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PL2714710T3 - Sposób wytwarzania estetrolowych związków pośrednich - Google Patents

Sposób wytwarzania estetrolowych związków pośrednich

Info

Publication number
PL2714710T3
PL2714710T3 PL12729054T PL12729054T PL2714710T3 PL 2714710 T3 PL2714710 T3 PL 2714710T3 PL 12729054 T PL12729054 T PL 12729054T PL 12729054 T PL12729054 T PL 12729054T PL 2714710 T3 PL2714710 T3 PL 2714710T3
Authority
PL
Poland
Prior art keywords
production
estetrol
intermediates
estetrol intermediates
Prior art date
Application number
PL12729054T
Other languages
English (en)
Inventor
Jean-Claude Pascal
Original Assignee
Estetra S.P.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Estetra S.P.R.L. filed Critical Estetra S.P.R.L.
Publication of PL2714710T3 publication Critical patent/PL2714710T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL12729054T 2011-06-01 2012-06-01 Sposób wytwarzania estetrolowych związków pośrednich PL2714710T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161492300P 2011-06-01 2011-06-01
EP11168561 2011-06-01

Publications (1)

Publication Number Publication Date
PL2714710T3 true PL2714710T3 (pl) 2017-03-31

Family

ID=45003353

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12729054T PL2714710T3 (pl) 2011-06-01 2012-06-01 Sposób wytwarzania estetrolowych związków pośrednich

Country Status (24)

Country Link
US (1) US11053274B2 (pl)
EP (1) EP2714710B1 (pl)
JP (2) JP6425540B2 (pl)
KR (1) KR101994805B1 (pl)
CN (2) CN103703014A (pl)
AU (1) AU2012264602B2 (pl)
BR (1) BR112013030830B1 (pl)
CA (1) CA2835981C (pl)
CY (1) CY1118150T1 (pl)
DK (1) DK2714710T3 (pl)
EA (1) EA023991B1 (pl)
ES (1) ES2579175T3 (pl)
HR (1) HRP20160692T2 (pl)
HU (1) HUE029252T2 (pl)
ME (1) ME02454B (pl)
MX (1) MX341561B (pl)
PL (1) PL2714710T3 (pl)
PT (1) PT2714710T (pl)
RS (1) RS54880B1 (pl)
SG (1) SG195118A1 (pl)
SI (1) SI2714710T1 (pl)
SM (1) SMT201600206B (pl)
WO (1) WO2012164096A1 (pl)
ZA (1) ZA201308446B (pl)

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WO2012164096A1 (en) 2011-06-01 2012-12-06 Estetra S.A. Process for the production of estetrol intermediates
US11053273B2 (en) 2011-06-01 2021-07-06 Estetra S.P.R.L. Process for the production of estetrol intermediates
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
WO2013050553A1 (en) 2011-10-07 2013-04-11 Estetra S.A. Process for the production of estetrol
CR20180041A (es) 2015-06-18 2018-05-03 Mithra Pharmaceuticals S A Unidad de dosificación orodispersable que contiene un componente estetrol.
DK3310345T3 (da) 2015-06-18 2021-05-25 Estetra Sprl Orodispersibel tablet indeholdende estetrol
JP6863547B2 (ja) 2015-06-18 2021-04-21 エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ エステトロール成分を含有する口腔内崩壊性投与単位
LT3310346T (lt) 2015-06-18 2021-06-10 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio
CN105837424A (zh) * 2016-03-31 2016-08-10 常州大学 一种1-氯-3-甲基-3-丁烯-2-酮的合成方法
CA3178291A1 (en) 2016-08-05 2018-04-12 Estetra Srl Method for the management of dysmenorrhea and menstrual pain
JP6935766B2 (ja) 2018-02-15 2021-09-15 日本精工株式会社 スピンドル装置
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
IT201900017414A1 (it) 2019-09-27 2021-03-27 Ind Chimica Srl Processo per la preparazione di (15α,16α,17β)-estra-1,3,5(10)-triene-3,15,16,17-tetrolo (Estetrolo) ed intermedi di detto processo
CN114514237B (zh) 2019-09-27 2024-07-26 工业化学有限公司 用于制备(15α,16α,17β)-雌-1,3,5(10)-三烯-3,15,16,17-四醇(雌四醇)的工艺及所述工艺的中间体
IT201900021879A1 (it) 2019-11-22 2021-05-22 Ind Chimica Srl PROCESSO PER LA PREPARAZIONE DI (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROLO (ESTETROLO) ED INTERMEDI DI DETTO PROCESSO
WO2023021026A1 (en) 2021-08-17 2023-02-23 Aspen Oss B.V. A synthetic pathway to estra-1,3,5(10)-triene-3,15a,16a,17b-tetrol
ES2976651A2 (es) 2021-10-01 2024-08-06 Ind Chimica Srl PROCESO PARA PREPARAR (15alfa,16alfa,17beta)-ESTRA-1,3,5(10)-TRIENO-3,15,16,17-TETROL (ESTETROL) Y ESTETROL MONOHIDRATO
WO2024160373A1 (en) 2023-02-02 2024-08-08 Industriale Chimica S.R.L. PROCESS FOR PREPARING (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROL (ESTETROL) MONOHYDRATE

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JP6863547B2 (ja) 2015-06-18 2021-04-21 エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ エステトロール成分を含有する口腔内崩壊性投与単位
LT3310346T (lt) 2015-06-18 2021-06-10 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio

Also Published As

Publication number Publication date
EP2714710B1 (en) 2016-04-06
NZ617613A (en) 2015-12-24
HUE029252T2 (en) 2017-02-28
JP2018024673A (ja) 2018-02-15
US11053274B2 (en) 2021-07-06
AU2012264602B2 (en) 2017-03-09
JP6425540B2 (ja) 2018-11-21
HRP20160692T2 (hr) 2016-09-23
KR20140036205A (ko) 2014-03-25
EP2714710A1 (en) 2014-04-09
ME02454B (me) 2016-09-20
SG195118A1 (en) 2013-12-30
US20140107358A1 (en) 2014-04-17
ZA201308446B (en) 2016-08-31
SI2714710T1 (sl) 2016-08-31
CN107266514A (zh) 2017-10-20
BR112013030830A2 (pt) 2016-08-30
JP6479912B2 (ja) 2019-03-06
WO2012164096A1 (en) 2012-12-06
DK2714710T3 (en) 2016-06-27
JP2014518199A (ja) 2014-07-28
ES2579175T3 (es) 2016-08-05
EA023991B1 (ru) 2016-08-31
KR101994805B1 (ko) 2019-07-01
RS54880B1 (sr) 2016-10-31
EA201301316A1 (ru) 2014-04-30
HRP20160692T1 (hr) 2016-08-12
SMT201600206B (it) 2016-08-31
MX341561B (es) 2016-08-25
PT2714710T (pt) 2016-07-12
CN103703014A (zh) 2014-04-02
BR112013030830B1 (pt) 2019-12-03
CY1118150T1 (el) 2017-06-28
CA2835981C (en) 2018-07-24
CA2835981A1 (en) 2012-12-06
MX2013014045A (es) 2014-08-22

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