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PE20110566A1 - Inhibidores ciclicos de 11beta-hidroxiesteroide deshidrogenasa 1 - Google Patents

Inhibidores ciclicos de 11beta-hidroxiesteroide deshidrogenasa 1

Info

Publication number
PE20110566A1
PE20110566A1 PE2011000071A PE2011000071A PE20110566A1 PE 20110566 A1 PE20110566 A1 PE 20110566A1 PE 2011000071 A PE2011000071 A PE 2011000071A PE 2011000071 A PE2011000071 A PE 2011000071A PE 20110566 A1 PE20110566 A1 PE 20110566A1
Authority
PE
Peru
Prior art keywords
phenyl
11beta
ethyl
methylpropyl
hydroxy
Prior art date
Application number
PE2011000071A
Other languages
English (en)
Inventor
Frank Himmelsbach
David A Claremon
Linghang Zhuang
Katerina Leftheris
Zhenrong Xu
Colin M Tice
Original Assignee
Boehringer Ingelheim Int
Vitae Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41090311&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110566(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2008/009017 external-priority patent/WO2009017664A1/en
Priority claimed from PCT/US2009/002653 external-priority patent/WO2009134400A1/en
Application filed by Boehringer Ingelheim Int, Vitae Pharmaceuticals Inc filed Critical Boehringer Ingelheim Int
Publication of PE20110566A1 publication Critical patent/PE20110566A1/es

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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pregnancy & Childbirth (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I, DONDE G1 ES ALQUILO C1-C4, ALCOXI C1-C4, HALOALQUILO C1-C4, ENTRE OTROS; n ES 0-2; G2a ES CICLOALQUILO C3-C4; G2b ES H, METILO, ETILO; R1 ES METILO, ETILO; R2 ES FENILO, FLUOROFENILO; R3 ES 2-HIDROXI-2-METILPROPILO, 2-CIANO-2-METILPROPILO. SON COMPUESTOS PREFERIDOS: (S)-6-(2-HIDROXI-2-METILPROPIL)-3-((S)-1-(4-(6-OXO-1,6-DIHIDROPIRIDIN-3-IL)FENIL)ETIL)-6-FENIL-1,3-OXAZINAN-2-ONA; (S)-3-((S)-1-(4-(1-(DIFLUOROMETIL)-6-OXO-1,6-DIHIDROPIRIDIN-3-IL)FENIL)ETIL)-6-(2-HIDROXI-2-METILPROPIL)-6-FENIL-1,3-OXAZINAN-2-ONA; ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES EFICACES DE 11BETA-HSD1 Y PUEDEN SER UTILES PARA PROMOVER LA CICATRIZACION
PE2011000071A 2008-07-25 2009-07-23 Inhibidores ciclicos de 11beta-hidroxiesteroide deshidrogenasa 1 PE20110566A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13714808P 2008-07-25 2008-07-25
PCT/US2008/009017 WO2009017664A1 (en) 2007-07-26 2008-07-25 CYCLIC INHIBITORS OF 11β-HYDROXYSTERIOD DEHYDROGENASE 1
US20678509P 2009-02-04 2009-02-04
PCT/US2009/002653 WO2009134400A1 (en) 2008-05-01 2009-04-30 Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1

Publications (1)

Publication Number Publication Date
PE20110566A1 true PE20110566A1 (es) 2011-09-02

Family

ID=41090311

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000071A PE20110566A1 (es) 2008-07-25 2009-07-23 Inhibidores ciclicos de 11beta-hidroxiesteroide deshidrogenasa 1

Country Status (24)

Country Link
US (3) US8114868B2 (es)
EP (2) EP2324018B1 (es)
JP (2) JP5379160B2 (es)
KR (1) KR20110050459A (es)
CN (3) CN102119160B (es)
AR (1) AR073348A1 (es)
AU (1) AU2009274567B2 (es)
CA (1) CA2730499A1 (es)
CL (2) CL2011000159A1 (es)
CO (1) CO6351743A2 (es)
DK (1) DK2324018T3 (es)
EA (2) EA020665B1 (es)
EC (1) ECSP10010633A (es)
ES (1) ES2432150T3 (es)
IL (1) IL210452A (es)
MA (1) MA32596B1 (es)
NZ (1) NZ590495A (es)
PE (1) PE20110566A1 (es)
PH (1) PH12014501532A1 (es)
PL (1) PL2324018T3 (es)
RU (1) RU2539979C2 (es)
TW (1) TW201004946A (es)
UY (1) UY32591A (es)
WO (1) WO2010011314A1 (es)

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JP5486928B2 (ja) 2007-02-26 2014-05-07 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックウレアおよびカルバメートインヒビター
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TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
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EP2300437B1 (en) * 2008-06-05 2013-11-20 Glaxo Group Limited Benzpyrazol derivatives as inhibitors of pi3 kinases
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PE20110566A1 (es) 2008-07-25 2011-09-02 Boehringer Ingelheim Int Inhibidores ciclicos de 11beta-hidroxiesteroide deshidrogenasa 1
JP5390610B2 (ja) 2008-07-25 2014-01-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成
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EP2406255B1 (en) 2009-03-09 2015-04-29 Glaxo Group Limited 4-oxadiazol-2-yl-indazoles as inhibitors of pi3 kinases
LT3210981T (lt) 2009-04-23 2019-04-10 Theravance Respiratory Company, Llc Diamidu junginiai, pasižymintys muskarininių receptorių atžvilgiu antagonistiniu ir beta 2 adrenerginių receptorių atžvilgiu agonistiniu aktyvumu
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BRPI1016219B8 (pt) 2009-04-30 2021-05-25 Glaxo Group Ltd composto indazol substituído com oxazol, e, composição farmacêutica
JP5656986B2 (ja) 2009-06-11 2015-01-21 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １，３−オキサジナン−２−オン構造に基づく１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
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JP5750449B2 (ja) 2009-11-05 2015-07-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規キラルリンリガンド
TWI531571B (zh) 2009-11-06 2016-05-01 維它藥物公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
JP2013531636A (ja) 2010-05-26 2013-08-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ２−オキソ−１，２−ジヒドロピリジン−４−イルボロン酸誘導体
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