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PL2511282T3 - Uracylowe nukleozydy spirooksetanowe - Google Patents

Uracylowe nukleozydy spirooksetanowe

Info

Publication number
PL2511282T3
PL2511282T3 PL12176402T PL12176402T PL2511282T3 PL 2511282 T3 PL2511282 T3 PL 2511282T3 PL 12176402 T PL12176402 T PL 12176402T PL 12176402 T PL12176402 T PL 12176402T PL 2511282 T3 PL2511282 T3 PL 2511282T3
Authority
PL
Poland
Prior art keywords
spirooxetane nucleosides
uracyl spirooxetane
uracyl
nucleosides
spirooxetane
Prior art date
Application number
PL12176402T
Other languages
English (en)
Inventor
Tim Hugo Maria Jonckers
Pierre Jean-Marie Bernard Raboisson
Koen Vandyck
Hoof Steven Maurice Paula Van
Lili Hu
Abdellah Tahri
Original Assignee
Janssen Products Lp
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Products Lp, Medivir Ab filed Critical Janssen Products Lp
Publication of PL2511282T3 publication Critical patent/PL2511282T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/503Pyridazines; Hydrogenated pyridazines spiro-condensed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02Acyclic radicals, not substituted by cyclic structures
    • C07H15/04Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18Acyclic radicals, substituted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/067Pyrimidine radicals with ribosyl as the saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PL12176402T 2009-05-14 2010-05-11 Uracylowe nukleozydy spirooksetanowe PL2511282T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09160215 2009-05-14
EP10718207A EP2430035B1 (en) 2009-05-14 2010-05-11 Uracyl spirooxetane nucleosides
EP12176402.1A EP2511282B1 (en) 2009-05-14 2010-05-11 Uracyl Spirooxetane Nucleosides

Publications (1)

Publication Number Publication Date
PL2511282T3 true PL2511282T3 (pl) 2014-09-30

Family

ID=40823307

Family Applications (2)

Application Number Title Priority Date Filing Date
PL10718207T PL2430035T3 (pl) 2009-05-14 2010-05-11 Uracylowe nukleozydy spirooksetanowe
PL12176402T PL2511282T3 (pl) 2009-05-14 2010-05-11 Uracylowe nukleozydy spirooksetanowe

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL10718207T PL2430035T3 (pl) 2009-05-14 2010-05-11 Uracylowe nukleozydy spirooksetanowe

Country Status (39)

Country Link
US (2) US8481510B2 (pl)
EP (2) EP2511282B1 (pl)
JP (2) JP5778135B2 (pl)
KR (1) KR101806837B1 (pl)
CN (1) CN102439024B (pl)
AP (1) AP2783A (pl)
AR (1) AR076579A1 (pl)
AU (1) AU2010247439B2 (pl)
BR (1) BRPI1010579A2 (pl)
CA (1) CA2760329C (pl)
CL (1) CL2011002859A1 (pl)
CO (1) CO6440533A2 (pl)
CR (1) CR20120297A (pl)
CY (2) CY1114081T1 (pl)
DK (2) DK2511282T3 (pl)
EA (1) EA022084B1 (pl)
EC (1) ECSP11011461A (pl)
ES (2) ES2411086T3 (pl)
HK (1) HK1166326A1 (pl)
HN (1) HN2011003014A (pl)
HR (2) HRP20130554T1 (pl)
IL (1) IL215955A (pl)
JO (1) JO3027B1 (pl)
ME (1) ME01478B (pl)
MX (1) MX2011012027A (pl)
MY (1) MY157018A (pl)
NI (1) NI201100197A (pl)
NZ (1) NZ596073A (pl)
PL (2) PL2430035T3 (pl)
PT (2) PT2430035E (pl)
RS (1) RS52822B (pl)
SG (1) SG175981A1 (pl)
SI (2) SI2430035T1 (pl)
SM (2) SMT201300078B (pl)
TW (1) TWI461432B (pl)
UA (1) UA105790C2 (pl)
UY (1) UY32642A (pl)
WO (1) WO2010130726A1 (pl)
ZA (1) ZA201108309B (pl)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EP2376515A1 (en) 2008-12-23 2011-10-19 Pharmasset, Inc. Synthesis of purine nucleosides
JO3027B1 (ar) 2009-05-14 2016-09-05 Janssen Products Lp نيوكليوسيدات يوراسيل سبيرواوكسيتان
DK2638054T3 (en) * 2010-11-10 2015-03-09 Janssen Products Lp URACYLSPIROOXETANNUCLEOSIDE PHOSPHORAMIDATES
US9006209B2 (en) 2010-11-10 2015-04-14 Janssen Products, Lp Uracyl spirooxetane nucleoside phosphoramidates
JP6069215B2 (ja) * 2010-11-30 2017-02-01 ギリアド ファーマセット エルエルシー 化合物
AU2015252113B2 (en) * 2010-11-30 2017-05-04 Gilead Pharmasset Llc Compounds
US8877733B2 (en) * 2011-04-13 2014-11-04 Gilead Sciences, Inc. 1′-substituted pyrimidine N-nucleoside analogs for antiviral treatment
US8980865B2 (en) 2011-12-22 2015-03-17 Alios Biopharma, Inc. Substituted nucleotide analogs
JP6140815B2 (ja) * 2012-05-25 2017-05-31 ヤンセン・サイエンシズ・アイルランド・ユーシー ウラシルスピロオキセタンヌクレオシド
RU2621709C2 (ru) 2013-03-08 2017-06-07 Наньцзин Саньхоме Фармасьютикал Ко., Лтд. Новое фосфорамидатное производное нуклеозида и его применение
WO2014169278A1 (en) 2013-04-12 2014-10-16 Achillion Pharmaceuticals, Inc. Highly active nucleoside derivative for the treatment of hcv
CN104231023B (zh) * 2013-06-06 2019-02-05 南京汇诚制药有限公司 三环稠杂环类核苷氨基磷酸酯化合物、其制备方法及应用
KR20160090798A (ko) * 2013-11-28 2016-08-01 얀센 사이언시즈 아일랜드 유씨 Hcv의 뉴클레오시드 저해제의 결정 형태
NZ773652A (en) 2015-03-06 2024-08-30 Atea Pharmaceuticals Inc Β-d-2’-deoxy-2’-α-fluoro-2’-β-c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment
LU100724B1 (en) 2016-07-14 2018-07-31 Atea Pharmaceuticals Inc Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
SI3512863T1 (sl) 2016-09-07 2022-04-29 Atea Pharmaceuticals, Inc. 2'-substituirani-N6-substituirani purinski nukleotidi za zdravljenje virusa RNA
US10519186B2 (en) 2017-02-01 2019-12-31 Atea Pharmaceuticals, Inc. Nucleotide hemi-sulfate salt for the treatment of hepatitis C virus
EP4335496A2 (en) 2018-01-10 2024-03-13 Nucorion Pharmaceuticals, Inc. Phosphor(n)amidatacetal and phosph(on)atalcetal compounds
CN112351799A (zh) 2018-04-10 2021-02-09 阿堤亚制药公司 具有硬化的hcv感染患者的治疗
MX2022000573A (es) 2019-07-17 2022-02-10 Nucorion Pharmaceuticals Inc Compuestos ciclicos de desoxirribonucleotido.
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
US20230201236A1 (en) * 2020-04-14 2023-06-29 Janssen Pharmaceuticals, Inc. Spirocyclic nucleoside analogues for the treatment of hepatitis e

