PL2184279T3 - Kompozycja farmaceutyczna zawierająca związek optycznie czynny mający aktywność agonisty receptora trombopoetyny i jego półprodukt - Google Patents

Kompozycja farmaceutyczna zawierająca związek optycznie czynny mający aktywność agonisty receptora trombopoetyny i jego półprodukt

Info

Publication number: PL2184279T3
Authority: PL; Poland
Prior art keywords: pharmaceutical composition; composition containing; active compound; optically active; receptor agonist
Prior art date: 2007-07-31

Application number

PL08791776T

Other languages

English (en)

Inventor

Masami Takayama

Noriyuki Kurose

Original Assignee

Shionogi & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-07-31

Filing date

2008-07-29

Publication date

2015-04-30

2008-07-29 Application filed by Shionogi & Co filed Critical Shionogi & Co

2015-04-30 Publication of PL2184279T3 publication Critical patent/PL2184279T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL08791776T 2007-07-31 2008-07-29 Kompozycja farmaceutyczna zawierająca związek optycznie czynny mający aktywność agonisty receptora trombopoetyny i jego półprodukt PL2184279T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2007198590		2007-07-31
PCT/JP2008/063541 WO2009017098A1 (ja)	2007-07-31	2008-07-29	トロンボポエチン受容体アゴニスト作用を有する光学活性な化合物を含有する医薬組成物およびその中間体
EP08791776.1A EP2184279B1 (en)	2007-07-31	2008-07-29	Pharmaceutical composition containing optically active compound having thrombopoietin receptor agonist activity and intermediate thereof

Publications (1)

Publication Number	Publication Date
PL2184279T3 true PL2184279T3 (pl)	2015-04-30

Family

ID=40304328

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL08791776T PL2184279T3 (pl)	2007-07-31	2008-07-29	Kompozycja farmaceutyczna zawierająca związek optycznie czynny mający aktywność agonisty receptora trombopoetyny i jego półprodukt

Country Status (21)

Country	Link
US (2)	US8530668B2 (pl)
EP (1)	EP2184279B1 (pl)
JP (1)	JP5164181B2 (pl)
KR (1)	KR20100027243A (pl)
CN (4)	CN103393678A (pl)
AU (1)	AU2008283357B2 (pl)
BR (1)	BRPI0814891A2 (pl)
CA (1)	CA2694567C (pl)
CY (1)	CY1116190T1 (pl)
DK (1)	DK2184279T3 (pl)
ES (1)	ES2528196T3 (pl)
FR (1)	FR19C1043I2 (pl)
HR (1)	HRP20150062T1 (pl)
MX (1)	MX2010001082A (pl)
NL (1)	NL300998I2 (pl)
PL (1)	PL2184279T3 (pl)
PT (1)	PT2184279E (pl)
RU (1)	RU2476429C2 (pl)
SI (1)	SI2184279T1 (pl)
TW (1)	TWI422371B (pl)
WO (1)	WO2009017098A1 (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI564008B (zh)	2010-09-30	2017-01-01	鹽野義製藥股份有限公司	難溶性藥物之溶解性改善製劑
JP6202620B2 (ja) *	2012-06-29	2017-09-27	塩野義製薬株式会社	トロンボポエチン受容体アゴニスト作用を有する化合物を含有する医薬組成物
US20140047572A1 (en) *	2012-08-13	2014-02-13	University Of Rochester	Thrombopoietin mimetics for the treatment of radiation or chemical induced bone marrow injury
CN105992761A (zh) *	2013-12-20	2016-10-05	盐野义制药株式会社	具有血小板生成素受体激动作用的光学活性的化合物及其中间体的制备方法
CN105412930A (zh) *	2015-08-07	2016-03-23	军事医学科学院华南干细胞与再生医学研究中心	血小板生成素受体激动剂在促进造血干细胞归巢中的用途
JP6168579B1 (ja) *	2016-02-12	2017-07-26	塩野義製薬株式会社	重度の肝機能障害のある患者のためのルストロンボパグを含有する血小板産生促進剤
CN106083759B (zh) *	2016-06-15	2022-02-15	上海丸全化学科技有限公司	一种芦曲泊帕的全新合成工艺
JP2019529342A (ja) *	2016-09-08	2019-10-17	四川科倫博泰生物医薬股▲フン▼有限公司ＳｉｃｈｕａｎＫｅｌｕｎ−ＢｉｏｔｅｃｈＢｉｏｐｈａｒｍａｃｅｕｔｉｃａｌＣｏ．，Ｌｔｄ．	新型２−アミドチアゾール誘導体、及びその製造方法と用途
CN106565625B (zh) *	2016-11-04	2018-01-30	杭州励德生物科技有限公司	一种抗血小板减少症新药Lusutrombopag中间体的制备方法
CN109311831B (zh) *	2017-02-14	2021-07-09	四川科伦药物研究院有限公司	4-苯基噻唑衍生物的晶型及其制备方法
CN109970678B (zh) *	2017-12-28	2024-03-08	四川科伦药物研究院有限公司	4-苯基噻唑衍生物无定形及其制备方法和用途
WO2019233328A1 (zh)	2018-06-08	2019-12-12	四川科伦药物研究院有限公司	4-苯基噻唑衍生物的晶型及其制备方法
CN113164455A (zh) *	2018-12-04	2021-07-23	盐野义制药株式会社	难溶性药物的固体分散体

