PE20160548A1 - Sulfonamidas como moduladores de canales de sodio - Google Patents
Sulfonamidas como moduladores de canales de sodioInfo
- Publication number
- PE20160548A1 PE20160548A1 PE2016000077A PE2016000077A PE20160548A1 PE 20160548 A1 PE20160548 A1 PE 20160548A1 PE 2016000077 A PE2016000077 A PE 2016000077A PE 2016000077 A PE2016000077 A PE 2016000077A PE 20160548 A1 PE20160548 A1 PE 20160548A1
- Authority
- PE
- Peru
- Prior art keywords
- sodium channel
- sulfonamides
- channel modulators
- compounds
- pharmaceutically acceptable
- Prior art date
Links
- 108010052164 Sodium Channels Proteins 0.000 title abstract 2
- 102000018674 Sodium Channels Human genes 0.000 title abstract 2
- 229940124530 sulfonamide Drugs 0.000 title 1
- 150000003456 sulfonamides Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Dermatology (AREA)
Abstract
La invencion se refiere a compuestos de formula I o a sales farmaceuticamente aceptables de los mismos, donde R1 es H, Cl, entre otros; R2 es entre otros H, Cl, CN; R3 es entre otros H, F, Cl; R4 es H; R5, R5', R6, R6' y R7 son entre otros H, F; utiles como inhibidores de canales de sodio. La invencion tambien proporciona composiciones farmaceuticamente aceptables que comprenden los compuestos de la invencion y metodos de uso de las composiciones en el tratamiento de diversos trastornos, incluyendo dolor
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361856146P | 2013-07-19 | 2013-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20160548A1 true PE20160548A1 (es) | 2016-05-21 |
Family
ID=51293175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2016000077A PE20160548A1 (es) | 2013-07-19 | 2014-07-18 | Sulfonamidas como moduladores de canales de sodio |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US11203571B2 (es) |
| EP (1) | EP3022175B1 (es) |
| JP (1) | JP6337109B2 (es) |
| KR (1) | KR102215620B1 (es) |
| CN (1) | CN105683157B (es) |
| AP (1) | AP2016009023A0 (es) |
| AU (1) | AU2014290411B2 (es) |
| BR (1) | BR112016000825B1 (es) |
| CA (1) | CA2918365C (es) |
| CL (1) | CL2016000106A1 (es) |
| EC (1) | ECSP16005566A (es) |
| ES (1) | ES2654393T3 (es) |
| GE (1) | GEP20207102B (es) |
| HK (1) | HK1223604A1 (es) |
| HU (1) | HUE037876T2 (es) |
| IL (1) | IL243671B (es) |
| MX (1) | MX364155B (es) |
| NO (1) | NO2918662T3 (es) |
| PE (1) | PE20160548A1 (es) |
| PH (1) | PH12016500105A1 (es) |
| RU (1) | RU2680401C2 (es) |
| SG (1) | SG11201600383SA (es) |
| UA (1) | UA119147C2 (es) |
| WO (1) | WO2015010065A1 (es) |
| ZA (1) | ZA201600380B (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE032169T2 (en) | 2013-01-31 | 2017-09-28 | Vertex Pharma | Quinoline and quinoxaline amides as modulators of sodium channels |
| ES2626555T3 (es) | 2013-01-31 | 2017-07-25 | Vertex Pharmaceuticals Incorporated | Pyridone amides como moduladores de canales de sodio |
| SG11201600383SA (en) | 2013-07-19 | 2016-02-26 | Vertex Pharma | Sulfonamides as modulators of sodium channels |
| UA121379C2 (uk) | 2013-12-13 | 2020-05-25 | Вертекс Фармасьютикалз Інкорпорейтед | Проліки піридонамідів, застосовувані як модулятори натрієвих каналів |
| AU2015242219A1 (en) | 2014-03-29 | 2016-10-06 | Lupin Limited | Sulfonamide compounds as Voltage gated sodium channel modulators |
| BR112019024016A2 (pt) * | 2017-05-16 | 2020-06-09 | Vertex Pharma | amidas de piridona deuteradas e profármacos das mesmas como moduladores de canais de sódio |
| WO2019014352A1 (en) | 2017-07-11 | 2019-01-17 | Vertex Pharmaceuticals Incorporated | CARBOXAMIDES AS INHIBITORS OF SODIUM CHANNELS |
| TW202002971A (zh) | 2018-02-12 | 2020-01-16 | 美商維泰克斯製藥公司 | 治療疼痛的方法 |
