PL184424B1 - Agoniści krwiotwórczych receptorów wieloczynnościowych - Google Patents

Agoniści krwiotwórczych receptorów wieloczynnościowych

Info

Publication number: PL184424B1
Authority: PL; Poland
Prior art keywords: seq; xaa; leu; arg; ala
Prior art date: 1995-10-05

Application number

PL96326072A

Other languages

English (en)

Polish (pl)

Other versions

PL326072A1 (en

Inventor

Yiqing Feng

Nicholas R. Staten

Charles M. Baum

Neena L. Summers

Maire H. Caparon

Christopher S. Bauer

Linda Zurfluh

John P. Mckearn

Barbara K. Klein

Stephen C. Lee

Charles A. Mcwherter

Judith G. Giri

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-05

Filing date

1996-10-04

Publication date

2002-10-31

1996-10-04 Application filed by Searle & Co filed Critical Searle & Co

1998-08-17 Publication of PL326072A1 publication Critical patent/PL326072A1/xx

2002-10-31 Publication of PL184424B1 publication Critical patent/PL184424B1/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

PL96326072A 1995-10-05 1996-10-04 Agoniści krwiotwórczych receptorów wieloczynnościowych PL184424B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US483495P	1995-10-05	1995-10-05
PCT/US1996/015774 WO1997012985A2 (fr)	1995-10-05	1996-10-04	Agonistes multifonctionnels des recepteurs hematopoietiques

Publications (2)

Publication Number	Publication Date
PL326072A1 PL326072A1 (en)	1998-08-17
PL184424B1 true PL184424B1 (pl)	2002-10-31

Family

ID=21712756

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL96326072A PL184424B1 (pl)	1995-10-05	1996-10-04	Agoniści krwiotwórczych receptorów wieloczynnościowych

Country Status (14)

Country	Link
EP (1)	EP0854928A2 (fr)
JP (1)	JPH11510062A (fr)
KR (1)	KR100456212B1 (fr)
CN (2)	CN1590407A (fr)
AU (1)	AU705083B2 (fr)
BR (1)	BRPI9610977A2 (fr)
CA (1)	CA2234061A1 (fr)
CZ (1)	CZ295518B6 (fr)
IL (1)	IL123832A0 (fr)
MX (1)	MX9802730A (fr)
NO (1)	NO981500L (fr)
NZ (1)	NZ320978A (fr)
PL (1)	PL184424B1 (fr)
WO (1)	WO1997012985A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5581476A (en)	1993-01-28	1996-12-03	Amgen Inc.	Computer-based methods and articles of manufacture for preparing G-CSF analogs
US6660257B1 (en)	1996-10-25	2003-12-09	Pharmacia Corporation	Circular permuteins of flt3 ligand
US6967092B1 (en)	1996-10-25	2005-11-22	Mc Kearn John P	Multi-functional chimeric hematopoietic receptor agonists
US5969105A (en) *	1996-10-25	1999-10-19	Feng; Yiqing	Stem cell factor receptor agonists
US6165476A (en) *	1997-07-10	2000-12-26	Beth Israel Deaconess Medical Center	Fusion proteins with an immunoglobulin hinge region linker
US6187564B1 (en)	1997-07-10	2001-02-13	Beth Israel Deaconess Medical Center	DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics
US6242570B1 (en)	1997-07-10	2001-06-05	Beth Israel Deaconess Medical Center	Production and use of recombinant protein multimers with increased biological activity
WO2001027621A2 (fr) *	1999-10-07	2001-04-19	Pharmacia Corporation	DOSAGE IMMUNOENZYMATIQUE D'INHIBITION (iELISA) PERMETTANT DE DETECTER ET QUANTIFIER LES ANTICORPS PRESENTS DANS DES PRELEVEMENTS BIOLOGIQUES
MXPA04000231A (es)	2001-07-11	2004-05-04	Maxygen Holdings Ltd	Conjugados del factor de estimulacion de colonias de granulocitos.
CA2607844C (fr)	2005-06-01	2012-07-10	Maxygen Holdings Ltd.	Polypeptides g-csf pegyles et procedes de production correspondants
WO2007075899A2 (fr) *	2005-12-21	2007-07-05	Maxygen, Inc.	Composes agonistes doubles et leur utilisation
CN102675472B (zh) *	2012-05-07	2014-07-30	北京诺派生物科技有限公司	用于检测猪繁殖与呼吸综合症患猪的试剂盒
WO2014100779A1 (fr)	2012-12-21	2014-06-26	Advanced Cell Technology, Inc.	Procédés de production de plaquettes à partir de cellules souches pluripotentes, et compositions associées
LT6161B (lt)	2013-09-27	2015-06-25	Uab Profarma	Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990012877A1 (fr) *	1989-04-19	1990-11-01	Cetus Corporation	Proteines m-csf multifonctionnelles et codage de genes pour celles-ci
US5738849A (en) *	1992-11-24	1998-04-14	G. D. Searle & Co.	Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US6057133A (en) *	1992-11-24	2000-05-02	G. D. Searle	Multivariant human IL-3 fusion proteins and their recombinant production
US5635599A (en) *	1994-04-08	1997-06-03	The United States Of America As Represented By The Department Of Health And Human Services	Fusion proteins comprising circularly permuted ligands

