LV10251B - Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d|indole - Google Patents

Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d|indole

Info

Publication number: LV10251B
Authority: LV; Latvia
Prior art keywords: tetrahydrobenz; propyl; amino; preparation; indole
Prior art date: 1990-02-26

Application number

LVP-93-509A

Other languages

English (en)

Other versions

LV10251A (lv

Inventor

Thomas Joseph Kress

David Lee Varie

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-26

Filing date

1993-06-08

Publication date

1995-04-20

1993-06-08 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1994-10-20 Publication of LV10251A publication Critical patent/LV10251A/xx

1995-04-20 Publication of LV10251B publication Critical patent/LV10251B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

LVP-93-509A 1990-02-26 1993-06-08 Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d|indole LV10251B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US48518590A	1990-02-26	1990-02-26

Publications (2)

Publication Number	Publication Date
LV10251A LV10251A (lv)	1994-10-20
LV10251B true LV10251B (en)	1995-04-20

Family

ID=23927224

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LVP-93-509A LV10251B (en)	1990-02-26	1993-06-08	Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d\|indole

Country Status (28)

Country	Link
US (1)	US5397799A (xx)
EP (1)	EP0444852B1 (xx)
JP (1)	JP3157007B2 (xx)
KR (1)	KR100208114B1 (xx)
CN (1)	CN1027503C (xx)
AT (1)	ATE126506T1 (xx)
AU (1)	AU629453B2 (xx)
BR (1)	BR9100767A (xx)
CA (1)	CA2037099C (xx)
CY (1)	CY1887A (xx)
DE (1)	DE69112099T2 (xx)
DK (1)	DK0444852T3 (xx)
ES (1)	ES2077796T3 (xx)
FI (1)	FI95464C (xx)
GR (1)	GR3017940T3 (xx)
HK (1)	HK175495A (xx)
HU (1)	HU217118B (xx)
IE (1)	IE67801B1 (xx)
IL (1)	IL97306A (xx)
LV (1)	LV10251B (xx)
NO (1)	NO174149C (xx)
NZ (1)	NZ237181A (xx)
PT (1)	PT96852B (xx)
RU (2)	RU2034837C1 (xx)
SG (1)	SG69975A1 (xx)
TW (1)	TW219933B (xx)
YU (1)	YU47594B (xx)
ZA (1)	ZA911258B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL97308A (en) *	1990-02-26	1996-10-31	Lilly Co Eli	Xahydrobenz [DC] Induced indoles in position 6, their preparation process and pharmaceutical preparations containing them
IL97309A (en) *	1990-02-26	1996-11-14	Lilly Co Eli	Intermediates for hexahydrobenz] [DC indoles and a process for making their pure enantiomers
US5302612A (en) *	1990-02-26	1994-04-12	Eli Lilly And Company	6-substituted-hexahydrobenz[cd]indoles
US5364856A (en) *	1991-03-28	1994-11-15	Eli Lilly And Company	6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
US5641794A (en) *	1991-03-28	1997-06-24	Eli Lilly Company	6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles
TW248556B (xx) *	1993-01-18	1995-06-01	Takeda Pharm Industry Co
US7588924B2 (en)	2006-03-07	2009-09-15	Procter & Gamble Company	Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
LT3357911T (lt) *	2006-06-26	2022-08-10	Akebia Therapeutics Inc.	Prolilo hidroksilazės inhibitoriai ir naudojimo būdai
IN2012DN04940A (xx)	2009-11-06	2015-09-25	Aerpio Therapeutics Inc
RU2602498C2 (ru)	2011-06-06	2016-11-20	Акебиа Терапеутикс Инк.	Соединения и композиции для стабилизации индуцируемого гипоксией фактора-2 альфа как способ лечения рака
NO2686520T3 (xx)	2011-06-06	2018-03-17
BR112015031027A2 (pt)	2013-06-13	2017-08-29	Akebia Therapeutics Inc	Uso de um composto, método in vitro, composição farmacêutica e forma de dosagem única
SG10202012791TA (en)	2013-11-15	2021-01-28	Akebia Therapeutics Inc	Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof
CA2974691A1 (en)	2015-01-23	2016-07-28	Akebia Therapeutics, Inc.	Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
CA2981176A1 (en)	2015-04-01	2017-10-06	Akebia Therapeutics, Inc.	Compositions and methods for treating anemia
JP7440989B2 (ja)	2018-05-09	2024-02-29	アケビアセラピューティクスインコーポレイテッド	２－［５－（３－クロロフェニル）－３－ヒドロキシピリジン－２－カルボニル］アミノ］酢酸を調製するための方法
US11524939B2 (en)	2019-11-13	2022-12-13	Akebia Therapeutics, Inc.	Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4110339A (en) *	1977-11-25	1978-08-29	Eli Lilly And Company	4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4576959A (en) *	1984-02-06	1986-03-18	Eli Lilly And Company	6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
US4745126A (en) *	1987-03-12	1988-05-17	Eli Lilly And Company	Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) *	1988-03-18	1989-09-28	Bayer Ag	1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) *	1989-04-11	1993-04-20	Eli Lilly And Company	Tetrahydrobenz(c,d)indole serotonin agonists
US5229409A (en) *	1990-08-15	1993-07-20	Eli Lilly And Company	6-substituted-tetrahydrobenz[cd]indoles