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1355916B1 (en) * 2001-01-22 2007-01-10 Merck & Co., Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
AU2005267421B2 (en) * 2004-06-24 2010-06-03 Merck Sharp & Dohme Corp. Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
CA2618335C (en) * 2005-08-15 2015-03-31 F.Hoffmann-La Roche Ag Antiviral phosphoramidates of 4'-substituted pronucleotides
JP2009526850A (ja) * 2006-02-14 2009-07-23 メルク エンド カムパニー インコーポレーテッド Rna依存性rnaウイルス感染を治療するためのヌクレオシドアリールホスホルアミデート
PA8852101A1 (es) * 2008-12-08 2010-07-27 Medivir Ab Nucleótidos uracil ciclopropílicos
JO3027B1 (ar) * 2009-05-14 2016-09-05 Janssen Products Lp نيوكليوسيدات يوراسيل سبيرواوكسيتان

Also Published As

Publication number Publication date
ES2411086T3 (es) 2013-07-04
KR20120018355A (ko) 2012-03-02
TW201100442A (en) 2011-01-01
TWI461432B (zh) 2014-11-21
ECSP11011461A (es) 2012-02-29
CY1114081T1 (el) 2016-07-27
AU2010247439B2 (en) 2014-09-25
EP2511282A1 (en) 2012-10-17
CY1115383T1 (el) 2017-01-04
CO6440533A2 (es) 2012-05-15
ES2477598T3 (es) 2014-07-17
US20130217648A1 (en) 2013-08-22
JP2012526764A (ja) 2012-11-01
AR076579A1 (es) 2011-06-22
NZ596073A (en) 2013-02-22
DK2430035T3 (da) 2013-05-27
RS52822B (en) 2013-10-31
EP2511282B1 (en) 2014-04-02
PT2430035E (pt) 2013-05-22
CN102439024A (zh) 2012-05-02
US20120065156A1 (en) 2012-03-15
AU2010247439A1 (en) 2011-12-01
US8481510B2 (en) 2013-07-09
ME01478B (me) 2014-04-20
SI2511282T1 (sl) 2014-09-30
AP2011005958A0 (en) 2011-10-31
EP2430035B1 (en) 2013-04-03
SG175981A1 (en) 2011-12-29
JP5778135B2 (ja) 2015-09-16
SMT201300078B (it) 2013-09-06
DK2511282T3 (da) 2014-07-07
EA201171406A1 (ru) 2012-05-30
EP2430035A1 (en) 2012-03-21
UA105790C2 (uk) 2014-06-25
HRP20130554T1 (en) 2013-07-31
JP2015180692A (ja) 2015-10-15
PL2430035T3 (pl) 2013-08-30
MY157018A (en) 2016-04-15
HRP20140605T1 (hr) 2014-09-26
IL215955A (en) 2015-03-31
MX2011012027A (es) 2012-02-28
HN2011003014A (es) 2014-06-30
CA2760329C (en) 2017-10-31
SI2430035T1 (sl) 2013-08-30
BRPI1010579A2 (pt) 2016-03-15
CN102439024B (zh) 2014-09-17
ZA201108309B (en) 2013-04-24
WO2010130726A1 (en) 2010-11-18
IL215955A0 (en) 2012-01-31
CR20120297A (es) 2012-10-25
JO3027B1 (ar) 2016-09-05
EA022084B1 (ru) 2015-10-30
US8933052B2 (en) 2015-01-13
CA2760329A1 (en) 2010-11-18
KR101806837B1 (ko) 2017-12-08
AP2783A (en) 2013-10-31
CL2011002859A1 (es) 2012-07-20
SMT201400085B (it) 2014-09-08
HK1166326A1 (en) 2012-10-26
PT2511282E (pt) 2014-07-11
NI201100197A (es) 2012-05-28
UY32642A (es) 2010-11-30

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