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2055712A1 (en) *	1995-06-07	2009-05-06	Glaxo Group Limited	Peptides and compounds that bind to a thrombopoietin receptor
JPH1072492A (ja)	1996-09-02	1998-03-17	Hokuriku Seiyaku Co Ltd	ペプチド化合物
JPH10287634A (ja)	1997-04-11	1998-10-27	Otsuka Pharmaceut Co Ltd	ベンゼン誘導体
JPH111477A (ja)	1997-06-12	1999-01-06	Hokuriku Seiyaku Co Ltd	１，４−ベンゾジアゼピン誘導体及びその用途
JPH11152276A (ja)	1997-11-20	1999-06-08	Hokuriku Seiyaku Co Ltd	ベンゾジアゼピン誘導体
GB9823871D0 (en) *	1998-10-30	1998-12-23	Pharmacia & Upjohn Spa	2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
GC0000177A (en)	1998-12-17	2006-03-29	Smithkline Beecham	Thrombopoietin mimetics
AU6023300A (en)	1999-07-26	2001-02-13	Shionogi & Co., Ltd.	Drug compositions exhibiting thrombopoietin agonism
TWI284639B (en)	2000-01-24	2007-08-01	Shionogi & Co	A compound having thrombopoietin receptor agonistic effect
CN1516696A (zh) *	2001-01-26	2004-07-28	盐野义制药株式会社	对血小板生成素受体具有激动作用的卤素化合物
US7169931B2 (en)	2001-01-26	2007-01-30	Shionogi & Co., Ltd.	Cyclic compounds exhibiting thrombopoietin receptor agonism
WO2002062775A1 (fr)	2001-02-02	2002-08-15	Yamanouchi Pharmaceutical Co., Ltd.	Dérivé de 2-acylaminothiazole ou son sel
ES2610611T3 (es)	2002-01-18	2017-04-28	Astellas Pharma Inc.	Derivado de 2-acilaminotiazol o sal del mismo
JP4317818B2 (ja)	2002-09-30	2009-08-19	アステラス製薬株式会社	２−アシルアミノチアゾール誘導体の新規な塩
US6737382B1 (en) *	2002-10-23	2004-05-18	Nippon Soda Co. Ltd.	Insecticidal aminothiazole derivatives
FR2854158B1 (fr) *	2003-04-25	2006-11-17	Sanofi Synthelabo	Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique
CN1835948B (zh)	2003-07-17	2010-05-26	安斯泰来制药有限公司	2-酰基氨基噻唑衍生物或其盐
CN103130739B (zh) *	2003-08-12	2015-09-16	盐野义制药株式会社	具有血小板生成素受体激动作用的化合物
CN1898221A (zh) *	2003-09-06	2007-01-17	沃泰克斯药物股份有限公司	Atp－结合弹夹转运蛋白的调控剂
JP4774995B2 (ja)	2005-01-12	2011-09-21	アステラス製薬株式会社	アシルアミノチアゾール誘導体を有効成分とする医薬組成物
JP4665769B2 (ja)	2005-01-12	2011-04-06	アステラス製薬株式会社	アシルアミノチアゾール誘導体の製造法
WO2007004038A1 (en)	2005-07-05	2007-01-11	Pfizer Products Inc.	Aminothiazole derivatives as agonists of the thrombopoietin receptor
US8515798B2 (en)	2005-09-27	2013-08-20	Accenture Global Services Gmbh	Closed-loop supply chain in the paper packaging sector
JP2009514941A (ja)	2005-11-08	2009-04-09	アステラス製薬株式会社	血小板減少症を治療する化合物および方法

