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KR860004036A - 트리아졸 유도체의 제조방법 - Google Patents

트리아졸 유도체의 제조방법 Download PDF

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Publication number
KR860004036A
KR860004036A KR1019850008862A KR850008862A KR860004036A KR 860004036 A KR860004036 A KR 860004036A KR 1019850008862 A KR1019850008862 A KR 1019850008862A KR 850008862 A KR850008862 A KR 850008862A KR 860004036 A KR860004036 A KR 860004036A
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KR
South Korea
Prior art keywords
sub
formula
substituents
phenyl group
independently selected
Prior art date
Application number
KR1019850008862A
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English (en)
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KR870001381B1 (ko
Inventor
켈빈 쿠퍼(외 2) 닥터
Original Assignee
윌리암 죤 윌슨
화이자 코포레이션
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Application filed by 윌리암 죤 윌슨, 화이자 코포레이션 filed Critical 윌리암 죤 윌슨
Publication of KR860004036A publication Critical patent/KR860004036A/ko
Application granted granted Critical
Publication of KR870001381B1 publication Critical patent/KR870001381B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

트리아졸 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 하기 일반식(II)의 케톤을 일반식 Q1MgBr, Q1MgI 또는 Q1Li(여기서, Q1은 Q가 R일 경우 R1이고, Q가 R1일 경우 R이다)의 시약과 반응시켜 X가 -OH인 일반식(I)의 화합물을 제조하거나, 수득된 생성물을 티오닐 클로라이드, 티오닐브로마이드 또는 디에틸아미노설퍼 트리플루오라이드와 반응시켜 각각 X가 Cl, Br 또는 F인 하기일반식(I)의 화합물로 전환시키거나, 수득된 생성물을 O-에스테르 또는 O-에테르로 전환시키고/시키거나; 하기 일반식(I)의 의 생성물을 제약학적으로나 농업적으로 허용되는 염으로 전환시킴을 특징으로하여, 하기 일반식(I)의 화합물이거나 X가 -OH인 이 화합물의 O-에스테르 또는 O-에테르, 또는 이들의 제약학적으로나 농업적으로 허용되는 염을 제조하는 방법.
    상기 일반식에서, R은 F,Cl,Br,I,CF,C1-C4알킬 및 C1-C4알콕시 중에서 각각 독립적으로 선택한 1 내지 3개의 치환체들에 의해 임의 치환된 페닐 그룹, 또는 5-클로로피리드-2-일 그룹이고; R1은 F,Cl,Br,I,CF3,C1-C4알킬 및 C1-C4알콕시 중에서 각각 독립적으로 선택한 1 내지 3개의 치환체들에 이해 임의 치환된 페닐그룹이고; X는 -OH, -F, -Cl 또는 -Br이다.
  2. 제1항에 있어서, R 및 R1이 각각 독립적으로, F,Cl,Br,I 및 CF3중에서 각각 독립적으로 선택한 1 내지 3개의 치환체에 의해 임의 치환된 페닐그룹인 방법.
  3. 제2항에 있어서, R 및 R1이 각각 독립적으로, F 및 Cl중에서 각각 독립적으로 선택한 1개 또는 2개의 치환체에 의해 치환된 페닐그룹인 방법.
  4. 제3항에 있어서, R 및 R1이 각각 독립적으로 2,4-디플루오로페닐, 4-플루오로페닐 또는 4-클로로페닐인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850008862A 1984-11-27 1985-11-27 트리아졸유도체의 제조방법 KR870001381B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB29932 1984-11-27
GB848429932A GB8429932D0 (en) 1984-11-27 1984-11-27 Triazole antifungal agents
GB84.29932 1984-11-27

Publications (2)

Publication Number Publication Date
KR860004036A true KR860004036A (ko) 1986-06-16
KR870001381B1 KR870001381B1 (ko) 1987-07-24

Family

ID=10570335

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850008862A KR870001381B1 (ko) 1984-11-27 1985-11-27 트리아졸유도체의 제조방법

Country Status (19)