1996
- 1996-10-04 CN CNA031551432A patent/CN1590407A/zh active Pending
- 1996-10-04 PL PL96326072A patent/PL184424B1/pl not_active IP Right Cessation
- 1996-10-04 KR KR10-1998-0702547A patent/KR100456212B1/ko not_active IP Right Cessation
- 1996-10-04 EP EP96936114A patent/EP0854928A2/fr not_active Withdrawn
- 1996-10-04 CN CN96198815A patent/CN1124348C/zh not_active Expired - Fee Related
- 1996-10-04 NZ NZ320978A patent/NZ320978A/en unknown
- 1996-10-04 IL IL12383296A patent/IL123832A0/xx unknown
- 1996-10-04 JP JP9514385A patent/JPH11510062A/ja not_active Abandoned
- 1996-10-04 CA CA002234061A patent/CA2234061A1/fr not_active Abandoned
- 1996-10-04 BR BRPI9610977A patent/BRPI9610977A2/pt not_active IP Right Cessation
- 1996-10-04 AU AU73844/96A patent/AU705083B2/en not_active Ceased
- 1996-10-04 WO PCT/US1996/015774 patent/WO1997012985A2/fr not_active Application Discontinuation
- 1996-10-04 CZ CZ1998965A patent/CZ295518B6/cs not_active IP Right Cessation
1998
- 1998-04-02 NO NO981500A patent/NO981500L/no not_active Application Discontinuation
- 1998-04-06 MX MX9802730A patent/MX9802730A/es not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR19990064068A (ko)	1999-07-26
NO981500D0 (no)	1998-04-02
WO1997012985A2 (fr)	1997-04-10
EP0854928A2 (fr)	1998-07-29
CN1590407A (zh)	2005-03-09
AU7384496A (en)	1997-04-28
WO1997012985A3 (fr)	1997-08-07
CZ295518B6 (cs)	2005-08-17
NO981500L (no)	1998-05-20
CN1204369A (zh)	1999-01-06
CN1124348C (zh)	2003-10-15
IL123832A0 (en)	1998-10-30
AU705083B2 (en)	1999-05-13
NZ320978A (en)	2001-03-30
MX9802730A (es)	1998-09-30
BRPI9610977A2 (pt)	2019-09-17
JPH11510062A (ja)	1999-09-07
PL326072A1 (en)	1998-08-17
KR100456212B1 (ko)	2005-01-15
CA2234061A1 (fr)	1997-04-10
CZ96598A3 (cs)	1998-09-16

Publication	Publication Date	Title
JP2001513999A (ja)	2001-09-11	トロンボポエチン受容体に対するアゴニスト抗体、及びそれらの治療学的使用
RO117110B1 (ro)	2001-10-30	POLIPEPTIDA LIGAND mpl, ACID NUCLEIC, CARE O CODIFICA, VECTOR DE EXPRESIE, PROCEDEU PENTRU PRODUCEREA POLIPEPTIDEI LIGAND, SI COMPOZITIE FARMACEUTICA CU ACEASTA
PL184424B1 (pl)	2002-10-31	Agoniści krwiotwórczych receptorów wieloczynnościowych
JPH11500308A (ja)	1999-01-12	新規ｃ−ＭＰＬリガンド
AU725547B2 (en)	2000-10-12	Multi-functional chimeric hematopoietic receptor agonists
US6436387B1 (en)	2002-08-20	Methods of ex-vivo expansion of hematopoietic cells using multivariant IL-3 hematopoiesis chimera proteins
US6730303B1 (en)	2004-05-04	Fused G-CSF and IL-3 proteins and uses thereof
AU717733B2 (en)	2000-03-30	Novel G-CSF receptor agonists
JP2010142247A (ja)	2010-07-01	Ｉｌ−６レセプター・ｉｌ−６直結融合蛋白質
US6967092B1 (en)	2005-11-22	Multi-functional chimeric hematopoietic receptor agonists
AU751498B2 (en)	2002-08-15	flt3 ligand chimeric proteins
AU722759B2 (en)	2000-08-10	Novel C-MPL receptor agonists
JP4524816B2 (ja)	2010-08-18	Ｉｌ−６レセプター・ｉｌ−６直結融合蛋白質
MXPA99003877A (en)	1999-10-14	Multi-functional chimeric hematopoietic receptor agonists
CZ346799A3 (cs)	2000-03-15	Chimérické proteiny jako flt3 ligandy

Legal Events

Date	Code	Title	Description
2008-03-31	LAPS	Decisions on the lapse of the protection rights	Effective date: 20061004