2008
- 2008-07-29 WO PCT/JP2008/063541 patent/WO2009017098A1/ja active Application Filing
- 2008-07-29 JP JP2009525398A patent/JP5164181B2/ja active Active
- 2008-07-29 CN CN2013103563691A patent/CN103393678A/zh active Pending
- 2008-07-29 US US12/671,476 patent/US8530668B2/en active Active
- 2008-07-29 EP EP08791776.1A patent/EP2184279B1/en active Active
- 2008-07-29 AU AU2008283357A patent/AU2008283357B2/en active Active
- 2008-07-29 CN CN201310356204.4A patent/CN103396313B/zh active Active
- 2008-07-29 CN CN2008801104301A patent/CN101809008B/zh active Active
- 2008-07-29 BR BRPI0814891-0A patent/BRPI0814891A2/pt not_active IP Right Cessation
- 2008-07-29 SI SI200831361T patent/SI2184279T1/sl unknown
- 2008-07-29 PT PT87917761T patent/PT2184279E/pt unknown
- 2008-07-29 CN CN201310356507.6A patent/CN103450110B/zh active Active
- 2008-07-29 MX MX2010001082A patent/MX2010001082A/es active IP Right Grant
- 2008-07-29 RU RU2010107169/04A patent/RU2476429C2/ru active
- 2008-07-29 DK DK08791776.1T patent/DK2184279T3/en active
- 2008-07-29 KR KR1020107002144A patent/KR20100027243A/ko active Search and Examination
- 2008-07-29 PL PL08791776T patent/PL2184279T3/pl unknown
- 2008-07-29 CA CA2694567A patent/CA2694567C/en active Active
- 2008-07-29 ES ES08791776.1T patent/ES2528196T3/es active Active
- 2008-07-30 TW TW097128751A patent/TWI422371B/zh active
2013
- 2013-02-13 US US13/766,752 patent/US8889722B2/en active Active
2015
- 2015-01-19 HR HRP20150062AT patent/HRP20150062T1/hr unknown
- 2015-01-21 CY CY20151100059T patent/CY1116190T1/el unknown
2019
- 2019-06-27 NL NL300998C patent/NL300998I2/nl unknown
- 2019-06-28 FR FR19C1043C patent/FR19C1043I2/fr active Active

Also Published As

Publication number	Publication date
CN103393678A (zh)	2013-11-20
CN103450110A (zh)	2013-12-18
FR19C1043I2 (fr)	2020-04-03
US20130217885A1 (en)	2013-08-22
CY1116190T1 (el)	2017-02-08
CN103396313A (zh)	2013-11-20
WO2009017098A1 (ja)	2009-02-05
PT2184279E (pt)	2015-02-05
EP2184279A1 (en)	2010-05-12
US8530668B2 (en)	2013-09-10
CA2694567A1 (en)	2009-02-05
JPWO2009017098A1 (ja)	2010-10-21
AU2008283357B2 (en)	2011-08-11
FR19C1043I1 (pl)	2019-08-09
EP2184279A4 (en)	2011-11-02
JP5164181B2 (ja)	2013-03-13
CN103450110B (zh)	2015-12-09
CN101809008B (zh)	2013-09-18
US20100267783A1 (en)	2010-10-21
TWI422371B (zh)	2014-01-11
AU2008283357A1 (en)	2009-02-05
NL300998I2 (nl)	2019-08-28
TW200914000A (en)	2009-04-01
CN103396313B (zh)	2015-05-13
ES2528196T3 (es)	2015-02-05
US8889722B2 (en)	2014-11-18
EP2184279B1 (en)	2014-11-12
BRPI0814891A2 (pt)	2015-08-18
NL300998I1 (nl)	2019-07-03
RU2476429C2 (ru)	2013-02-27
KR20100027243A (ko)	2010-03-10
RU2010107169A (ru)	2011-09-10
MX2010001082A (es)	2010-03-01
CA2694567C (en)	2013-04-23
HRP20150062T1 (hr)	2015-04-10
SI2184279T1 (sl)	2015-04-30
DK2184279T3 (en)	2015-01-26
CN101809008A (zh)	2010-08-18

