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KR920007995A - 벤즈아미드 유도체 - Google Patents

벤즈아미드 유도체

Info

Publication number
KR920007995A
KR920007995A KR1019910018181A KR910018181A KR920007995A KR 920007995 A KR920007995 A KR 920007995A KR 1019910018181 A KR1019910018181 A KR 1019910018181A KR 910018181 A KR910018181 A KR 910018181A KR 920007995 A KR920007995 A KR 920007995A
Authority
KR
South Korea
Prior art keywords
lower alkyl
general formula
hydrogen atom
benzamide
benzamide derivatives
Prior art date
Application number
KR1019910018181A
Other languages
English (en)
Other versions
KR100209118B1 (ko
Inventor
히로미치 후지와라
아끼히꼬 오가와
히데요 사끼야마
도시아끼 다무라
Original Assignee
시누치 다다미
데이코쿠 케미컬 인더스트리 컴패니 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 시누치 다다미, 데이코쿠 케미컬 인더스트리 컴패니 리미티드 filed Critical 시누치 다다미
Publication of KR920007995A publication Critical patent/KR920007995A/ko
Application granted granted Critical
Publication of KR100209118B1 publication Critical patent/KR100209118B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

내용 없음

Description

벤즈아미드 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식으로 표현되는 벤즈아미드 유도체 :
    상기식에서, R1은 수소원자, 저급알킬, 할로겐 치환 저급알킬 또는 아랄킬기이고; R2는 수소원자 또는 저급 알킬기이다.
  2. 하기 일반식으로 표현되는 벤즈아미드 유도체 :
  3. 히기 일반식으로 표현되는 (2'S,4'S)-벤즈아미드 유도체 :
  4. 하기 일반식의 벤즈아미드 유도체 또는 이것의 산부가염 및 약제학적으로 수용할 수 있는 담체를 포함하는 약제 조성물 :
    상기식에서, R1은 수소원자, 저급알킬, 할로겐 치환된 저급알킬 또는 아랄킬기이고; R2는 수소원자 또는 저급알킬기이다.
  5. 위장관의 활성을 촉진시키기 위한 제제로서 제4항의 약제조성물의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019910018181A 1990-10-16 1991-10-16 벤즈아미드 유도체 KR100209118B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP277976/90 1990-10-16
JP27797690 1990-10-16

Publications (2)

Publication Number Publication Date
KR920007995A true KR920007995A (ko) 1992-05-27
KR100209118B1 KR100209118B1 (ko) 1999-07-15

Family

ID=17590893

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910018181A KR100209118B1 (ko) 1990-10-16 1991-10-16 벤즈아미드 유도체

Country Status (9)

Country Link
US (1) US5143935A (ko)
EP (1) EP0481756B1 (ko)
JP (1) JP2529912B2 (ko)
KR (1) KR100209118B1 (ko)
AT (1) ATE155127T1 (ko)
DE (1) DE69126758T2 (ko)
DK (1) DK0481756T3 (ko)
ES (1) ES2106058T3 (ko)
TW (1) TW228520B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7665694A (en) * 1993-09-21 1995-04-10 Yamanouchi Pharmaceutical Co., Ltd. N-(3-pyrrolidinyl)benzamide derivative
KR100333501B1 (ko) * 2000-01-19 2002-04-25 박호군 벤즈아미드 화합물 및 그 제조방법
EP1547593A4 (en) * 2002-09-12 2009-12-23 Nagase Chemtex Corp MEDICINAL COMPOSITION
JP4760139B2 (ja) * 2004-05-28 2011-08-31 田辺三菱製薬株式会社 ピロリジン誘導体およびその製法
TW200602314A (en) * 2004-05-28 2006-01-16 Tanabe Seiyaku Co A novel pyrrolidine compound and a process for preparing the same
KR100881040B1 (ko) * 2005-03-11 2009-02-05 나가세케무텍쿠스가부시키가이샤 의약 조성물
JP4943826B2 (ja) * 2005-11-25 2012-05-30 田辺三菱製薬株式会社 医薬組成物
JP2010031063A (ja) * 2009-11-18 2010-02-12 Nagase Chemtex Corp 医薬組成物
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
WO2024077078A2 (en) * 2022-10-05 2024-04-11 The Research Foundation For The State University Of New York Sterylglucosidase inhibiting compositions and method of using

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593146A (en) * 1976-11-05 1981-07-15 Beecham Group Ltd Octahydro-quinolizinyl benzamide derivatives
US4143150A (en) * 1977-08-19 1979-03-06 A. H. Robins Company, Inc. Derivatives of oxanilic acid
DE2855853C2 (de) * 1978-12-22 1986-09-11 Yamanouchi Pharmaceutical Co., Ltd., Tokio/Tokyo N-(1-Benzyl-2-methyl-3-pyrrolidinyl)-5-chlor-2-methoxy-4-methylaminobenzamid dessen Säureadditionssalze, Verfahren zu deren Herstellung und ihre Verwendung
GB8718346D0 (en) * 1987-08-03 1987-09-09 Fordonal Sa Substituted benzamides
IT1216120B (it) * 1988-03-17 1990-02-22 Poli Ind Chimica Spa Derivati n_cicloalchilaminoetilbenzamidici, loro preparazione e composizioni farmaceutiche che li contengono.

Also Published As

Publication number Publication date
KR100209118B1 (ko) 1999-07-15
DK0481756T3 (da) 1998-02-16
US5143935A (en) 1992-09-01
JP2529912B2 (ja) 1996-09-04
EP0481756B1 (en) 1997-07-09
JPH0517434A (ja) 1993-01-26
EP0481756A2 (en) 1992-04-22
ATE155127T1 (de) 1997-07-15
ES2106058T3 (es) 1997-11-01
DE69126758T2 (de) 1998-02-12
TW228520B (ko) 1994-08-21
DE69126758D1 (de) 1997-08-14
EP0481756A3 (en) 1992-08-26

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