX9603205A/es not_active IP Right Cessation
- 1995-02-02 NZ NZ330060A patent/NZ330060A/xx unknown
- 1995-02-02 NZ NZ281421A patent/NZ281421A/en unknown
- 1995-02-02 PL PL95315791A patent/PL315791A1/xx unknown
- 1995-02-02 EP EP04020846A patent/EP1482044A3/en not_active Withdrawn
- 1995-02-02 AT AT95910141T patent/ATE302275T1/de not_active IP Right Cessation
- 1995-02-02 KR KR1019960704258A patent/KR100370264B1/ko not_active IP Right Cessation
- 1995-02-02 DE DE69534381T patent/DE69534381T2/de not_active Expired - Fee Related
- 1995-06-06 US US08/468,609 patent/US6030812A/en not_active Expired - Fee Related
- 1995-06-06 US US08/469,318 patent/US6022535A/en not_active Expired - Fee Related
1996
- 1996-08-01 NO NO963225A patent/NO963225L/no not_active Application Discontinuation
- 1996-08-02 FI FI963072A patent/FI963072A/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
US6057133A (en)	2000-05-02
EP1482044A2 (en)	2004-12-01
US6030812A (en)	2000-02-29
CZ289904B6 (cs)	2002-04-17
EP0742826B1 (en)	2005-08-17
CN1227604A (zh)	1999-09-01
FI963072A0 (fi)	1996-08-02
CA2182484A1 (en)	1995-08-10
MX9603205A (es)	1997-03-29
NO963225D0 (no)	1996-08-01
JPH10502801A (ja)	1998-03-17
CZ229896A3 (en)	1996-12-11
AU1835695A (en)	1995-08-21
KR100370264B1 (ko)	2003-05-09
RO118016B1 (ro)	2002-12-30
PL315791A1 (en)	1996-12-09
EP0742826A1 (en)	1996-11-20
DE69534381T2 (de)	2006-11-23
NZ330060A (en)	1999-11-29
DE69534381D1 (de)	2005-09-22
KR970700766A (ko)	1997-02-12
US6022535A (en)	2000-02-08
EP1482044A3 (en)	2005-05-18
AU697433B2 (en)	1998-10-08
FI963072A (fi)	1996-08-02
ATE302275T1 (de)	2005-09-15
NO963225L (no)	1996-09-25
NZ281421A (en)	1998-05-27
WO1995021254A1 (en)	1995-08-10

Publication	Publication Date	Title
BR9506733A (pt)	1997-09-23	Proteina de fusão de hematopoiese il-3 multivarian
DE69333243D1 (de)	2003-11-13	Mutierte polypeptide des interleukin-3(il-3)
EP0722461A4 (en)	1997-02-26	EXPRESSION OF FUSION POLYPEPTIDES TRANSPORTED OUT OF CYTOPLASM WITHOUT HEAD SEQUENCE
MX9203440A (es)	1992-07-01	Proteinas procoagulantes novedosas.
NO965411L (no)	1997-02-14	N-terminalt forlengede proteiner uttrykt i gjær
ES2184728T3 (es)	2003-04-16	Proteinas de union a la fibronectina.
BR9710433A (pt)	1999-10-05	Proteínas associada a escherichia coli patogênica
DE69827262D1 (de)	2004-12-02	Penaeidine: antimikrobielle peptide aus krebstieren
NZ335382A (en)	2001-03-30	Multi-functional chimeric hematopoietic polypeptides of IL-3, GCSF, Flt3L, EPO, stem cell factor, cmpl link with or without linker group consisting of Alanine, Glycine and/or Serine for treating autoimmune and tumour related diseases
ATE481420T1 (de)	2010-10-15	Il-21-derivate
DE69233245D1 (de)	2003-12-11	Verfahren zur Herstellung von Peptiden
ATE317443T1 (de)	2006-02-15	N-terminal verlängerte proteine exprimiert in hefe
SE8801723D0 (sv)	1988-05-06	Fibronectin binding protein as well as its preparation
WO1999002708A8 (en)	1999-04-01	Fusion proteins comprising sequences derived from bovine if1 atpase inhibitor protein
KR930000684A (ko)	1993-01-15	클로닝된 글루탐산 탈탄산효소
JPS642583A (en)	1989-01-06	Recombinant dna and production of polypeptide using said dna
KR840004162A (ko)	1984-10-10	동물 인터페론

Legal Events

Date	Code	Title	Description
2005-03-29	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2006-05-02	B06G	Technical and formal requirements: other requirements [chapter 6.7 patent gazette]	Free format text: A REQUERENTE DEVERA COMPLEMENTAR A TAXA RELATIVA A 43 (QUARENTA E TRES) REIVINDICACOES EXCEDENTES.
2006-10-24	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2007-04-27	B09B	Patent application refused [chapter 9.2 patent gazette]	Free format text: DE ACORDO COM O ART. 36 DA LPI (LEI 9279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR.PORTANTO, INDEFIRO O PRESENTE PEDIDO.