1990
- 1990-06-26 TW TW079105258A patent/TW219933B/zh active
1991
- 1991-02-20 ZA ZA911258A patent/ZA911258B/xx unknown
- 1991-02-20 IL IL9730691A patent/IL97306A/en not_active IP Right Cessation
- 1991-02-21 NZ NZ237181A patent/NZ237181A/en unknown
- 1991-02-22 JP JP05064391A patent/JP3157007B2/ja not_active Expired - Fee Related
- 1991-02-22 PT PT96852A patent/PT96852B/pt not_active IP Right Cessation
- 1991-02-25 RU SU914894699A patent/RU2034837C1/ru not_active IP Right Cessation
- 1991-02-25 FI FI910895A patent/FI95464C/fi active
- 1991-02-25 KR KR1019910003029A patent/KR100208114B1/ko not_active IP Right Cessation
- 1991-02-25 AU AU71971/91A patent/AU629453B2/en not_active Ceased
- 1991-02-25 YU YU32791A patent/YU47594B/sh unknown
- 1991-02-25 HU HU91629A patent/HU217118B/hu unknown
- 1991-02-25 NO NO910735A patent/NO174149C/no unknown
- 1991-02-25 IE IE62591A patent/IE67801B1/en not_active IP Right Cessation
- 1991-02-26 SG SG1996007257A patent/SG69975A1/en unknown
- 1991-02-26 CA CA002037099A patent/CA2037099C/en not_active Expired - Fee Related
- 1991-02-26 ES ES91301501T patent/ES2077796T3/es not_active Expired - Lifetime
- 1991-02-26 CN CN91101296A patent/CN1027503C/zh not_active Expired - Fee Related
- 1991-02-26 BR BR919100767A patent/BR9100767A/pt not_active Application Discontinuation
- 1991-02-26 DE DE69112099T patent/DE69112099T2/de not_active Expired - Fee Related
- 1991-02-26 EP EP91301501A patent/EP0444852B1/en not_active Expired - Lifetime
- 1991-02-26 DK DK91301501.2T patent/DK0444852T3/da active
- 1991-02-26 AT AT91301501T patent/ATE126506T1/de not_active IP Right Cessation
1992
- 1992-12-03 RU RU9292004575A patent/RU2083561C1/ru not_active IP Right Cessation
1993
- 1993-05-19 US US08/064,539 patent/US5397799A/en not_active Expired - Lifetime
- 1993-06-08 LV LVP-93-509A patent/LV10251B/xx unknown
1995
- 1995-11-01 GR GR950403048T patent/GR3017940T3/el unknown
- 1995-11-16 HK HK175495A patent/HK175495A/xx not_active IP Right Cessation
1996
- 1996-04-05 CY CY188796A patent/CY1887A/xx unknown

