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PE20091961A1 - Nuevos derivados azabiciclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen - Google Patents

Nuevos derivados azabiciclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen

Info

Publication number
PE20091961A1
PE20091961A1 PE2009000758A PE2009000758A PE20091961A1 PE 20091961 A1 PE20091961 A1 PE 20091961A1 PE 2009000758 A PE2009000758 A PE 2009000758A PE 2009000758 A PE2009000758 A PE 2009000758A PE 20091961 A1 PE20091961 A1 PE 20091961A1
Authority
PE
Peru
Prior art keywords
azabycle
propoxi
preparation procedure
hex
derivatives
Prior art date
Application number
PE2009000758A
Other languages
English (en)
Inventor
Patrick Casara
Alain Dhainaut
Fany Panayi
Anne-Marie Chollet
Pierre Lestage
Anita Roger
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of PE20091961A1 publication Critical patent/PE20091961A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

REFERIDA A UN DERIVADO AZABICICLICO DE FORMULA (I), DONDE ALK ES UN ALQUILENO C2-C6 LINEAL O RAMIFICADO; W ES UN GRUPO -NR'-C(=O)-R O -C(=O)-NR'-R; R Y R' SON H O UN GRUPO ALQUILO C1-C6 LINEAL O RAMIFICADO OPCIONALMENTE SUSTITUIDO CON HALOGENO, OH O ALCOXI C1-C6. SON COMPUESTOS PREFERIDOS: N-(4-{3-[(1R,5S)-3-AZABICICLO[3.1.0]HEX-3-IL]PROPOXI}FENIL)-N-METILACETAMIDA, 4-{3-[(1R,5S)-3-AZABICICLO[3.1.0]HEX-3-IL]PROPOXI}BENZAMIDA, N-(4-{3-[(1R,5S)-3-AZABICICLO[3.1.0]HEX-3-IL]PROPOXI}FENIL)-2-METOXIACETAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INTERACTUAN CON LOS SISTEMAS HISTAMINERGICOS CENTRALES Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS COGNITIVOS Y PSICOCOMPORTAMENTALES ASOCIADOS CON EL ENVEJECIMIENTO CEREBRAL O ENFERMEDADES TALES COMO ALZHEIMER, PARKINSON, ENFERMEDAD DE PICK, ENTRE OTRAS
PE2009000758A 2008-06-13 2009-06-01 Nuevos derivados azabiciclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen PE20091961A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0803297A FR2932479A1 (fr) 2008-06-13 2008-06-13 Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
PE20091961A1 true PE20091961A1 (es) 2010-01-23

Family

ID=40227963

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000758A PE20091961A1 (es) 2008-06-13 2009-06-01 Nuevos derivados azabiciclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen

Country Status (29)

Country Link
US (1) US7906547B2 (es)
EP (1) EP2133333A1 (es)
JP (1) JP2009298790A (es)
KR (1) KR20090129958A (es)
CN (1) CN101602706A (es)
AP (1) AP2009004891A0 (es)
AR (1) AR072101A1 (es)
AU (1) AU2009202341A1 (es)
BR (1) BRPI0902395A2 (es)
CA (1) CA2668527A1 (es)
CL (1) CL2009001377A1 (es)
CO (1) CO6190096A1 (es)
CR (1) CR10844A (es)
EA (1) EA200900692A1 (es)
EC (1) ECSP099396A (es)
FR (1) FR2932479A1 (es)
GT (1) GT200900150A (es)
MA (1) MA31141B1 (es)
MX (1) MX2009005891A (es)
MY (1) MY144748A (es)
NI (1) NI200900114A (es)
NZ (1) NZ577438A (es)
PE (1) PE20091961A1 (es)
SG (1) SG158015A1 (es)
SV (1) SV2009003292A (es)
TW (1) TW201000101A (es)
UY (1) UY31857A1 (es)
WO (1) WO2009150331A1 (es)
ZA (1) ZA200903939B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10892398B2 (en) * 2019-03-28 2021-01-12 Johannes Pollanen Qubit hardware for electrons on helium
EP4251148A1 (en) 2020-11-27 2023-10-04 Richter Gedeon Nyrt. Histamine h3 receptor antagonists/inverse agonists for the treatment of autism spectrum disorder

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6515013B2 (en) * 2000-07-13 2003-02-04 Abbott Laboratories 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
ATE400553T1 (de) * 2002-12-10 2008-07-15 Ranbaxy Lab Ltd 3,6-disubstituierte azabicyclo 3.1.0 - hexanderivative als antagonisten des muscarinrezeptors
FR2866647B1 (fr) * 2004-02-20 2006-10-27 Servier Lab Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1707203A1 (en) * 2005-04-01 2006-10-04 Bioprojet Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands
KR100969402B1 (ko) * 2005-04-08 2010-07-14 화이자 프로덕츠 인크. Ｉ형 글리신 수송 억제제로서의 비시클릭 [3.1.0]헤테로아릴 아미드
EP1842846A1 (en) * 2006-04-07 2007-10-10 Santhera Pharmaceuticals (Schweiz) AG Phenylpiperidine derivatives as melanocortin-4 receptor modulators
GB2454615A (en) * 2006-07-21 2009-05-13 Lupin Ltd Antidiabetic azabicyclo (3.1.0) hexan compounds

Also Published As

Publication number Publication date
AR072101A1 (es) 2010-08-04
CN101602706A (zh) 2009-12-16
JP2009298790A (ja) 2009-12-24
SG158015A1 (en) 2010-01-29
ZA200903939B (en) 2010-04-28
WO2009150331A1 (fr) 2009-12-17
US20090312389A1 (en) 2009-12-17
ECSP099396A (es) 2010-01-29
GT200900150A (es) 2011-08-25
TW201000101A (en) 2010-01-01
CL2009001377A1 (es) 2010-05-28
AP2009004891A0 (en) 2009-06-30
MX2009005891A (es) 2010-02-17
NI200900114A (es) 2010-02-03
BRPI0902395A2 (pt) 2010-04-20
EP2133333A1 (fr) 2009-12-16
AU2009202341A1 (en) 2010-01-07
MA31141B1 (fr) 2010-02-01
CA2668527A1 (fr) 2009-12-13
UY31857A1 (es) 2009-08-31
MY144748A (en) 2011-10-31
NZ577438A (en) 2010-09-30
CO6190096A1 (es) 2010-08-19
CR10844A (es) 2009-07-23
EA200900692A1 (ru) 2009-12-30
SV2009003292A (es) 2010-02-01
FR2932479A1 (fr) 2009-12-18
KR20090129958A (ko) 2009-12-17
US7906547B2 (en) 2011-03-15

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