| CA3105748A1 (en) | 2018-07-09 | 2020-01-16 | Lieber Institute, Inc. | Pyridazine compounds for inhibiting nav1.8 |
| AU2019301628B2 (en) * | 2018-07-09 | 2024-10-31 | Lieber Institute, Inc. | Pyridine carboxamide compounds for inhibiting NaV1.8 |
| US20220119363A1 (en) * | 2018-11-02 | 2022-04-21 | Merck Sharp & Dohme Corp. | 2-amino-n-phenyl-nicotinamides as nav1.8 inhibitors |
| AU2019372057A1 (en) | 2018-11-02 | 2021-05-27 | Merck Sharp & Dohme Llc | 2-amino-N-heteroaryl-nicotinamides as NAV1.8 inhibitors |
| US20220110923A1 (en) | 2019-01-10 | 2022-04-14 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| WO2020146682A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| WO2020176763A1 (en) | 2019-02-27 | 2020-09-03 | Vertex Pharmaceuticals Incorporated | Dosage form comprising prodrug of na 1.8 sodium channel inhibitor |
| WO2020219867A1 (en) | 2019-04-25 | 2020-10-29 | Vertex Pharmaceuticals Incorporated | Pyridone amide co-crystal compositions for the treatment of pain |
| US11834441B2 (en) | 2019-12-06 | 2023-12-05 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofurans as modulators of sodium channels |
| AU2021293176A1 (en) | 2020-06-17 | 2023-02-02 | Merck Sharp & Dohme Llc | 2-oxoimidazolidine-4-carboxamides as Nav1.8 inhibitors |
| WO2022192487A2 (en) * | 2021-03-11 | 2022-09-15 | Latigo Biotherapeutics, Inc. | Methyl-substituted pyridine and pyridazine compounds, derivatives thereof, and methods of their use |
| WO2022235859A1 (en) | 2021-05-07 | 2022-11-10 | Merck Sharp & Dohme Llc | Cycloalkyl 3-oxopiperazine carboxamides and cycloheteroalkyl 3-oxopiperazine carboxamides as nav1.8 inhibitors |
| WO2022256708A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Solid dosage forms and dosing regimens comprising (2r,3s,4s,5r)-4-[[3-(3,4-difluoro-2-methoxy-phenyl)-4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide |
| AU2022285758A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran analogs as modulators of sodium channels |
| KR20240031300A (ko) | 2021-06-04 | 2024-03-07 | 버텍스 파마슈티칼스 인코포레이티드 | 나트륨 채널 조절제로서의 n-(하이드록시알킬 (헤테로)아릴) 테트라하이드로푸란 카르복스아미드 |
| EP4347032A1 (en) | 2021-06-04 | 2024-04-10 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels |
| CA3221960A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels |
| AU2022286438A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels |
| AU2023255771A1 (en) | 2022-04-22 | 2024-10-31 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| AU2023255558A1 (en) | 2022-04-22 | 2024-10-31 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2023205468A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| US20230373925A1 (en) | 2022-04-22 | 2023-11-23 | Vertex Pharma | Heteroaryl compounds for the treatment of pain |
| CN116947713A (zh) * | 2022-04-25 | 2023-10-27 | 中国科学院上海药物研究所 | 并环类化合物及其应用 |
| WO2023211990A1 (en) | 2022-04-25 | 2023-11-02 | Siteone Therapeutics, Inc. | Bicyclic heterocyclic amide inhibitors of na v1.8 for the treatment of pain |
| CN117586180A (zh) * | 2022-08-12 | 2024-02-23 | 广州费米子科技有限责任公司 | 用作电压-门控钠通道抑制剂的化合物 |
| WO2024123815A1 (en) | 2022-12-06 | 2024-06-13 | Vertex Pharmaceuticals Incorporated | Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels |
| WO2024217344A1 (zh) * | 2023-04-19 | 2024-10-24 | 中国科学院上海药物研究所 | Nav1.8抑制剂及其制备方法和用途 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5716981A (en) | 1993-07-19 | 1998-02-10 | Angiogenesis Technologies, Inc. | Anti-angiogenic compositions and methods of use |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| EP1303757B1 (en) | 2000-07-10 | 2006-10-11 | Vertex Pharmaceuticals (San Diego) LLC | Ion channel assay methods |
| US20040220170A1 (en) | 2003-05-01 | 2004-11-04 | Atkinson Robert N. | Pyrazole-amides and sulfonamides as sodium channel modulators |