Also Published As

Publication number	Publication date
DK0444852T3 (da)	1995-12-11
IE910625A1 (en)	1991-08-28
IE67801B1 (en)	1996-05-01
EP0444852A3 (en)	1992-02-19
IL97306A (en)	1996-10-16
FI95464B (fi)	1995-10-31
US5397799A (en)	1995-03-14
RU2034837C1 (ru)	1995-05-10
NO910735D0 (no)	1991-02-25
FI910895A0 (fi)	1991-02-25
JP3157007B2 (ja)	2001-04-16
AU7197191A (en)	1991-08-29
ATE126506T1 (de)	1995-09-15
DE69112099D1 (de)	1995-09-21
RU2083561C1 (ru)	1997-07-10
CY1887A (en)	1996-04-05
YU47594B (sh)	1995-10-24
DE69112099T2 (de)	1996-02-08
NO174149C (no)	1994-03-23
LV10251A (lv)	1994-10-20
EP0444852B1 (en)	1995-08-16
EP0444852A2 (en)	1991-09-04
BR9100767A (pt)	1991-10-29
PT96852A (pt)	1991-10-31
CA2037099A1 (en)	1991-08-27
TW219933B (xx)	1994-02-01
ZA911258B (en)	1992-10-28
FI910895A (fi)	1991-08-27
AU629453B2 (en)	1992-10-01
CN1027503C (zh)	1995-01-25
HUT56542A (en)	1991-09-30
GR3017940T3 (en)	1996-02-29
JPH04217662A (ja)	1992-08-07
KR910021375A (ko)	1991-12-20
HU217118B (hu)	1999-11-29
ES2077796T3 (es)	1995-12-01
YU32791A (sh)	1994-01-20
NZ237181A (en)	1992-06-25
NO174149B (no)	1993-12-13
CN1054589A (zh)	1991-09-18
CA2037099C (en)	2001-09-11
NO910735L (no)	1991-08-27
IL97306A0 (en)	1992-05-25
PT96852B (pt)	1998-07-31
SG69975A1 (en)	2000-01-25
KR100208114B1 (ko)	1999-07-15
HK175495A (en)	1995-11-24
FI95464C (fi)	1996-02-12

Publication	Publication Date	Title
LV10251B (en)	1995-04-20	Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d\|indole
IE782325L (en)	1979-05-25	TETRAHYDROBENZ £cd\| INDOLES
AU2378988A (en)	1989-04-20	4-(N-3-pyridylmethyl)-amino-1,2,4-triazinones
AU3430689A (en)	1989-10-05	Prevention of lens-related tissue growth in the eye
TW239862B (xx)	1995-02-01
AU7941691A (en)	1992-01-02	Antimigraine alkoxypyrimidine derivatives
AU3122789A (en)	1989-09-28	Skin improving composition and method using GLA and/or DGLA
EP0485218A3 (en)	1992-10-28	Process for preparing (1'r,3s)-3-(1'-hydroxy-ethyl)-azetidin-2-one and derivatives thereof
RU92004575A (ru)	1995-09-27	Кристаллическая соль 4-(ди-н-пропил) амино-6-аминокарбонил-1,3,4,5-тетрагидробенз (cd) индола и ее 4p и 4s-изомеры
AU623688B2 (en)	1992-05-21	Substituted 1,4-dihydro-4-oxo-1-pyrodinyl- (quinoline or naphthyridine) derivatives
EP0462837A3 (en)	1992-09-23	Preparation of indole derivatives
AU7418887A (en)	1987-12-17	Indole derivatives
AU6682686A (en)	1987-06-25	3-(2-aminoethyl) indoles derivatives
PH23992A (en)	1990-02-09	Optically active 2,3-dihydrobenzoxazine derivatives and process for preparing the same
AU590603B2 (en)	1989-11-09	A method of preparing indoles or indole derivatives, coupled via position 4, 5, 6, or 7, the indoles or indole derivatives concerned, as well as the use thereof
AU1951388A (en)	1989-10-05	Method of sterilizing anthers utilizing carboxylic acid derivatives
AU609158B2 (en)	1991-04-26	Method of sterilizing anthers utilizing substituted maleamino acids
AU7983787A (en)	1988-04-21	Wheelchair having seated & upright modes
EP0275104A3 (en)	1989-08-30	Process for preparing 2,3-dihydro-1h-imidazolylalkoxyindene derivatives and pharmaceutically acceptable salts
PL274219A1 (en)	1990-02-19	Method of obtaining novel derivatives of 4-oxo-1,2,3,4-tetrahydrocinnoline
IE862252L (en)	1987-02-23	"a method of preparing indoles or indole derivatives,¹coupled via position 4,5,6, or 7, the indoles or indole¹derivatives concerned, as well as the use thereof"