IL123832A0 - Multi-functional hematopoietic receptor antagonists - Google Patents

Multi-functional hematopoietic receptor antagonists

Info

Publication number: IL123832A0
Authority: IL; Israel
Prior art keywords: receptor antagonists; hematopoietic receptor; functional hematopoietic; functional; antagonists
Prior art date: 1995-10-05

Application number

IL12383296A

Other languages

English (en)

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-05

Filing date

1996-10-04

Publication date

1998-10-30

1996-10-04 Application filed by Searle & Co filed Critical Searle & Co

1998-10-30 Publication of IL123832A0 publication Critical patent/IL123832A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

IL12383296A 1995-10-05 1996-10-04 Multi-functional hematopoietic receptor antagonists IL123832A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US483495P	1995-10-05	1995-10-05
PCT/US1996/015774 WO1997012985A2 (en)	1995-10-05	1996-10-04	Multi-functional hematopoietic receptor agonists

Publications (1)

Publication Number	Publication Date
IL123832A0 true IL123832A0 (en)	1998-10-30

Family

ID=21712756

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12383296A IL123832A0 (en)	1995-10-05	1996-10-04	Multi-functional hematopoietic receptor antagonists

Country Status (14)

Country	Link
EP (1)	EP0854928A2 (xx)
JP (1)	JPH11510062A (xx)
KR (1)	KR100456212B1 (xx)
CN (2)	CN1590407A (xx)
AU (1)	AU705083B2 (xx)
BR (1)	BRPI9610977A2 (xx)
CA (1)	CA2234061A1 (xx)
CZ (1)	CZ295518B6 (xx)
IL (1)	IL123832A0 (xx)
MX (1)	MX9802730A (xx)
NO (1)	NO981500L (xx)
NZ (1)	NZ320978A (xx)
PL (1)	PL184424B1 (xx)
WO (1)	WO1997012985A2 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5581476A (en)	1993-01-28	1996-12-03	Amgen Inc.	Computer-based methods and articles of manufacture for preparing G-CSF analogs
US6660257B1 (en)	1996-10-25	2003-12-09	Pharmacia Corporation	Circular permuteins of flt3 ligand
US6967092B1 (en)	1996-10-25	2005-11-22	Mc Kearn John P	Multi-functional chimeric hematopoietic receptor agonists
US5969105A (en) *	1996-10-25	1999-10-19	Feng; Yiqing	Stem cell factor receptor agonists
US6165476A (en) *	1997-07-10	2000-12-26	Beth Israel Deaconess Medical Center	Fusion proteins with an immunoglobulin hinge region linker
US6187564B1 (en)	1997-07-10	2001-02-13	Beth Israel Deaconess Medical Center	DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics
US6242570B1 (en)	1997-07-10	2001-06-05	Beth Israel Deaconess Medical Center	Production and use of recombinant protein multimers with increased biological activity
WO2001027621A2 (en) *	1999-10-07	2001-04-19	Pharmacia Corporation	Competitive inhibition elisa for antibody detection
MXPA04000231A (es)	2001-07-11	2004-05-04	Maxygen Holdings Ltd	Conjugados del factor de estimulacion de colonias de granulocitos.
CA2607844C (en)	2005-06-01	2012-07-10	Maxygen Holdings Ltd.	Pegylated g-csf polypeptides and methods of producing same
WO2007075899A2 (en) *	2005-12-21	2007-07-05	Maxygen, Inc.	Dual agonist compounds and uses thereof
CN102675472B (zh) *	2012-05-07	2014-07-30	北京诺派生物科技有限公司	用于检测猪繁殖与呼吸综合症患猪的试剂盒
WO2014100779A1 (en)	2012-12-21	2014-06-26	Advanced Cell Technology, Inc.	Methods ofr production of platelets from pluripotent stem cells and compositions thereof
LT6161B (lt)	2013-09-27	2015-06-25	Uab Profarma	Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990012877A1 (en) *	1989-04-19	1990-11-01	Cetus Corporation	Multifunctional m-csf proteins and genes encoding therefor
US5738849A (en) *	1992-11-24	1998-04-14	G. D. Searle & Co.	Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US6057133A (en) *	1992-11-24	2000-05-02	G. D. Searle	Multivariant human IL-3 fusion proteins and their recombinant production
US5635599A (en) *	1994-04-08	1997-06-03	The United States Of America As Represented By The Department Of Health And Human Services	Fusion proteins comprising circularly permuted ligands