| EP2332912A1 (en) | 2003-08-08 | 2011-06-15 | Vertex Pharmaceuticals Incorporated | Heteroarylaminosulfonylphenylderivates for use as sodium or calcium channel blockers in the treatment of pain |
| JP4056081B1 (ja) | 2004-07-23 | 2008-03-05 | ファイザー・インク | ピリジン誘導体 |
| TWI285415B (en) * | 2005-08-01 | 2007-08-11 | Advanced Semiconductor Eng | Package structure having recession portion on the surface thereof and method of making the same |
| WO2007120647A2 (en) | 2006-04-11 | 2007-10-25 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of voltage-gated sodium channels |
| GEP20125379B (en) | 2007-05-03 | 2012-01-10 | Pfizer Ltd | 2 -pyridine carboxamide derivatives as sodium channel modulators |
| JP5436434B2 (ja) * | 2007-10-11 | 2014-03-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | 電位開口型ナトリウムチャネルの阻害剤として有用なアミド |
| CN101883760A (zh) | 2007-10-11 | 2010-11-10 | 沃泰克斯药物股份有限公司 | 用作电压-门控钠通道抑制剂的杂芳基酰胺类 |
| JP5562859B2 (ja) | 2007-10-11 | 2014-07-30 | バーテックス ファーマシューティカルズ インコーポレイテッド | 電位開口型ナトリウムチャネルの阻害剤として有用なアリールアミド |
| CA2812526A1 (en) | 2010-05-06 | 2011-11-10 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
| US9120752B2 (en) * | 2010-07-16 | 2015-09-01 | Purdue Pharma, L.P. | Pyridine compounds as sodium channel blockers |
| DK2670752T3 (en) | 2011-02-02 | 2016-07-04 | Vertex Pharma | PYRROLOPYRAZINE SPIROCYCLIC PIPERIDINAMIDE AS ION CHANNEL MODULATORS |
| US10385070B2 (en) | 2011-02-18 | 2019-08-20 | Vertex Pharmaceuticals Incorporated | Chroman-spirocyclic piperidine amides as modulators of ion channels |
| MX347982B (es) | 2011-03-14 | 2017-05-22 | Vertex Pharma | Morfolina-piperidina espirociclica-amidas como moduladores de canales ionicos. |
| BR112013032813A2 (pt) | 2011-06-20 | 2016-08-16 | Du Pont | composto de fórmula, composição e método para o tratamento, controle, prevenção ou proteção dos animais contra a infecção por helmintos |
| US9365588B2 (en) | 2011-11-04 | 2016-06-14 | Vertex Pharmaceuticals Incorporated | Benzoxazines as modulators of ion channels |
| US9403839B2 (en) | 2012-01-16 | 2016-08-02 | Vertex Pharmaceuticals Incorporated | Pyran-spirocyclic piperidine amides as modulators of ion channels |
| AU2014212431B2 (en) | 2013-01-31 | 2018-04-05 | Vertex Pharmaceuticals Incorporated | Amides as modulators of sodium channels |
| HUE032169T2 (en) | 2013-01-31 | 2017-09-28 | Vertex Pharma | Quinoline and quinoxaline amides as modulators of sodium channels |
| ES2626555T3 (es) | 2013-01-31 | 2017-07-25 | Vertex Pharmaceuticals Incorporated | Pyridone amides como moduladores de canales de sodio |
| SG11201600383SA (en) | 2013-07-19 | 2016-02-26 | Vertex Pharma | Sulfonamides as modulators of sodium channels |
| UA121379C2 (uk) | 2013-12-13 | 2020-05-25 | Вертекс Фармасьютикалз Інкорпорейтед | Проліки піридонамідів, застосовувані як модулятори натрієвих каналів |
| WO2019014352A1 (en) | 2017-07-11 | 2019-01-17 | Vertex Pharmaceuticals Incorporated | CARBOXAMIDES AS INHIBITORS OF SODIUM CHANNELS |
-
2014
- 2014-07-18 SG SG11201600383SA patent/SG11201600383SA/en unknown
- 2014-07-18 GE GEAP201414060A patent/GEP20207102B/en unknown
- 2014-07-18 UA UAA201601499A patent/UA119147C2/uk unknown
- 2014-07-18 US US14/906,089 patent/US11203571B2/en active Active
- 2014-07-18 WO PCT/US2014/047265 patent/WO2015010065A1/en active Application Filing
- 2014-07-18 CA CA2918365A patent/CA2918365C/en active Active
- 2014-07-18 AU AU2014290411A patent/AU2014290411B2/en active Active
- 2014-07-18 KR KR1020167004279A patent/KR102215620B1/ko active IP Right Grant
- 2014-07-18 HU HUE14748056A patent/HUE037876T2/hu unknown
- 2014-07-18 AP AP2016009023A patent/AP2016009023A0/en unknown