Publication	Publication Date	Title
EP2184279A4 (en)	2011-11-02	PHARMACEUTICAL COMPOSITION COMPRISING AN OPTICALLY ACTIVE COMPOUND WITH THROMBOPOIETIN RECEPTOR AGONIST EFFECT AND INTERMEDIATE PRODUCT THEREOF
EP2130552A4 (en)	2011-03-02	PHARMACEUTICAL COMPOSITION COMPRISING AN ANTI-GRP78 ANTIBODY AS AN ACTIVE SUBSTANCE
EP2078731A4 (en)	2012-08-01	PHARMACEUTICAL COMPOSITION COMPRISING ANTI-HB-EGF ANTIBODY AS ACTIVE INGREDIENT
EP2172223A4 (en)	2012-09-26	COMPOSITION CONTAINING A PHYSIOLOGICALLY ACTIVE SUBSTANCE
ZA200801275B (en)	2008-12-31	Pharmaceutical preparation containing meloxicam
IL210195A (en)	2015-08-31	Benzoxazines, benzazazines, and related compounds with nos inhibitory activity, medicinal preparations and their use
ZA200808530B (en)	2009-12-30	Pharmaceutical composition for external use
ZA200808531B (en)	2009-12-30	Pharmaceutical composition for external use
EP2183213A4 (en)	2013-08-07	OPTICALLY ACTIVE (R) -ARYLOXYPROPIONIC ACID AMIDE AND HERBICIDES COMPOSITION CONTAINING THEREOF
EP2081550A4 (en)	2013-12-11	COATING CAPSULES WITH ACTIVE PHARMACEUTICAL INGREDIENTS
BRPI0821115A2 (pt)	2015-06-16	Composto derivado de aminotriazol, medicamento, composição farmacêutica e uso do composto
EP2040721A4 (en)	2010-03-03	HONEY CONTAINING MEDICAL COMPOSITIONS
AP2975A (en)	2014-09-30	Pharmaceutical formulations containing dopamine receptor ligands
IL204942A0 (en)	2010-11-30	Heterocyclic compound and pharmaceutical composition thereof
ZA200808162B (en)	2009-12-30	Active ingredient combinations with insecticidal properties
AP3542A (en)	2016-01-13	Anti-malarial pharmaceutical composition
EP2062579A4 (en)	2010-03-03	SOLID PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION COMPRISING OPTICALLY STABLE RAMOSETRON
EP2468771A4 (en)	2013-06-05	PHARMACEUTICAL COMPOSITION WITH AN ANTIBODY TO HB-EGF AS AN ACTIVE SUBSTANCE
DE602008005137D1 (de)	2011-04-07	Chinolonverbindung und pharmazeutische zusammensetzung
EP2070919A4 (en)	2010-05-05	SPIROCHINONE COMPOUND AND PHARMACEUTICAL COMPOSITION
IL209698A (en)	2016-03-31	Use of Niportimox for the preparation of pharmaceuticals and preparations containing this Niportimox
EP2006287A4 (en)	2010-05-05	COMPOUND HAVING ANTIMALARIAL ACTIVITY AND ANTIMALARIAL DRUG CONTAINING IT AS AN ACTIVE SUBSTANCE
EP2320879A4 (en)	2014-03-05	PHARMACEUTICAL COMPOSITION COMPRISES JASMONATES
BRPI0923763A2 (pt)	2016-01-26	composto, utilização de um composto e composição farmacêutica
BRPI0810057A2 (pt)	2014-10-21	Composição farmacêutica contendo floroglucinol e paracetamol