Country Link
US (1) US4767777A (ko)
EP (1) EP0183494B1 (ko)
JP (1) JPS61137868A (ko)
KR (1) KR870001381B1 (ko)
AT (1) ATE39923T1 (ko)
AU (1) AU556517B2 (ko)
CA (1) CA1276935C (ko)
DE (1) DE3567455D1 (ko)
DK (1) DK162990C (ko)
ES (1) ES8607258A1 (ko)
FI (1) FI854660A (ko)
GB (1) GB8429932D0 (ko)
GR (1) GR852833B (ko)
HU (1) HUT41394A (ko)
IE (1) IE58146B1 (ko)
IL (1) IL77151A0 (ko)
PH (1) PH21332A (ko)
PL (1) PL145094B1 (ko)
PT (1) PT81556B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8414519D0 (en) * 1984-06-07 1984-07-11 Pfizer Ltd Triazole antifungal agents
GB8511344D0 (en) * 1985-05-03 1985-06-12 Ici Plc Heterocyclic compounds
DE3608727A1 (de) * 1986-03-15 1987-09-17 Hoechst Ag 1,1-disubstituierte cyclopropanderivate, verfahren zu ihrer herstellung sowie ihre verwendung als antimykotika oder als zwischenprodukte
US5247094A (en) * 1990-01-24 1993-09-21 Bayer Aktiengesellschaft 1-(3- or 5-halo-1,2,4-triazol-1-yl)ethyl phenyl ketone intermediates
US5223178A (en) * 1990-12-10 1993-06-29 Rohm And Haas Company Use of certain triazoles to protect materials from fungal attack, articles and compositions
EP0597049A1 (en) * 1992-03-04 1994-05-18 Jemlan, Inc. Antifungal agents
TWI290549B (en) * 2000-06-02 2007-12-01 Astrazeneca Ab Process for the preparation of cyclopropyl carboxylic acid ester and derivatives
AR075257A1 (es) 2008-02-01 2011-03-23 Hexima Ltd Sistema de proteccion de plantas contra la infeccion por agentes patogenos
US9889184B2 (en) 2008-08-05 2018-02-13 Hexima Limited Anti-pathogen systems
BR112013020131A8 (pt) 2011-02-07 2018-01-09 Hexima Ltd defensinas de plantas modificadas úteis como agentes antipatogênicas

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH658654A5 (de) * 1983-03-04 1986-11-28 Sandoz Ag Azolderivate, verfahren zu ihrer herstellung und mittel die diese verbindungen enthalten.
NL8402755A (nl) * 1983-09-22 1985-04-16 Sandoz Ag Azool-derivaten, werkwijze voor het bereiden daarvan, preparaten die ze bevatten, en toepassing daarvan.
GB8414519D0 (en) * 1984-06-07 1984-07-11 Pfizer Ltd Triazole antifungal agents
DE3440114A1 (de) * 1984-11-02 1986-05-07 Bayer Ag, 5090 Leverkusen Antimykotische mittel
CN1008735B (zh) * 1984-11-02 1990-07-11 拜尔公司 以取代的氮杂茂基甲基-环丙基-甲醇衍生物为活性成分的组合物

Also Published As

Publication number Publication date
AU556517B2 (en) 1986-11-06
PH21332A (en) 1987-10-13
KR870001381B1 (ko) 1987-07-24
PT81556A (en) 1985-12-01
JPS61137868A (ja) 1986-06-25
GR852833B (ko) 1986-03-27
US4767777A (en) 1988-08-30
DK162990B (da) 1992-01-06
ATE39923T1 (de) 1989-01-15
HUT41394A (en) 1987-04-28
FI854660A0 (fi) 1985-11-26
GB8429932D0 (en) 1985-01-03
DK545385D0 (da) 1985-11-26
EP0183494A3 (en) 1986-12-30
PT81556B (pt) 1988-03-03
EP0183494B1 (en) 1989-01-11
PL256439A1 (en) 1987-02-23
DK162990C (da) 1992-05-25
DK545385A (da) 1986-05-28
CA1276935C (en) 1990-11-27
FI854660A (fi) 1986-05-28
IE58146B1 (en) 1993-07-14
AU5035985A (en) 1986-06-05
PL145094B1 (en) 1988-08-31
ES8607258A1 (es) 1986-05-16
EP0183494A2 (en) 1986-06-04
IE852970L (en) 1986-05-27
ES549298A0 (es) 1986-05-16
JPH0533702B2 (ko) 1993-05-20
DE3567455D1 (en) 1989-02-16
IL77151A0 (en) 1986-04-29

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