- 2014-07-18 JP JP2016527141A patent/JP6337109B2/ja active Active
- 2014-07-18 MX MX2016000646A patent/MX364155B/es active IP Right Grant
- 2014-07-18 PE PE2016000077A patent/PE20160548A1/es unknown
- 2014-07-18 BR BR112016000825-1A patent/BR112016000825B1/pt active IP Right Grant
- 2014-07-18 CN CN201480046803.9A patent/CN105683157B/zh active Active
- 2014-07-18 ES ES14748056.0T patent/ES2654393T3/es active Active
- 2014-07-18 RU RU2016105511A patent/RU2680401C2/ru active
- 2014-07-18 EP EP14748056.0A patent/EP3022175B1/en active Active
-
2015
- 2015-03-11 NO NO15158669A patent/NO2918662T3/no unknown
-
2016
- 2016-01-15 CL CL2016000106A patent/CL2016000106A1/es unknown
- 2016-01-18 PH PH12016500105A patent/PH12016500105A1/en unknown
- 2016-01-18 ZA ZA2016/00380A patent/ZA201600380B/en unknown
- 2016-01-19 IL IL243671A patent/IL243671B/en active IP Right Grant
- 2016-02-11 EC ECIEPI20165566A patent/ECSP16005566A/es unknown
- 2016-10-14 HK HK16111872.2A patent/HK1223604A1/zh unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20160548A1 (es) | Sulfonamidas como moduladores de canales de sodio | |
| UY35288A (es) | Piridonamidas como moduladores de canales de sodio | |
| ECSP16025201A (es) | Profármacos de amidas de piridona útiles como moduladores de canales de sodio | |
| CO2020000145A2 (es) | Carboxamidas como moduladores de los canales de sodio | |
| CO2019013021A2 (es) | Amidas de piridona deuteradas y sus profármacos como moduladores de los canales de sodio | |
| CO2017004481A2 (es) | Compuestos de indol carboxamida utiles como inhibidores de cinasas | |
| DOP2022000115A (es) | Tetrahidrofuranos sustituidos como moduladores de canales de sodio | |
| BR112015018284A2 (pt) | amidas como moduladores de canais de sódio | |
| BR112015017997A2 (pt) | amidas de quinolina e quinazolina como moduladores de canais de sódio | |
| UY33961A (es) | Compuestos de bis(fuoroalquil)-1,4-benziodiazepinona | |
| UY35377A (es) | Compuestos de 1,3-oxazin-2-amina fusionados con ciclopropilo perfluorado como inhibidores de beta-secretasa y métodos de uso | |
| CO7160015A2 (es) | Benzamidas n-sustituidas y su uso en el tratamiento del dolor | |
| ECSP15012804A (es) | Alcoxipirazoles como activadores de guanilato ciclasa soluble | |
| PE20160801A1 (es) | Derivados de heterobicicloaril como inhibidores rorc2 y metodos de uso de los mismos | |
| PE20151892A1 (es) | Compuestos tetraciclicos sustituidos con heterociclo y metodos de uso de los mismos para el tratamiento de enfermedades viricas | |
| UY35551A (es) | Derivados heteroarilos como inhibidores de aldosterona sintasa | |
| CL2003002769A1 (es) | Compuestos derivados de carboxamida de tiazolilpirrol; procedimiento para su preparacion; composiciones farmaceuticas que los comprenden; y su uso para el tratamiento y/o profilaxis de enfermedades asociadas con la modulacion de receptores canabinoid | |
| UY35320A (es) | ?COMPUESTOS DE HEXAHIDROPIRANO[3,4-d][1,3]TIAZIN-2-AMINA SUSTITUIDA CON HETEROARILO?. | |
| CO2023017899A2 (es) | N-(hidroxialquil(hetero)aril) tetrahidrofurano carboxamidas como moduladores de canales de sodio | |
| UY36257A (es) | “compuestos de imidazopiridazina”. | |
| CU20160140A7 (es) | CROMENE Y 1,1 A,2,7B- tetrahidrociclopropa[C]CROMENE PIRIDOPIRAZINEDIONES COMO MODULADORES DE GAMMA-SECRETASA | |
| UY35419A (es) | Inhibidores de cdk9 quinasa de pirrolo (2,3- b) piridina | |
| PE20150638A1 (es) | Aminas ciclicas | |
| CL2017002498A1 (es) | Piridopirimidinonas y su uso como modulares del receptor nmda | |
| UY31680A1 (es) | "agonistas de los receptores muscarínicos, composiciones, métodos de tratamiento en que se emplean y sus procesos de preparación-176" |