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PE20071029A1 - Compuestos de cinamida no peptidicos biciclicos como inhibidores de beta amiloides - Google Patents

Compuestos de cinamida no peptidicos biciclicos como inhibidores de beta amiloides

Info

Publication number
PE20071029A1
PE20071029A1 PE2006001479A PE2006001479A PE20071029A1 PE 20071029 A1 PE20071029 A1 PE 20071029A1 PE 2006001479 A PE2006001479 A PE 2006001479A PE 2006001479 A PE2006001479 A PE 2006001479A PE 20071029 A1 PE20071029 A1 PE 20071029A1
Authority
PE
Peru
Prior art keywords
compounds
inhibitors
cyane
benzyliden
metoxy
Prior art date
Application number
PE2006001479A
Other languages
English (en)
Inventor
Teiji Kimura
Koki Kawano
Eriko Doi
Noritaka Kitazawa
Mamoru Takaishi
Koichi Ito
Toshihiko Kaneko
Takeo Sasaki
Takehiko Miyagawa
Hiroaki Hagiwara
Yu Yoshida
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of PE20071029A1 publication Critical patent/PE20071029A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

REFERIDA A UN COMPUESTO CINAMIDA DE FORMULA (I), DONDE LA LINEA PUNTEADA REPRESENTA UN ENLACE SIMPLE O UN ENLACE DOBLE; Ar1 ES FENILO O PIRIDINILO OPCIONALMENTE SUSTITUIDOS CON HALOGENO, HIDROXILO, CIANO, CICLOALQUILO C3-C8, ENTRE OTROS; R1 Y R2 SON HALOGENO, CIANO, OH, CICLOALQUILO C3-C8, CICLOALCOXI C3-C8, ENTRE OTROS; Z1 ES METILENO O VIVNILENO OPCIONALMENTE SUSTITUIDOS CON HALO, CIANO, OH, CICLOALQUILO C3-C8, ENTRE OTROS; p, q Y r SON UN NUMERO ENTERO DE 0 A 2. SON COMPUESTOS PREFERIDOS: (E)-(3S)-(3,4,5-TRIFLUOROFENIL)-6-[3-METOXI-4-(4-METIL-1H-IMIDAZOL-1-IL)-BENCILIDEN]-(9R)-HEXAHIDROINDOLIZIN-5-ONA, (E)-(3S)-(3,4-DIFLUOROFENIL)-6-[3-METOXI-4-(4-METIL-1H-IMIDAZOL-1-IL)-BENCILIDEN]-(9R)-HEXAHIDROINDOLIZIN-5-ONA, (E)-(6R,9aS)-6-(4-FLUOROFENIL)-3-[3-METOXI-4-(4-METIL-1H-IMIDAZOL-1-IL)-BENCILIDEN]OCTAHIDROQUINOLIZIN-4-ONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PRODUCCION DE BETA AMILOIDE Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES NEURODEGENERATIVAS TALES COMO LA ENFERMEDAD DE ALZHEIMER Y EL SINDROME DE DOWN
PE2006001479A 2005-11-24 2006-11-21 Compuestos de cinamida no peptidicos biciclicos como inhibidores de beta amiloides PE20071029A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005337963 2005-11-24
JP2006205538 2006-07-28

Publications (1)

Publication Number Publication Date
PE20071029A1 true PE20071029A1 (es) 2007-11-17

Family

ID=38067057

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001479A PE20071029A1 (es) 2005-11-24 2006-11-21 Compuestos de cinamida no peptidicos biciclicos como inhibidores de beta amiloides

Country Status (26)

Country Link
US (1) US8048878B2 (es)
EP (1) EP1953158B1 (es)
JP (1) JP5178203B2 (es)
KR (1) KR101296239B1 (es)
AR (1) AR057915A1 (es)
AU (1) AU2006317468B2 (es)
BR (1) BRPI0618890A2 (es)
CA (1) CA2629512C (es)
CR (1) CR9983A (es)
EA (1) EA014427B1 (es)
EC (1) ECSP088466A (es)
ES (1) ES2394364T3 (es)
GE (1) GEP20115172B (es)
HK (1) HK1122806A1 (es)
HN (1) HN2008000792A (es)
MA (1) MA29968B1 (es)
ME (1) ME00040B (es)
MY (1) MY144596A (es)
NO (1) NO20082805L (es)
NZ (1) NZ568422A (es)
PE (1) PE20071029A1 (es)
PL (1) PL1953158T3 (es)
RS (1) RS20080242A (es)
SA (1) SA06270432B1 (es)
TW (1) TWI370130B (es)
WO (1) WO2007060821A1 (es)

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Also Published As

Publication number Publication date
TW200804372A (en) 2008-01-16
CA2629512A1 (en) 2007-05-31
AU2006317468B2 (en) 2011-10-13
AR057915A1 (es) 2007-12-26
MY144596A (en) 2011-10-14
GEP20115172B (en) 2011-03-10
EP1953158B1 (en) 2012-09-12
ES2394364T3 (es) 2013-01-31
RS20080242A (xx) 2009-09-08
WO2007060821A1 (ja) 2007-05-31
EP1953158A4 (en) 2010-09-01
EP1953158A1 (en) 2008-08-06
KR101296239B1 (ko) 2013-08-13
EA200801417A1 (ru) 2009-02-27
KR20080072057A (ko) 2008-08-05
HN2008000792A (es) 2010-09-17
AU2006317468A1 (en) 2007-05-31
PL1953158T3 (pl) 2013-02-28
EA014427B1 (ru) 2010-12-30
NO20082805L (no) 2008-08-20
TWI370130B (en) 2012-08-11
BRPI0618890A2 (pt) 2013-01-08
CR9983A (es) 2008-08-21
SA06270432B1 (ar) 2011-06-22
MA29968B1 (fr) 2008-11-03
JP5178203B2 (ja) 2013-04-10
JPWO2007060821A1 (ja) 2009-05-07
NZ568422A (en) 2010-09-30
US8048878B2 (en) 2011-11-01
ECSP088466A (es) 2008-08-29
CA2629512C (en) 2014-04-22
ME00040B (me) 2010-06-10
US20090181945A1 (en) 2009-07-16
HK1122806A1 (en) 2009-05-29

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