1996
- 1996-10-04 CN CNA031551432A patent/CN1590407A/zh active Pending
- 1996-10-04 PL PL96326072A patent/PL184424B1/pl not_active IP Right Cessation
- 1996-10-04 KR KR10-1998-0702547A patent/KR100456212B1/ko not_active IP Right Cessation
- 1996-10-04 EP EP96936114A patent/EP0854928A2/en not_active Withdrawn
- 1996-10-04 CN CN96198815A patent/CN1124348C/zh not_active Expired - Fee Related
- 1996-10-04 NZ NZ320978A patent/NZ320978A/en unknown
- 1996-10-04 IL IL12383296A patent/IL123832A0/xx unknown
- 1996-10-04 JP JP9514385A patent/JPH11510062A/ja not_active Abandoned
- 1996-10-04 CA CA002234061A patent/CA2234061A1/en not_active Abandoned
- 1996-10-04 BR BRPI9610977A patent/BRPI9610977A2/pt not_active IP Right Cessation
- 1996-10-04 AU AU73844/96A patent/AU705083B2/en not_active Ceased
- 1996-10-04 WO PCT/US1996/015774 patent/WO1997012985A2/en not_active Application Discontinuation
- 1996-10-04 CZ CZ1998965A patent/CZ295518B6/cs not_active IP Right Cessation
1998
- 1998-04-02 NO NO981500A patent/NO981500L/no not_active Application Discontinuation
- 1998-04-06 MX MX9802730A patent/MX9802730A/es not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR19990064068A (ko)	1999-07-26
NO981500D0 (no)	1998-04-02
WO1997012985A2 (en)	1997-04-10
EP0854928A2 (en)	1998-07-29
PL184424B1 (pl)	2002-10-31
CN1590407A (zh)	2005-03-09
AU7384496A (en)	1997-04-28
WO1997012985A3 (en)	1997-08-07
CZ295518B6 (cs)	2005-08-17
NO981500L (no)	1998-05-20
CN1204369A (zh)	1999-01-06
CN1124348C (zh)	2003-10-15
AU705083B2 (en)	1999-05-13
NZ320978A (en)	2001-03-30
MX9802730A (es)	1998-09-30
BRPI9610977A2 (pt)	2019-09-17
JPH11510062A (ja)	1999-09-07
PL326072A1 (en)	1998-08-17
KR100456212B1 (ko)	2005-01-15
CA2234061A1 (en)	1997-04-10
CZ96598A3 (cs)	1998-09-16

Publication	Publication Date	Title
HU9601529D0 (en)	1996-07-29	Pyrimidinedion-, pyrimidinetrion-, triazinedion-, tetrahydro-quinazolinedion- derivatives as alpha-adrenerg receptor antagonists
HU9603525D0 (en)	1997-02-28	Vironectin receptor antagonists
IL125030A0 (en)	1999-01-26	Vitronectin receptor antagonists
AU7692996A (en)	1997-06-27	Receptor antagonists
IL125033A0 (en)	1999-01-26	Vitronectin receptor antagonists
IL125034A0 (en)	1999-01-26	Vitronectin receptor antagonists
EP0763035A4 (en)	1997-10-01	ENDOTHELIN RECEPTOR ANTAGONISTS
ZA955391B (en)	1996-02-09	Vitronectin receptor antagonists
AU4746297A (en)	1998-04-24	Vitronectin receptor antagonists
IL111431A0 (en)	1994-12-29	Endothelin receptor antagonists
EP0810994A4 (en)	1998-05-06	FIBRINOGENIC RECEPTOR ANTAGONISTS
EP0866705A4 (en)	1999-03-03	FIBRINOGENIC RECEPTOR ANTAGONISTS
HU9601176D0 (en)	1996-06-28	Adhesion-receptor antagonists
HU9501931D0 (en)	1995-09-28	Endothelin receptor antagonists
IL123832A0 (en)	1998-10-30	Multi-functional hematopoietic receptor antagonists
EP0766684A4 (en)	1997-07-16	ENDOTHELINE RECEPTOR ANTAGONISTS
IL129565A0 (en)	2000-02-29	Multi-functional chimeric hematopoietic receptor agonists
GB9517098D0 (en)	1995-10-25	Receptor
AU6961796A (en)	1997-04-01	Improved interleukin-6 receptor antagonist
PL320638A1 (en)	1997-10-13	Antagonists of endothein receptors
HU9602054D0 (en)	1996-09-30	Endothelin receptor antagonists
HUP9902817A3 (en)	2001-03-28	Endothelin receptor antagonists
EP0854721A4 (en)	1998-12-02	ENDOTHELIN RECEPTOR ANTAGONISTS
HU9600333D0 (en)	1996-04-29	Adhesive receptor antagonists
EP0768878A4 (en)	1999-02-17	ENDOTHELINE RECEPTOR ANTAGONISTS